Cited by 501Tryptophan and brain disordersSchizophrenia research and treatmentNeuroinflammation and Neurodegeneration Mechanisms

Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis

Upthegrove, Rachel, Manzanares-Teson, Nuria, Barnes, Nicholas M.·2014·Schizophrenia Research

Abstract

This systematic review sets out to give a comprehensive overview of the cytokine profile at the onset of psychosis un-confounded by medication. We aim to provide insight into the early pathophysiological process of psychosis and areas for future research of potential biomarkers able to chart the extent of illness or effectiveness of treatment. Following PRISMA guidelines, a systematic primary search identified 4638 citations, 4651 studies were retrieved and screened, and 23 studies met the inclusion criteria (published in English before June 2013, patients with neuroleptic naive first episode psychosis, and assessed circulating cytokines). These reported 570 patients, 683 healthy control subjects, and 20 cytokine/cytokine receptors. Papers that contained sufficient stratified data were included in a random-effects pooled effect size meta-analysis. Highly significant effect sizes were found for elevated IL-1β, sIL-2r, IL-6, and TNF-α. Non-significant effect size estimates were obtained for IL-2, IL-4, and IFN-γ. Thus, we found significant elevation in pro-inflammatory cytokine levels in the serum of patients with medication-naive first episode psychosis. This adds to the evidence of a pro-inflammatory immune deregulation in schizophrenia and suggests these cytokines should be the focus for further research in biomarkers of progress and extent of illness. Future studies should focus on the medication-naive group at the early stages of illness with numbers large enough to allow for the control of other potential confounding factors.

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Crossref · 10.1016/j.schres.2014.03.005

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Authors
Upthegrove, R., Manzanares-Teson, N., & Barnes, N. M.
Affiliations
  • Birmingham and Solihull Mental Health NHS Foundation Trust (GB)
  • University of Birmingham (GB)
Corresponding author
Upthegrove, Rachel
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2014-05
Volume
155
Issue
1-3
Pages
101-108
ISSN
0920-9964 (ISSN-L)
OpenAlex
W1969833165
Cited by
501
References
57
Citations by year
2026: 29 · 2025: 38 · 2024: 34 · 2023: 46 · 2022: 41 · 2021: 51 · 2020: 42 · 2019: 48 · 2018: 52 · 2017: 47 · 2016: 37 · 2015: 28 · 2014: 7
FWCI
3.13
Type
journal article
Language
en
Open access
closed
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
first-episode psychosis, cytokines
MeSH terms
Humans, Psychotic Disorders, Antipsychotic Agents, Cytokines, Databases, Factual

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