Cited by 192Physical Activity and HealthCardiovascular and exercise physiologyExercise and Physiological Responses

A test of the catecholamines hypothesis for an acute exercise–cognition interaction

McMorris, T., Collard, K., Corbett, J., Dicks, M., Swain, J.P.·2008·Pharmacology Biochemistry and Behavior

Abstract

The purpose of the study was to examine the usage of norepinephrine (NE) and dopamine (DA) in the brain when exercising while simultaneously undertaking cognitive tests. Plasma concentrations of the NE metabolite 3-methoxy 4-hydroxyphenylglycol (MHPG) and the DA metabolite homovanillic acid (HVA) showed a linear increase from rest to exercising at 40% and 80% maximum power output (W.max) while simultaneously undertaking cognitive tasks (random number generation (RNG) and response time). Delta plasma concentrations of MHPG and HVA at each exercise intensity while undertaking cognitive tasks and while exercising without cognitive tasks did not differ. Taking blood samples at 0, 1, 3, and 5 min following cessation of exercise did not affect results. Regression correlations showed that delta MHPG and HVA plasma concentrations at the 1 and 3 min sampling times were strong predictors of delta RNG, response time and movement time. Reaction time at 80% W.max significantly increased, while movement time at 80% W.max significantly decreased. It was concluded that these results provide no support for a direct effect of increased catecholamines concentrations on cognitive performance during exercise. The regression data suggest that there is some relationship between exercise, catecholamines concentrations and cognition.

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Crossref · 10.1016/j.pbb.2007.11.007

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  • Prolonged physical activity causes an increase in NA and 5-HT activation associated with regulation of synapse plasticity and signs of neuroprotection in the brain.

    “Indeed, prolonged physical activity causes an increase in NA and 5-HT activation associated with regulation of synapse plasticity and the signs of neuroprotection in the brain [197,198].”

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Authors
McMorris, T., Collard, K., Corbett, J., Dicks, M., & Swain, J. P.
Affiliations
  • University of Chichester (GB)
  • University of Plymouth (GB)
  • University of Portsmouth (GB)
  • University of Otago (NZ)
  • Canterbury Christ Church University (GB)
Corresponding author
McMorris, T.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2008-03
Volume
89
Issue
1
Pages
106-115
ISSN
0091-3057 (ISSN-L)
OpenAlex
W1989747921
Cited by
192
References
27
Citations by year
2026: 7 · 2025: 4 · 2024: 5 · 2023: 14 · 2022: 10 · 2021: 14 · 2020: 16 · 2019: 19 · 2018: 13 · 2017: 4 · 2016: 12 · 2015: 21 · 2014: 6 · 2013: 8 · 2012: 11
FWCI
4.68
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
catecholamines, norepinephrine, dopamine, physical activity, cognitive performance, reaction time, MHPG, homovanillic acid, random number generation, movement time
MeSH terms
Adult, Catecholamines, Cognition, Exercise Test, Heart Rate, Homovanillic Acid, Humans, Male, Methoxyhydroxyphenylglycol, Psychomotor Performance, Reaction Time, Regression Analysis, Exercise

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