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Cited by 155Sleep and related disordersGenetic Neurodegenerative DiseasesCircadian rhythm and melatonin

Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease

Aziz, N. Ahmad, Anguelova, Galia V., Marinus, Johan, Lammers, Gert Jan, Roos, Raymund A.C.·2010·Parkinsonism & Related Disorders
DOI 10.1016/j.parkreldis.2010.02.009
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Abstract

Objective Sleep disturbances are a prominent feature of Huntington's disease (HD) and can substantially impair patients' quality of life. However, sleep complaints and their association with other symptoms and signs of HD have not yet been assessed in large groups of patients or premanifest mutation carriers. Therefore, we aimed to delineate the nature of subjective sleep disturbances and identify important correlates of sleep impairment in HD patients and premanifest mutation carriers.Subjects & methods Using standardized questionnaires (including Epworth's Sleepiness Scale, Pittsburgh Sleep Quality Index, SCOPA-SLEEP, and Beck's Depression Inventory), daytime sleepiness, night-time sleep, and depressed mood were assessed in 63 HD patients, 21 premanifest mutation carriers and 84 controls.Results Night-time sleep impairment was significantly more prevalent in HD patients compared with controls (58.1% vs. 34.9%, p = 0.012), but daytime sleepiness was not (12.7% vs. 7.9%, p = 0.560). Depression was the only independent correlate of night-time sleep impairment in HD patients, accounting for 10% of the variance. Compared with controls, both sleep onset latency and wake-up time were significantly delayed in HD patients. Moreover, in HD patients, later wake-up time was significantly associated with cognitive score (r = -0.43), total functional capacity (r = -0.54) and depressive symptoms (r = +0.47). In general, the degree of sleep (phase) changes in premanifest mutation carriers lay in between those of HD patients and controls.Conclusions HD is primarily accompanied by night-time sleep disturbances and a delayed sleep phase, which are associated with depression and lower cognitive as well as functional performance.

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  • PD is strongly associated with REM sleep behaviour disorder, as well as excessive daytime sleepiness, insomnia and restless legs syndrome.

    “PD, in particular, is strongly associated with rapid eye moment (reM) sleep behaviour disorder (RBD), as well as excessive daytime sleepiness, insomnia and restless legs syndrome270–273.”

    From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [273]

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Authors
Aziz, N. A., Anguelova, G. V., Marinus, J., Lammers, G. J., & Roos, R. A. C.
Affiliations
Leiden University Medical Center (NL)
Corresponding author
Aziz, N. Ahmad
ORCID
Venue
Parkinsonism & Related Disorders
Publisher
Elsevier BV
Published
2010-06
Volume
16
Issue
5
Pages
345-350
ISSN
1353-8020 (ISSN-L)
DOI
10.1016/j.parkreldis.2010.02.009
OpenAlex
W2006623685
Cited by
155
References
32
Citations by year
2026: 4 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 8 · 2020: 7 · 2019: 14 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 14 · 2014: 12 · 2013: 7 · 2012: 10
FWCI
11.30
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Parkinsonism & Related Disorders (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
Huntington's disease, sleep disorders
MeSH terms
Adult, Circadian Rhythm, Cognition Disorders, Depression, Female, Humans, Huntington Disease, Male, Middle Aged, Psychiatric Status Rating Scales, Retrospective Studies, Sleep, Statistics as Topic, Reproducibility of Results, Statistics, Nonparametric, Sleep Disorders, Circadian Rhythm

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