Altered Gut Microbiota in Parkinson’s Disease Patients/Healthy Spouses and Its Association with Clinical Features
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INTRODUCTION: Increasing evidence shows that gut microbiota dysbiosis may play important roles in the occurrence and progression of Parkinson's disease (PD), but the findings are inconsistent. Besides, the effect of family environment on gut microbiota dysbiosis remains unclear. METHODS: We characterized the gut microbial compositions of 63 PD patients, 63 healthy spouses (HS) and 74 healthy people (HP) using 16S rRNA sequencing. Clinical phenotypes and microbial composition were analyzed comprehensively. RESULTS: There were markedly different microbial compositions among PD, HS and HP samples by alpha/beta diversity. We also found differential microbial compositions among Hoehn & Yahr stage/disease duration. Eight inflammation-associated microbial genera shared a continuously increase trend with increased Hoehn & Yahr stage and disease duration, indicating characteristic bacteria associated with deterioration in PD. Additionally, seven bacterial markers were identified for accurately differentiating PD patients from the controls (area under the curve [AUC]: 0.856). CONCLUSIONS: Our study shows altered gut microbiota in PD patients. Importantly, inflammation-associated microbial genera may play roles in PD progression. Differential microbial compositions in HS and HP samples demonstrate that the gut microbiota are also affected by family environment. Disease-associated metagenomics studies should consider the family environmental factor. Our research provides an important reference and improves the understanding of gut microbiota in PD patients.
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Feces from Parkinson's disease patients are enriched in opportunistic pathogens and pro-inflammatory taxa at the expense of anti-inflammatory microbes and SCFAs-producing bacteria, especially butyrate.
“feces from PD patients are enriched in opportunistic pathogens and pro-inflammatory taxa at the expense of anti-inflammatory microbes and SCFAs-producing bacteria, especially butyrate [47,48,49,50,51]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [47]
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Gut microbiota and psychiatric disorders
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Self-citationLiu, S., Zhao, Q., Tang, J., Li, X., Wang, J., Zhao, Y., Yang, Z., Pan, X., Xiang, R. H., Tian, J., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70424 · Cited by 4 · see citing works
Self-citationDietary sugar intake, genetic susceptibility, and risk of dementia: A prospective cohort study
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Gut microbiome differences in Parkinson’s disease patients in Central Kerala population
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Stereotactic infusion of rotenone into the SN induced a late-stage model of Parkinson's disease
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Chisoi, A., Dobrin, N., Cozaru, G. C., Ionescu, A.-C., Aşchie, M., Kajanto, L. A., Vlad, S. E., Enciu, M., Popovici, I. A., & Cîmpineanu, B. (2025) · Biomedicines · doi:10.3390/biomedicines13102411 · Cited by 4 · see citing works
Multiomic Analysis Reveals Molecular Pathways Associated with Intestinal Aggregation of α-Synuclein
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Gut microbiota and motoric-cognitive frailty in hospitalized older persons
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Gut Lachnospiraceae improves white matter injury-related cognitive decline by increasing L-arginine
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Identifying candidate gut microbiota indicators for Alzheimer’s disease through integrated data
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Self-citationRole of Gastrointestinal Dysbiosis and Fecal Transplantation in Parkinson’s Disease
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Parkinson Hastalığı ve Mikrobiyota
Dolar, G., Çamcı, G., Yakar, H. K., & Oğuz, S. (2024) · Black Sea Journal of Health Science · doi:10.19127/bshealthscience.1539735
Mind diet adherence associated with lower Zonulin levels in older Parkinson's patients
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Gut microbiota alterations linked to classical scrapie in sheep
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- Authors
- Zhang, F., Yue, L., Fang, X., Wang, G., Li, C., Sun, X., Jia, X., Yang, J., Song, J., Zhang, Y., Guo, C., Ma, G., Sang, M., Chen, F., & Wang, P.
- Affiliations
- Hubei University of Medicine (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Sang, Ming
- Chen, Fei
- Wang, Puqing
- ORCID
- Venue
- Parkinsonism & Related Disorders
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 81
- Pages
- 84-88
- ISSN
- 1353-8020 (ISSN-L)
- OpenAlex
- W3093912144
- Cited by
- 111
- References
- 14
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 18 · 2023: 17 · 2022: 24 · 2021: 15
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Parkinsonism & Related Disorders (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Hubei University of Medicine
- National Natural Science Foundation of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Parkinson's disease, gut microbiota
- MeSH terms
- Gastrointestinal Microbiome, Aged, Female, Humans, Inflammation, Male, Middle Aged, Parkinson Disease, RNA, Ribosomal, 16S, Spouses, Metagenomics, Healthy Volunteers, Dysbiosis
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