From cue to meaning: Brain mechanisms supporting the construction of expectations of pain
Open accessAbstract
The brain mechanisms by which sensory cues become transformed into expectations of impending events are a critical component of cognitive tuning of sensory processing. However, distinctions among the afferent processing of cue-related activity itself versus those mechanisms supporting the contextual meaning imparted to the cue remain limited. Do sensory cues with equal meaning engage similar patterns of brain activations even if they are delivered in separate modalities? To address this question, we used functional magnetic resonance imaging of an expectation paradigm in which cues were delivered with visual or innocuous thermal stimuli. Cues were designed to be highly meaningful because they predicted the delivery of high and low painful stimuli. As expected, the cues themselves activated unimodal sensory cortices. This cue modality-specific activation was transformed into a pattern of activity reflecting cue meaning. Cues signaling high pain produced greater activity in the left dorsolateral prefrontal cortex and anterior cingulate cortex. Such activity is consistent with the graded encoding of the magnitude of expected pain. In contrast, cues signaling low pain produced greater activity in the right intraparietal sulcus. This activation may reflect processes directing spatial attention to the stimulated body region in order to more accurately evaluate the relatively weak, low pain stimulus. Taken together, these findings indicate that cues arising from different sensory modalities ultimately engage common brain mechanisms that reflect the meaning of the cue. This meaning-related activity is presumably critical for preparing sensory systems to optimally process afferent information.
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Higher-order regions such as ACC, dACC, and PFC support the contextual meaning of pain.
“The contextual meaning of pain is then facilitated through activation of higher-order brain regions, including the anterior cingulate cortex (ACC), dorsal ACC (dACC), and prefrontal cortex (PFC).80–82”
From Mindfulness meditation-based pain relief: a mechanistic account (2016) · cites this paper as [82]
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- Authors
- Lobanov, O. V., Zeidan, F., McHaffie, J. G., Kraft, R. A., & Coghill, R. C.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Coghill, Robert C.
- Venue
- Pain
- Published
- 2014-01
- Volume
- 155
- Issue
- 1
- Pages
- 129-136
- ISSN
- 0304-3959 (ISSN-L)
- PMC
- PMC3947355
- OpenAlex
- W2163237764
- Cited by
- 38
- References
- 42
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 6 · 2015: 5 · 2013: 1
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01 NS 39426, R01NS039426)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- pain anticipation, sensory cues, multisensory integration, visual cues, thermal pain, dorsolateral prefrontal cortex, anterior cingulate cortex, intraparietal sulcus, spatial attention, sensory prediction
- MeSH terms
- Adult, Analysis of Variance, Brain, Brain Mapping, Cues, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Pain, Photic Stimulation, Psychophysics, Logistic Models, Young Adult, Visual Analog Scale, Healthy Volunteers
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