The DOI matches its Crossref record; 54 of the 56 references it cites were found in a registry or an index.
Peripheral and central components of habituation of heat pain perception and evoked potentials in humans
Abstract
For the neurophysiological examination of nociceptive pathways, contact-heat evoked potentials (contact-heat EPs) are elicited by repetitive brief noxious heat stimuli. Suppression of heat responses in primary nociceptive neurons during repetitive stimulation has been shown in animal models in vivo and in vitro. We now investigated whether heat pain and contact-heat EPs in humans display equivalent signs of habituation. Heat pain and EPs were elicited in 16 volunteers with a contact thermode (30 degrees Cs(-1)). Heat pulses at three intensities (pain threshold, moderate noxious and maximum available) were applied to the right forearm either by moving the thermode after each pulse to variable locations or when fixed to one location (inter-stimulus intervals 8-10s). Contact-heat EPs consisted of an early negativity in temporal leads (N1), followed by a biphasic response at the vertex (N2-P2). Pain ratings and contact-heat EPs (N1 and N2-P2 components) displayed significant temperature dependence. N2-P2 correlated positively with ratings. With stimulation at variable locations, both measures slowly decreased with time constants tau of 2 min (ratings) and 12 min (EPs). With stimulation at a fixed location, habituation was much faster for both, ratings (tau=10s) and EPs (tau=33 s). As a consequence, both measures were significantly reduced (p<0.005) leading to a rightward shift of the stimulus-response function by 5 degrees C. In conclusion, human heat pain perception and contact-heat EPs display signs of rapid habituation when stimulation is restricted to a fixed location and thus, reflect fatigue of peripheral nociceptive neurons. Habituation within the central nervous system is slower and less pronounced.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, it is important to note that responses to a cue could change over the course of the experimental session due to factors such as fatigue, habituation or learning23–28.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [23]
Citations
Cites
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Keeping pain out of mind: The role of the dorsolateral prefrontal cortex in pain modulation
Lorenz, J., Minoshima, S., & Casey, K. L. (2003) · Brain · doi:10.1093/brain/awg102 · Cited by 952
Peripheral and central mechanisms of cutaneous hyperalgesia
Treede, R., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90027-c · Cited by 917
Self-citationWind-up of spinal cord neurones and pain sensation: much ado about something?
Herrero, J. F., Laird, J. M. A., & Lopez-Garcia, J. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00051-9 · Cited by 714
Price, D. D., Hu, J. W., Dubner, R. A., & Gracely, R. H. (1977) · Pain · doi:10.1016/0304-3959(77)90035-5 · Cited by 589
Brain generators of laser-evoked potentials: from dipoles to functional significance
Garcia-Larrea, L., Frot, M., & Valeriani, M. (2003) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/j.neucli.2003.10.008 · Cited by 541
EFNS guidelines on neuropathic pain assessment
Cruccu, G., Anand, P., Attal, N., García-Larrea, L., Haanpää, M. L., Jørum, E., Serra, J., & Jensen, T. S. (2004) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00791.x · Cited by 534
LaMotte, R. H., & Campbell, J. N. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.2.509 · Cited by 456
Cited by
Sorted by citations
Items 101–200 of 226
Somatotopic organization of brainstem analgesic circuitry
Crawford, L. S., Mendoza, F. A. T., Robertson, R. V., Meylakh, N., Macey, P. M., Bannister, K., Wager, T. D., Macefield, V. G., Keay, K. A., & Henderson, L. A. (2025) · Science · doi:10.1126/science.adu8846 · Cited by 20
Enax‐Krumova, E., Plaga, A.-C., Schmidt, K., Özgül, Ö. S., Eitner, L., Tegenthoff, M., & Höffken, O. (2020) · Brain Sciences · doi:10.3390/brainsci10100684 · Cited by 17
Repetitive ipsilateral painful A ‐delta fibre stimuli induce bilateral LEP amplitude habituation
Hüllemann, P., Mahn, F., Shao, Y., Watfeh, R., Wasner, G. L., Binder, A., & Baron, R. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00335.x · Cited by 17
Reches, A., Nir, R., Shram, M. J., Dickman, D., Laufer, I., Shani‐Hershkovich, R., Stern, Y., Weiss, M., Yarnitsky, D., & Geva, A. B. (2015) · European Journal of Pain · doi:10.1002/ejp.716 · Cited by 16
Dangers, L., Laviolette, L., Similowski, T., & Morélot‐Panzini, C. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00358 · Cited by 15
Normothermic Mouse Functional MRI of Acute Focal Thermostimulation for Probing Nociception
Reimann, H. M., Hentschel, J., Marek, J., Huelnhagen, T., Todiraş, M., Kox, S., Waiczies, S., Hodge, R., Bäder, M., Pohlmann, A., et al. (2016) · Scientific Reports · doi:10.1038/srep17230 · Cited by 16
Is touch gating due to sensory or cognitive interference?
Harper, D., & Hollins, M. (2012) · Pain · doi:10.1016/j.pain.2012.02.011 · Cited by 19
Albu, S., & Meagher, M. W. (2019) · Experimental Brain Research · doi:10.1007/s00221-019-05545-8 · Cited by 18
Linde, L. D., Haefeli, J., Jutzeler, C. R., Rösner, J., McDougall, J., Curt, A. E. P., & Kramer, J. L. K. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00459 · Cited by 16
Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions
van der Miesen, M. M., Vossen, C. J., & Joosten, E. A. J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134305 · Cited by 15
Test-Retest Reliability of Thermal Temporal Summation Using an Individualized Protocol
Kong, J., Johnson, K. A., Balise, R. R., & Mackey, S. (2012) · F1000Research · doi:10.7490/f1000research.1090773.1 · Cited by 15
The neuroscience of vision and pain: evolution of two disciplines
Finlay, B. L. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0292 · Cited by 15
Central habituation and distraction alter C‐fibre‐mediated laser‐evoked potential amplitudes
Hüllemann, P., Shao, Y., Manthey, G., Binder, A., & Baron, R. (2015) · European Journal of Pain · doi:10.1002/ejp.735 · Cited by 15
Awareness of Temperature and Pain Sensation
Valls‐Solé, J., Castellote, J. M., Köfler, M., Casanova‐Mollá, J., Kumru, H., & Schestatsky, P. (2012) · Journal of Pain · doi:10.1016/j.jpain.2011.11.003 · Cited by 14
Pain‐autonomic interaction is a reliable measure of pain habituation in healthy subjects
Schoenmacker, I. D., Leu, C., Curt, A. E. P., & Hubli, M. (2022) · European Journal of Pain · doi:10.1002/ejp.1990 · Cited by 13
Reliability of task-based fMRI in the dorsal horn of the human spinal cord
Dabbagh, A., Horn, U., Kaptan, M., Mildner, T., Müller, R., Lepsien, J., Weiskopf, N., Brooks, J. C. W., Finsterbusch, J., & Eippert, F. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00273 · Cited by 15
Ruscheweyh, R., Bäumler, M., Feller, M., Krafft, S., Sommer, J. B., & Straube, A. M. (2015) · Pain · doi:10.1097/j.pain.0000000000000327 · Cited by 13
Double-Cone Coil TMS Stimulation of the Medial Cortex Inhibits Central Pain Habituation
D’Agata, F., Cicerale, A., Mingolla, A., Caroppo, P., Orsi, L., Mortara, P., Troni, W., & Pinessi, L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128765 · Cited by 13
Thermal pain and detection threshold modulation in augmented reality
Eckhoff, D., Sandor, C., Cheing, G. L. Y., Schnupp, J. W. H., & Cassinelli, Á. (2022) · Frontiers in Virtual Reality · doi:10.3389/frvir.2022.952637 · Cited by 12
Ultrasound stimulation of the motor cortex during tonic muscle contraction
Heimbuch, I. S., Fan, T. K., Wu, A. D., Faas, G. C., Charles, A. C., & Iacoboni, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267268 · Cited by 12
Lejeune, N., Petrossova, E., Frahm, K. S., & Mouraux, A. (2022) · Clinical Neurophysiology · doi:10.1016/j.clinph.2022.11.008 · Cited by 12
Reliability study of thermal quantitative sensory testing in healthy Chinese
Wang, R., Cui, L., Zhou, W., Wang, C., Zhang, J., Wang, K., & Svensson, P. J. (2014) · Somatosensory & Motor Research · doi:10.3109/08990220.2014.914485 · Cited by 12
Neural correlates of heat-evoked pain memory in humans
Wang, L., Gui, P., Li, L., Ku, Y., Bodner, M., Fan, G., Zhou, Y., & Dong, X.-W. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00126.2015 · Cited by 12
Laser-evoked potentials in painful radiculopathy
Hüllemann, P., von der Brelie, C., Manthey, G., Düsterhöft, J., Helmers, A., Synowitz, M., Gierthmühlen, J., & Baron, R. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.09.100 · Cited by 12
Squintani, G. M., Rasera, A., Segatti, A., Concon, E., Bonetti, B., Valeriani, M., & Tinazzi, M. (2020) · European Journal of Pain · doi:10.1002/ejp.1693 · Cited by 11
Albu, S., Gómez‐Soriano, J., Bravo-Esteban, E., García, R. P., Kumru, H., Ávila-Martín, G., Galán-Arriero, I., & Taylor, J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.067 · Cited by 11
Paul, K., Tik, M., Hahn, A., Sladky, R., Geissberger, N., Wirth, E.-M., Kranz, G. S., Pfabigan, D. M., Kraus, C., Lanzenberger, R. R., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-01881-4 · Cited by 11
Ristić, D., & Ellrich, J. (2013) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12133 · Cited by 11
Deficient Pain Modulation in Patients with Chronic Hemiplegic Shoulder Pain
Kashi, Y., Ratmansky, M., & Defrin, R. (2017) · Pain Practice · doi:10.1111/papr.12658 · Cited by 11
Effect of odor pleasantness on heat-induced pain: An fMRI study
Jo, H., Wudarczyk, O. A., Leclerc, M., Regenbogen, C., Lampert, A., Rothermel, M., & Habel, U. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00328-0 · Cited by 12
Bergamasco, L., Edwards-Callaway, L., Bello, N. M., Mijares, S. H., Cull, C. A., Mosher, R. A., & Coetzee, J. F. (2021) · Animals · doi:10.3390/ani11061791 · Cited by 11
Heat-Induced Action Potential Discharges in Nociceptive Primary Sensory Neurons of Rats
Greffrath, W., Schwarz, S. T., Büsselberg, D., & Treede, R. (2009) · Journal of Neurophysiology · doi:10.1152/jn.90916.2008 · Cited by 11
Self-citationThermal grill conditioning: Effect on contact heat evoked potentials
Jutzeler, C. R., Warner, F. M., Wanek, J., Curt, A. E. P., & Kramer, J. L. K. (2017) · Scientific Reports · doi:10.1038/srep40007 · Cited by 12
Luebke, L., von Selle, J., Adamczyk, W. M., Knorr, M. J., Carvalho, G. F., Gouverneur, P., Luedtke, K., & Szikszay, T. M. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.08.005 · Cited by 10
Hoff, D. A. L., Krarup, A. L., Lelic, D., Olesen, S. S., Dimcevski, G. G., Hansen, T. M., Brock, C., Hatlebakk, J. G., & Drewes, A. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12196 · Cited by 10
Lütolf, R., Rösner, J., Curt, A. E. P., & Hubli, M. (2021) · Journal of Neurotrauma · doi:10.1089/neu.2021.0280 · Cited by 10
Establishment of MOS-SF36 percentile ranks in the general youth French population
Trognon, A., Tinti, E., Beaupain, B., Donadieu, J., & Musiol, M. (2022) · BMC Psychology · doi:10.1186/s40359-022-00786-9 · Cited by 11
Temporal properties of pain contrast enhancement using repetitive stimulation
Szikszay, T. M., Adamczyk, W. M., Lévénez, J. L. M., Gouverneur, P., & Luedtke, K. (2022) · European Journal of Pain · doi:10.1002/ejp.1971 · Cited by 10
Heterotopic and homotopic nociceptive conditioning stimulation: Distinct effects of pain modulation
Haefeli, J., Kramer, J. L. K., Blum, J., & Curt, A. E. P. (2014) · European Journal of Pain · doi:10.1002/j.1532-2149.2014.00454.x · Cited by 10
la Rosa, A. L., Fernández, I., García‐Vázquez, C., Arroyo, C. A.-D., González-García, M. J., & Enríquez‐de‐Salamanca, A. (2019) · Ocular Immunology and Inflammation · doi:10.1080/09273948.2019.1690005 · Cited by 13
Förtsch, E.-M. A. D., Baumgart, P., Teismann, T., Ruscheweyh, R., & Hasenbring, M. I. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113512 · Cited by 13
Fabig, S., Kersebaum, D., Lassen, J., Sendel, M., Jendral, S., Muntean, A. C., Baron, R., & Hüllemann, P. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.08.017 · Cited by 10
King, C. D., Goodin, B. R., Glover, T. L., Riley, J. L., Hou, W., Staud, R. M., & Fillingim, R. B. (2012) · Pain · doi:10.1016/j.pain.2012.12.009 · Cited by 10
Effectiveness of High-Frequency Electrical Stimulation Following Sensitization With Capsaicin
Jutzeler, C. R., Curt, A. E. P., & Kramer, J. L. K. (2015) · Journal of Pain · doi:10.1016/j.jpain.2015.03.005 · Cited by 10
Cold evoked potentials: Acquisition from cervical dermatomes
Rösner, J., Rinert, J., Ernst, M., Curt, A. E. P., & Hubli, M. (2018) · Neurophysiologie Clinique · doi:10.1016/j.neucli.2018.11.003 · Cited by 10
Kong, J., Bagarinao, E., Olshen, R. A., & Mackey, S. (2019) · Journal of Pain Research · doi:10.2147/jpr.s212137 · Cited by 9
Scheuren, P. S., Hupp, M., Pfender, N., Seif, M., Zipser, C. M., Wanivenhaus, F., Spirig, J. M., Betz, M., Freund, P., Schubert, M. J. W., et al. (2024) · European Journal of Neurology · doi:10.1111/ene.70001 · Cited by 8
Schaldemose, E. L., Andersen, N. T., Finnerup, N. B., & Fardo, F. (2022) · Temperature · doi:10.1080/23328940.2022.2088028 · Cited by 8
Castellote, J. M., & Valls‐Solé, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-39509-3 · Cited by 8
Radiation of pain: psychophysical evidence for a population coding mechanism in humans
Adamczyk, W. M., Ramu, V., Jackson, C., Schulze, G., Goldschneider, K. R., Kashikar‐Zuck, S., King, C. D., & Coghill, R. C. (2024) · Pain · doi:10.1097/j.pain.0000000000003474 · Cited by 7
The roles of neural adaptation and sensitization in contact lens discomfort
Situ, P., Begley, C. G., & SIMPSON, T. L. (2024) · The Ocular Surface · doi:10.1016/j.jtos.2024.07.003 · Cited by 7
Contact heat-evoked potentials as a useful means in patients with Guillain–Barré syndrome
Zhang, C., Xie, B.-D., Li, X., & Yao, Y. (2014) · Neurological Sciences · doi:10.1007/s10072-014-1682-z · Cited by 7
Dangers, L., Laviolette, L., Charbit, B., Similowski, T., & Morélot‐Panzini, C. (2016) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2016.06.007 · Cited by 7
Combining EEG and fMRI in Pain Research
Iannetti, G. D., & Mouraux, A. (2009) · Springer eBooks · doi:10.1007/978-3-540-87919-0_18 · Cited by 7
Painful Cutaneous Laser Stimulation for Temporal Summation of Pain Assessment
Wang, D., Moosa, S., Ishaque, M., Finan, P. H., Quigg, M., Elias, W. J., & Liu, C. J. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.07.012 · Cited by 6
Luebke, L., Lopes, C. G., Myka, Y., Lumma, A., Adamczyk, W. M., Carvalho, G. F., Scholten-Peeters, G. G. M., Luedtke, K., & Szikszay, T. M. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104611 · Cited by 6
Scheuren, P. S., Nauer, N., Rösner, J., Curt, A. E. P., & Hubli, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07967-x · Cited by 6
Somatosensory and trigeminal pathway abnormalities in Chinese patients with trigeminal neuralgia
Li, Y., Yang, G., Zhai, X., Kang, Y., & Xie, Q. (2022) · Odontology · doi:10.1007/s10266-022-00737-1 · Cited by 6
A Novel Stimulation Paradigm to Limit the Habituation of the Nociceptive Withdrawal Reflex
Gervasio, S., Laursen, C. B., Andersen, O. K., Hennings, K., & Spaich, E. G. (2018) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2018.2828221 · Cited by 6
Xu, H., Yi, Y.-L., Xue, C., Guo, Z.-Q., Ding, L., & Jia, J. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-02096-y · Cited by 6
Pain-Related Vertex Evoked Potentials. Comparison of Surface Electrical to Heat Stimulation
Guiloff, R. J., Campero, M., Barraza, G., Treede, R., Matamala, J. M., & Castillo, J. L. (2022) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000929 · Cited by 5
Self-citationSchoenmacker, I. D., Scheuren, P. S., Sirucek, L., Lütolf, R., Gorrell, L. M., Rösner, J., Curt, A. E. P., Schweinhardt, P., & Hubli, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-73158-5 · Cited by 5
Warm‐, hot‐ and pain‐related neural activities depending on baseline skin temperatures
Nakata, H., Kakigi, R., & Shibasaki, M. (2018) · European Journal of Pain · doi:10.1002/ejp.1275 · Cited by 4
Revealing the time course of laser‐evoked potential habituation by high temporal resolution analysis
Kersebaum, D., Fabig, S., Sendel, M., Muntean, A. C., Baron, R., & Hüllemann, P. (2021) · European Journal of Pain · doi:10.1002/ejp.1823 · Cited by 4
Mostafa, R., McNair, N. A., Tan, W., Saunders, C., Colagiuri, B., & Barnes, K. (2024) · Communications Psychology · doi:10.1038/s44271-024-00069-6 · Cited by 4
Donaldson, G. W. (2014) · Journal of Pain & Relief · doi:10.4172/2167-0846.1000156 · Cited by 4
Novel neurophysiological evidence for preserved pain habituation across chronic pain conditions
Schoenmacker, I. D., Marques, D. C., Scheuren, P. S., Lütolf, R., Gorrell, L. M., Mehli, S. C., Curt, A. E. P., Rösner, J., & Hubli, M. (2024) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.07.007 · Cited by 6
Towards perception awareness: Perceptual event detection for Brain computer interfaces
Nejati, H., Tsourides, K., Pomponiu, V., Ehrenberg, E., Cheung, N. M., & Sinha, P. (2015) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2015.7318650 · Cited by 4
Reminders of Mortality Alter Pain-Evoked Potentials in a Chinese Sample
Wang, C., & Jing, T. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.01667 · Cited by 4
Temporal and spatial summation of laser heat stimuli in cultured nociceptive neurons of the rat
Jubileum, E., Binzen, U., Treede, R., & Greffrath, W. (2022) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-022-02728-1 · Cited by 4
Self-citationAuditory and Nociceptive Stimuli Responses in the Electroencephalogram
Melia, U. S. P., Claria, F., Valls‐Solé, J., Caminal, P., & Vallverdú, M. (2014) · Methods of Information in Medicine · doi:10.3414/me13-02-0044 · Cited by 4
Gács, B., Szolcsányi, T., & Csathó, Á. (2017) · European Journal of Pain · doi:10.1002/ejp.1017 · Cited by 4
Scheuren, P. S., Ortiz, O., Linde, L. D., Choles, C. M., MacMillan, E. L., & Kramer, J. L. K. (2025) · Neurobiology of Pain · doi:10.1016/j.ynpai.2025.100204 · Cited by 3
Kamper-Fuhrmann, E., Winkler, A., Hahn, A., & Hermann, C. (2022) · Journal of Pain · doi:10.1016/j.jpain.2022.12.010 · Cited by 4
Contact-Heat Evoked Potentials: Insights into Pain Processing in CRPS Type I
Allmendinger, F., Scheuren, P. S., Schoenmacker, I. D., Brunner, F., Rösner, J., Curt, A. E. P., & Hubli, M. (2024) · Journal of Pain Research · doi:10.2147/jpr.s436645 · Cited by 3
Virtual reality improves pain threshold and recall in healthy adults: A randomized, crossover study
Rodríguez, S., Jimenez, R. T., Wang, E., Zuniga‐Hernandez, M., Titzler, J., Jackson, C., Suen, M. Y., Yamaguchi, C., Ko, B., Kong, J., et al. (2025) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2025.111816 · Cited by 3
Pain Representations in the Self and Others: A Behavioral Study of the Congruency Effect
Meng, J., Shen, L., Zhen-Yong, L. V., Yang, Z., Hong, C., & Todd, J. (2013) · Acta Psychologica Sinica · doi:10.3724/sp.j.1041.2012.01515 · Cited by 3
Kamm, K., Pomschar, A., Ruscheweyh, R., Straube, A. M., Reiser, M. F., Hernádi, I., László, J. F., & Ertl-Wagner, B. B. (2018) · European Journal of Pain · doi:10.1002/ejp.1299 · Cited by 3
Inverse source imaging methods in recovering distributed brain sources
Ding, L., & Yuan, H. (2012) · Biomedical Engineering Letters · doi:10.1007/s13534-012-0047-x · Cited by 3
Reliability of task-based fMRI in the dorsal horn of the human spinal cordPreprint
Dabbagh, A., Horn, U., Kaptan, M., Mildner, T., Müller, R., Lepsien, J., Weiskopf, N., Brooks, J. C. W., Finsterbusch, J., & Eippert, F. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.22.572825 · Cited by 3
Reliable Biomarkers of Descending Pain Inhibition: A Laser‐Evoked Potential and Behavioural Study
Wang, D., Zhang, X., Ye, S., Carter, W., Finan, P. H., Quigg, M., Moosa, S., Elias, W. J., & Liu, C. (2025) · European Journal of Pain · doi:10.1002/ejp.70181 · Cited by 2
Exploring the Use of the Current Perception Threshold in Pharyngeal Paresthesia Patients
Xuelai, L. I. U., Xueyan, L., & Xu, W. (2022) · Dysphagia · doi:10.1007/s00455-021-10401-5 · Cited by 2
Júlio, S. U., Schneuwly, M., Scheuren, P. S., Pfender, N., Zipser, C. M., Hubli, M., & Schubert, M. J. W. (2024) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.09.015 · Cited by 2
Clinical neurophysiology of neuropathic pain
Hubli, M., & Leone, C. M. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.10.005 · Cited by 2
Electrophysiological Evidence for Impaired Central Pain Modulation in Parkinson's Disease
Kersebaum, D., Lassen, J., Forstenpointner, J., Sendel, M., Fabig, S., Nölker, S., Sachau, J., Paschen, S., Berg, D., Baron, R., et al. (2025) · Movement Disorders · doi:10.1002/mds.70004 · Cited by 2
Cutaneous Heat Transfer and Its Effect on Contact Heat Evoked Brain Potentials
Marmaras, A., Wydenkeller, S., Tobler, M., Wirz, R., Dimos Poulikakos, A., & Kurtcuoglu, V. (2012) · Experimental Heat Transfer · doi:10.1080/08916152.2012.675800 · Cited by 2
Measurements of Temporal Summation of Heat Pain: a Pilot Investigation in Healthy Humans
Usichenko, T. I., Møller, N., Janner, H., Lotze, M., & Hahnenkamp, K. (2018) · Neurophysiology · doi:10.1007/s11062-019-09773-0 · Cited by 2
Zhang, J., Embray, L., Yanovsky, Y., Brankačk, J., & Draguhn, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613801 · Cited by 2
The Impact of Adverse Childhood Events on Temporal Summation of Second Pain
You, D. S. (2012) · OakTrust (Texas A&M University Libraries) · Cited by 2
Franz, S., Heutehaus, L., Tappe‐Theodor, A., Weidner, N., Treede, R., & Schuh‐Hofer, S. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1141690 · Cited by 1
Self-citationHau, M., Sirucek, L., Schoenmacker, I. D., Lütolf, R., Gorrell, L. M., Hubli, M., & Schweinhardt, P. (2025) · European Journal of Pain · doi:10.1002/ejp.70067 · Cited by 1
Perception of first and second pain during offset analgesia
Poehlmann, J., von Lemm, B., Luebke, L., Adamczyk, W. M., Luedtke, K., & Szikszay, T. M. (2025) · Experimental Brain Research · doi:10.1007/s00221-025-07176-8 · Cited by 1
Sensory processing and neurophysiological evaluation in children
Hermann, C. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199642656.003.0040 · Cited by 1
Combining Electroencephalography and Functional Magnetic Resonance Imaging in Pain Research
Iannetti, G. D., & Mouraux, A. (2022) · Springer eBooks · doi:10.1007/978-3-031-07121-8_21 · Cited by 1
Divarco, R., Sternkopf, F., Karst, M., ALTENMÜLLER, E. O., Ramasawmy, P., Antal, A., & Lee, A. (2024) · European Journal of Pain · doi:10.1002/ejp.4738 · Cited by 1
Adaptation to tonic heat in healthy subjects and patients with sensory polyneuropathy
Campolo, M., Correa, L. I., Gabarrón, E., Albayrak, M., Quintero‐Diaz, C., Castellote, J. M., Casanova‐Mollá, J., & Valls‐Solé, J. (2022) · European Journal of Pain · doi:10.1002/ejp.1930 · Cited by 1
Relationship between pain and anxiety in rats
Roeska, K. (2010) · Gutenberg Open Science · doi:10.25358/openscience-1591 · Cited by 1
Ultrasound stimulation of the motor cortex during tonic muscle contractionPreprint
Heimbuch, I. S., Fan, T. K., Wu, A. D., Faas, G. C., Charles, A. C., & Iacoboni, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.03.442483 · Cited by 1
Csifcsák, G. (2011) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.1213
Electrophysiological Markers for Neuropathic Pain in Spinal Cord Injured Subjects
Wydenkeller, S. (2009) · Zurich Open Repository and Archive (University of Zurich) · doi:10.3929/ethz-a-005773226
Metadata
- Authors
- Greffrath, W., Baumgärtner, U., & Treede, R.-D.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Greffrath, Wolfgang
- Venue
- Pain
- Published
- 2007-12
- Volume
- 132
- Issue
- 3
- Pages
- 301-311
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2068862426
- Cited by
- 226
- References
- 56
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 13 · 2023: 9 · 2022: 20 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 17
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- thermal pain, habituation, contact heat evoked potentials, nociception, stimulus-response function, pain threshold, thermode
- MeSH terms
- Adult, Central Nervous System, Evoked Potentials, Somatosensory, Female, Habituation, Psychophysiologic, Hot Temperature, Humans, Male, Pain, Pain Measurement, Pain Threshold, Peripheral Nervous System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review