Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes
Abstract
For thousands of years, cinnamon has been used as a traditional treatment in China. However, there are no studies to date that investigate whether cinnamon supplements are able to aid in the treatment of type 2 diabetes in Chinese subjects. We hypothesized cinnamon should be effective in improving blood glucose control in Chinese patients with type 2 diabetes. To address this hypothesis, we performed a randomized, double-blinded clinical study to analyze the effect of cinnamon extract on glycosylated hemoglobin A(1c) and fasting blood glucose levels in Chinese patients with type 2 diabetes. A total of 66 patients with type 2 diabetes were recruited and randomly divided into 3 groups: placebo and low-dose and high-dose supplementation with cinnamon extract at 120 and 360 mg/d, respectively. Patients in all 3 groups took gliclazide during the entire 3 months of the study. Both hemoglobin A(1c) and fasting blood glucose levels were significantly reduced in patients in the low- and high-dose groups, whereas they were not changed in the placebo group. The blood triglyceride levels were also significantly reduced in the low-dose group. The blood levels of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and liver transaminase remained unchanged in the 3 groups. In conclusion, our study indicates that cinnamon supplementation is able to significantly improve blood glucose control in Chinese patients with type 2 diabetes.
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Most clinical trials administering cinnamon as extracts, capsules or supplements at 0.5 g to 6 g per day in subjects with T2DM have reported a generally favorable effect of cinnamon on postprandial/fasting hyperglycemia and diurnal glucose fluctuations.
“Most of the studies have reported a generally favorable effect of cinnamon on postprandial/fasting hyperglycemia and diurnal glucose fluctuations [368,369,370,371,372,373,374,375].”
From Effects of diet, lifestyle, Chrononutrition and alternative dietary interventions on postprandial Glycemia and insulin resistance (2022) · cites this paper as [372]
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- Authors
- Lu, T., Sheng, H., Wu, J., Cheng, Y., Zhu, J., & Chen, Y.
- Affiliations
- Jiangsu University (CN)
- Shanghai Xuhui Central Hospital (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Chen, Yan
- Venue
- Nutrition Research
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 32
- Issue
- 6
- Pages
- 408-412
- ISSN
- 0271-5317 (ISSN-L)
- OpenAlex
- W2033747510
- Cited by
- 178
- References
- 13
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 20 · 2021: 22 · 2020: 15 · 2019: 14 · 2018: 14 · 2017: 11 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 5 · 2012: 1
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- cinnamon extract, type 2 diabetes, fasting blood glucose, HbA1c, glycemic control, dietary supplementation, gliclazide, triglycerides, Chinese patients
- MeSH terms
- Aged, Blood Glucose, China, Cinnamomum zeylanicum, Diabetes Mellitus, Type 2, Double-Blind Method, Fasting, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Cholesterol, HDL, Cholesterol, LDL, Middle Aged, Plant Extracts, Dietary Supplements, Asian People
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