A brief cognitive-behavioural intervention for pain reduces secondary hyperalgesia
Open accessAbstract
Repeated exposure to pain can result in sensitization of the central nervous system, enhancing subsequent pain and potentially leading to chronicity. The ability to reverse this sensitization in a top-down manner would be of tremendous clinical benefit, but the degree that this can be accomplished volitionally remains unknown. Here we investigated whether a brief (~5 min) cognitive-behavioural intervention could modify pain perception and reduce central sensitization (as reflected by secondary hyperalgesia). In each of 8 sessions, 2 groups of healthy human subjects received a series of painful thermal stimuli that resulted in secondary hyperalgesia. One group (regulate) was given brief pain-focused cognitive training at each session, while the other group (control) received a non-pain-focused intervention. The intervention selectively reduced pain unpleasantness but not pain intensity in the regulate group. Furthermore, secondary hyperalgesia was significantly reduced in the regulate group compared with the control group. Reduction in secondary hyperalgesia was associated with reduced pain catastrophizing, suggesting that changes in central sensitization are related to changes in pain-related cognitions. Thus, we demonstrate that central sensitization can be modified volitionally by altering pain-related thoughts.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Targeting maladaptive cognitions such as catastrophizing may help reduce central sensitization.
“While the current evidence is promising, though not yet definitive, it suggests that targeting maladaptive cognitions such as catastrophizing may help reduce central sensitization.47,48”
From Acceptance and commitment therapy for prevention of chronic pain after total knee arthroplasty. (2026) · cites this paper as [48]
The inclusion of a pain assessment reflects recent findings about the high comorbidity prevalence in depression with respect to chronic pain and the possible efficacy of behavioral pain reduction methods.
“The inclusion of a pain assessment reflects recent findings about the high comorbidity prevalence in depression with respect to chronic pain [47] and the possible efficacy of behavioral pain reduction methods [48,49].”
From Online Mindfulness-Based Cognitive Behavioral Therapy Intervention for Youth With Major Depressive Disorders: Randomized Controlled Trial. (2021) · cites this paper as [48]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1970) · Cited by 24,983 · see citing works
Pain mechanisms: a new theory.
Melzack, R., & Wall, P. D. (1965) · Science · doi:10.1126/science.150.3699.971 · Cited by 11,108 · see citing works
Cognitive Therapy for Depression
(2012) · PsycEXTRA Dataset · doi:10.1037/e675542012-001 · Cited by 9,678 · see citing works
The Pain Catastrophizing Scale: Development and validation.
Sullivan, M. J. L., Bishop, S. R., & Pivik, J. (1995) · Psychological Assessment · doi:10.1037//1040-3590.7.4.524 · Cited by 8,227 · see citing works
Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients
Beck, A. T., Steer, R. A., Ball, R., & Ranieri, W. F. (1996) · Journal of Personality Assessment · doi:10.1207/s15327752jpa6703_13 · Cited by 5,965 · see citing works
Central sensitization: implications for the diagnosis and treatment of pain
Woolf, C. J. (2011) · Pain · doi:10.1016/j.pain.2010.09.030 · Cited by 4,771 · see citing works
The validation of visual analogue scales as ratio scale measures for chronic and experimental pain
Price, D. D., McGrath, P. A., Rafii, A., & Buckingham, B. (1983) · Pain · doi:10.1016/0304-3959(83)90126-4 · Cited by 3,921 · see citing works
Melzack, R., & Wall, P. D. (1996) · Pain Forum · doi:10.1016/s1082-3174(96)80062-6 · Cited by 2,786 · see citing works
Bonica, J. J., Melzack, R., & Wall, P. D. (1999) · Cited by 2,533 · see citing works
(1993) · Medical Entomology and Zoology · Cited by 2,491 · see citing works
Rosenstiel, A. K., & Keefe, F. J. (1983) · Pain · doi:10.1016/0304-3959(83)90125-2 · Cited by 2,314 · see citing works
Cognitive and emotional control of pain and its disruption in chronic pain
Bushnell, M. C., Čeko, M., & Low, L. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3516 · Cited by 2,076 · see citing works
Psychological therapies for the management of chronic pain (excluding headache) in adults
Williams, A. C. D. C., Eccleston, C., & Morley, S. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007407.pub3 · Cited by 1,634 · see citing works
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488 · see citing works
Central sensitization and LTP: do pain and memory share similar mechanisms?
Ji, R., Kohno, T., Moore, K. A., & Woolf, C. J. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.017 · Cited by 1,462 · see citing works
Chronic pain and medullary descending facilitation
Porreca, F. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02157-4 · Cited by 1,007 · see citing works
Pain and Behavioral Medicine: A Cognitive-Behavioral Perspective
Turk, D., Meichenbaum, D. H., Genest, M., & Berntzen, D. (1984) · Scandinavian Journal of Behaviour Therapy · doi:10.1080/16506078409455719 · Cited by 977 · see citing works
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839 · see citing works
Central nervous system mechanisms of pain modulation
Fields, H. L., Basbaum, A. I., & Heinricher, M. M. (2006) · Elsevier eBooks · doi:10.1016/b0-443-07287-6/50012-6 · Cited by 757 · see citing works
Valet, M., Sprenger, T., Boecker, H., Willoch, F., Rummeny, E., Conrad, B., Erhard, P., & Tolle, T. R. (2004) · Pain · doi:10.1016/j.pain.2004.02.033 · Cited by 708 · see citing works
Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network
Bingel, U., Lorenz, J., Schoell, E., Weiller, C., & Büchel, C. (2006) · Pain · doi:10.1016/j.pain.2005.08.027 · Cited by 567 · see citing works
Arendt‐Nielsen, L., & Yarnitsky, D. (2009) · Journal of Pain · doi:10.1016/j.jpain.2009.02.002 · Cited by 548 · see citing works
Supraspinal contributions to hyperalgesia
Urban, M. O., & Gebhart, G. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7687 · Cited by 518 · see citing works
Direct evidence for spinal cord involvement in placebo analgesia
Eippert, F., Finsterbusch, J., Bingel, U., & Büchel, C. (2009) · Science · doi:10.1126/science.1180142 · Cited by 512 · see citing works
Descending control of persistent pain: inhibitory or facilitatory?
Vanegas, H., & Schaible, H. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.004 · Cited by 510 · see citing works
BEECHER, H. K. (1946) · Annals of Surgery · doi:10.1097/00000658-194601000-00008 · Cited by 443 · see citing works
Descending analgesia – When the spine echoes what the brain expects
Goffaux, P., Redmond, W. J., Rainville, P., & Marchand, S. (2007) · Pain · doi:10.1016/j.pain.2006.11.011 · Cited by 342 · see citing works
Cognitive-behavioral therapy increases prefrontal cortex gray matter in patients with chronic pain
Seminowicz, D. A., Shpaner, M., Keaser, M. L., Krauthamer, G. M., Mantegna, J., Dumas, J. A., Newhouse, P. A., Filippi, C. G., Keefe, F. J., & Naylor, M. R. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2013.07.020 · Cited by 305 · cited 1× · see citing works
“Recent work demonstrates that CBT alters both functional activation [21] and brain structure [35] in regions involved in cognitive modulation and descending control of pain in chronic pain populations, suggesting that plasticity that underlies the observed reductions in central sensitization could be similar to that p…”
Individual differences in endogenous pain modulation as a risk factor for chronic pain
Edwards, R. R. (2005) · Neurology · doi:10.1212/01.wnl.0000171862.17301.84 · Cited by 283 · see citing works
Cerebral and Spinal Modulation of Pain by EmotionsPreprint
Roy, M., Piché, M., Chen, J.-I., Peretz, I., & Rainville, P. (2009) · Nature Precedings · doi:10.1073/pnas.0904706106 · Cited by 277 · see citing works
Jensen, K. B., Kosek, E., Wicksell, R., Kemani, M., Olsson, G., Merle, J. V., Kadetoff, D., & Ingvar, M. (2012) · PAIN · doi:10.1016/j.pain.2012.04.010 · Cited by 230 · see citing works
Edwards, R. R., Smith, M. T., Stonerock, G. L., & Haythornthwaite, J. A. (2006) · Clinical Journal of Pain · doi:10.1097/01.ajp.0000210914.72794.bc · Cited by 224 · see citing works
Affective modulation of nociception at spinal and supraspinal levels
Rhudy, J. L., Williams, A. E., McCabe, K. M., Nguyê˜n, M. A. T. V., & Rambo, P. (2005) · Psychophysiology · doi:10.1111/j.1469-8986.2005.00313.x · Cited by 218 · see citing works
Contact heat-evoked temporal summation: Tonic versus repetitive-phasic stimulation
Granot, M., Granovsky, Y., Sprecher, E., Nir, R., & Yarnitsky, D. (2006) · Pain · doi:10.1016/j.pain.2006.02.003 · Cited by 203 · see citing works
Salomons, T. V., Johnstone, T., Backonja, M.-M., Shackman, A. J., & Davidson, R. J. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.6.993 · Cited by 195 · see citing works
Self-citation(2004) · Medical Entomology and Zoology · Cited by 150 · see citing works
Cognitive behavioral therapy for fibromyalgia
Bennett, R. M., & Nelson, D. V. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0245 · Cited by 149 · see citing works
Urban, M. O., Jiang, M. C., & Gebhart, G. F. (1996) · Brain Research · doi:10.1016/0006-8993(96)00631-2 · Cited by 137 · see citing works
Danziger, N., Fournier, E., Bouhassira, D., Michaud, D., de Broucker, T., Santarcangelo, E. L., Carli, G., Chertock, L., & Willer, J. C. (1998) · Pain · doi:10.1016/s0304-3959(97)00208-x · Cited by 135 · see citing works
George, S. Z., Wittmer, V. T., Fillingim, R. B., & Robinson, M. E. (2007) · Journal of Pain · doi:10.1016/j.jpain.2006.05.009 · Cited by 135 · see citing works
Secondary hyperalgesia to heat stimuli after burn injury in man
Pedersen, J. L., & Kehlet, H. (1998) · Pain · doi:10.1016/s0304-3959(98)00070-0 · Cited by 92 · see citing works
Central nervous system mechanisms of pain
Lenz, F. A., Dougherty, P. M., & Greenspan, J. D. (2002) · Cambridge University Press eBooks · doi:10.1017/cbo9781316134993.060 · Cited by 87 · see citing works
Goodin, B. R., Glover, T. L., Sotolongo, A. S., King, C. D., Sibille, K. T., Herbert, M. S., Cruz‐Almeida, Y., Sanden, S. H., Staud, R. M., Redden, D. T., et al. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.10.007 · Cited by 83 · see citing works
Rhudy, J. L., Martin, S. L., Terry, E. L., France, C. R., Bartley, E. J., DelVentura, J. L., & Kerr, K. L. (2011) · Pain · doi:10.1016/j.pain.2010.12.041 · Cited by 80 · see citing works
Herrero, J. F., & Cerveró, F. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12588-x · Cited by 80 · see citing works
Seifert, F. C., Bschorer, K., Col, R. D., Filitz, J., Peltz, E., Koppert, W., & Maihöfner, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4654-08.2009 · Cited by 68 · see citing works
Emery, C. F., Keefe, F. J., France, C. R., Affleck, G. G., Waters, S., Fondow, M. D. M., McKee, D. C., France, J. L., Hackshaw, K. V., Caldwell, D. S., et al. (2006) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2005.07.008 · Cited by 50 · see citing works
Bridging the gap with the five-factor model.
Costa, P. T., & McCrae, R. R. (2010) · Personality Disorders Theory Research and Treatment · doi:10.1037/a0020264 · Cited by 43 · see citing works
(1978)
Flagged first, then by citations
Research works printed but not linked: 1
- Beck A. Cognitive therapy of depression. New York: Guilford Press; 1979.
Cited by
Sorted by citations
Kucyi, A., & Davis, K. D. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.006 · Cited by 587 · see citing works
Self-citationAn Evaluation of Central Sensitization in Patients With Sickle Cell Disease
Campbell, C. M., Moscou-Jackson, G., Carroll, C. P., Kiley, K. B., Haywood, C., Lanzkron, S., Hand, M., Edwards, R. R., & Haythornthwaite, J. A. (2016) · Journal of Pain · doi:10.1016/j.jpain.2016.01.475 · Cited by 114 · see citing works
Best Evidence Rehabilitation for Chronic Pain Part 5: Osteoarthritis
Rice, D. A., McNair, P. J., Huysmans, E., Letzen, J. E., & Finan, P. H. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111769 · Cited by 91 · see citing works
Dynamic Changes of Functional Pain Connectome in Women with Primary Dysmenorrhea
Wu, T.-H., Tu, C., Chao, H., Li, W., Low, I., Chuang, C.-Y., Yeh, T., Cheng, C.-M., Chou, C.-C., Chen, L., et al. (2016) · Scientific Reports · doi:10.1038/srep24543 · Cited by 70 · see citing works
Darnall, B. D., & Colloca, L. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.07.022 · Cited by 65 · see citing works
Mathur, V. A., Moayedi, M., Keaser, M. L., Khan, S. A., Hubbard, C. S., Goyal, M., & Seminowicz, D. A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00489 · Cited by 58 · see citing works
Self-citationVita, M. J. D., Maisto, S. A., Ansell, E. B., Zale, E. L., & Ditre, J. W. (2019) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000258 · Cited by 53 · see citing works
The Opportunity to Avoid Pain May Paradoxically Increase Fear
van Vliet, C., Meulders, A., Vancleef, L. M. G., & Vlaeyen, J. W. S. (2018) · Journal of Pain · doi:10.1016/j.jpain.2018.05.003 · Cited by 52 · see citing works
Ritvo, P., Knyahnytska, Y., Pirbaglou, M., Wang, W., Tomlinson, G., Zhao, H., Linklater, R., Bai, S., Kirk, M., Katz, J., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/24380 · Cited by 48 · see citing works
“The inclusion of a pain assessment reflects recent findings about the high comorbidity prevalence in depression with respect to chronic pain [47] and the possible efficacy of behavioral pain reduction methods [48,49].”
de Tommaso, M., Sciruicchio, V., Delussi, M. D., Vecchio, E., Goffredo, M., Simeone, M., & Barbaro, M. G. F. (2017) · The Journal of Headache and Pain · doi:10.1186/s10194-017-0764-8 · Cited by 48 · see citing works
Traxler, J., Hanssen, M. M., Lautenbacher, S., Ottawa, F., & Peters, M. L. (2018) · European Journal of Pain · doi:10.1002/ejp.1294 · Cited by 45 · see citing works
Advances in targeting central sensitization and brain plasticity in chronic pain
Bazzari, A. H., & Bazzari, F. H. (2022) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-022-00472-y · Cited by 40 · see citing works
Cognitive behavioral training reverses the effect of pain exposure on brain network activity
Kucyi, A., Salomons, T. V., & Davis, K. D. (2016) · Pain · doi:10.1097/j.pain.0000000000000592 · Cited by 39 · see citing works
Self-citationMoayedi, M. (2014) · Pain · doi:10.1016/j.pain.2014.07.023 · Cited by 37 · see citing works
Self-citationTaub, C. J., Sturgeon, J. A., Johnson, K. A., Mackey, S., & Darnall, B. D. (2017) · Pain Research and Management · doi:10.1155/2017/7892494 · Cited by 37 · see citing works
Brazenor, G. A., Malham, G. M., & Teddy, P. J. (2021) · Pain Medicine · doi:10.1093/pm/pnab319 · Cited by 36 · see citing works
Gil‐Martínez, A., Grande‐Alonso, M., Touche, R. L., Lara‐Lara, M., López‐López, A., & Fernández‐Carnero, J. (2016) · Pain Research and Management · doi:10.1155/2016/3945673 · Cited by 35 · see citing works
Goodlev, E. R., DiScala, S., Darnall, B. D., Hanson, M., Petok, A., & Silverman, M. A. (2019) · Journal of Palliative Medicine · doi:10.1089/jpm.2019.0171 · Cited by 33 · see citing works
The Impact of Smoking on the Development and Severity of Chronic Pain
Robinson, C. L., Kim, R. S., Li, M. J., Ruan, Q. Z., Surapaneni, S., Jones, M., Pak, D., & Southerland, W. A. (2022) · Current Pain and Headache Reports · doi:10.1007/s11916-022-01060-8 · Cited by 33 · see citing works
Torta, D. M. E., Laurentis, M. D., Eichin, K. N., von Leupoldt, A., van den Broeke, E. N., & Vlaeyen, J. W. S. (2020) · Pain · doi:10.1097/j.pain.0000000000001841 · Cited by 32 · see citing works
Enhanced Area of Secondary Hyperalgesia in Women with Multiple Stressful Life Events: A Pilot Study
You, D. S., Creech, S. K., & Meagher, M. W. (2016) · Pain Medicine · doi:10.1093/pm/pnw049 · Cited by 31 · see citing works
Greenwald, J. D., & Shafritz, K. M. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00018 · Cited by 31 · see citing works
Secondary Hyperalgesia Phenotypes Exhibit Differences in Brain Activation during Noxious Stimulation
Asghar, M. S., Pereira, M. P., Werner, M. U., Mårtensson, J., Larsson, H. B. W., & Dahl, J. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0114840 · Cited by 29 · see citing works
Designing and conducting proof-of-concept chronic pain analgesic clinical trials
Campbell, C. M., Gilron, I., Doshi, T. L., & Raja, S. N. (2018) · PAIN Reports · doi:10.1097/pr9.0000000000000697 · Cited by 29 · see citing works
Perceived Ineffectiveness of Pharmacological Treatments for Dysmenorrhea
Chen, C. X., Carpenter, J. S., LaPradd, M. L., Ofner, S., & Fortenberry, J. D. (2020) · Journal of Women s Health · doi:10.1089/jwh.2020.8581 · Cited by 27 · see citing works
Hansen, M. S., Horjales-Araújo, E., & Dahl, J. B. (2015) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.12555 · Cited by 27 · see citing works
van Aken, M., Oosterman, J., van Rijn, T., Woudsma, K., Ferdek, M., Ruigt, G., Kozicz, T., Braat, D., Peeters, A., & Nap, A. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.06.040 · Cited by 26 · see citing works
Gevers‐Montoro, C., Romero-Santiago, B., Medina-García, I., Larranaga-Arzamendi, B., Álvarez, L., Ortega, A., & Piché, M. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.02.014 · Cited by 21 · see citing works
Sturycz, C. A., Hellman, N. M., Payne, M. F., Kuhn, B. L., Hahn, B. J., Lannon, E. W., Palit, S., Guereca, Y. M., Toledo, T. A., Shadlow, J. O., et al. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.02.006 · Cited by 19 · see citing works
Slowly repeated evoked pain (SREP) as a central sensitization marker in episodic migraine patients
de la Coba, P., Bruehl, S. P., & del Paso, G. A. R. (2021) · Scientific Reports · doi:10.1038/s41598-021-84157-1 · Cited by 16 · see citing works
Filbrich, L., van den Broeke, E. N., Legrain, V., & Mouraux, A. (2019) · Cortex · doi:10.1016/j.cortex.2019.11.014 · Cited by 16 · see citing works
The impact of the social context on the development of secondary hyperalgesia: an experimental study
Jaltare, K. P., Vanderijst, L., Karos, K., & Torta, D. M. E. (2023) · Pain · doi:10.1097/j.pain.0000000000002971 · Cited by 16 · see citing works
Pain catastrophizing may moderate the association between pain and secondary hyperalgesia
Pressman, A., Peterlin, B. L., Tompkins, D. A., Salas, R. M. E., Buenaver, L. F., Haythornthwaite, J. A., & Campbell, C. M. (2017) · Journal of Applied Biobehavioral Research · doi:10.1111/jabr.12096 · Cited by 14 · see citing works
Rice, D. A., Parker, R. S., Lewis, G. N., Kluger, M. T., & McNair, P. J. (2016) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000464 · Cited by 13 · see citing works
Jaltare, K. P., Meyers, E., & Torta, D. M. E. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.104567 · Cited by 12 · see citing works
Ferrandis, E. D., Ferrando, M., Garrido, M. J. G., & Andreu‐Vaillo, Y. (2017) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2114 · Cited by 12 · see citing works
Schütze, R., Rees, C. S., Smith, A. J., Slater, H., Catley, M. J., & O’Sullivan, P. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00910 · Cited by 12 · see citing works
Güereca, Y. M., Kell, P. A., Kuhn, B. L., Hellman, N. M., Sturycz, C. A., Toledo, T. A., Huber, F. A., Demuth, M., Lannon, E. W., Palit, S., et al. (2022) · Journal of Pain · doi:10.1016/j.jpain.2021.12.010 · Cited by 12 · see citing works
Porta, D. D., Vilz, M.-L., Kuzminova, A., Filbrich, L., Mouraux, A., & Legrain, V. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.997230 · Cited by 12 · see citing works
Ge, S., Hu, Q., Guo, Y., Xu, K., Xia, G., & Sun, C. (2021) · Neural Plasticity · doi:10.1155/2021/6690414 · Cited by 11 · see citing works
Mammadkhanlı, O., Kehaya, S., Solak, S., & Yağmurlu, K. (2024) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2024.03.034 · Cited by 10 · see citing works
Attention and pain: are auditory distractors special?
Sloan, P., & Hollins, M. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-4903-x · Cited by 10 · see citing works
Rhudy, J. L., Hellman, N. M., Sturycz, C. A., Toledo, T. A., & Palit, S. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.10.006 · Cited by 9 · see citing works
Porta, D. D., Scheirman, E., & Legrain, V. (2024) · Pain · doi:10.1097/j.pain.0000000000003225 · Cited by 7 · see citing works
Hansen, M. S., Wetterslev, J., Pipper, C. B., Asghar, M. S., & Dahl, J. B. (2017) · Journal of Pain Research · doi:10.2147/jpr.s121189 · Cited by 7 · see citing works
Adverse life events, sensitization of spinal nociception, and chronic pain risk
Rhudy, J. L., & Hellman, N. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820589-1.00032-4 · Cited by 7 · see citing works
Rhudy, J. L., Kuhn, B. L., Demuth, M. J., Huber, F. A., Hellman, N. M., Toledo, T. A., Lannon, E. W., Palit, S., Payne, M. F., Sturycz, C. A., et al. (2021) · Journal of Pain · doi:10.1016/j.jpain.2021.04.014 · Cited by 7 · see citing works
Factors influencing the hypoalgesic effects of virtual reality
Shafir, R., Watson, L., Felix, R. B., Muhammed, S., Fisher, J. P., Hu, P. F.-M., Wang, Y., & Colloca, L. (2025) · Pain · doi:10.1097/j.pain.0000000000003549 · Cited by 6 · see citing works
Hansen, M. S., Wetterslev, J., Pipper, C. B., Asghar, M. S., & Dahl, J. B. (2015) · BMC Anesthesiology · doi:10.1186/s12871-016-0193-2 · Cited by 5 · see citing works
Study protocol: an observational study of distress, immune function and persistent pain in HIV
Madden, V. J., Msolo, N. K., Mqadi, L., Lesosky, M., Bedwell, G. J., Hutchinson, M. R., Peter, J., Parker, R., Schrepf, A., Edwards, R. R., et al. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059723 · Cited by 4 · see citing works
Bedwell, G. J., Chikezie, P. C., Siboza, F. T., Mqadi, L., Rice, A. S. C., Kamerman, P. R., Parker, R., & Madden, V. J. (2023) · Journal of Pain · doi:10.1016/j.jpain.2023.06.013 · Cited by 4 · see citing works
Meeker, T. J., Schmid, A., Liu, Y., Keaser, M. L., Dorsey, S. G., Seminowicz, D. A., & Greenspan, J. D. (2021) · European Journal of Pain · doi:10.1002/ejp.1815 · Cited by 4 · see citing works
Functional human brain connectivity during labor and its alteration under epidural analgesia
Yang, F., Chao, A., Lin, S., Chao, A., Wang, T., Chang, Y., Chang, H., & Wang, J. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00216-2 · Cited by 4 · see citing works
Iannitelli, A., & Tirassa, P. (2016) · Wiley eBooks · doi:10.1002/9781118455968.ch13 · Cited by 4 · see citing works
High cognitive load may prevent the development of nociceptive hypersensitivityPreprint
Torta, D. M. E., Laurentis, M. D., Eichin, K. N., von Leupoldt, A., van den Broeke, E., & Vlaeyen, J. W. S. (2019) · doi:10.31234/osf.io/zq5sx · Cited by 4 · see citing works
Meyers, E., Della Porta, D., Torta, D. M., & van den Broeke, E. N. (2025) · PAIN Reports · doi:10.1097/pr9.0000000000001291 · Cited by 3 · see citing works
The thermal grill elicits central sensitization
Cormie, M. A., Seminowicz, D. A., & Moayedi, M. (2025) · Pain · doi:10.1097/j.pain.0000000000003776 · Cited by 3 · see citing works
Self-citationComplementary and Alternative (CAM) Treatment Options for Women with Pelvic Pain
Srinivasan, M., Torres, J. E., McGeary, D. D., & Nagpal, A. (2020) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-020-00264-6 · Cited by 3 · see citing works
Shen, Z., Sun, J., Liu, B., Jiang, Y., Wu, Y., Wang, J., Shao, X., & Fang, J. (2017) · Medical Science Monitor · doi:10.12659/msm.903292 · Cited by 3 · see citing works
Methodology and applicability of the human contact burn injury model: A systematic review
Springborg, A. H., Wessel, C. R., Andersen, L. P. K., & Werner, M. U. (2021) · PLoS ONE · doi:10.1371/journal.pone.0254790 · Cited by 3 · see citing works
Acceptance and commitment therapy for prevention of chronic pain after total knee arthroplasty.
Giusti, E. M., Castelnuovo, G., Manna, C., Varallo, G., Cattivelli, R., Petrachi, B. V., Stramba-Badiale, M., & Spatola, C. A. M. (2026) · Pain Medicine · doi:10.1093/pm/pnaf145 · Cited by 2 · see citing works
“47,48 Therefore, the NOPAIN treatment can be refined by more explicitly targeting pain catastrophizing and promoting greater engagement in movement and exercise, potentially impacting the various factors linked to moderate-to-severe pain at follow-up.”
The Psychological Management of Acute Pain After Abdominal Surgery
Rockett, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-94482-1_14 · Cited by 2 · see citing works
Abssy, S. S., Osborne, N. R., Osokin, E. E., Tomin, R., Honigman, L., Khan, J. S., Vera, N. W. D., Furman, A. J., Mazaheri, A., Seminowicz, D. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.30.605813 · Cited by 2 · see citing works
Self-citationDeegan, O., Yoshitani, M., Fullen, B. M., Gordon, M., McDonagh, O., Sheerin, O., Murphy, J., Oyebode, O., Segurado, R., Hearty, C., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0323508 · Cited by 1 · see citing works
Pain and Value-Based Decision-Making: An Introduction and Implications for Neuroeconomics
López-Guzmán, S., & Atlas, L. Y. (2025) · Springer eBooks · doi:10.1007/978-3-032-02925-6_12 · Cited by 1 · see citing works
Abssy, S. S., Osborne, N. R., Osokin, E. E., Tomin, R., Honigman, L., Khan, J. S., Vera, N. W. D., Furman, A. J., Mazaheri, A., Seminowicz, D. A., et al. (2024) · eLife · doi:10.7554/elife.101986 · Cited by 1 · see citing works
Self-citationAbssy, S. S., Osborne, N. R., Osokin, E. E., Tomin, R., Honigman, L., Khan, J. S., Vera, N. W. D., Furman, A. J., Mazaheri, A., Seminowicz, D. A., et al. (2024) · eLife · doi:10.7554/elife.101986.1 · Cited by 1 · see citing works
Self-citationBehandeling van centrale sensitisatiepijn: bottom-up, top-down behandeling of beide?
Nijs, J. (2015) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-0925-2_5
Should Investigators Introspect on Their Own Pain Experiences as Study Co-Participants?
van Rysewyk, S., & von Baeyer, C. L. (2016) · Springer eBooks · doi:10.1007/978-3-319-49022-9_11
Albu, S., Linsenbardt, H. R., & Meagher, M. W. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820589-1.00033-6
Supraspinal facilitation to repetitive painful stimulation: a laser-evoked potential study
Archibald, J., Ortiz, O., Enzler, A., Rösner, J., & Kramer, J. L. K. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00283.2022
Madden, V. J., Mqadi, L., Arendse, G., Bedwell, G. J., Msolo, N. K., Lesosky, M., Hutchinson, M. R., Peter, J., Schrepf, A., Parker, R., et al. (2025) · Pain · doi:10.1097/j.pain.0000000000003748
Distress is positively associated with induced secondary hyperalgesia in people with suppressed HIV
Mqadi, L., Bedwell, G. J., Msolo, N. K., Arendse, G., Lesosky, M., Kamerman, P. R., Hutchinson, M. R., Schrepf, A., Edwards, R. R., Joska, J. A., et al. (2025) · Journal of Pain · doi:10.1016/j.jpain.2025.105600
Vera, N. W. D., Abssy, S. S., Seminowicz, D. A., & Moayedi, M. (2026) · Journal of Pain · doi:10.1016/j.jpain.2026.106253
Self-citation
- Authors
- Salomons, T. V., Moayedi, M., Erpelding, N., & Davis, K. D.
- Affiliations
- University Health Network (CA)
- University of Toronto (CA)
- Corresponding author
- Davis, Karen D.
- Venue
- Pain
- Published
- 2014-08
- Volume
- 155
- Issue
- 8
- Pages
- 1446-1452
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2105744208
- Cited by
- 76
- References
- 49
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 3 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 2
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Fonds National de la Recherche Luxembourg (PDR-09-023)
- University of Toronto
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Keywords
- cognitive-behavioural intervention, secondary hyperalgesia, central sensitization, pain catastrophizing, pain perception, pain unpleasantness, pain-related cognitions, thermal pain, pain intensity
- MeSH terms
- Adult, Female, Hot Temperature, Humans, Hyperalgesia, Male, Pain, Psychotherapy, Brief, Cognitive Behavioral Therapy, Treatment Outcome, Young Adult, Pain Management
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
