Fucosylated Chondroitin Sulfate against Parkinson’s Disease through Inhibiting Inflammation Induced by Gut Dysbiosis
Abstract
Growing evidence for the importance of the gut-brain axis in Parkinson’s disease (PD) has attracted researchers’ interest in the possible application of microbiota-based treatment approaches. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we looked into the prospect of treating PD with fucosylated chondroitin sulfate obtained from sea cucumbers Isostichopus badionotus (fCS- Ib ). We showed that giving fCS- Ib polysaccharide orally greatly reduced the motor deficits, dopamine depletion, and alpha-synuclein increase caused by MPTP in the substantia nigra (SN). It appears that the anti-PD action of fCS- Ib polysaccharide could be attained by squelching inflammation. Glial cell hyperactivation in SN and overproduction of proinflammatory substances in serum could both be suppressed by fCS- Ib polysaccharide injection. The bacterial DNA in fresh colonic feces was submitted to 16S rRNA and untargeted metabolic analyses to confirm the participation of the microbiota-gut-brain axis in the aforementioned interpretation. The findings showed that the MPTP treatment-induced decrease in norank_f_Muribaculaceae and the increase in Staphylococcus were reversed by the administration of fCS- Ib polysaccharide. The NF-κB signaling pathway was shown to be involved in the fCS- Ib polysaccharide-induced anti-inflammation. In conclusion, our research demonstrated for the first time how fCS- Ib polysaccharide combats PD by reducing inflammation caused by gut microbial dysbiosis.
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A reduction in Muribaculaceae was reported in PD animal models, which is in agreement with the significant reduction of Bacteroidota, the phylum containing the Muribaculaceae genus, in both PD patients and PD animal models.
“In addition, a reduction in Muribaculaceae was reported in PD animal models [61], which is in agreement with the significant reduction of Bacteroidota, the phylum containing the Muribaculaceae genus, in both PD patients [62] and PD animal models [63].”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [61]
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Self-citation
- Authors
- Liu, Y., Liu, X., Ye, Q., Wang, Y., Zhang, J., Lin, S., Wang, G., Yang, X., Zhang, J., Chen, S., & Wu, N.
- Affiliations
- Jinan University (CN)
- Zhejiang University (CN)
- Corresponding author
- Zhang, Jichun
- Chen, Shiguo
- Wu, Nian
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2022-10-13
- Volume
- 70
- Issue
- 42
- Pages
- 13676-13691
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W4304945320
- Cited by
- 16
- References
- 68
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 1
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Central University Basic Research Fund of China (11620323)
- Natural Science Foundation of Guangdong Province (2020A1515110784)
- Medical Science and Technology Research Foundation of Guangdong Province (A2021246)
- MOE Key Laboratory for Regenerative Medicine, Jinan University (ZSYXM202216)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- fucosylated chondroitin sulfate, Parkinson's disease, gut-brain axis, gut dysbiosis, MPTP-induced neurotoxicity, sea cucumber polysaccharides, Isostichopus badionotus, neuroinflammation, substantia nigra, dopamine depletion, alpha-synuclein, glial activation, NF-κB signaling, Staphylococcus, Muribaculaceae, 16S rRNA, fecal microbiota, anti-inflammatory therapy
- MeSH terms
- Animals, Chondroitin Sulfates, Disease Models, Animal, DNA, Bacterial, Dopamine, Inflammation, Intestines, Mice, Inbred C57BL, Parkinson Disease, Polysaccharides, RNA, Ribosomal, 16S, Sea Cucumbers, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, NF-kappa B, Mice, alpha-Synuclein, Dysbiosis
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