Cited by 623Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingDeep Brain Stimulation and Movement Disorders

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Neuropathology of Parkinson disease

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Dickson, Dennis W.·2018·Parkinsonism & Related Disorders

DOI 10.1016/j.parkreldis.2017.07.033PMC PMC5718208

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Abstract

Introduction Parkinson's disease (PD) is characterized by bradykinesia, rigidity, postural instability and tremor. Several pathologic processes can produce this syndrome, but neurodegeneration accompanied by neuronal inclusions composed of α-synuclein (Lewy bodies) is considered the typical pathologic correlate of PD.Methods The neuropathologic features of PD are reviewed based upon personal experience and review of the literature. Molecular pathology of PD is summarized from cell biological and animal studies.Results The pathologic feature that correlates with signs and symptoms of PD is neuronal loss in the substantia nigra with dopaminergic denervation of the striatum. Neuronal degeneration in the substantia nigra preferentially affects the ventrolateral cell group that projects to posterolateral putamen and is accompanied by formation of Lewy bodies composed of aggregated α-synuclein. Some patients with PD are found at autopsy to have other pathologic processes, such as multiple system atrophy, progressive supranuclear palsy and cerebrovascular disease (vascular Parkinsonism). The peripheral autonomic nervous system is also affected. The triggering event in PD is unknown, but recent studies suggest a role for loss of nuclear membrane integrity. Once α-synuclein aggregates forms, evidence supports cell-to-cell propagation.Conclusion PD is a multisystem synucleinopathy caused by poorly characterized genetic and environmental factors that produces degeneration in selectively vulnerable neuronal populations.

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Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
α-Synuclein in Lewy bodies
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069
Self-citation
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium
McKeith, I. G., Boeve, B. F., Dickson, D. W., Halliday, G., Taylor, J.-P., Weintraub, D., Aarsland, D., Galvin, J., Attems, J., Ballard, C. G., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004058 · Cited by 4,476
Self-citation
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
Self-citation
AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's disease
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schols, L., & Riess, O. (1998) · Nature Genetics · doi:10.1038/ng0298-106 · Cited by 3,836
AGEING AND PARKINSON'S DISEASE: SUBSTANTIA NIGRA REGIONAL SELECTIVITY
FEARNLEY, J. M., & LEES, A. J. (1991) · Brain · doi:10.1093/brain/114.5.2283 · Cited by 3,529
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,087
Self-citation
Clinical diagnostic criteria for dementia associated with Parkinson’s disease
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027
Self-citation
Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990
The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
Zarranz, J. J., Alegre, J., Gómez‐Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., et al. (2004) · Annals of Neurology · doi:10.1002/ana.10795 · Cited by 2,737
Stages in the development of Parkinson’s disease-related pathology
Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H., & Del Tredici, K. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0956-9 · Cited by 2,689
α-synuclein locus duplication as a cause of familial Parkinson's disease
Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17103-1 · Cited by 2,029
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
Burré, J., Sharma, M., Tsetsenis, T., Buchman, V. L., Etherton, M. R., & Südhof, T. C. (2010) · Science · doi:10.1126/science.1195227 · Cited by 1,907
The substantia nigra of the human brain
Damier, P., Hirsch, É. C., Agid, Y., & Graybiel, A. M. (1999) · Brain · doi:10.1093/brain/122.8.1437 · Cited by 1,827
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
(1998) · Europe PMC (PubMed Central) · Cited by 1,594
Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
Conway, K. A., Harper, J. D., & Lansbury, P. T. (1998) · Nature Medicine · doi:10.1038/3311 · Cited by 1,520
Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
Luk, K. C., Kehm, V. M., Zhang, B., O’Brien, P., Trojanowski, J. Q., & Lee, V. M. ‐. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112457 · Cited by 1,136
Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder
Schenck, C. H., Bundlie, S. R., & Mahowald, M. W. (1996) · Neurology · doi:10.1212/wnl.46.2.388 · Cited by 1,083
A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly
Giasson, B. I., Murray, I. V. J., Trojanowski, J. Q., & Lee, V. M.-Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008919200 · Cited by 1,080
The Lewy body variant of Alzheimer's disease: A clinical and pathologic entity
Hansen, L., Salmon, D., Galasko, D., Masliah, E., Katzman, R., DeTeresa, R., Thal, L., Pay, M. M., Hofstetter, R., Klauber, M., et al. (1990) · Neurology · doi:10.1212/wnl.40.1.1 · Cited by 1,068
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.
Anglade, P., Vyas, S., Javoy-Agid, F., Herrero, M. T., Michel, P. P., Marquez, J., Prigent, A., Ruberg, M., Hirsch, É. C., & Agid, Y. (1997) · PubMed · Cited by 1,045
Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
Papp, M. I., Kahn, J. E., & Lantos, P. L. (1989) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(89)90219-0 · Cited by 991
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
Boeve, B. F., Silber, M. H., Saper, C. B., Ferman, T. J., Dickson, D. W., Parisi, J. E., Benarroch, E. E., Ahlskog, J. E., Smith, G. E., Caselli, R., et al. (2007) · Brain · doi:10.1093/brain/awm056 · Cited by 986
Self-citation
Neuropathological assessment of Parkinson’s disease: refining the diagnostic criteria
Dickson, D. W., Braak, H., Duda, J. E., Duyckaerts, C., Gasser, T., Halliday, G. M., Hardy, J., Leverenz, J. B., Del Tredici, K., Wszolek, Z. K., et al. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70238-8 · Cited by 972
Self-citation
A Clinicopathologic Study of 100 Cases of Parkinson's Disease
Hughes, A. J., Daniel, S. E., Blankson, S., & Lees, A. J. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540020018011 · Cited by 945
Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons
Murphy, D. D., Rueter, S. M., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03214.2000 · Cited by 927
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Danzer, K. M., Kranich, L. R., Ruf, W. P., Cagsal‐Getkin, O., Winslow, A. R., Zhu, L., Vanderburg, C. R., & McLean, P. J. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-42 · Cited by 880
Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
Giasson, B. I., Forman, M. S., Higuchi, M., Golbe, L. I., Graves, C. L., Kotzbauer, P. T., Trojanowski, J. Q., & Lee, V. M.-Y. (2003) · Science · doi:10.1126/science.1082324 · Cited by 879
Frequency of Bowel Movements and the Future Risk of Parkinson’s Disease
Abbott, R. D., Petrovitch, H., White, L. R., Masaki, K. H., Tanner, C. M., Curb, J. D., Grandinetti, A., Blanchette, P. L., Popper, J. S., & Ross, G. W. (2001) · Neurology · doi:10.1212/wnl.57.3.456 · Cited by 839
Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease
Hughes, A. J., Daniel, S. E., & Lees, A. J. (2001) · Neurology · doi:10.1212/wnl.57.8.1497 · Cited by 807
Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid
Conway, K. A., Harper, J. D., & Lansbury, P. T. (2000) · Biochemistry · doi:10.1021/bi991447r · Cited by 786
Where Does Parkinson Disease Pathology Begin in the Brain?
Del Tredici, K., Rüb, U., de Vos, R. A. I., Bohl, J. R. E., & Braak, H. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.5.413 · Cited by 773
Dementia with Lewy bodies.
McKeith, I. G. (2004) · Europe PMC (PubMed Central) · Cited by 756
Lewy Bodies in Alzheimer's Disease: A Neuropathological Review of 145 Cases Using α‐Synuclein Immunohistochemistry
Hamilton, R. L. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00269.x · Cited by 754
Pathology of Parkinson’s disease
Jellinger, K. A. (1991) · Molecular and Chemical Neuropathology · doi:10.1007/bf03159935 · Cited by 708
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
Tu, P., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., Trojanowski, J. Q., & Lee, V. M. ‐. (1998) · Annals of Neurology · doi:10.1002/ana.410440324 · Cited by 686
Proteasomal function is impaired in substantia nigra in Parkinson’s disease
McNaught, K. S. P., & Jenner, P. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01701-8 · Cited by 653
α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
Chen, L., & Feany, M. Β. (2005) · Nature Neuroscience · doi:10.1038/nn1443 · Cited by 634
Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe
Harding, A., Broe, G. A., & Halliday, G. M. (2002) · Brain · doi:10.1093/brain/awf033 · Cited by 609
The parkinson's complex: Parkinsonism is just the tip of the iceberg
Langston, J. W. (2006) · Annals of Neurology · doi:10.1002/ana.20834 · Cited by 608
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease
Hurtig, H. I., Trojanowski, J. Q., Galvin, J. E., Ewbank, D., Schmidt, M. L., Lee, V. M. Y., Clark, C., Glosser, G., Stern, M. B., Gollomp, S. M., et al. (2000) · Neurology · doi:10.1212/wnl.54.10.1916 · Cited by 604
A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis
Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., & Zigmond, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03090.2002 · Cited by 598
Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.
Gibb, W. R. G., & Lees, A. J. (1991) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.5.388 · Cited by 574
α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins
Ostrerova, N., Petrucelli, L., Farrer, M. J., Mehta, N., Choi, P., Hardy, J., & Wolozin, B. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05782.1999 · Cited by 560
Basal forebrain neurons in the dementia of Parkinson disease
Whitehouse, P. J., Hedreen, J. C., White, C. L., & Price, D. L. (1983) · Annals of Neurology · doi:10.1002/ana.410130304 · Cited by 535
Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein Genes
Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65722-7 · Cited by 533
Frontotemporal Lobar Degeneration
Rabinovici, G. D., & Miller, B. L. (2010) · CNS Drugs · doi:10.2165/11533100-000000000-00000 · Cited by 518
Aggregation promoting C-terminal truncation of α-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
Li, W., West, N. C., Colla, E., Pletniková, O., Troncoso, J. C., Marsh, L., Dawson, T. M., Jäkälä, P., Hartmann, T., Price, D. L., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406976102 · Cited by 479
NACP/α-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson’s disease brains
Wakabayashi, K., Hayashi, S., Yoshimoto, M., Kudo, H., & Takahashi, H. (2000) · Acta Neuropathologica · doi:10.1007/pl00007400 · Cited by 451
Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids
Perrin, R. J., Woods, W. S., Clayton, D. F., & George, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004851200 · Cited by 444
A Structural and Functional Role for 11-mer Repeats in α-Synuclein and Other Exchangeable Lipid Binding Proteins
Bussell, R., & Eliezer, D. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00520-5 · Cited by 437
Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome
Williams, D. R., Holton, J. L., Strand, C., Pittman, A. M., de Silva, R., Lees, A. J., & Révész, T. (2007) · Brain · doi:10.1093/brain/awm104 · Cited by 435
Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair
Rubinsztein, D. C., DiFiglia, M., Heintz, N., Nixon, R. A., Qin, Z., Ravikumar, B., Stefanis, L., & Tolkovsky, A. M. (2005) · Autophagy · doi:10.4161/auto.1.1.1513 · Cited by 424
Lewy bodies are ubiquitinated
Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00687787 · Cited by 409
Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies
Ishizawa, T., Mattila, P. M., Davies, P., Wang, D., & Dickson, D. W. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.389 · Cited by 402
Self-citation
Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease?
Kosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984) · PubMed · Cited by 401
Olfactory dysfunction in Parkinson's disease.
Hawkes, C. H., Shephard, B. C., & Daniel, S. E. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.5.436 · Cited by 399
β-Synuclein Inhibits α-Synuclein Aggregation
Hashimoto, M., Rockenstein, E., Mante, M., Mallory, M., & Masliah, E. (2001) · Neuron · doi:10.1016/s0896-6273(01)00462-7 · Cited by 398
Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication
Fuchs, J., Nilsson, C., Kachergus, J. M., Munz, M., Larsson, E., Schüle, B., Langston, J. W., Middleton, F. A., Ross, O. A., Hulihan, M., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000254458.17630.c5 · Cited by 397
Parkinson Disease Neuropathology
Apaydın, H., Ahlskog, J. E., Parisi, J. E., Boeve, B. F., & Dickson, D. W. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.102 · Cited by 397
Self-citation
Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
Kalia, L. V., Lang, A. E., Hazrati, L., Fujioka, S., Wszołek, Z. K., Dickson, D. W., Ross, O. A., Deerlin, V. M. V., Trojanowski, J. Q., Hurtig, H. I., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2704 · Cited by 396
Self-citation
Pathology and Biology of the Lewy Body
Pollanen, M. S., Dickson, D. W., & Bergeron, C. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199305000-00001 · Cited by 396
Self-citation
Nigral and Cortical Lewy Bodies and Dystrophic Nigral Neurites in Parkinsonʼs Disease and Cortical Lewy Body Disease Contain α-synuclein Immunoreactivity
Irizarry, M. C., Growdon, W., Gómez‐Isla, T., Newell, K. L., George, J. M., Clayton, D. F., & Hyman, B. T. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199804000-00005 · Cited by 394
The pedunculopontine nucleus in Parkinson's disease
Zweig, R. M., Jankel, W. R., Hedreen, J. C., Mayeux, R. P., & Price, D. L. (1989) · Annals of Neurology · doi:10.1002/ana.410260106 · Cited by 388
Clinicopathological investigation of vascular parkinsonism, including clinical criteria for diagnosis
Zijlmans, J. C. M., Daniel, S. E., Hughes, A. J., Révész, T., & Lees, A. J. (2004) · Movement Disorders · doi:10.1002/mds.20083 · Cited by 381
Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease
Halliday, G. M., Blumbergs, P. C., Cotton, R. G. H., Blessing, W. W., & Geffen, L. B. (1990) · Brain Research · doi:10.1016/0006-8993(90)90733-r · Cited by 379
When DLB, PD, and PSP masquerade as MSA
Koga, S., Aoki, N., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Josephs, K. A., Wszołek, Z. K., Langston, J. W., & Dickson, D. W. (2015) · Neurology · doi:10.1212/wnl.0000000000001807 · Cited by 368
Self-citation
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0345-7 · Cited by 364
Self-citation
Post mortem studies in Parkinson’s disease — is it possible to detect brain areas for specific symptoms?
Jellinger, K. A. (1999) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6360-3_1 · Cited by 359
Alzheimer Disease With Amygdala Lewy Bodies: A Distinct Form of α-Synucleinopathy
Uchikado, H., Lin, W.-L., DeLucia, M. W., & Dickson, D. W. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000225908.90052.07 · Cited by 359
Self-citation
Accumulation of Phosphorylated α-Synuclein in Aging Human Brain
Saito, Y., Kawashima, A., Ruberu, N. N., Fujiwara, H., Koyama, S., Sawabe, M., Arai, T., Nagura, H., Yamanouchi, H., Hasegawa, M., et al. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.6.644 · Cited by 354
Neuropathology of dementia in Parkinson's disease: A prospective, community‐based study
Aarsland, D., Perry, R., Brown, A. D., Larsen, J. O., & Ballard, C. G. (2005) · Annals of Neurology · doi:10.1002/ana.20635 · Cited by 347
α‐Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects
Bloch, A., Probst, A., Bissig, H., Adams, H., & Tolnay, M. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00727.x · Cited by 337
Diffuse lewy body disease in Japan
Kosaka, K. (1990) · Journal of Neurology · doi:10.1007/bf00314594 · Cited by 335
Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra
Rinne, J. O., Rummukainen, J., Paljärvi, L., & Rinne, U. K. (1989) · Annals of Neurology · doi:10.1002/ana.410260107 · Cited by 330
α‐Synuclein pathology does not predict extrapyramidal symptoms or dementia
Parkkinen, L., Kauppinen, T., Pirttilä, T., Autere, J. M., & Alafuzoff, I. I. (2004) · Annals of Neurology · doi:10.1002/ana.20321 · Cited by 328
Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases
Duda, J. E., Giasson, B. I., Mabon, M. E., Lee, V. M. ‐., & Trojanowski, J. Q. (2002) · Annals of Neurology · doi:10.1002/ana.10279 · Cited by 322
Facilitation at single synapses probed with optical quantal analysis
Oertner, T. G., Sabatini, B. L., Nimchinsky, E. A., & Svoboda, K. (2002) · Nature Neuroscience · doi:10.1038/nn867 · Cited by 320
Aggregated α-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo
Periquet, M., Fulga, T. A., Myllykangas, L., Schlossmacher, M. G., & Feany, M. Β. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0285-07.2007 · Cited by 299
Cortical Lewy body pathology in the diagnosis of dementia
Harding, A. J., & Halliday, G. M. (2001) · Acta Neuropathologica · doi:10.1007/s004010100390 · Cited by 298
Widespread Alterations of α-Synuclein in Multiple System Atrophy
Dickson, D. W., Liu, W.-K., Hardy, J., Farrer, M. J., Mehta, N. D., Uitti, R. J., Mark, M. H., Zimmerman, T., Golbe, L. I., Sage, J., et al. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65226-1 · Cited by 298
Self-citation
Subclinical dopaminergic dysfunction in asymptomatic Parkinson's disease patients' relatives with a decreased sense of smell
Berendse, H. W., Booij, J., Francot, C. M. J. E., Bergmans, P., Hijman, R., Stoof, J. C., & Wolters, E. C. (2001) · Annals of Neurology · doi:10.1002/ana.1049 · Cited by 298
Incidental Lewy body disease in a patient with REM sleep behavior disorder
Uchiyama, M., Isse, K., Tanaka, K., Yokota, N., Hamamoto, M., Aida, S., Ito, Y., Yoshimura, M., & Okawa, M. (1995) · Neurology · doi:10.1212/wnl.45.4.709 · Cited by 297
Amygdala pathology in Parkinson's disease
Braak, H., Braak, E., Yilmazer‐Hanke, D., de Vos, R. A. I., Jansen, E. N. H., Böhl, J., & Jellinger, K. A. (1994) · Acta Neuropathologica · doi:10.1007/bf00296485 · Cited by 297
Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease
Dickson, D. W., Ruan, D. T., Crystal, H., Mark, M. H., Davies, P., Kress, Y., & Yen, S. H. (1991) · Neurology · doi:10.1212/wnl.41.9.1402 · Cited by 293
Self-citation
Morphogenesis of Lewy Bodies: Dissimilar Incorporation of α-Synuclein, Ubiquitin, and p62
Kuusisto, E., Parkkinen, L., & Alafuzoff, I. I. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.12.1241 · Cited by 291
Lewy body–type degeneration in cardiac plexus in Parkinson’s and incidental Lewy body diseases
Iwanaga, K., Wakabayashi, K., Yoshimoto, M., Tomita, I., Satoh, H., Takashima, H., Satoh, A., Seto, M., Tsujihata, M., & Takahashi, H. (1999) · Neurology · doi:10.1212/wnl.52.6.1269 · Cited by 277
Lewy Bodies of Parkinson's Disease Contain Neurofilament Antigens
Goldman, J. E., Yen, S.-H. C., Chiu, F., & Peress, N. S. (1983) · Science · doi:10.1126/science.6308771 · Cited by 268
Parkinson's disease: Neuron loss in the nucleus basalis without concomitant Alzheimer's disease
Nakano, I., & Hirano, A. (1984) · Annals of Neurology · doi:10.1002/ana.410150503 · Cited by 260
Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by α-synuclein immunocytochemistry
Braak, H., Sandmann-Keil, D., Gai, W., & Braak, E. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00208-6 · Cited by 243
Expanding the spectrum of neuronal pathology in multiple system atrophy
Cykowski, M. D., Coon, E. A., Powell, S. Z., Jenkins, S. M., Benarroch, E. E., Low, P. A., Schmeichel, A. M., & Parisi, J. E. (2015) · Brain · doi:10.1093/brain/awv114 · Cited by 241
Calcium, Bioenergetics, and Neuronal Vulnerability in Parkinson's Disease
Surmeier, D. J., & Schumacker, P. T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.410530 · Cited by 240
Circadian rhythm of periodic limb movements and sensory symptoms of restless legs syndrome
Trenkwalder, C., Hening, W. A., Walters, A. S., Campbell, S. S., Rahman, K., & Chokroverty, S. (1999) · Movement Disorders · doi:10.1002/1531-8257(199901)14:1 · Cited by 226
α-Synuclein redistributes to neuromelanin lipid in the substantia nigra early in Parkinson's disease
Halliday, G. M., Ophof, A., Broe, M., Jensen, P. H., Kettle, E., Fedorow, H., Cartwright, M., Carew‐Jones, F., Shepherd, C. E., & Double, K. L. (2005) · Brain · doi:10.1093/brain/awh584 · Cited by 224
On the origin and significance of neuromelanin.
Dg, G. (1979) · PubMed · Cited by 223
CONCENTRIC HYALIN INTRANEURONAL INCLUSIONS OF LEWY TYPE IN THE BRAINS OF ELDERLY PERSONS (50 INCIDENTAL CASES): RELATIONSHIP TO PARKINSONISM
Forno, L. S. (1969) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1969.tb01316.x · Cited by 218
α-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
Beyer, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0104-6 · Cited by 216
Multiple System Atrophy: A Sporadic Synucleinopathy
Dickson, D. W., Lin, W.-L., Liu, W.-K., & Yen, S.-H. C. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00553.x · Cited by 212
Self-citation
Autonomic Dysfunction in Parkinson's Disease
Koike, Y., & Takahashi, A. (2008) · European Neurology · doi:10.1159/000113470 · Cited by 211
The distribution of Lewy bodies in pure autonomic failure: autopsy findings and review of the literature
Hague, K., Lento, P., Morgello, S., Caro, S., & Kaufmann, H. (1997) · Acta Neuropathologica · doi:10.1007/s004010050693 · Cited by 209
The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease
Churchyard, A., & Lees, A. J. (1997) · Neurology · doi:10.1212/wnl.49.6.1570 · Cited by 207
Characterization of the Precursor Protein of the Non-Aβ Component of Senile Plaques (NACP) in the Human Central Nervous System
Irizarry, M. C., Kim, T., McNamara, M. J., Tanzi, R. E., George, J. M., Clayton, D. F., & Hyman, B. T. (1996) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199608000-00004 · Cited by 205
Diffuse Lewy body disease
Dickson, D. W., Davies, P., Mayeux, R. P., Crystal, H., Horoupian, D. S., Thompson, A. J., & Goldman, J. E. (1987) · Acta Neuropathologica · doi:10.1007/bf00686786 · Cited by 204
Self-citation
α-Synuclein pathology in Parkinson’s and Alzheimer’s disease brain: incidence and topographic distribution—a pilot study
Jellinger, K. A. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0725-y · Cited by 201
The Definition of Multiple System Atrophy
Lantos, P. L. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199812000-00001 · Cited by 199
Inflammation in Parkinson's disease.
McGeer, P. L., Yasojima, K., & McGeer, E. G. (2001) · PubMed · Cited by 196
Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.
Lennox, G. G., Lowe, J. S., Landon, M., Byrne, E. J., Mayer, R. J., & Godwin-Austen, R. B. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.11.1236 · Cited by 184
Distinctive neuropathology revealed by α-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p
Gwinn, K. A., Mehta, N. D., Farrer, M. J., Maraganore, D. M., Muenter, M. D., Yen, S. H., Hardy, J., & Dickson, D. W. (2000) · Acta Neuropathologica · doi:10.1007/s004010051177 · Cited by 180
Self-citation
Peripheral sympathetic dysfunction in patients with Parkinson's disease without autonomic failure is heart selective and disease specific
Taki, J., Nakajima, K., Hwang, E.-H., Matsunari, I., Komai, K., Yoshita, M., Sakajiri, K., & Tonami, N. (2000) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590050544 · Cited by 176
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
Iwatsubo, T., Yamaguchi, H., Fujimuro, M., Yokosawa, H., Ihara, Y., Trojanowski, J. Q., & Lee, V. M. (1996) · Europe PMC (PubMed Central) · Cited by 165
Diagnostic accuracy of progressive supranuclear palsy in the Society for Progressive Supranuclear Palsy Brain Bank
Josephs, K. A., & Dickson, D. W. (2003) · Movement Disorders · doi:10.1002/mds.10488 · Cited by 164
Self-citation
α-Synuclein Is Phosphorylated by Members of the Src Family of Protein-tyrosine Kinases
Ellis, C. E., Schwartzberg, P. L., Grider, T. L., Fink, D. W., & Nussbaum, R. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010316200 · Cited by 163
α-Synuclein and the Lewy body disorders
Dickson, D. W. (2001) · Current Opinion in Neurology · doi:10.1097/00019052-200108000-00001 · Cited by 163
Self-citation
The pathology of the human locus ceruleus.
Mann, D. M. A., Yates, P. O., & Hawkes, J. (1983) · PubMed · Cited by 161
Dementia with Lewy bodies and Parkinson's disease with dementia: Are they different?
Tsuboi, Y., & Dickson, D. W. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.10.014 · Cited by 155
Self-citation
Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain
Crowther, R. A., Daniel, S. E., & Goedert, M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01440-3 · Cited by 154
Cytoplasmic argyrophilic inclusions in neurons of pontine nuclei in patients with olivopontocerebellar atrophy: immunohistochemical and ultrastructural studies
Kato, S., & Nakamura, H. (1990) · Acta Neuropathologica · doi:10.1007/bf00294235 · Cited by 145
Research Evaluation and Prospective Diagnosis of Dementia With Lewy Bodies
López, O. L., Becker, J. T., Kaufer, D., Hamilton, R. L., Sweet, R. A., Klunk, W. E., & DeKosky, S. T. (2002) · Archives of Neurology · doi:10.1001/archneur.59.1.43 · Cited by 144
Occipital hypoperfusion in Parkinson's disease without dementia: correlation to impaired cortical visual processing
Abe, Y. (2003) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.74.4.419 · Cited by 139
Filaments of Lewy bodies contain insoluble cytoskeletal elements.
Galloway, P. G., Mulvihill, P., & Perry, G. L. (1992) · PubMed Central · Cited by 131
Analysis of the Adrenal Gland Is Useful for Evaluating Pathology of the Peripheral Autonomic Nervous System in Lewy Body Disease
Fumimura, Y., Ikemura, M., Saito, Y., Sengoku, R., Kanemaru, K., Sawabe, M., Arai, T., Ito, G., Iwatsubo, T., Fukayama, M., et al. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3180517454 · Cited by 131
Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease
Mattila, P. M., Röyttä, M., Torikka, H., Dickson, D. W., & Rinne, J. O. (1998) · Acta Neuropathologica · doi:10.1007/s004010050843 · Cited by 130
Self-citation
Regional Distribution of α-Synuclein Pathology in Unimpaired Aging and Alzheimer Disease
Parkkinen, L., Soininen, H. S., & Alafuzoff, I. I. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.4.363 · Cited by 129
α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals
Klos, K. J., Ahlskog, J. E., Josephs, K. A., Apaydın, H., Parisi, J. E., Boeve, B. F., DeLucia, M. W., & Dickson, D. W. (2006) · Neurology · doi:10.1212/01.wnl.0000204179.88955.fa · Cited by 127
Self-citation
Cleavage of α-Synuclein by Calpain: Potential Role in Degradation of Fibrillized and Nitrated Species of α-Synuclein
Mishizen-Eberz, A. J., Norris, E. H., Giasson, B. I., Hodara, R., Ischiropoulos, H., Lee, V. M. ‐., Trojanowski, J. Q., & Lynch, D. R. (2005) · Biochemistry · doi:10.1021/bi047846q · Cited by 119
Casein Kinase II-mediated Phosphorylation Regulates α-Synuclein/Synphilin-1 Interaction and Inclusion Body Formation
Lee, G., Tanaka, M., Park, K., Lee, S. S., Kim, Y. M., Junn, E., Lee, S., & Mouradian, M. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312760200 · Cited by 115
Genes and parkinsonism
Hardy, J., Cookson, M., & Singleton, A. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00350-8 · Cited by 115
Relationships between Lewy bodies and pale bodies in Parkinson's disease
Dale, G. E., Probst, A., Luthert, P., Martin, J., Anderton, B. H., & Leigh, P. N. (1992) · Acta Neuropathologica · doi:10.1007/bf00310030 · Cited by 114
Abnormal distribution of the non-Abeta component of Alzheimer's disease amyloid precursor/alpha-synuclein in Lewy body disease as revealed by proteinase K and formic acid pretreatment.
Takeda, A., Hashimoto, M., Mallory, M. E., Sundsumo, M., Hansen, L., Sisk, A., & Masliah, E. (1998) · PubMed · Cited by 114
Voluntary motor commands in human ballistic movements
Desmedt, J. E., & Godaux, E. (1979) · Annals of Neurology · doi:10.1002/ana.410050503 · Cited by 113
The Role of α‐Synuclein in Both Neuroprotection and Neurodegeneration
Sidhu, A., Wersinger, C., Moussa, C., & Vernier, P. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.016 · Cited by 110
Pure autonomic failure in association with human α-synucleinopathy
Arai, K., Kato, N., Kashiwado, K., & Hattori, T. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01623-2 · Cited by 108
When does Parkinson's disease begin?
Wc, K. (1992) · PubMed · Cited by 99
DCTN1-related neurodegeneration: Perry syndrome and beyond
Konno, T., Ross, O. A., Teive, H. A. G., Sławek, J. W., Dickson, D. W., & Wszołek, Z. K. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.06.004 · Cited by 98
Self-citation
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies
Katsuse, O., Iseki, E., Marui, W., & Kosaka, K. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00037-6 · Cited by 98
Differential Expression and Distribution of α-, β-, and γ-Synuclein in the Developing Human Substantia Nigra
Galvin, J. E., Schuck, T., Lee, V. M. ‐., & Trojanowski, J. Q. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7615 · Cited by 92
Tau and Synuclein and Their Role in Neuropathology
Dickson, D. W. (1999) · Brain Pathology · doi:10.1111/j.1750-3639.1999.tb00548.x · Cited by 83
Self-citation
Clinical correlates of the pathology underlying parkinsonism: A population perspective
Bower, J. H., Dickson, D. W., Taylor, L. M., Maraganore, D. M., & Rocca, W. A. (2002) · Movement Disorders · doi:10.1002/mds.10202 · Cited by 80
Self-citation
Mechanisms of cell death in neurodegenerative disorders
Jellinger, K. A., & Stadelmann, C. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6781-6_13 · Cited by 80
Widespread and abundant α‐synuclein pathology in a neurologically unimpaired subject
Parkkinen, L., Pirttilä, T., Tervahauta, M., & Alafuzoff, I. I. (2005) · Neuropathology · doi:10.1111/j.1440-1789.2005.00644.x · Cited by 74
Hypothalamic Regulation of Sleep
Salín-Pascual, R. J. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00318-9 · Cited by 71
Substantia Nigra Marinesco Bodies Are Associated with Decreased Striatal Expression of Dopaminergic Markers
Beach, T. G., Walker, D. G., Sue, L. I., Newell, A., Adler, C., & Joyce, J. N. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.4.329 · Cited by 66
Parkinson's disease genetic mutations increase cell susceptibility to stress: Mutant α-synuclein enhances H2O2- and Sin-1-induced cell death
Jiang, H., Wu, Y.-C., Nakamura, M., Liang, Y., Tanaka, Y., Holmes, S., Dawson, V. L., Dawson, T. M., Ross, C. A., & Smith, W. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.017 · Cited by 62
Idiopathic parkinsonism with lewy-type inclusions in cerebral cortex. A case report
Ikeda, K., Ikeda, S., Yoshimura, T., Kato, H., & Namba, M. (1978) · Acta Neuropathologica · doi:10.1007/bf00689769 · Cited by 55
Monoclonal antibodies to purified cortical lewy bodies recognize the mid‐size neurofilament subunit
Galvin, J. E., Lee, V. M. ‐., Baba, M., Mann, D. M. A., Dickson, D. W., Yamaguchi, H., Schmidt, M. L., Iwatsubo, T., & Trojanowski, J. Q. (1997) · Annals of Neurology · doi:10.1002/ana.410420410 · Cited by 51
Self-citation
Absence of Lewy pathology associated with PINK1 homozygous mutation
Takanashi, M., Li, Y., & Hattori, N. (2016) · Neurology · doi:10.1212/wnl.0000000000002744 · Cited by 47
Differential Cytotoxicity of Human Wild Type and Mutant α-Synuclein in Human Neuroblastoma SH-SY5Y Cells in the Presence of Dopamine
Moussa, C., Wersinger, C., Tomita, Y. A., & Sidhu, A. (2004) · Biochemistry · doi:10.1021/bi036114f · Cited by 47
α-Synuclein has structural and functional similarities to small heat shock proteins
Kim, T. D., Choi, E., Rhim, H., Paik, S. R., & Yang, C. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.208 · Cited by 44
Detergent‐Insoluble Cortical Lewy Body Fibrils Share Epitopes with Neurofilament and τ
Pollanen, M. S., Bergeron, C., & Weyer, L. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb10074.x · Cited by 43
Diversity of pathological features other than Lewy bodies in familial Parkinson's disease due to SNCA mutations.
Fujishiro, H., Imamura, A., Lin, W.-L., Uchikado, H., Mark, M. H., Golbe, L. I., Markopoulou, K., Wszołek, Z. K., & Dickson, D. W. (2013) · Europe PMC (PubMed Central) · Cited by 37
Self-citation
Parkinson's Disease and Dementia with Neuronal Inclusions in the Cerebral Cortex: Lewy Bodies or Pick Bodies
Tiller-Borcich, J. K., & Forno, L. S. (1988) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198809000-00004 · Cited by 34
Circadian rhythm of vigilance in rats: Modulation by short light-dark cycles
Borbély, A. A. (1975) · Neuroscience Letters · doi:10.1016/0304-3940(75)90014-2 · Cited by 33
Proaggregant nuclear factor(s) trigger rapid formation of α-synuclein aggregates in apoptotic neurons
Jiang, P., Gan, M., Yen, S.-H. C., Moussaud, S., McLean, P. J., & Dickson, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1542-4 · Cited by 32
Self-citation
Colloid (hyaline) inclusion bodies in the central nervous system: Their presence in the substantia nigra is diagnostic of Parkinson's disease
Pappolla, M. A., Shank, D. L., Alzofon, J., & Dudley, A. W. (1988) · Human Pathology · doi:10.1016/s0046-8177(88)80312-5 · Cited by 31
Deposition of detergent-resistant neurofilaments into Lewy body fibrils
Pollanen, M. S., Bergeron, C., & Weyer, L. (1993) · Brain Research · doi:10.1016/0006-8993(93)91307-e · Cited by 29
Gaze‐evoked blepharoclonus
Keane, J. R. (1978) · Annals of Neurology · doi:10.1002/ana.410030310 · Cited by 28
Histones facilitate α-synuclein aggregation during neuronal apoptosis
Jiang, P., Gan, M., Yen, S.-H. C., McLean, P. J., & Dickson, D. W. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1660-z · Cited by 27
Self-citation
Retrograde labeling of central nervous pathways with tritiated or Evans blue-labeled bovine serum albumin
Steward, O., & Scoville, S. A. (1976) · Neuroscience Letters · doi:10.1016/0304-3940(76)90072-0 · Cited by 24
THE CENTENARY OF FRIEDERICH H. LEWY 1885–1950
Gibb, W. R. G., & Poewe, W. (1986) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1986.tb00135.x · Cited by 24
Gallyas-positive, tau-negative glial inclusions in Parkinson's disease midbrain
Wakabayashi, K., & Takahashi, H. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13080-9 · Cited by 23
Lobar atrophy with dense-core (brain stem type) Lewy bodies in a patient with dementia
Masliah, E., Galasko, D. R., Wiley, C. A., & Hansen, L. A. (1990) · Acta Neuropathologica · doi:10.1007/bf00307702 · Cited by 17
Juvenile onset Parkinsonism with “pure nigral” degeneration and POLG1 mutation
Mehta, S. H., Dickson, D. W., Morgan, J. C., Singleton, A., Majounie, E., & Sethi, K. D. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.06.013 · Cited by 14
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Neural correlates of action: Comparing meta-analyses of imagery, observation, and execution
Hardwick, R. M., Caspers, S., Eickhoff, S. B., & Swinnen, S. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.003 · Cited by 948
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Authors: Dickson, D. W.
Affiliations: Mayo Clinic (US)
Corresponding author: Dickson, Dennis W.
ORCID: Dickson, Dennis W.
Venue: Parkinsonism & Related Disorders
Publisher: Elsevier BV
Published: 2018-01
Volume: 46
Pages: S30-S33
ISSN: 1353-8020 (ISSN-L)
DOI: 10.1016/j.parkreldis.2017.07.033
PMC: PMC5718208
OpenAlex: W2501464909
Cited by: 623
References: 166
Citations by year: 2026: 53 · 2025: 80 · 2024: 80 · 2023: 82 · 2022: 100 · 2021: 91 · 2020: 63 · 2019: 39 · 2018: 22
FWCI: 4.61
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 318 d)
Locations: Parkinsonism & Related Disorders (acceptedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NINDS (P50-NS072187)
Mangurian Foundation Lewy Body Dementia Program
CurePSP/Tau Consortium Brain Bank
The Robert E. Jacoby Professorship
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: Parkinson's disease, neuropathology
MeSH terms: Neuropathology, Brain, Humans, Parkinson Disease

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Neuropathology of Parkinson disease

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