Cited by 84Substance Abuse Treatment and OutcomesVirtual Reality Applications and ImpactsEEG and Brain-Computer Interfaces

Quantitative electroencephalographic (qEEG) correlates of craving during virtual reality therapy in alcohol-dependent patients

Lee, Sang Hoon, Han, Doug Hyun, Oh, Seman, Lyoo, In Kyoon, Lee, Young Sik, Renshaw, Perry F., Lukas, Scott E.·2009·Pharmacology Biochemistry and Behavior

Abstract

Virtual reality (VR) is an evolving technology that is being applied to treat a wide range of medical and psychiatric diseases. A virtual reality therapy (VRT) with multisensory stimulation has been applied to patients with alcohol dependence (ADP). We hypothesized that the VRTP for alcohol dependence would reduce the craving for alcohol and increase alpha wave activity in frontal areas of individuals with ADP. Twenty ADP and eighteen ADP were exposed to a series of 10 VRTP sessions (VRTP-ADP) and cognitive behavioral therapy (nVRTP-ADP), respectively. Fifteen healthy controls were exposed to VRTP for comparing the changes of craving and EEG during all three phases of VRTP. The VRTP-ADP exhibited a greater decrease in craving after the 10th VRTP session, when compared to the nVRTP-ADP. Compared to the healthy control subjects, VRTP-ADP group showed higher magnitude of the change in craving throughout VRTP sessions. These results suggest that VRTP may be useful as an adjunct to treating alcohol dependence but may also serve as an evaluation tool to identify high-risk patients.

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Crossref · 10.1016/j.pbb.2008.08.014

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Authors
Lee, S. H., Han, D. H., Oh, S., Lyoo, I. K., Lee, Y. S., Renshaw, P. F., & Lukas, S. E.
Affiliations
  • Chung-Ang University Healthcare System (KR)
  • Seoul National University (KR)
  • University of Utah (US)
  • Harvard University (US)
Corresponding author
Han, Doug Hyun
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2009-01
Volume
91
Issue
3
Pages
393-397
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2021029484
Cited by
84
References
43
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 11 · 2022: 5 · 2021: 12 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 1
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Funders
National Institute on Drug Abuse (K24DA015116, DA015116, DA003H3)
Topics
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Physical Sciences › Computer Science › Human-Computer Interaction › Virtual Reality Applications and Impacts
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
virtual reality therapy, alcoholism, alcohol craving, quantitative EEG, alpha activity, frontal cortex, multisensory stimulation, cognitive behavioral therapy, adjunctive therapy, high-risk patient identification
MeSH terms
Adult, Alcoholism, Alpha Rhythm, Aversive Therapy, Computer Graphics, Electroencephalography, Environment, Humans, Inpatients, Male, Middle Aged, Reality Therapy, Cognitive Behavioral Therapy

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