Temporal frequency of subthreshold oscillations scales with entorhinal grid cell field spacing
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Grid cells in layer II of rat entorhinal cortex fire to spatial locations in a repeating hexagonal grid, with smaller spacing between grid fields for neurons in more dorsal anatomical locations. Data from in vitro whole-cell patch recordings showed differences in frequency of subthreshold membrane potential oscillations in entorhinal neurons that correspond to different positions along the dorsal-to-ventral axis, supporting a model of physiological mechanisms for grid cell responses.
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These systems are highly structured temporally, e.g., containing nested gamma and theta oscillation structures that are phase locked to sequences of place-cell responses, interfering oscillators frequency-shifted by the animal's motion velocity, tuned cellular resonances, and other neural phenomena that lie far outside a conventional artificial neural network description.
“These systems are highly structured temporally, e.g., containing nested gamma and theta oscillation structures that are phased locked to sequences of place-cell responses, interfering oscillators frequency-shifted by the animal's motion velocity (Zilli and Hasselmo, 2010), tuned cellular resonances (Giocomo et al., 2007; Buzsáki, 2010), and other neural phenomena that lie far outside a convention”
From Toward an integration of deep learning and neuroscience (2016) · cites this paper as Giocomo et al., 2007
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Self-citation
- Authors
- Giocomo, L. M., Zilli, E. A., Fransén, E., & Hasselmo, M. E.
- Affiliations
- Boston University (US)
- Center for Memory and Brain, Department of Psychology, Program in Neuroscience, Boston University, 2 Cummington Street, Boston, MA 02215, USA.
- Corresponding author
- Giocomo, Lisa M.
- Hasselmo, Michael E.
- Venue
- Science
- Published
- 2007-03-23
- Volume
- 315
- Issue
- 5819
- Pages
- 1719-1722
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2950607
- OpenAlex
- W2128189925
- Cited by
- 377
- References
- 26
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 16 · 2023: 4 · 2022: 14 · 2021: 12 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 16 · 2016: 22 · 2015: 12 · 2014: 27 · 2013: 45 · 2012: 40
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-71702, MH 60013, R01MH060013, R01MH061492, P50MH071702)
- National Institute on Drug Abuse (DA 16454, R01DA016454)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- grid cells, entorhinal cortex, subthreshold oscillations, membrane potential oscillations, dorsal-ventral axis, spatial coding
- MeSH terms
- Algorithms, Animals, Computer Simulation, Dendrites, Electric Stimulation, Female, Male, Mathematics, Membrane Potentials, Models, Neurological, Movement, Neurons, Periodicity, Space Perception, Time Factors, Patch-Clamp Techniques, Entorhinal Cortex, Rats, Long-Evans, Rats, In Vitro Techniques
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