Quantitative electroencephalographic (qEEG) correlates of craving during virtual reality therapy in alcohol-dependent patients
Abstract
Virtual reality (VR) is an evolving technology that is being applied to treat a wide range of medical and psychiatric diseases. A virtual reality therapy (VRT) with multisensory stimulation has been applied to patients with alcohol dependence (ADP). We hypothesized that the VRTP for alcohol dependence would reduce the craving for alcohol and increase alpha wave activity in frontal areas of individuals with ADP. Twenty ADP and eighteen ADP were exposed to a series of 10 VRTP sessions (VRTP-ADP) and cognitive behavioral therapy (nVRTP-ADP), respectively. Fifteen healthy controls were exposed to VRTP for comparing the changes of craving and EEG during all three phases of VRTP. The VRTP-ADP exhibited a greater decrease in craving after the 10th VRTP session, when compared to the nVRTP-ADP. Compared to the healthy control subjects, VRTP-ADP group showed higher magnitude of the change in craving throughout VRTP sessions. These results suggest that VRTP may be useful as an adjunct to treating alcohol dependence but may also serve as an evaluation tool to identify high-risk patients.
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The estimated sample size will be calculated using G*Power 3.1.9.7, repeated measure ANOVA within-between interaction, type I error 0.05, power 0.8, three groups, five measures, and effect size 0.13 cited from a randomized clinical trial.
“The estimated sample size will be calculated using the G*Power 3.1.9.7 sample size calculator, using the sample size calculation for repeated measure ANOVA and within–between interaction, whereby the type I error was 0.05, the power was 0.8”
Cites
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346 · see citing works
Emotion, Decision Making and the Orbitofrontal Cortex
Bechara, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.295 · Cited by 3,589 · see citing works
Burdea, G., & Coiffet, P. (2003) · PRESENCE Virtual and Augmented Reality · doi:10.1162/105474603322955950 · Cited by 2,332 · see citing works
Naltrexone in the Treatment of Alcohol Dependence
Volpicelli, J. R. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820110040006 · Cited by 1,828 · see citing works
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595 · see citing works
Force and Touch Feedback for Virtual Reality
Burdea, G. (1996) · Cited by 1,017 · see citing works
Reward processing in primate orbitofrontal cortex and basal ganglia
Schultz, W. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.272 · Cited by 942 · see citing works
The neurobiology of craving: Implications for the understanding and treatment of addiction.
Wise, R. A. (1988) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.97.2.118 · Cited by 564 · see citing works
Using alcohol expectancies to predict adolescent drinking behavior after one year.
Christiansen, B. A., Smith, G. T., Roehling, P. V., & Goldman, M. S. (1989) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.57.1.93 · Cited by 545 · see citing works
Virtual Reality Exposure Therapy for Vietnam Veterans With Posttraumatic Stress Disorder
Rothbaum, B. O., Hodges, L. F., Ready, D. J., Graap, K. M., & Alarcón, R. D. (2001) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v62n0808 · Cited by 531 · see citing works
Myrick, H., Anton, R. F., Li, X., Henderson, S., Drobes, D., Voronin, K., & George, M. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300295 · Cited by 521 · see citing works
George, M. S., Anton, R. F., Bloomer, C., Tenebäck, C. C., Drobes, D. J., Lorberbaum, J. P., Nahas, Z. H., & Vincent, D. J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.345 · Cited by 382 · see citing works
Ludwig, A. M. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760100093015 · Cited by 371 · see citing works
Coiffet, G. B. G. A. (1993) · Cited by 359 · see citing works
Subcortical Correlates of Craving in Recently Abstinent Alcoholic Patients
Schneider, F. W., Habel, U., Wagner, M., Franke, P. E., Salloum, J. B., Shah, N. J., Toni, I., Sulzbach, C., Hönig, K., Maier, W., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1075 · Cited by 319 · see citing works
Cognitive behavioral therapy for public-speaking anxiety using virtual reality for exposure
Anderson, P. L., Zimand, E., Hodges, L. F., & ROTHBAUM, B. O. (2005) · Depression and Anxiety · doi:10.1002/da.20090 · Cited by 289 · see citing works
Acamprosate in alcohol dependence: how does it work?
Littleton, J. M. (1995) · Addiction · doi:10.1046/j.1360-0443.1995.90911793.x · Cited by 278 · see citing works
Acamprosate in alcohol dependence: how does it work?
Littleton, J. M. (1995) · Addiction · doi:10.1111/j.1360-0443.1995.tb01088.x · Cited by 177 · see citing works
Lee, J.-H., Lim, Y., Wiederhold, B. K., & Graham, S. J. (2005) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-005-6377-z · Cited by 153 · see citing works
Smoking cues in a virtual world provoke craving in cigarette smokers.
Baumann, S. B., & Sayette, M. (2006) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.20.4.484 · Cited by 132 · see citing works
Virtual reality simulators: Current status in acquisition and assessment of surgical skills
Cosman, P. H., Cregan, P. C., Martin, C. J., & Cartmill, J. (2002) · ANZ Journal of Surgery · doi:10.1046/j.1445-2197.2002.02293.x · Cited by 126 · see citing works
EEG alpha activity increases during transient episodes of ethanol-induced euphoria
Lukas, S. E., Mendelson, J. H., Benedikt, R. A., & Jones, B. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90403-x · Cited by 123 · see citing works
Self-citationElectroencephalographic activity and plasma ACTH during ethanol-induced euphoria
Lukas, S. E., & Mendelson, J. H. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90084-4 · Cited by 95 · see citing works
Self-citationFocal cerebral blood flow change during craving for alcohol measured by SPECT
Modell, J. G., & Mountz, J. M. (1995) · Journal of Neuropsychiatry · doi:10.1176/jnp.7.1.15 · Cited by 91 · see citing works
Electroencephalographic correlates of marihuana-induced euphoria
Lukas, S. E., Mendelson, J. H., & Benedikt, R. A. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(94)01067-u · Cited by 76 · see citing works
Self-citationVIRTUAL REALITY THERAPY: AN EFFECTIVE TREATMENT FOR PHOBIAS
North, M. M., North, S. M., & Coble, J. R. (1998) · Studies in health technology and informatics · doi:10.3233/978-1-60750-902-8-112 · Cited by 74 · see citing works
Jang, D. P., Ku, J. H., Choi, Y. H., Wiederhold, B. K., Nam, S. W., Kim, I. Y., & Kim, S. I. (2002) · IEEE Transactions on Information Technology in Biomedicine · doi:10.1109/titb.2002.802374 · Cited by 62 · see citing works
Virtual Reality Exposure in the Treatment of Social Phobia
Klinger, É., Patrick, L., Stéphane, R., Isabelle, C., Françoise, L., & Nugues, P. (2004) · Studies in health technology and informatics · doi:10.3233/978-1-60750-943-1-91 · Cited by 62 · see citing works
Lukas, S. E., Mendelson, J. H., Kouri, E. M., Bolduc, M., & Amass, L. (1990) · Alcohol · doi:10.1016/0741-8329(90)90034-a · Cited by 51 · see citing works
Self-citationBauer, L. O., & Kranzler, H. R. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91224-6 · Cited by 48 · see citing works
Lambrey, S., & Berthoz, A. (2003) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(03)00127-2 · Cited by 44 · see citing works
High sensitivity to multisensory conflicts in agoraphobia exhibited by virtual reality
Viaud‐Delmon, I., Warusfel, O., Seguelas, A., Rio, E., & Jouvent, R. (2005) · European Psychiatry · doi:10.1016/j.eurpsy.2004.10.004 · Cited by 42 · see citing works
New Methodologies for Pharmacological Treatment Trials for Alcohol Dependence
Anton, R. F. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01183.x · Cited by 41 · see citing works
An appraisal of chemical aversion (emetic therapy) approaches to alcoholism treatment
Elkins, R. L. (1991) · Behaviour Research and Therapy · doi:10.1016/0005-7967(91)90123-k · Cited by 40 · see citing works
X Liu, P. D. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00192-9 · Cited by 28 · see citing works
Multiple Sensory Cues Underlying the Perception of Translation and Path
Yong, N. A., Paige, G. D., & Seidman, S. H. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00694.2006 · Cited by 28 · see citing works
Memory association and personality as predictors of alcohol use: Mediation and moderator effects.
Stacy, A. W., & Newcomb, M. D. (1998) · Experimental and Clinical Psychopharmacology · doi:10.1037//1064-1297.6.3.280 · Cited by 27 · see citing works
Differences of Photographs Inducing Craving Between Alcoholics and Non-alcoholics
Lee, E. M., Namkoong, K., Lee, C. H., An, S. K., & Lee, B. O. (2006) · Yonsei Medical Journal · doi:10.3349/ymj.2006.47.4.491 · Cited by 23 · see citing works
Mihai, A., Damsa, C., Allen, M. H., et al. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01667.x · Cited by 19 · see citing works
Complexity Changes of the EEG Induced by Alcohol Cue Exposure in Alcoholics and Social Drinkers
Kim, D., Jeong, J., Kim, K., Chae, J., Jin, S., Ahn, K. J., Myrick, H., Yoon, S. J., Kim, H., & Kim, S. Y. (2003) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000100943.83959.1f · Cited by 18 · see citing works
Memory association and personality as predictors of alcohol use: Mediation and moderator effects.
Stacy, A. W., & Newcomb, M. D. (1998) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.6.3.280 · Cited by 17 · see citing works
Smith, J. W., & Frawley, P. (1990) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(90)90002-8 · Cited by 16 · see citing works
Chemical Aversion Treatment of Alcohol Dependence. II. Future Research Directions for the ′90s
Howard, M. O., & Jenson, J. M. (1990) · International Journal of the Addictions · doi:10.3109/10826089009056227 · Cited by 10 · see citing works
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Virtual reality therapy in mental health
Emmelkamp, P. M. G., & Meyerbröker, K. (2021) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-115923 · Cited by 363 · see citing works
Virtual reality in the diagnostic and therapy for mental disorders: A systematic review
Wiebe, A., Kannen, K., Selaskowski, B., Mehren, A., Thöne, A.-K., Pramme, L., Blumenthal, N., Li, M., Asché, L., Jonas, S., et al. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102213 · Cited by 223 · see citing works
The use of virtual reality in craving assessment and cue-exposure therapy in substance use disorders
Hone-Blanchet, A., Wensing, T., & Fecteau, S. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00844 · Cited by 188 · see citing works
Evidence on Virtual Reality-Based Therapies for Psychiatric Disorders: Meta-Review of Meta-Analyses
Dellazizzo, L., Potvin, S., Luigi, M., & Dumais, A. (2020) · Journal of Medical Internet Research · doi:10.2196/20889 · Cited by 135 · see citing works
Virtual Reality for the Enhancement of Emotion Regulation
Colombo, D., Díaz‐García, A., Fernandez‐Álvarez, J., & Botella, C. (2021) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2618 · Cited by 120 · see citing works
Applications of Virtual Reality in Individuals with Alcohol Misuse: A Systematic Review
Ghiţă, A., & Gutiérrez-Maldonado, J. (2018) · Addictive Behaviors · doi:10.1016/j.addbeh.2018.01.036 · Cited by 98 · see citing works
Virtual reality exposure therapy on alcohol and nicotine: a systematic review
Trahan, M. H., Maynard, B. R., Smith, K. S., Farina, A. S. J., & Khoo, Y. M. (2019) · Research on Social Work Practice · doi:10.1177/1049731518823073 · Cited by 39 · see citing works
Deng, H., Zhang, R., Wang, C., Zhang, B., Wang, J., Wang, S., Zhang, J., Shari, N. I., & Leong Bin Abdullah, M. F. I. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1215963 · Cited by 5 · see citing works
“The sessions will be held three times a week; hence, a total duration of 4 weeks is needed (32).”
Background
- Authors
- Lee, S. H., Han, D. H., Oh, S., Lyoo, I. K., Lee, Y. S., Renshaw, P. F., & Lukas, S. E.
- Affiliations
- Chung-Ang University Healthcare System (KR)
- Seoul National University (KR)
- University of Utah (US)
- Harvard University (US)
- Corresponding author
- Han, Doug Hyun
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 91
- Issue
- 3
- Pages
- 393-397
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2021029484
- Cited by
- 84
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Institute on Drug Abuse (K24DA015116, DA015116, DA003H3)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- virtual reality therapy, alcoholism, alcohol craving, quantitative EEG, alpha activity, frontal cortex, multisensory stimulation, cognitive behavioral therapy, adjunctive therapy, high-risk patient identification
- MeSH terms
- Adult, Alcoholism, Alpha Rhythm, Aversive Therapy, Computer Graphics, Electroencephalography, Environment, Humans, Inpatients, Male, Middle Aged, Reality Therapy, Cognitive Behavioral Therapy
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