Dopaminergic system and dream recall: an MRI study in Parkinson's disease patients
Open accessAbstract
We investigated the role of the dopamine system [i.e., subcortical-medial prefrontal cortex (mPFC) network] in dreaming, by studying patients with Parkinson's Disease (PD) as a model of altered dopaminergic transmission. Subcortical volumes and cortical thickness were extracted by 3T-MR images of 27 PD patients and 27 age-matched controls, who were asked to fill out a dream diary upon morning awakening for one week. PD patients do not substantially differ from healthy controls with respect to the sleep, dream, and neuroanatomical measures. Multivariate correlational analyses in PD patients show that dopamine agonist dosage is associated to qualitatively impoverished dreams, as expressed by lower bizarreness and lower emotional load values. Visual vividness (VV) of their dream reports positively correlates with volumes of both the amygdalae and with thickness of the left mPFC. Emotional load also positively correlates with hippocampal volume. Beside the replication of our previous finding on the role of subcortical nuclei in dreaming experience of healthy subjects, this represents the first evidence of a specific role of the amygdala-mPFC dopaminergic network system in dream recall. The association in PD patients between higher dopamine agonist dosages and impoverished dream reports, however, and the significant correlations between VV and mesolimbic regions, however, provide an empirical support to the hypothesis that a dopamine network plays a key role in dream generation. The causal relation is however precluded by the intrinsic limitation of assuming the dopamine agonist dosage as a measure of the hypodopaminergic state in PD. Periodicals, Inc.
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Many afferent and efferent fibers of the posterior and anterior dream systems are connected with the limbic system.
“many of the afferent and efferent fibers of these two systems are connected with the limbic system”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as De Gennaro et al., 2016
The Introduction (page unavailable) says the medial prefrontal cortex connects directly and indirectly to the hippocampus and amygdala, supporting a connection for one of the discussed systems. The Discussion (page unavailable) distinguishes the posterior temporoparietal system from the mesolimbic system, but does not say that afferent and efferent fibers of both systems connect with the limbic system. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe ventromesial frontal white matter takes part in the interplay between basal forebrain and limbic structures.
“the ventromesial frontal white matter seems to take a part in the interplay between basal forebrain and limbic structures”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as De Gennaro et al., 2016
The Introduction (page unavailable) describes connections between the medial prefrontal cortex and the hippocampus and amygdala. The Discussion (page unavailable) identifies dopaminergic projections in ventromedial frontal white matter and separately discusses basal-forebrain lesions, but does not establish that this white matter mediates an interplay between the basal forebrain and limbic structures. (LLM, conf=0.77)
Experimental — accuracy not yet measuredRecent findings on Parkinson's Disease confirmed an essential interplay between the mPFC and mesolimbic-dopamine system for dreaming.
“the recent findings on PD confirmed the evidence of an essential interplay between the mPFC and mesolimbic-dopamine system for dreaming”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as De Gennaro et al., 2016
The Abstract and Discussion report associations between dream-report features, mPFC thickness, amygdala volume, and dopamine agonist dosage in patients with Parkinson’s disease. The authors call this empirical support for a dopamine network’s role in dreaming, but say a causal relation cannot be established. The claim’s language of a confirmed, essential interplay overstates that evidence. (LLM, conf=0.87)
Experimental — accuracy not yet measuredAccording to the paralimbic hypothesis, emotional salience of dream imagery is due to the activation of the paralimbic cortices by the amygdala, while bizarreness of dream contents is a consequence of prefrontal deactivation, reducing the higher order control on amygdalar and hippocampal functioning.
“According to this hypothesis, emotional salience of dream imagery is due to the activation of the paralimbic cortices by the amygdala,87,88 while bizarreness of dream contents is a consequence of prefrontal deactivation, reducing the higher order control on the amygdalar and hippocampal functioning.110”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [88]
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredLower bizarreness and lower emotional load have been found in Parkinson's disease patients with a hypodopaminergic state.
“At the same time, lower bizarreness and lower emotional load has been found in Parkinson’s disease (PD) patients with a hypodopaminergic state.”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [88]
Parkinson's Disease patients did not differ from healthy subjects with respect to sleep and dream characteristics or neuroanatomical measures.
“PD patients did not differ from healthy subjects with respect to sleep and dream characteristics or the neuroanatomical measures”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as De Gennaro et al., 2016
Higher dopamine agonist dosage is associated with qualitatively impoverished dream experience, as indicated by reduced bizarreness and emotional load levels.
“higher dopamine agonist dosage was associated with qualitatively impoverished DE, as indicated by reduced bizarreness and emotional load levels”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as De Gennaro et al., 2016
Vividness in dream experience is related to the amygdalae and the thickness of the left mPFC.
“confirming that vividness is related to the amygdalae and also the thickness of the left mPFC”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as De Gennaro et al., 2016
Emotional load is positively correlated with hippocampal volume, suggesting a role of the amygdala-mPFC dopaminergic network system in dream recall.
“while emotional load is positively correlated with hippocampal volume, suggesting a role of amygdala–mPFC dopaminergic network system in dream recall.88”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [88]
Visual vividness has been found to positively correlate with the volume of amygdala and the thickness of the left medial prefrontal cortex in Parkinson's disease patients.
“Visual vividness has been found to positively correlate with the volume of amygdala and the thickness of the left medial prefrontal cortex (mPFC) in PD patients”
From Spotlight on dream recall: the ages of dreams (2018) · cites this paper as [88]
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Gott, J. A., Stücker, S., Kanske, P., Haaker, J., & Dresler, M. (2024) · Consciousness and Cognition · doi:10.1016/j.concog.2023.103608 · Cited by 25 · see citing works
- Authors
- De Gennaro, L., Lanteri, O., Piras, F., Scarpelli, S., Assogna, F., Ferrara, M., Caltagirone, C., & Spalletta, G.
- Affiliations
- Department of Psychology University of Rome “Sapienza,” Rome Italy
- Sapienza University of Rome (IT)
- Centro Ricerche Enrico Fermi (IT)
- Fondazione Santa Lucia (IT)
- Department of Life, Health and Environmental Sciences University of L'aquila Italy
- University of Rome Tor Vergata (IT)
- Baylor College of Medicine (US)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2015-12-24
- Volume
- 37
- Issue
- 3
- Pages
- 1136-1147
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6867535
- OpenAlex
- W2198267268
- Cited by
- 45
- References
- 70
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 3
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- Luigi De Gennaro from Ministero della Salute (Ministry of Health) (RF-2009-1528677)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- dream recall, dopaminergic system, Parkinson's disease, dopamine agonists, medial prefrontal cortex, amygdala, hippocampus, dream vividness, dream bizarreness, mesolimbic system, subcortical volume, cortical thickness
- MeSH terms
- Adult, Aged, Antiparkinson Agents, Brain, Dreams, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Organ Size, Parkinson Disease, Mental Recall, Sleep, Dopamine Agonists
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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