CoChat
Sign Up
Cited by 98Fatty Acid Research and HealthNutritional Studies and DietCardiac Health and Mental Health

Effects of Omega-3 fatty acid on major cardiovascular events and mortality in patients with coronary heart disease: A meta-analysis of randomized controlled trials

Wen, Y.T., Dai, J.H., Gao, Q.·2014·Nutrition, Metabolism and Cardiovascular Diseases
DOI 10.1016/j.numecd.2013.12.004
Open this paper in CoChat — free account

Abstract

Aim There is considerable discrepancy regarding the protective effects of Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) in patients with coronary heart disease (CHD) from the early-phase clinical randomized controlled trials (RCTs). We conducted a meta-analysis of RCTs to address this issue.Data synthesis Pubmed, the Cochrane Central Register of Controlled Trials, and EMBASE databases (∼ May 2013) were systematically searched. Odds ratios (OR) and associated 95% CI were retrieved by using random-effect model according to heterogeneity. A total of 14 RCTs involving 16,338 individuals in the Omega-3 PUFAs group and 16,318 in the control group were identified. Patients assigned to Omega-3 PUFAs did not demonstrate satisfactory improvements on major cardiovascular events (OR, 0.93; 95% CI, 0.86 to 1.01; P = 0.08; I(2) = 46%). By contrast, the reduced risks of death from cardiac causes, sudden cardiac death and death from all causes (OR, 0.88; 95% CI, 0.80 to 0.96; P = 0.003; I(2) = 0%; OR, 0.86; 95% CI, 0.76 to 0.98; P = 0.03; I(2) = 29%; and OR, 0.92; 95% CI, 0.85 to 0.99; P = 0.02; I(2) = 6%; respectively) were shown.Conclusions Supplement of Omega-3 PUFAs in patients with CHD is not associated with a protective effect on major cardiovascular events, while it does exert beneficial effects in reducing death from cardiac causes, sudden cardiac death and death from all causes. However, with currently available cardio-protective therapies, whether dietary supplementation with Omega-3 PUFAs should be still considered in patients with CHD is currently debated.

Integrity signals

Registry

Crossref · 10.1016/j.numecd.2013.12.004

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Wen, Y. T., Dai, J. H., & Gao, Q.
Affiliations
  • Nanjing University (CN)
  • Nanjing Drum Tower Hospital (CN)
Corresponding author
Gao, Q.
ORCID
Venue
Nutrition, Metabolism and Cardiovascular Diseases
Publisher
Elsevier BV
Published
2014-05
Volume
24
Issue
5
Pages
470-475
ISSN
0939-4753 (ISSN-L)
DOI
10.1016/j.numecd.2013.12.004
OpenAlex
W1981591363
Cited by
98
References
40
Citations by year
2025: 4 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 18 · 2015: 12 · 2014: 4
FWCI
1.28
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nutrition Metabolism and Cardiovascular Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education of the People's Republic of China (20110091120031)
  • Ministry of Science and Technology of the People's Republic of China (2009CB918704)
  • National Natural Science Foundation of China (81030013, 81100386)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
omega-3 polyunsaturated fatty acids, coronary artery disease, cardiovascular events, mortality, sudden cardiac death, cardiovascular mortality, all-cause mortality, dietary supplementation, cardioprotection
MeSH terms
Coronary Disease, Humans, Fatty Acids, Omega-3, Randomized Controlled Trials as Topic, Databases, Factual, Death, Sudden, Cardiac, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review