Cited by 899Memory and Neural MechanismsMemory Processes and InfluencesCognitive Functions and Memory

Multiple routes to memory: distinct medial temporal lobe processes build item and source memories

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Davachi, Lila, Mitchell, Jason P., Wagner, Anthony D.·2003·Proceedings of the National Academy of Sciences

Abstract

A central function of memory is to permit an organism to distinguish between stimuli that have been previously encountered and those that are novel. Although the medial temporal lobe (which includes the hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortices) is known to be crucial for recognition memory, controversy remains regarding how the specific subregions within the medial temporal lobe contribute to recognition. We used event-related functional MRI to examine the relation between activation in distinct medial temporal lobe subregions during memory formation and the ability (i) to later recognize an item as previously encountered (item recognition) and (ii) to later recollect specific contextual details about the prior encounter (source recollection). Encoding activation in hippocampus and in posterior parahippocampal cortex predicted later source recollection, but was uncorrelated with item recognition. In contrast, encoding activation in perirhinal cortex predicted later item recognition, but not subsequent source recollection. These outcomes suggest that the subregions within the medial temporal lobe subserve distinct, but complementary, learning mechanisms.

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Authors
Davachi, L., Mitchell, J. P., & Wagner, A. D.
Affiliations
Harvard University (US)
Venue
Proceedings of the National Academy of Sciences
Published
2003-02-10
Volume
100
Issue
4
Pages
2157-2162
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2153591523
Cited by
899
References
72
Citations by year
2026: 10 · 2025: 16 · 2024: 20 · 2023: 28 · 2022: 17 · 2021: 18 · 2020: 36 · 2019: 36 · 2018: 30 · 2017: 57 · 2016: 30 · 2015: 46 · 2014: 37 · 2013: 40 · 2012: 50
FWCI
24.33
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (F32MH012793, MH 60941, MH12793, R01MH060941)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
medial temporal lobe, recognition memory, item recognition, source memory, recollection, hippocampus, parahippocampal cortex, perirhinal cortex, entorhinal cortex, memory encoding, memory formation
MeSH terms
Adolescent, Adult, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Task Performance and Analysis, Temporal Lobe

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