Behavioral and endocrine effects of chronic exposure to low doses of chlorobenzenes in Wistar rats
Abstract
Chlorobenzenes have often been applied to study persistent organic pollutants with endocrine disruptor effects (POP/EDCs), but with the focus mainly on physiological aspects. Few data exist on the effects of chlorobenzenes and most POP/EDCs on anxiety or other arginine-vasopressin (AVP)- and oxytocin (OXT)-mediated behavior, albeit exposure to POP/EDCs or their ambient mixtures, even in low doses, may pose health risks for subjects living in contaminated areas and/or consuming polluted food. Our primary aim was therefore to demonstrate behavioral effects of longterm exposure to a discrete dose of a chlorobenzene mixture, and to draw attention to the results of subtoxic oral exposure on anxiety-related elements and the possible underlying endocrine processes. Adult male Wistar rats were treated daily with a mixture (ClB) of 1 μg/kg each of hexachlorobenzene and 1,2,4-trichlorobenzene via a gastric tube for 30, 60 or 90 days. After exposure, anxiety-related behavioral elements were determined in open-field and elevated plus maze tests. At euthanasia, the plasma levels of AVP, OXT and adrenocorticotrophic hormone (ACTH) were measured. Simultaneously, pituicytes from subjects were cultured to study the levels of basal and serotonin- or norepinephrinestimulated AVP and OXT secretion. Various anxiety-related behavioral elements were observed to be increased in both tests. The plasma AVP, OXT and ACTH concentrations were increased, to extents depending on the duration of exposure. T…
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Long-term exposure to chlorobenzenes may disrupt neurohypophysial AVP and OT release.
“A single paper also suggests that long-term exposure to chlorobenzenes (solvents) may also disrupt neurohypophysial AVP and OT release (149).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [149]
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- Authors
- Nagyeri, G., Valkusz, Z., Radacs, M., Ocsko, T., Hausinger, P., Laszlo, M., Laszlo, F. A., Juhasz, A., Julesz, J., & Galfi, M.
- Affiliations
- University of Szeged (HU)
- Venue
- Neurotoxicology and Teratology
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 34
- Issue
- 1
- Pages
- 9-19
- ISSN
- 0892-0362 (ISSN-L)
- OpenAlex
- W1989298345
- Cited by
- 17
- References
- 65
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2019: 2 · 2017: 3 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurotoxicology and Teratology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Food and Drug Administration
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- chlorobenzene, hexachlorobenzene, 1,2,4-trichlorobenzene, persistent organic pollutants, endocrine disruptors, anxiety-like behavior, vasopressin, oxytocin, ACTH, pituicytes, serotonin, norepinephrine, chronic low-dose exposure, elevated plus maze, open field test, Wistar rats
- MeSH terms
- Animals, Anxiety Disorders, Behavior, Animal, Chlorobenzenes, Chronic Disease, Disease Models, Animal, Dose-Response Relationship, Drug, Environmental Exposure, Hypothalamo-Hypophyseal System, Male, Rats, Wistar, Coculture Techniques, Rats, Primary Cell Culture
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