Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms
Open accessAbstract
Ever since Akkermansia muciniphila was discovered and characterized two decades ago, numerous studies have shown that the lack or decreased abundance of this commensal bacterium was linked with multiple diseases (such as obesity, diabetes, liver steatosis, inflammation and response to cancer immunotherapies). Although primarily based on simple associations, there are nowadays an increasing number of studies moving from correlations to causality. The causal evidence derived from a variety of animal models performed in different laboratories and recently was also recapitulated in a human proof-of-concept trial. In this Review, we cover the history of the discovery of A. muciniphila and summarize the numerous findings and main mechanisms of action by which this intestinal symbiont improves health. A comparison of this microorganism with other next-generation beneficial microorganisms that are being developed is also made.
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Hallmarks of aging: An expanding universe
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- Authors
- Cani, P. D., Depommier, C., Derrien, M., Everard, A., & de Vos, W. M.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Danone (France) (FR)
- Corresponding author
- Cani, Patrice D.
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2022-05-31
- Volume
- 19
- Issue
- 10
- Pages
- 625-637
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W4281797937
- Cited by
- 1,192
- References
- 152
- Citations by year
- 2026: 288 · 2025: 378 · 2024: 323 · 2023: 164 · 2022: 35 · 2017: 1
- FWCI
- 23.66
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-06-23)
- Open access
- green
- research.wur.nl
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Digital Access to Libraries (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- Akkermansia muciniphila, gut microbiota, intestinal symbionts, obesity, diabetes mellitus, hepatic steatosis, inflammation, cancer immunotherapy, metabolic disorders, causal evidence, beneficial microorganisms
- MeSH terms
- Akkermansia, Animals, Humans, Intestines, Obesity, Verrucomicrobia
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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