Cited by 1,192Gut microbiota and healthProbiotics and Fermented FoodsMicrobial Metabolites in Food Biotechnology

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

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Cani, Patrice D., Depommier, Clara, Derrien, Muriel, Everard, Amandine, de Vos, Willem M.·2022·Nature Reviews Gastroenterology & Hepatology

Abstract

Ever since Akkermansia muciniphila was discovered and characterized two decades ago, numerous studies have shown that the lack or decreased abundance of this commensal bacterium was linked with multiple diseases (such as obesity, diabetes, liver steatosis, inflammation and response to cancer immunotherapies). Although primarily based on simple associations, there are nowadays an increasing number of studies moving from correlations to causality. The causal evidence derived from a variety of animal models performed in different laboratories and recently was also recapitulated in a human proof-of-concept trial. In this Review, we cover the history of the discovery of A. muciniphila and summarize the numerous findings and main mechanisms of action by which this intestinal symbiont improves health. A comparison of this microorganism with other next-generation beneficial microorganisms that are being developed is also made.

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Crossref · 10.1038/s41575-022-00631-9

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Authors
Cani, P. D., Depommier, C., Derrien, M., Everard, A., & de Vos, W. M.
Affiliations
  • Walloon Excellence in Lifesciences and Biotechnology (BE)
  • Danone (France) (FR)
Corresponding author
Cani, Patrice D.
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2022-05-31
Volume
19
Issue
10
Pages
625-637
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W4281797937
Cited by
1,192
References
152
Citations by year
2026: 288 · 2025: 378 · 2024: 323 · 2023: 164 · 2022: 35 · 2017: 1
FWCI
23.66
Type
journal article
Language
en
Open access
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion)
  • Digital Access to Libraries (submittedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
Akkermansia muciniphila, gut microbiota, intestinal symbionts, obesity, diabetes mellitus, hepatic steatosis, inflammation, cancer immunotherapy, metabolic disorders, causal evidence, beneficial microorganisms
MeSH terms
Akkermansia, Animals, Humans, Intestines, Obesity, Verrucomicrobia

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