Alzheimer Disease With Amygdala Lewy Bodies: A Distinct Form of α-Synucleinopathy
Open accessAbstract
Lewy bodies (LBs) are alpha-synuclein-immunoreactive neuronal inclusions with a predilection for specific cortical and subcortical regions, including the amygdala. In this study, the presence of LBs was assessed in 347 cases of Alzheimer disease (AD). In 87 cases, LB pathology was diagnostic of brainstem (n=3), transitional (n=32), or diffuse (n=52) Lewy body disease (LBD). The remaining 260 cases of AD were screened for amygdala LBs (AD/ALB) and 62 (24%) cases were found. If AD/LBD cases are included, LBs were detected in 149 (43%) cases of AD. The presence alpha-synuclein pathology was assessed in multiple brain regions of the 62 cases of AD/ALB and 57 randomly selected cases of AD, and only sparse alpha-synuclein pathology was detected in both. The burden of alpha-synuclein pathology in brainstem nuclei, amygdala, and neocortex was significant lower in AD/ALB than in AD/LBD. In comparison to AD/LBD, AD/ALB did not differ in age at death, disease duration, male-to-female ratio, brain weight, Braak neurofibrillary tangle stage, average senile plaque density, or apolipoprotein E epsilon4 allele frequency. The results suggest that AD/ALB is pathologically different from AD/LBD, suggesting that it is a neuropathologically distinct and isolated alpha-synucleinopathy.
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Lewy bodies are frequent in the setting of moderate-to-severe levels of AD neuropathologic change.
“LBs are frequent in the setting of moderate-to-severe levels of AD neuropathologic change [27,59], including some early-onset familial AD cases [32,33].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [59]
Amygdala-predominant LBD typically occurs in the context of advanced AD neuropathologic change.
““Amygdala-predominant LBD” typically occurs in the context of advanced AD neuropathologic change [59].”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [59]
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Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium
McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O'Brien, J. T., Feldman, H., Cummings, J., Duda, J. E., Lippa, C., Perry, E. K., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000187889.17253.b1 · Cited by 5,069 · see citing works
Self-citationThe relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
Gibb, W. R., & Lees, A. J. (1988) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.6.745 · Cited by 3,481 · see citing works
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668 · see citing works
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380 · see citing works
Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
Giasson, B. I., Forman, M. S., Higuchi, M., Golbe, L. I., Graves, C. L., Kotzbauer, P. T., Trojanowski, J. Q., & Lee, V. M.-Y. (2003) · Science · doi:10.1126/science.1082324 · Cited by 879 · cited 1× · see citing works
“Giasson et al pointed out that tau and >-synuclein may reciprocally promote aggregation in vitro (42).”
BackgroundMasliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., & Mucke, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211412398 · Cited by 607 · see citing works
Lippa, C. F., Fujiwara, H., Mann, D. M. A., Giasson, B., Baba, M., Schmidt, M. L., Nee, L. E., O'Connell, B., Pollen, D. A., St. George-Hyslop, P., et al. (1998) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65722-7 · Cited by 533 · see citing works
Arai, Y., Yamazaki, M., Mori, O., Muramatsu, H., Asano, G., & Katayama, Y. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03082-1 · Cited by 173 · see citing works
Flagged first, then by citations
Research works printed but not linked: 46
- McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology 1996;47:1113 Y24
- Dickson DW, Crystal HA, Mattiace LA, et al. Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 1992;13:179 Y89
- Hyman BT, Trojanowski JQ. Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuro- pathol Exp Neurol 1997;56:1095 Y97
- Hansen L, Salmon D, Galasko D, et al. The Lewy body variant of Alzheimer_s disease: a clinical and pathologic entity. Neurology 1990; 40:1 Y8
- Mikolaenko I, Pletnikova O, Kawas CH, et al. Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). J Neuro- pathol Exp Neurol 2005;64:156 Y 62
- Parkkinen L, Soininen H, Alafuzoff I. Regional distribution of alpha-synuclein pathology in unimpaired aging and Alzheimer disease. J Neuropathol Exp Neurol 2003;62:363 Y 67
- Saito Y, Kawashima A, Ruberu NN, et al. Accumulation of phosphory- lated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol 2003;62:644 Y54
- Dickson DW. Alpha-synuclein and the Lewy body disorders. Curr Opin Neurol 2001;14:423 Y 32
- Jellinger KA. Alpha-synuclein pathology in Parkinson_s and Alzheimer_s disease brain: incidence and topographic distributionVa pilot study. Acta Neuropathol (Berl) 2003;106:191 Y 201
- Hamilton RL. Lewy bodies in Alzheimer_s disease: a neuropatholog- ical review of 145 cases using alpha-synuclein immunohistochemistry. Brain Pathol 2000;10:378 Y84
- Marui W, Iseki E, Ueda K, et al. Occurrence of human alpha-synuclein immunoreactive neurons with neurofibrillary tangle formation in the limbic areas of patients with Alzheimer_s disease. J Neurol Sci 2000;174: 81 Y84
- Schmidt ML, Martin JA, Lee VM, Trojanowski JQ. Convergence of Lewy bodies and neurofibrillary tangles in amygdala neurons of Alzheimer_s disease and Lewy body disorders. Acta Neuropathol (Berl) 1996;91:475 Y81
- Lippa CF, Schmidt ML, Lee VM, et al. Antibodies to alpha-synuclein detect Lewy bodies in many Down_s syndrome brains with Alzheimer_s disease. Ann Neurol 1999;45:353 Y57
- Rezaie P, Cairns NJ, Chadwick A, et al. Lewy bodies are located pref- erentially in limbic areas in diffuse Lewy body disease. Neurosci Lett 1996;212:111 Y14
- Marui W, Iseki E, Nakai T, et al. Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies. J Neurol Sci 2002;195:153 Y59
- Harding AJ, Broe GA, Halliday GM. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 2002; 125:391 Y 403
- Hopper MW, Vogel FS. The limbic system in Alzheimer_s disease. A neuropathologic investigation. Am J Pathol 1976;85:1 Y20
- Mann DM, Yates PO, Marcyniuk B, et al. The topography of plaques and tangles in Down_s syndrome patients of different ages. Neuropathol Appl Neurobiol 1986;12:447 Y57
- Vereecken TH, Vogels OJ, Nieuwenhuys R. Neuron loss and shrinkage in the amygdala in Alzheimer_s disease. Neurobiol Aging 1994;15:45 Y54
- Tsuchiya K, Kosaka K. Neuropathological study of the amygdala in presenile Alzheimer_s disease. J Neurol Sci 1990;100:165 Y73
- Zald DH. The human amygdala and the emotional evaluation of sensory stimuli. Brain Res Brain Res Rev 2003;41:88 Y123
- Rolls E. Neurophysiology and functions of the primate amygdala. In: Aggleton JP, ed. The Amygdala. New York: Wiley-Liss, 1992:143 Y 65
- Barker WW, Luis CA, Kashuba A, et al. Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord 2002;16:203 Y12
- Khachaturian ZS. Diagnosis of Alzheimer_s disease. Arch Neurol 1985; 42:1097 Y105
- Gloor P. The amygdala system. In: Gloor P, ed. The Temporal Lobe and Limbic System. New York: Oxford University Press, 1997:591 Y721
- Gwinn-Hardy K, Mehta ND, Farrer M, et al. Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p. Acta Neuropathol (Berl) 2000; 99:663 Y72
- Uchikado H, Delledonne A, Uitti R, Dickson DW. Coexistence of PSP and MSA: A case report and review of the literature. Acta Neuropathol (Berl) 2006;111:186 Y92
- Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation. Am J Pathol 2003;162:213 Y18
- Crook R, Hardy J, Duff K. Single-day apolipoprotein E genotyping. J Neurosci Methods 1994;53:125 Y27
- Baker M, Litvan I, Houlden H, et al. Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Hum Mol Genet 1999;8:7111 Y15
- Braak H, Del Tredici K, Rub U, et al. Staging of brain pathology related to sporadic Parkinson_s disease. Neurobiol Aging 2003;24:197 Y211
- Perry RH, Irving D, Blessed G, et al. Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci 1990;95:119 Y39
- Kosaka K. Diffuse Lewy body diseases in Japan. J Neurol 1990;237: 197 Y204
- Uchikado H, DelleDonne A, Ahmed Z, Dickson DW. Lewy bodies in progressive supranuclear palsy represent an independent disease process. J Neuropathol Exp Neurol 2006;65:387 Y95
- Marui W, Iseki E, Kato M, et al. Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer_s disease. Acta Neuropathol (Berl) 2004;108:121 Y28
- Geddes JW. Alpha-synuclein: A potent inducer of tau pathology. Exp Neurol 2005;192:244 Y50
- Iseki E, Marui W, Kosaka K, et al. Frequent coexistence of Lewy bodies and neurofibrillary tangles in the same neurons of patients with diffuse Lewy body disease. Neurosci Lett 1999;265:9 Y12
- Iseki E, Takayama N, Marui W, et al. Relationship in the formation process between neurofibrillary tangles and Lewy bodies in the hip- pocampus of dementia with Lewy bodies brains. J Neurol Sci 2002;195: 85 Y91
- Saito Y, Ruberu NN, Sawabe M, et al. Lewy body-related alpha- synucleinopathy in aging. J Neuropathol Exp Neurol 2004; 63:742 Y49
- Pletnikova O, West N, Lee MK, et al. Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiol Aging 2005;26:1183 Y92
- Lewis J, Dickson DW, Lin WL, et al. Enhanced neurofibrillary de- generation in transgenic mice expressing mutant tau and APP. Science 2001;293:1487 Y91
- Tsuang DW, Wilson RK, Lopez OL, et al. Genetic association between the APOE*4 allele and Lewy bodies in Alzheimer disease. Neurology 2005;64:509 Y13
- Lopez OL, Wisniewski S, Hamilton RL, et al. Predictors of progression in patients with AD and Lewy bodies. Neurology 2000;54:1774 Y79
- Heyman A, Fillenbaum GG, Gearing M, et al. Comparison of Lewy body variant of Alzheimer_s disease with pure Alzheimer_s disease: Consortium to establish a registry for Alzheimer_s disease, part XIX. Neurology 1999;52:1839 Y 44
- Serby M, Brickman AM, Haroutunian V, et al. Cognitive burden and excess Lewy-body pathology in the Lewy-body variant of Alzheimer disease. Am J Geriatr Psychiatry 2003;11:371 Y74
- Merdes AR, Hansen LA, Jeste DV, et al. Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies. Neurology 2003;60:1586 Y90
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- Authors
- Uchikado, H., Lin, W.-L., DeLucia, M. W., & Dickson, D. W.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Dickson, Dennis W.
- ORCID
- Dickson, Dennis W.
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-07
- Volume
- 65
- Issue
- 7
- Pages
- 685-697
- ISSN
- 0022-3069 (ISSN-L)
- PMC
- PMC5706655
- OpenAlex
- W1968324269
- Cited by
- 359
- References
- 10
- Citations by year
- 2026: 16 · 2025: 33 · 2024: 30 · 2023: 15 · 2022: 17 · 2021: 17 · 2020: 13 · 2019: 22 · 2018: 14 · 2017: 17 · 2016: 7 · 2015: 12 · 2014: 17 · 2013: 13 · 2012: 14
- FWCI
- 13.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mayo Foundation for Medical Education and Research (AG17216, AG03949, AG16574, AG14449)
- National Institutes of Health (AG03949, NS40256, AG14449, P50-AG25711, AG16574, AG17216)
- National Institute on Aging (P50 AG25711, P50‐AG16574, P01-AG-17216, P01AG03949, P01AG014449, P01AG003949, P01 AG14449, P50AG025711, P01AG017216, P50AG016574)
- National Institute of Neurological Disorders and Stroke (P50-NS40256, P50NS040256)
- State of Florida
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, synucleinopathies, Lewy body disease, alpha-synuclein pathology, amygdala, brainstem, amyloid plaques, APOE ε4
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amygdala, Demography, Female, Humans, Male, Middle Aged, Neurons, Retrospective Studies, Statistics as Topic, Lewy Bodies, Lewy Body Disease, alpha-Synuclein
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