The DOI matches its Crossref record; 54 of the 56 references it cites were found in a registry or an index.
Peripheral and central components of habituation of heat pain perception and evoked potentials in humans
Abstract
For the neurophysiological examination of nociceptive pathways, contact-heat evoked potentials (contact-heat EPs) are elicited by repetitive brief noxious heat stimuli. Suppression of heat responses in primary nociceptive neurons during repetitive stimulation has been shown in animal models in vivo and in vitro. We now investigated whether heat pain and contact-heat EPs in humans display equivalent signs of habituation. Heat pain and EPs were elicited in 16 volunteers with a contact thermode (30 degrees Cs(-1)). Heat pulses at three intensities (pain threshold, moderate noxious and maximum available) were applied to the right forearm either by moving the thermode after each pulse to variable locations or when fixed to one location (inter-stimulus intervals 8-10s). Contact-heat EPs consisted of an early negativity in temporal leads (N1), followed by a biphasic response at the vertex (N2-P2). Pain ratings and contact-heat EPs (N1 and N2-P2 components) displayed significant temperature dependence. N2-P2 correlated positively with ratings. With stimulation at variable locations, both measures slowly decreased with time constants tau of 2 min (ratings) and 12 min (EPs). With stimulation at a fixed location, habituation was much faster for both, ratings (tau=10s) and EPs (tau=33 s). As a consequence, both measures were significantly reduced (p<0.005) leading to a rightward shift of the stimulus-response function by 5 degrees C. In conclusion, human heat pain perception and contact-heat EPs display signs of rapid habituation when stimulation is restricted to a fixed location and thus, reflect fatigue of peripheral nociceptive neurons. Habituation within the central nervous system is slower and less pronounced.
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“However, it is important to note that responses to a cue could change over the course of the experimental session due to factors such as fatigue, habituation or learning23–28.”
From Boundary effects of expectation in human pain perception (2019) · cites this paper as [23]
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Cites
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., & Julius, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80564-4 · Cited by 3,086
Advances in Pain Research and Therapy
Wang, J. K. (1980) · Anesthesia & Analgesia · doi:10.1213/00000539-198002000-00022 · Cited by 2,263
Evidence for a central component of post-injury pain hypersensitivity
Woolf, C. J. (1983) · Nature · doi:10.1038/306686a0 · Cited by 2,157
Keeping pain out of mind: The role of the dorsolateral prefrontal cortex in pain modulation
Lorenz, J., Minoshima, S., & Casey, K. L. (2003) · Brain · doi:10.1093/brain/awg102 · Cited by 952
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Treede, R., Meyer, R. A., Raja, S. N., & Campbell, J. N. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90027-c · Cited by 917
Self-citationWind-up of spinal cord neurones and pain sensation: much ado about something?
Herrero, J. F., Laird, J. M. A., & Lopez-Garcia, J. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00051-9 · Cited by 714
Price, D. D., Hu, J. W., Dubner, R. A., & Gracely, R. H. (1977) · Pain · doi:10.1016/0304-3959(77)90035-5 · Cited by 589
Brain generators of laser-evoked potentials: from dipoles to functional significance
Garcia-Larrea, L., Frot, M., & Valeriani, M. (2003) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/j.neucli.2003.10.008 · Cited by 541
EFNS guidelines on neuropathic pain assessment
Cruccu, G., Anand, P., Attal, N., García-Larrea, L., Haanpää, M. L., Jørum, E., Serra, J., & Jensen, T. S. (2004) · European Journal of Neurology · doi:10.1111/j.1468-1331.2004.00791.x · Cited by 534
LaMotte, R. H., & Campbell, J. N. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.2.509 · Cited by 456
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Tin, S. N. W. (2013) · theses.fr (ABES) · doi:10.70675/4b466f3cz6842z42a8zab62z3ec9e12aa180
Zanner, R., Untergehrer, G., Jordan, D., Kreuzer, M., & Schneider, G. H. (2026) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-026-01501-4
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Metadata
- Authors
- Greffrath, W., Baumgärtner, U., & Treede, R.-D.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Greffrath, Wolfgang
- Venue
- Pain
- Published
- 2007-12
- Volume
- 132
- Issue
- 3
- Pages
- 301-311
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2068862426
- Cited by
- 226
- References
- 56
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 13 · 2023: 9 · 2022: 20 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 14 · 2016: 12 · 2015: 15 · 2014: 14 · 2013: 18 · 2012: 17
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- thermal pain, habituation, contact heat evoked potentials, nociception, stimulus-response function, pain threshold, thermode
- MeSH terms
- Adult, Central Nervous System, Evoked Potentials, Somatosensory, Female, Habituation, Psychophysiologic, Hot Temperature, Humans, Male, Pain, Pain Measurement, Pain Threshold, Peripheral Nervous System
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