Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor
Abstract
This study was to examine the effects of treadmill exercise on the expression of brain-derived neurotrophic factor (BDNF) in rat hippocampus. After 1-wk treadmill familiarization, animals in exercise groups received a 4-wk exercise training or an acute exercise. They were sacrificed 2 h or 2 d after exercise and their hippocampal BDNF mRNA and protein levels were determined. We demonstrated that 1) hippocampal BDNF mRNA and protein levels were both elevated in response to exercise training at 2 h after the last run but not after 2 d; 2) an acute moderate exercise (1 or 3 d) increased BDNF protein levels; 3) acute severe exercise increased BDNF protein and mRNA levels in animals under a familiarization regimen, while suppressed the BDNF mRNA level in rats without treadmill familiarization, paralleling the stress effect of immobilization/water exposure. We conclude that compulsive treadmill exercise with pre-familiarization acutely upregulates rat hippocampal BDNF gene expression.
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Physical exercise improves cognitive function, learning and memory, and significantly moderates age-related cognitive decline.
“improves cognitive function, learning and memory, and significantly moderates age-related cognitive decline [2, 97, 104, 110, 187, 188, 200], reviewed in [10].”
From The neuropathology of sport (2014) · cites this paper as [97]
Treadmill exercise improves hippocampus-dependent spatial learning and memory as well as aversive memory.
“Treadmill exercise also improves hippocampus-dependent spatial learning and memory as well as aversive memory [2, 3, 25, 97, 112, 174, 186, 187].”
From The neuropathology of sport (2014) · cites this paper as [97]
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- Authors
- Huang, A. M., Jen, C. J., Chen, H. F., Yu, L., Kuo, Y. M., & Chen, H. I.
- Affiliations
- National Cheng Kung University (TW)
- ORCID
- Venue
- Journal of Neural Transmission
- Published
- 2005-10-27
- Volume
- 113
- Issue
- 7
- Pages
- 803-811
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W1972402714
- Cited by
- 155
- References
- 37
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 19 · 2014: 14 · 2013: 10 · 2012: 9
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- brain-derived neurotrophic factor, BDNF expression, compulsive exercise, treadmill exercise, hippocampus, acute exercise, exercise training, restraint stress, neurotrophins
- MeSH terms
- Animals, Exercise Test, Gene Expression Regulation, Hippocampus, Male, Neuronal Plasticity, Physical Conditioning, Animal, RNA, Messenger, Stress, Physiological, Down-Regulation, Up-Regulation, Rats, Wistar, Maze Learning, Brain-Derived Neurotrophic Factor, Rats
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