CoChat
Sign Up
Cited by 415Temporomandibular Joint DisordersMenstrual Health and DisordersSalivary Gland Disorders and Functions

Changes in temporomandibular pain and other symptoms across the menstrual cycle

LeResche, Linda, Mancl, Lloyd, Sherman, Jeffrey J, Gandara, Beatrice, Dworkin, Samuel F·2003·Pain
DOI 10.1016/j.pain.2003.06.001
Open this paper in CoChat — free account

Abstract

The objective of this study was to assess changes in levels of clinical temporomandibular (TMD) pain in relation to phases of the menstrual cycle. TMD cases were 35 women not using oral contraceptives (OCs); 35 women using OCs; and 21 men. Controls were 35 normally cycling women without TMD or other chronic pains. Subjects kept daily diaries over three menstrual cycles, reporting average and worst pain, general and premenstrual symptoms. Data were subject-centered and de-trended using the residuals from a random-effects linear regression model. To test for cyclic variation, cycles were standardized to 28 days and data were grouped into 9 periods/cycle (Days 1-3, 4-6, em leader, 22-24, 25-28). Overall levels of average pain, worst pain and symptoms did not differ across TMD subject groups. For worst pain, multivariate analysis of variance revealed a statistically significant difference across 3-day periods for normally cycling women with TMD (P=0.011) and for women using OCs (P=0.017). In both groups, TMD pain levels rose toward the end of the cycle and peaked during menstruation. In women not using OCs, there was a secondary pain peak at Days 13-15, around the time of ovulation. This peak was not seen in women using OCs. There was no statistically significant difference over time periods for men (P=0.94). Similar patterns were found for average pain, as well as PMS symptoms and general somatic symptoms. These results suggest that TMD pain in women is highest at times of lowest estrogen, but rapid estrogen change may also be associated with increased pain.

Integrity signals

Registry

Crossref · 10.1016/j.pain.2003.06.001

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Asian Americans report greater daily joint pain intensity than non-Hispanic whites and show enhanced sensitivity to thermal and mechanical pain stimuli in the laboratory.

    “Similar findings have been noted for Asian Americans, who report a greater intensity of daily joint pain than non-Hispanic whites, and who demonstrate enhanced sensitivity to thermal and mechanical pain stimuli applied in a laboratory setting 225, 226.”

    From Evaluating psychosocial contributions to chronic pain outcomes (2018) · cites this paper as [225]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
LeResche, L., Mancl, L., Sherman, J. J., Gandara, B., & Dworkin, S. F.
Affiliations
University of Washington (US)
Corresponding author
LeResche, Linda
ORCID
Mancl, Lloyd
Venue
Pain
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-12
Volume
106
Issue
3
Pages
253-261
ISSN
0304-3959 (ISSN-L)
DOI
10.1016/j.pain.2003.06.001
OpenAlex
W2004934852
Cited by
415
References
30
Citations by year
2026: 8 · 2025: 12 · 2024: 14 · 2023: 9 · 2022: 13 · 2021: 16 · 2020: 16 · 2019: 19 · 2018: 24 · 2017: 14 · 2016: 23 · 2015: 14 · 2014: 30 · 2013: 17 · 2012: 25
FWCI
32.18
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01de012470-05)
  • National Institute of Dental and Craniofacial Research (R01 DE 12470)
Topics
  • Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
  • Health Sciences › Medicine › Physiology › Salivary Gland Disorders and Functions
Keywords
temporomandibular disorders, menstrual cycle, oral contraceptives, premenstrual symptoms, ovulation, estrogen, somatic symptoms
MeSH terms
Adult, Analysis of Variance, Female, Humans, Male, Medical Records, Menstrual Cycle, Pain Measurement, Prospective Studies, Temporomandibular Joint Disorders, Chi-Square Distribution, Statistics, Nonparametric

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review