Ih from synapses to networks: HCN channel functions and modulation in neurons

Ion Channels/Excitable Membranes

(2011) · Springer eBooks · doi:10.1007/springerreference_33998 · Cited by 4,066 · see citing works

Ion Channels/Excitable Membranes

Terlau, H., & Kirchhoff, F. (2006) · Springer eBooks · doi:10.1007/3-540-29623-9_5640 · Cited by 1,805 · see citing works

The functional states of the thalamus and the associated neuronal interplay.

Steriade, M., & Llinas, R. R. (1988) · Physiological Reviews · doi:10.1152/physrev.1988.68.3.649 · Cited by 1,746 · see citing works

Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function

Robinson, R. B., & Siegelbaum, S. A. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142734 · Cited by 1,177 · see citing works

Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons

Pape, H.-C. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001503 · Cited by 1,152 · see citing works

Properties of a hyperpolarization‐activated cation current and its role in rhythmic oscillation in thalamic relay neurones.

McCormick, D. A., & Pape, H. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018331 · Cited by 1,140 · see citing works

Resonance, oscillation and the intrinsic frequency preferences of neurons

Hutcheon, B., & Yarom, Y. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01547-2 · Cited by 1,121 · see citing works

Voltage-clamp analysis of muscarinic excitation in hippocampal neurons

Halliwell, J. V., & Adams, P. R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90954-4 · Cited by 1,046 · see citing works

Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation

Larson, J., Wong, D., & Lynch, G. (1986) · Brain Research · doi:10.1016/0006-8993(86)90579-2 · Cited by 1,037 · see citing works

Hyperpolarization-Activated Cation Channels: From Genes to Function

Biel, M., Wahl‐Schott, C., Michalakis, S., & Zong, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00029.2008 · Cited by 1,005 · see citing works

Voltage Sensor of Kv1.2: Structural Basis of Electromechanical Coupling

Long, S. B., Campbell, E. B., & MacKinnon, R. (2005) · Science · doi:10.1126/science.1116270 · Cited by 982 · see citing works

Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons

Magee, J. C. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07613.1998 · Cited by 981 · see citing works

A family of hyperpolarization-activated mammalian cation channels

Ludwig, A., Zong, X., Jeglitsch, M., Hofmann, F. B., & Biel, M. (1998) · Nature · doi:10.1038/31255 · Cited by 944 · see citing works

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP

DiFrancesco, D., & Tortora, P. (1991) · Nature · doi:10.1038/351145a0 · Cited by 850 · see citing works

Dendritic integration of excitatory synaptic input

Magee, J. C. (2000) · Nature reviews. Neuroscience · doi:10.1038/35044552 · Cited by 737 · see citing works

Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain

Santoro, B., Liu, D. T., Yao, H., Bartsch, D., Kandel, E. R., Siegelbaum, S. A., & Tibbs, G. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81434-8 · Cited by 705 · see citing works

α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex

Wang, M., Ramos, B. P., Paspalas, C. D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Brennan, A., Dudley, A., Nou, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.015 · Cited by 672 · see citing works

Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons

Magee, J. C., & Cook, E. P. (2000) · Nature Neuroscience · doi:10.1038/78800 · Cited by 646 · see citing works

Dendritic spikes as a mechanism for cooperative long-term potentiation

Golding, N. L., Staff, N. P., & Spruston, N. (2002) · Nature · doi:10.1038/nature00854 · Cited by 623 · see citing works

Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons

Magee, J. C. (1999) · Nature Neuroscience · doi:10.1038/9158 · Cited by 617 · see citing works

Dendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons.

Rall, W., Burke, R. E., Smith, T., Nelson, P. G., & Frank, K. (1967) · Journal of Neurophysiology · doi:10.1152/jn.1967.30.5.1169 · Cited by 607 · see citing works

Molecular and Functional Heterogeneity of Hyperpolarization-Activated Pacemaker Channels in the Mouse CNS

Santoro, B., Chen, S., Lüthi, A., Pavlidis, P., Shumyatsky, G. P., Tibbs, G. R., & Siegelbaum, S. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-14-05264.2000 · Cited by 600 · see citing works

Structural basis for modulation and agonist specificity of HCN pacemaker channels

Zagotta, W. N., Olivier, N. B., Black, K. D., Young, E. C., Olson, R., & Gouaux, E. (2003) · Nature · doi:10.1038/nature01922 · Cited by 589 · see citing works

How does adrenaline accelerate the heart?

Brown, H. F., DiFrancesco, D., & Noble, S. J. (1979) · Nature · doi:10.1038/280235a0 · Cited by 585 · see citing works

Dendritic action potentials and computation in human layer 2/3 cortical neurons

Gidon, A., Zolnik, T. A., Fidzinski, P., Bolduan, F., Papoutsi, A., Poirazi, P., Holtkamp, M., Vida, I., & Larkum, M. E. (2020) · Science · doi:10.1126/science.aax6239 · Cited by 572 · see citing works

Subthreshold Na+-dependent theta-like rhythmicity in stellate cells of entorhinal cortex layer II

Alonso, Á., & Llinás, R. R. (1989) · Nature · doi:10.1038/342175a0 · Cited by 568 · see citing works

Mechanisms and functions of theta rhythms

Colgin, L. L. (2013) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062012-170330 · Cited by 559 · see citing works

Immunohistochemical localization of Ih channel subunits, HCN1–4, in the rat brain

Notomi, T., & Shigemoto, R. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.11039 · Cited by 558 · see citing works

Molecular mechanism of cAMP modulation of HCN pacemaker channels

Wainger, B. J., DeGennaro, M., Santoro, B., Siegelbaum, S. A., & Tibbs, G. R. (2001) · Nature · doi:10.1038/35081088 · Cited by 520 · see citing works

The hyperpolarization‐activated current (Ih) and its contribution to pacemaker activity in rat CA1 hippocampal stratum oriens‐alveus interneurones.

Maccaferri, G., & McBain, C. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021754 · Cited by 503 · see citing works

A Behavioral Role for Dendritic Integration

Nolan, M. F., Malleret, G., Dudman, J. T., Buhl, D. L., Santoro, B., Gibbs, E., Vronskaya, S., Buzsáki, G., Siegelbaum, S. A., Kandel, E. R., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.020 · Cited by 472 · see citing works

Molecular identification of a hyperpolarization-activated channel in sea urchin sperm

Gauss, R., Seifert, R., & Kaupp, U. B. (1998) · Nature · doi:10.1038/31248 · Cited by 471 · see citing works

Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites

Lőrincz, A., Notomi, T., Tamás, G., Shigemoto, R., & Nusser, Z. (2002) · Nature Neuroscience · doi:10.1038/nn962 · Cited by 442 · see citing works

A voltage‐clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones.

Mayer, M. L., & Westbrook, G. L. (1983) · The Journal of Physiology · doi:10.1113/jphysiol.1983.sp014747 · Cited by 436 · see citing works

Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current

Pape, H., & McCormick, D. A. (1989) · Nature · doi:10.1038/340715a0 · Cited by 429 · see citing works

Noradrenergic and serotonergic modulation of a hyperpolarization‐activated cation current in thalamic relay neurones.

McCormick, D. A., & Pape, H. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018332 · Cited by 422 · see citing works

Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide

Chen, S., Wang, J., & Siegelbaum, S. A. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.5.491 · Cited by 416 · see citing works

Two forms of electrical resonance at theta frequencies, generated by M‐current, h‐current and persistent Na+current in rat hippocampal pyramidal cells

Hu, H., Vervaeke, K., & Storm, J. F. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.029249 · Cited by 410 · see citing works

Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids

Lacey, M. G., Mercuri, N. B., & North, R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-04-01233.1989 · Cited by 406 · see citing works

I h Channels Contribute to the Different Functional Properties of Identified Dopaminergic Subpopulations in the Midbrain

Neuhoff, H., Neu, A. D., Liss, B., & Roeper, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-01290.2002 · Cited by 400 · see citing works

Structures of the Human HCN1 Hyperpolarization-Activated Channel

Lee, C., & MacKinnon, R. (2017) · Cell · doi:10.1016/j.cell.2016.12.023 · Cited by 393 · see citing works

Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing

Giocomo, L. M., Zilli, E. A., Fransén, E., & Hasselmo, M. E. (2007) · Science · doi:10.1126/science.1139207 · Cited by 377 · see citing works

Neurophysiology of HCN channels: From cellular functions to multiple regulations

He, C., Chen, F., Li, B., & Hu, Z. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.001 · Cited by 351 · see citing works

Site Independence of EPSP Time Course Is Mediated by DendriticI h in Neocortical Pyramidal Neurons

Williams, S. R., & Stuart, G. J. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.3177 · Cited by 349 · see citing works

The Hyperpolarization-Activated HCN1 Channel Is Important for Motor Learning and Neuronal Integration by Cerebellar Purkinje Cells

Nolan, M. F., Malleret, G., Lee, K. H., Gibbs, E., Dudman, J. T., Santoro, B., Yin, D., Thompson, R. F., Siegelbaum, S. A., Kandel, E. R., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00884-5 · Cited by 320 · see citing works

Properties and Role of I h in the Pacing of Subthreshold Oscillations in Entorhinal Cortex Layer II Neurons

Dickson, C. T., Magistretti, J., Shalinsky, M. H., Fransén, E. A., Hasselmo, M. E., & Alonso, Á. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.83.5.2562 · Cited by 317 · see citing works

Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro

Harris, N. C., & Constanti, A. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.74.6.2366 · Cited by 298 · see citing works

State-Dependent Dendritic Computation in Hippocampal CA1 Pyramidal Neurons

Gasparini, S., & Magee, J. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4428-05.2006 · Cited by 298 · see citing works

From Subthreshold to Firing-Rate Resonance

Richardson, M. J. E., Brunel, N., & Hakim, V. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00955.2002 · Cited by 285 · see citing works

Modulation of neuronal firing mode in cat and guinea pig LGNd by histamine: possible cellular mechanisms of histaminergic control of arousal

McCormick, D. A., & Williamson, A. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-10-03188.1991 · Cited by 284 · see citing works

Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis

Seifert, R., Scholten, A., Gauss, R., Mincheva, A., Lichter, P., & Kaupp, U. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9391 · Cited by 278 · see citing works

Molecular Characterization of the Hyperpolarization-activated Cation Channel in Rabbit Heart Sinoatrial Node

Ishii, T. M., Takano, M., Xie, L.-H., Noma, A., & Ohmori, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12835 · Cited by 276 · see citing works

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels

Santoro, B., Grant, S. G. N., Bartsch, D., & Kandel, E. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14815 · Cited by 275 · see citing works

A Behavioral Role for Dendritic IntegrationHCN1 Channels Constrain Spatial Memory and Plasticity at Inputs to Distal Dendrites of CA1 Pyramidal Neurons

Nolan, M. F., Malleret, G., Dudman, J. T., Buhl, D. L., Santoro, B., GIBBS, E., Vronskaya, S., Buzsáki, G., Siegelbaum, S. A., & Kandel, E. R. (2004) · Cell · doi:10.1016/s0092-8674(04)01055-4 · Cited by 274 · see citing works

Encyclopedia of Computational Neuroscience

Jaeger, D., & Jung, R. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6675-8 · Cited by 271 · see citing works

Subthreshold membrane resonance in neocortical neurons

Hutcheon, B., Miura, R. M., & Puil, E. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.2.683 · Cited by 261 · see citing works

Long-Term Potentiation in Rat Hippocampal Neurons Is Accompanied by Spatially Widespread Changes in Intrinsic Oscillatory Dynamics and Excitability

Narayanan, R., & Johnston, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.033 · Cited by 257 · see citing works

Anomalous rectification in neurons from cat sensorimotor cortex in vitro

Spain, W. J., Schwindt, P. C., & Crill, W. E. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.57.5.1555 · Cited by 254 · see citing works

Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells

Maccaferri, G., Mangoni, M. E., Lazzari, A. D., & DiFrancesco, D. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.6.2129 · Cited by 254 · see citing works

Electrophysiology of dopaminergic and non‐dopaminergic neurones of the guinea‐pig substantia nigra pars compacta in vitro.

Yung, W., Häusser, M., & Jack, J. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018571 · Cited by 252 · see citing works

Signaling of Layer 1 and Whisker-Evoked Ca2+and Na+Action Potentials in Distal and Terminal Dendrites of Rat Neocortical Pyramidal NeuronsIn VitroandIn Vivo

Larkum, M. E., & Zhu, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-06991.2002 · Cited by 249 · see citing works

Differential Distribution of Four Hyperpolarization-Activated Cation Channels in Mouse Brain

Moosmang, S., Biel, M., Hofmann, F. B., & Ludwig, A. (1999) · Biological Chemistry · doi:10.1515/bc.1999.121 · Cited by 245 · see citing works

Noradrenergic modulation of firing pattern in guinea pig and cat thalamic neurons, in vitro

McCormick, D. A., & Prince, D. A. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.3.978 · Cited by 243 · see citing works

Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain

Monteggia, L. M., Eisch, A. J., Tang, M. D., Kaczmarek, L. K., & Nestler, E. J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00155-8 · Cited by 232 · see citing works

Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels

Beaumont, V., & Zucker, R. S. (2000) · Nature Neuroscience · doi:10.1038/72072 · Cited by 226 · see citing works

Nitric oxide controls oscillatory activity in thalamocortical neurons

Pape, H., & Mager, R. (1992) · Neuron · doi:10.1016/0896-6273(92)90182-d · Cited by 223 · see citing works

Electrophysiological and morphological characteristics of three subtypes of rat globus pallidus neurone in vitro

Cooper, A. J., & Stanford, I. M. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00291.x · Cited by 223 · see citing works

Action of the hyperpolarization-activated current ( I h ) blocker ZD 7288 in hippocampal CA1 neurons

Gasparini, S., & DiFrancesco, D. (1997) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050488 · Cited by 222 · see citing works

HCN1 Channels Constrain Synaptically Evoked Ca2+ Spikes in Distal Dendrites of CA1 Pyramidal Neurons

Tsay, D., Dudman, J. T., & Siegelbaum, S. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.11.015 · Cited by 217 · see citing works

Hyperpolarization‐activated cation channels in fast‐spiking interneurons of rat hippocampus

Aponte, Y., Lien, C., Reisinger, E., & Jonas, P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.104042 · Cited by 213 · see citing works

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction

Santoro, B., Wainger, B. J., & Siegelbaum, S. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3300-04.2004 · Cited by 210 · see citing works

Cellular mechanisms underlying cholinergic and noradrenergic modulation of neuronal firing mode in the cat and guinea pig dorsal lateral geniculate nucleus

McCormick, D. A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-01-00278.1992 · Cited by 206 · see citing works

Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages

Männikkö, R., Elinder, F., & Larsson, H. P. (2002) · Nature · doi:10.1038/nature01038 · Cited by 198 · see citing works

Assessing the role of Ih channels in synaptic transmission and mossy fiber LTP

Chevaleyre, V., & Castillo, P. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142213199 · Cited by 195 · see citing works

HCN1 Channels Control Resting and Active Integrative Properties of Stellate Cells from Layer II of the Entorhinal Cortex

Nolan, M. F., Dudman, J. T., Dodson, P. D., & Santoro, B. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2358-07.2007 · Cited by 194 · see citing works

Mechanisms of Persistent Activity in Cortical Circuits: Possible Neural Substrates for Working Memory

Zylberberg, J., & Strowbridge, B. W. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070815-014006 · Cited by 192 · see citing works

Synchronized Oscillations in the Inferior Olive Are Controlled by the Hyperpolarization-Activated Cation Current I h

Bal, T., & McCormick, D. A. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.6.3145 · Cited by 191 · see citing works

Differences in subthreshold resonance of hippocampal pyramidal cells and interneurons: the role of h‐current and passive membrane characteristics

Zemankovics, R., Káli, S., Paulsen, O., Freund, T. F., & Hájos, N. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.185975 · Cited by 183 · see citing works

Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapses

Huang, Z., Luján, R., Kadurin, I., Uebele, V. N., Renger, J. J., DOLPHIN, A. C., & Shah, M. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2757 · Cited by 173 · see citing works

The h Channel Mediates Location Dependence and Plasticity of Intrinsic Phase Response in Rat Hippocampal Neurons

Narayanan, R., & Johnston, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0835-08.2008 · Cited by 172 · see citing works

Contribution of TWIK-Related Acid-Sensitive K+Channel 1 (TASK1) and TASK3 Channels to the Control of Activity Modes in Thalamocortical Neurons

Meuth, S. G., Budde, T., Kanyshkova, T. G., Broicher, T., Munsch, T., & Pape, H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06460.2003 · Cited by 170 · see citing works

Tuning of Synaptic Integration in the Medial Entorhinal Cortex to the Organization of Grid Cell Firing Fields

Garden, D. L. F., Dodson, P. D., O’Donnell, C., White, M. D., & Nolan, M. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.044 · Cited by 165 · see citing works

TRIP8b Splice Variants Form a Family of Auxiliary Subunits that Regulate Gating and Trafficking of HCN Channels in the Brain

Santoro, B., Piskorowski, R. A., Pian, P., Hu, L., Liu, H., & Siegelbaum, S. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.009 · Cited by 164 · see citing works

Complementary Theta Resonance Filtering by Two Spatially Segregated Mechanisms in CA1 Hippocampal Pyramidal Neurons

Hu, H., Vervaeke, K., Graham, L. J., & Storm, J. F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0187-09.2009 · Cited by 162 · see citing works

Functional Expression of the Human HCN3 Channel

Stieber, J., Stöckl, G., Herrmann, S., Haßfurth, B., & Hofmann, F. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502508200 · Cited by 161 · see citing works

Grid Cells Use HCN1 Channels for Spatial Scaling

Giocomo, L. M., Hussaini, S. A., Fan, Z., Kandel, E. R., Moser, M., & Moser, E. I. (2011) · Cell · doi:10.1016/j.cell.2011.08.051 · Cited by 158 · see citing works

Temporal synchrony and gamma-to-theta power conversion in the dendrites of CA1 pyramidal neurons

Vaidya, S. P., & Johnston, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3562 · Cited by 158 · see citing works

Mediation of Hippocampal Mossy Fiber Long-Term Potentiation by Presynaptic I h Channels

Mellor, J. R., Nicoll, R. A., & Schmitz, D. (2002) · Science · doi:10.1126/science.1064285 · Cited by 157 · see citing works

Alternatively Spliced Isoforms of TRIP8b Differentially Control h Channel Trafficking and Function

Lewis, A. S., Schwartz, E., Chan, C. S., Noam, Y., Shin, M., Wadman, W. J., Surmeier, D. J., Baram, T. Z., Macdonald, R. L., & Chetkovich, D. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0856-09.2009 · Cited by 150 · see citing works

Distribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons

Harnett, M. T., Magee, J. C., & Williams, S. R. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2813-14.2015 · Cited by 148 · see citing works

The Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: From Biophysics to Pharmacology of a Unique Family of Ion Channels

Sartiani, L., Mannaioni, G., Masi, A., Novella Romanelli, M., & Cerbai, E. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014035 · Cited by 143 · see citing works

Serotonin augments the cationic current Ih in central neurons

Bobker, D. H., & Williams, J. T. (1989) · Neuron · doi:10.1016/0896-6273(89)90041-x · Cited by 139 · see citing works

Protein kinase A-independent modulation of ion channels in the brain by cyclic AMP.

Pedarzani, P., & Storm, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11716 · Cited by 138 · see citing works

Hyperpolarization‐activated currents in presynaptic terminals of mouse cerebellar basket cells

Southan, A. P., Morris, N. P., Stephens, G. J., & Robertson, B. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00091.x · Cited by 137 · see citing works

Variability in the subcellular distribution of ion channels increases neuronal diversity

Nusser, Z. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.01.003 · Cited by 135 · see citing works

Association with the Auxiliary Subunit PEX5R/Trip8b Controls Responsiveness of HCN Channels to cAMP and Adrenergic Stimulation

Zolles, G., Wenzel, D., Bildl, W., Schulte, U., Hofmann, A., Müller, C. S., Thumfart, J. O., Vlachos, A., Deller, T., Pfeifer, A., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.008 · Cited by 135 · see citing works

Adenosine promotes burst activity in guinea‐pig geniculocortical neurones through two different ionic mechanisms.

Pape, H. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019026 · Cited by 133 · see citing works

The Murine HCN3 Gene Encodes a Hyperpolarization-activated Cation Channel with Slow Kinetics and Unique Response to Cyclic Nucleotides

Mistrík, P., Mader, R. M., Michalakis, S., Weidinger, M., Pfeifer, A., & Biel, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502696200 · Cited by 131 · see citing works

Towards an integrated view of HCN channel role in epilepsy

Noam, Y., Bernard, C., & Baram, T. Z. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.06.013 · Cited by 130 · see citing works

Transcriptional channelopathies: An emerging class of disorders

Waxman, S. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35090026 · Cited by 127 · see citing works

Voltage Sensor Movements during Hyperpolarization in the HCN Channel

Lee, C., & MacKinnon, R. (2019) · Cell · doi:10.1016/j.cell.2019.11.006 · Cited by 127 · see citing works

Spatial compartmentalization and functional impact of conductance in pyramidal neurons

Williams, S. R. (2004) · Nature Neuroscience · doi:10.1038/nn1305 · Cited by 126 · see citing works

Knock-Out of HCN1 Subunit Flattens Dorsal-Ventral Frequency Gradient of Medial Entorhinal Neurons in Adult Mice

Giocomo, L. M., & Hasselmo, M. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0609-09.2009 · Cited by 119 · see citing works

HCN2 ion channels: an emerging role as the pacemakers of pain

Emery, E. C., Young, G. T., & McNaughton, P. A. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.04.004 · Cited by 118 · see citing works

Dysfunction of Cortical Dendritic Integration in Neuropathic Pain Reversed by Serotoninergic Neuromodulation

Santello, M., & Nevian, T. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.003 · Cited by 118 · see citing works

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy

Shin, M., Brager, D. H., Jaramillo, T. C., Johnston, D., & Chetkovich, D. M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.06.013 · Cited by 113 · see citing works

Time Constants of h Current in Layer II Stellate Cells Differ along the Dorsal to Ventral Axis of Medial Entorhinal Cortex

Giocomo, L. M., & Hasselmo, M. E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3196-08.2008 · Cited by 109 · see citing works

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders

Santoro, B., & Shah, M. M. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023356 · Cited by 108 · see citing works

Serotonin modulates spike probability in the axon initial segment through HCN channels

Ko, K. W., Rasband, M. N., Meseguer, V., Krämer, R., & Golding, N. L. (2016) · Nature Neuroscience · doi:10.1038/nn.4293 · Cited by 96 · see citing works

Differential expression of HCN subunits alters voltage-dependent gating of h-channels in CA1 pyramidal neurons from dorsal and ventral hippocampus

Dougherty, K. A., Nicholson, D. A., Diaz, L. M., Buss, E. W., Neuman, K. M., Chetkovich, D. M., & Johnston, D. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00010.2013 · Cited by 94 · see citing works

Local and Global Effects ofIhDistribution in Dendrites of Mammalian Neurons

Angelo, K., London, M., Christensen, S. R., & Häusser, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5284-06.2007 · Cited by 92 · see citing works

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

Porro, A., Saponaro, A., Gasparri, F., et al. (2019) · eLife · doi:10.7554/elife.49672 · Cited by 92 · see citing works

Prefrontal Cortex HCN1 Channels Enable Intrinsic Persistent Neural Firing and Executive Memory Function

Thuault, S., Malleret, G., Constantinople, C. M., Nicholls, R. E., Chen, I., Zhu, J., Panteleyev, A. A., Vronskaya, S., Nolan, M. F., Bruno, R. M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2427-12.2013 · Cited by 91 · see citing works

A biophysical signature of network affiliation and sensory processing in mitral cells

Angelo, K., Rancz, E. A., Pimentel, D. O., Hundahl, C. A., Hannibal, J., Fleischmann, A., Pichler, B., & Margrie, T. W. (2012) · Nature · doi:10.1038/nature11291 · Cited by 90 · see citing works

Cardiac and neuronal HCN channelopathies

Rivolta, I., Binda, A., Masi, A., & DiFrancesco, J. C. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02384-3 · Cited by 90 · see citing works

ZD 7288 inhibits T-type calcium current in rat hippocampal pyramidal cells

Sanchez‐Alonso, J. L., Halliwell, J. V., & Colino, A. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.05.016 · Cited by 89 · see citing works

Postnatal Expression Pattern of HCN Channel Isoforms in Thalamic Neurons: Relationship to Maturation of Thalamocortical Oscillations

Kanyshkova, T. G., Pawlowski, M., Meuth, P., Dubé, C. M., Bender, R. A., Brewster, A. L., Baumann, A., Baram, T., Pape, H., & Budde, T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0689-09.2009 · Cited by 84 · see citing works

Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function

Saponaro, A., Pauleta, S. R., Cantini, F., Matzapetákis, M., Hammann, C., Donadoni, C., Hu, L., Thiel, G., Banci, L., Santoro, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1410389111 · Cited by 79 · see citing works

Local Control of Postinhibitory Rebound Spiking in CA1 Pyramidal Neuron Dendrites

Ascoli, G. A., Gasparini, S., Medinilla, V., & Migliore, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4066-09.2010 · Cited by 74 · see citing works

Membrane Resonance in Bursting Pacemaker Neurons of an Oscillatory Network Is Correlated with Network Frequency

Tohidi, V., & Farzan Nadim, A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0545-09.2009 · Cited by 74 · see citing works

The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System

Zobeiri, M., Chaudhary, R., Blaich, A., Rottmann, M., Herrmann, S., Meuth, P., Bista, P., Kanyshkova, T., Lüttjohann, A., Narayanan, V., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz047 · Cited by 74 · see citing works

Localization of HCN1 Channels to Presynaptic Compartments: Novel Plasticity That May Contribute to Hippocampal Maturation

Bender, R. A., Kirschstein, T., Kretz, O., Brewster, A. L., Richichi, C., Rüschenschmidt, C., Shigemoto, R., Beck, H., Frotscher, M., & Baram, T. Z. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4699-06.2007 · Cited by 73 · see citing works

Preferential localization of the hyperpolarization‐activated cyclic nucleotide‐gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum

Luján, R., Albasanz, J. L., Shigemoto, R., & Juiz, J. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04043.x · Cited by 73 · see citing works

Population diversity and function of hyperpolarization-activated current in olfactory bulb mitral cells

Angelo, K., & Margrie, T. W. (2011) · Scientific Reports · doi:10.1038/srep00050 · Cited by 70 · see citing works

Postnatal Development of Dendritic Synaptic Integration in Rat Neocortical Pyramidal Neurons

Atkinson, S. E., & Williams, S. R. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00083.2009 · Cited by 70 · see citing works

Double trouble? Potential for hyperexcitability following both channelopathic up- and downregulation of Ih in epilepsy

Dyhrfjeld‐Johnsen, J. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.01.005.2009 · Cited by 70 · see citing works

An Essential Role for Modulation of Hyperpolarization-Activated Current in the Development of Binaural Temporal Precision

Khurana, S., Liu, Z., Lewis, A. S., Rosa, K., Chetkovich, D. M., & Golding, N. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3882-11.2012 · Cited by 67 · see citing works

Walking toward a convergence in aging research

Smith, M. A. (2009) · Frontiers in Neuroscience · doi:10.3389/neuro.01.012.2009 · Cited by 67 · see citing works

The HCN channel voltage sensor undergoes a large downward motion during hyperpolarization

Dai, G., Aman, T. K., DiMaio, F., et al. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0259-1 · Cited by 65 · see citing works

Trafficking and Gating of Hyperpolarization-activated Cyclic Nucleotide-gated Channels Are Regulated by Interaction with Tetratricopeptide Repeat-containing Rab8b-interacting Protein (TRIP8b) and Cyclic AMP at Distinct Sites

Han, Y. S., Noam, Y., Lewis, A. S., Gallagher, J. J., Wadman, W. J., Baram, T. Z., & Chetkovich, D. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.236125 · Cited by 63 · see citing works

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels: An Emerging Role in Neurodegenerative Diseases

Chang, X., Wang, J., Jiang, H. F., Shi, L., & Xie, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00141 · Cited by 63 · see citing works

Selective Participation of Somatodendritic HCN Channels in Inhibitory But Not Excitatory Synaptic Integration in Neurons of the Subthalamic Nucleus

Atherton, J. F., Kitano, K., Baufreton, J., Fan, K. Y., Wokosin, D. L., Tkatch, T., Shigemoto, R., Surmeier, D. J., & Bevan, M. D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3898-10.2010 · Cited by 61 · see citing works

Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development

Dufour, M. A., Woodhouse, A., & Goaillard, J. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23382 · Cited by 61 · see citing works

Action of serotonin on the hyperpolarization‐activated cation current (Ih) in rat CA1 hippocampal neurons

Gasparini, S., & DiFrancesco, D. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00728.x · Cited by 61 · see citing works

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Saponaro, A., Cantini, F., Porro, A., Bucchi, A., DiFrancesco, D., Maione, V., Donadoni, C., Introini, B., Mesirca, P., Mangoni, M. E., et al. (2018) · eLife · doi:10.7554/elife.35753 · Cited by 61 · see citing works

Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels

Flynn, G. E., & Zagotta, W. N. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805596115 · Cited by 61 · see citing works

An axon-specific expression of HCN channels catalyzes fast action potential signaling in GABAergic interneurons

Roth, F. C., & Hu, H. (2020) · Nature Communications · doi:10.1038/s41467-020-15791-y · Cited by 61 · see citing works

Ih-mediated depolarization enhances the temporal precision of neuronal integration

Pavlov, I., Scimemi, A., Savtchenko, L. P., Kullmann, D. M., & Walker, M. C. (2011) · Nature Communications · doi:10.1038/ncomms1202 · Cited by 59 · see citing works

Dendritic HCN2 Channels Constrain Glutamate-Driven Excitability in Reticular Thalamic Neurons

Ying, S., Jia, F., Abbas, S. Y., Hofmann, F. B., Ludwig, A., & Goldstein, P. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1630-07.2007 · Cited by 59 · see citing works

Persistent Discharges in Dentate Gyrus Perisoma-Inhibiting Interneurons Require Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Activation

Elgueta, C., Köhler, J., & Bartos, M. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3671-14.2015 · Cited by 57 · see citing works

Theta-frequency membrane resonance and its ionic mechanisms in rat subicular pyramidal neurons

Wang, W., Wan, Y.-H., Zhu, J.-L., Lei, G., Wang, Y., Zhang, P., & Hu, S.-J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.033 · Cited by 56 · see citing works

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

Kasimova, M. A., Tewari, D., Cowgill, J. B., et al. (2019) · eLife · doi:10.7554/elife.53400 · Cited by 56 · see citing works

In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons

Otomo, K., Perkins, J., Kulkarni, A. S., Stojanovic, S., Roeper, J., & Paladini, C. A. (2020) · Nature Communications · doi:10.1038/s41467-020-20041-2 · Cited by 53 · see citing works

Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons

Abbas, S. Y., Ying, S., & Goldstein, P. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.034 · Cited by 52 · see citing works

The fast and slow ups and downs of HCN channel regulation

Lewis, A. S., Estep, C. M., & Chetkovich, D. M. (2010) · Channels · doi:10.4161/chan.4.3.11630 · Cited by 48 · see citing works

Gating mechanism of hyperpolarization-activated HCN pacemaker channels

Ramentol, R., Perez, M. E., & Larsson, H. P. (2020) · Nature Communications · doi:10.1038/s41467-020-15233-9 · Cited by 48 · see citing works

Ionic Basis for Membrane Potential Resonance in Neurons of the Inferior Olive

Makidono, Y., Nakayama, H., Yamasaki, M., Miyazaki, T., Kobayashi, K., Watanabe, M., Kano, M., Sakimura, K., & Hashimoto, K. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.053 · Cited by 45 · see citing works

Hyperpolarization-activated cation current is involved in modulation of the excitability of rat retinal ganglion cells by dopamine

Chen, L., & Yang, X. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.015 · Cited by 44 · see citing works

HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons

Byczkowicz, N., Eshra, A., Montanaro, J., Trevisiol, A., Hirrlinger, J., Kole, M. H. P., Shigemoto, R., & Hallermann, S. (2019) · eLife · doi:10.7554/elife.42766 · Cited by 44 · see citing works

Structural Mechanism for the Regulation of HCN Ion Channels by the Accessory Protein TRIP8b

DeBerg, H. A., Bankston, J. R., Rosenbaum, J. C., et al. (2015) · Structure · doi:10.1016/j.str.2015.02.007 · Cited by 42 · see citing works

Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMP

Hu, L., Santoro, B., Saponaro, A., Liu, H., Moroni, A., & Siegelbaum, S. A. (2013) · The Journal of General Physiology · doi:10.1085/jgp.201311013 · Cited by 41 · see citing works

Cell type‐dependent expression of HCN1 in the main olfactory bulb

Holderith, N. B., Shigemoto, R., & Nusser, Z. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02756.x · Cited by 40 · see citing works

Reversed somatodendritic Ih gradient in a class of rat hippocampal neurons with pyramidal morphology

Bullis, J. B., Jones, T. D., & Poolos, N. P. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.123836 · Cited by 39 · see citing works

Nitric oxide selectively suppresses I H currents mediated by HCN1‐containing channels

Kopp‐Scheinpflug, C., Pigott, B. M., & Forsythe, I. D. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282194 · Cited by 36 · see citing works

The role of two-pore-domain background K+ (K2P) channels in the thalamus

Bista, P., Cerina, M., Ehling, P., Leist, M., Pape, H., Meuth, S. G., & Budde, T. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1632-x · Cited by 36 · see citing works

Bipolar switching by HCN voltage sensor underlies hyperpolarization activation

Cowgill, J. B., Klenchin, V. A., Alvarez-Baron, C. P., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1816724116 · Cited by 33 · see citing works

Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide–gated cation channel

Groß, C., Saponaro, A., Santoro, B., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002139 · Cited by 32 · see citing works

Post-Inhibitory Rebound Spikes in Rat Medial Entorhinal Layer II/III Principal Cells: In Vivo, In Vitro, and Computational Modeling Characterization

Ferrante, M., Shay, C. F., Tsuno, Y., Chapman, G. W., & Hasselmo, M. E. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw058 · Cited by 31 · see citing works

Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b

Bankston, J. R., DeBerg, H. A., Stoll, S., & Zagotta, W. N. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.800722 · Cited by 31 · see citing works

Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures

Hammelmann, V., Stieglitz, M. S., Hülle, H., Meur, K. L., Kass, J., Brümmer, M., Grüner, C., Rötzer, R. D., Fenske, S., Hartmann, J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126418 · Cited by 30 · see citing works

High dendritic expression of Ih in the proximity of the axon origin controls the integrative properties of nigral dopamine neurons

Engel, D., & Seutin, V. (2015) · The Journal of Physiology · doi:10.1113/jp271052 · Cited by 27 · see citing works

The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms

Wang, Z., Blanco, I., Hayoz, S., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013281 · Cited by 26 · see citing works

Electrical Resonance in the θ Frequency Range in Olfactory Amygdala Neurons

Vera, J. R., Pezzoli, M., Pereira, U., Bacigalupo, J., & Sanhueza, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085826 · Cited by 24 · see citing works

Biophysical analysis of an HCN1 epilepsy variant suggests a critical role for S5 helix Met-305 in voltage sensor to pore domain coupling

Hung, A., Forster, I. C., McKenzie, C. E., et al. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.07.005 · Cited by 22 · see citing works

The HCN channel as a pharmacological target: Why, where, and how to block it

Balducci, V., Credi, C., Sacconi, L., Romanelli, M. N., Sartiani, L., & Cerbai, E. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.07.010 · Cited by 21 · see citing works

cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4

Porro, A., Thiel, G., Moroni, A., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00771 · Cited by 18 · see citing works

Features of proximal and distal excitatory synaptic inputs to layer V neurons of the rat medial entorhinal cortex

Medinilla, V., Johnson, O., & Gasparini, S. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.237172 · Cited by 16 · see citing works

Do the functional properties of HCN1 mutants correlate with the clinical features in epileptic patients?

Porro, A., Abbandonato, G., Veronesi, V., et al. (2021) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2021.07.008 · Cited by 16 · see citing works

Q10: The Effect of Temperature on Ion Channel Kinetics

Sterratt, D. C. (2014) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-7320-6_236-1 · Cited by 14 · see citing works

Hyperpolarization-Activated Currents and Subthreshold Resonance in Granule Cells of the Olfactory Bulb

Hu, R., Ferguson, K., Whiteus, C., Meijer, D. H., & Araneda, R. C. (2016) · eNeuro · doi:10.1523/eneuro.0197-16.2016 · Cited by 14 · see citing works

Ionic conductance associated with electrical activity of guinea‐pig red nucleus neurones in vitro.

Kubota, M., Nakamura, M., & Tsukahara, N. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015668 · Cited by 12 · see citing works

Interneuron Functional Diversity in the Mouse Accessory Olfactory Bulb

Maksimova, M. A., Cansler, H. L., Zuk, K. E., Torres, J. M., Roberts, D. J., & Meeks, J. P. (2019) · eNeuro · doi:10.1523/eneuro.0058-19.2019 · Cited by 12 · see citing works

Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons

Bohannon, A. S., & Hablitz, J. J. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00020 · Cited by 11 · see citing works

Mechanisms for the resonant property in rodent neurons

Hashimoto, K. (2019) · Neuroscience Research · doi:10.1016/j.neures.2019.12.013 · Cited by 8 · see citing works

Vascular mechanotransduction

Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273 · see citing works

Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum

Guerrini, R., Conti, V., Mantegazza, M., Balestrini, S., Galanopoulou, A. S., & Benfenati, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00063.2021 · Cited by 196 · see citing works

The enigmatic HCN channels: A cellular neurophysiology perspective

Mishra, P., & Narayanan, R. (2025) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.26643 · Cited by 40 · see citing works

HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice

Cao, X., Zhu, M., Xu, G., Li, F., Yan, Y., Zhang, J., Wang, J., Zeng, F., Bao, Y., Zhang, X., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14831 · Cited by 9 · see citing works

Downregulation of the HCN1 Channel Alleviates Anxiety- and Depression-Like Behaviors in Mice With Cerebral Ischemia-Reperfusion Injury by Suppressing the NLRP3 Inflammasome

Zhou, M., Tao, X., Lin, K., Leng, C., Yang, Y., Gui, Y., Sun, Y., Zhou, M., Sun, B., Xia, Y., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.038263 · Cited by 6 · see citing works

Upregulated HCN currents and reduced intrinsic excitability in prefrontal cortical pyramidal neurons after maternal separation

Wang, X., Luo, F., & Li, B. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107186 · Cited by 1 · see citing works

Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery

Tanaka, M. (2026) · Biomedicines · doi:10.3390/biomedicines14061265

Conductance change during the inhibitory potential in the guinea‐pig taenia coli

Tomita, T. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp009964 · Cited by 83 · see citing works

ACh-Evoked complex membrane potential changes in mouse submaxillary gland acini

Wakui, M., & Nishiyama, A. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00587476 · Cited by 8 · see citing works

Membrane potential and resistance measurement in acinar cells from salivary glands in vitro: effect of acetylcholine

Nishiyama, A., & Petersen, O. H. (1974) · The Journal of Physiology · doi:10.1113/jphysiol.1974.sp010700 · Cited by 59 · see citing works

Hyperpolarizing membrane potential changes in a cloned monkey kidney cell line

Chang, H., Yamashita, N., Ogata, E., et al. (1985) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00582564 · Cited by 5 · see citing works

Beta-adrenergic actions on membrane electrical properties of dissociated smooth muscle cells

Yamaguchi, H., Honeyman, T. W., & Fay, F. S. (1988) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1988.254.3.c423 · Cited by 21 · see citing works