Neuroinflammation in psychiatric disorders: An introductory primer
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Glucocorticoid desensitization dampens the immune system's response to cortisol, leading to elevated peripheral pro-inflammatory factors (TNF, IL-17, IL-1β, IL-6) and sustained neuroinflammation marked by chronic microglial and astrocyte activation.
“This desensitization dampens the immune system’s response to cortisol, ultimately leading to elevated peripheral pro-inflammatory factors (e.g., TNF, IL-17, IL-1β, IL-6) and sustained neuroinflammation, marked by chronic microglial and astrocyte activation [29,31,32,33,34].”
From Comparative Analysis of HPA-Axis Dysregulation and Dynamic Molecular Mechanisms in Acute Versus Chronic Social Defeat Stress (2025) · cites this paper as [33]
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Yang, J., Jia, Y., Guo, T., Zhang, S., Huang, J., Lu, H., Li, L., Xu, J., Liu, G., & Xiao, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136063 · Cited by 11 · see citing works
- Authors
- Dunn, G. A., Loftis, J. M., & Sullivan, E. L.
- Affiliations
- University of Oregon (US)
- Oregon Health & Science University (US)
- Oregon National Primate Research Center (US)
- Corresponding author
- Sullivan, Elinor L.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 196
- Pages
- 172981
- ISSN
- 0091-3057 (ISSN-L)
- PMC
- PMC7430067
- OpenAlex
- W3039036667
- Cited by
- 73
- References
- 25
- Citations by year
- 2026: 20 · 2025: 20 · 2024: 16 · 2023: 12 · 2022: 4 · 2021: 1
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Drug Abuse (R41DA047865)
- Department of Veterans Affairs (1I01BX002061)
- Veterans Health Administration Office of Research and Development
- National Institute of Mental Health (R01 MH107508R01, R01 738MH117177-01)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- neuroinflammation, schizophrenia, bipolar disorder, major depressive disorder, CD163+ macrophages, substantia nigra, cerebral peduncle, tyrosine hydroxylase, dopaminergic neurons, perivascular macrophages, gray and white matter
- MeSH terms
- Mental Disorders, Humans, Inflammation, Nervous System Diseases
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