Cited by 37RNA Interference and Gene DeliveryTreatment of Major DepressionDNA and Nucleic Acid Chemistry

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Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.

Bortolozzi, Analia, Manashirov, Sharon, Chen, Alon, Artigas, Francesc·2021·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2021.107873

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Abstract

Remarkable advances in understanding the role of RNA in health and disease have expanded considerably in the last decade. RNA is becoming an increasingly important target for therapeutic intervention; therefore, it is critical to develop strategies for therapeutic modulation of RNA function. Oligonucleotides, including antisense oligonucleotide (ASO), small interfering RNA (siRNA), microRNA mimic (miRNA), and anti-microRNA (antagomir) are perhaps the most direct therapeutic strategies for addressing RNA. Among other mechanisms, most oligonucleotide designs involve the formation of a hybrid with RNA that promotes its degradation by activation of endogenous enzymes such as RNase-H (e.g., ASO) or the RISC complex (e.g. RNA interference - RNAi for siRNA and miRNA). However, the use of oligonucleotides for the treatment of brain disorders is seriously compromised by two main limitations: i) how to deliver oligonucleotides to the brain compartment, avoiding the action of peripheral RNAses? and once there, ii) how to target specific neuronal populations? We review the main molecular pathways in major depressive disorder (MDD) and Parkinson's disease (PD), and discuss the challenges associated with the development of novel oligonucleotide therapeutics. We pay special attention to the use of conjugated ligand-oligonucleotide approach in which the oligonucleotide sequence is covalently bound to monoamine transporter inhibitors (e.g. sertraline, reboxetine, indatraline). This strategy allows their selective accumulation in the monoamine neurons of mice and monkeys after their intranasal or intracerebroventricular administration, evoking preclinical changes predictive of a clinical therapeutic action after knocking-down disease-related genes. In addition, recent advances in oligonucleotide therapeutic clinical trials are also reviewed.

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Alarcón-Arís, D., Recasens, A., Galofré, M., Carballo‐Carbajal, I., Zacchi, N., Ruiz‐Bronchal, E., Pavia-Collado, R., Chica, R., Ferrés‐Coy, A., Santos, M., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.11.015 · Cited by 140
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Sheline, Y. I. (1996) · PubMed · Cited by 137
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Stahl, S. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00957-4 · Cited by 134
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Miller, S., & Muqit, M. M. K. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.029 · Cited by 133
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Whiffin, N., Armean, I. M., Kleinman, A., Marshall, J. L., Minikel, E. V., Goodrich, J. K., Quaife, N. M., Cole, J. B., Wang, Q. S., Karczewski, K. J., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0893-5 · Cited by 126
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Gu, G., Reyes, P. F., Golden, G. T., Woltjer, R. L., Hulette, C., Montine, T. J., & Zhang, J. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.7.634 · Cited by 122
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Sullivan, G. M., Ogden, R. T., Oquendo, M. A., Kumar, J. S. D., Simpson, N. R., Huang, Y., Mann, J. J., & Parsey, R. V. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.028 · Cited by 122
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Pickrell, A. M., Pinto, M., Hida, A., & Moraes, C. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4871-11.2011 · Cited by 120
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Yi, L., Li, J., Liu, B., Luo, L., Liu, Q., & Geng, D. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130169 · Cited by 120
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Khodr, C. E., Sapru, M. K., Pedapati, J., Han, Y. S., West, N. C., Kells, A. P., Bankiewicz, K. S., & Bohn, M. C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.04.036 · Cited by 119
Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation
Zheng, Y., Zhang, Y., Yau, Y. H. C., Zeighami, Y., Larcher, K. M.-H., Mišić, B., & Dagher, A. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000495 · Cited by 119
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Nakagawa, O., Ming, X., Huang, L., & Juliano, R. L. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102635c · Cited by 119
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O'Connor, R. M., Grenham, S., Dinan, T. G., & Cryan, J. F. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000448 · Cited by 114
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Setsuie, R., Wang, Y.-L., Mochizuki, H., Osaka, H., Hayakawa, H., Ichihara, N., Li, H., Furuta, A., Sano, Y., Sun, Y., et al. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.07.015 · Cited by 113
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Soni, V., Kohli, D. V., & Jain, S. K. (2008) · Journal of drug targeting · doi:10.1080/10611860701725381 · Cited by 96
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Zhang, Y., Zhu, X., Bai, M., Zhang, L., Xue, L., & Yi, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069934 · Cited by 84
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Mannironi, C., Camon, J., Vito, F. D., Biundo, A., Stefano, M. E. D., Persiconi, I., Bozzoni, I., Fragapane, P., Mele, A., & Presutti, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073385 · Cited by 81
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Self-citation
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Thakker, D. R., Hoyer, D., & Cryan, J. F. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.08.006 · Cited by 78
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George, J., Mok, S., Moses, D., Wilkins, S., Bush, A., Cherny, R., & Finkelstein, D. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602814 · Cited by 77
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Cicchetti, D., Rogosch, F. A., Sturge‐Apple, M. L., & Toth, S. L. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp078 · Cited by 76
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Xu, J., Wang, R., Liu, Y., Liu, D., Jiang, H., & Pan, F. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.08.010 · Cited by 76
Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies.
Słodziński, H., Moran, L. B., Michael, G. J., Wang, B., Novoselov, S. S., Cheetham, M. E., Pearce, R. K. B., & Graeber, M. B. (2009) · PubMed · Cited by 75
Acute 5-HT1A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions
Ferrés‐Coy, A., Santana, N., Castañé, A., Cortés, R., Carmona, M. C., Tóth, M., Montefeltro, A., Artigas, F., & Bortolozzi, A. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2795-9 · Cited by 75
Self-citation
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Hong-luan, Y., Fan, C., Yang, L., Yu, S., Song, Q., Wang, P., & Mao, X. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492684 · Cited by 74
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Fullana, M. N., Ruiz‐Bronchal, E., Ferrés‐Coy, A., Juárez‐Escoto, E., Artigas, F., & Bortolozzi, A. A. (2019) · Glia · doi:10.1002/glia.23593 · Cited by 73
Self-citation
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Henrich, M. T., Geibl, F. F., Lee, B., Chiu, W., Koprich, J. B., Brotchie, J. M., Timmermann, L., Decher, N., Matschke, L. A., & Oertel, W. H. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0541-1 · Cited by 70
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Yang, X., Yang, Q., Wang, X., Luo, C., Wan, Y., Li, J., Liu, K., Zhou, M., & Zhang, C. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8312-z · Cited by 69
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Negishi, Y., Yamane, M., Kurihara, N., Endo‐Takahashi, Y., Sashida, S., Takagi, N., Suzuki, R., & Maruyama, K. (2015) · Pharmaceutics · doi:10.3390/pharmaceutics7030344 · Cited by 68
Ketamine may exert antidepressant effects via suppressing NLRP3 inflammasome to upregulate AMPA receptors
Li, J., Liu, L.-L., Su, W., Wang, B., Zhang, T., Zhang, Y., & Jiang, C. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.022 · Cited by 68
Understanding cognitive deficits in Parkinson’s disease: lessons from preclinical animal modelsPreprint
Solari, N., Bonito-Oliva, A., Fisone, G., & Brambilla, R. (2013) · Learning & Memory · doi:10.1101/lm.032029.113 · Cited by 65
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Borsotto, M., Veyssière, J., Maati, H. M. O., Devader, C., Mazella, J., & Heurteaux, C. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12953 · Cited by 65
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Lin, E., & Chen, P. S. (2008) · Pharmacogenomics · doi:10.2217/14622416.9.7.935 · Cited by 63
Epigenetics and Depression: An Update
Lin, E., & Tsai, S. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.07.17.2 · Cited by 63
Aptamer and its applications in neurodegenerative diseases
Qu, J. T., Yu, S., Yuan, Z., Zheng, Y., Yang, H., & Zhang, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2345-4 · Cited by 62
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Salganik, M., Sergeyev, V., Shinde, V. M., Meyers, C., Gorbatyuk, M. S., Lin, J. H., Zolotukhin, S., & Gorbatyuk, O. S. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.018 · Cited by 61
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Cóppola-Segovia, V., Cavarsan, C. F., Maia, F. G., Ferraz, A. C., Nakao, L. S., Lima, M. M., & Zanata, S. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0114-x · Cited by 61
Strand Invasion of Mixed-Sequence, Double-Helical B-DNA by γ-Peptide Nucleic Acids Containing G-Clamp Nucleobases under Physiological Conditions
Rapireddy, S., Bahal, R., & Ly, D. H. (2011) · Biochemistry · doi:10.1021/bi2002554 · Cited by 60
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier
Godinho, B. M. D. C., Henninger, N., Bouley, J., Alterman, J. F., Haraszti, R. Á., Gilbert, J. W., Sapp, E., Coles, A. H., Biscans, A., Nikan, M., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.08.005 · Cited by 60
Attenuation of α2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood
Shishkina, G. T., Kalinina, T., & Dygalo, N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.015 · Cited by 59
RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA)
Verbeure, B. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.24.4941 · Cited by 59
Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
Li, D., Mastaglia, F. L., Fletcher, S., & Wilton, S. D. (2020) · Medicinal Research Reviews · doi:10.1002/med.21718 · Cited by 59
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Ferrés‐Coy, A., Galofré, M., Pilar-Cuéllar, F., Vidal, R., Paz, V., Ruiz‐Bronchal, E., Campa, L., Pazos, Á., Caso, J. R., Leza, J. C., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.80 · Cited by 58
Self-citation
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Volk, N., Paul, E. D., Haramati, S., Eitan, C., Fields, B. K. K., Zwang, R., Gil, S., Lowry, C. A., & Chen, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0855-14.2014 · Cited by 58
Self-citation
Nucleic Acid–Based Therapeutics for Parkinson's Disease
Nakamori, M., Junn, E., Mochizuki, H., & Mouradian, M. M. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00714-7 · Cited by 58
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Lou, D., Wang, J., & Wang, X. (2019) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2019.101470 · Cited by 58
MicroRNA-155 deletion reduces anxiety- and depressive-like behaviors in mice
Fonken, L. K., Gaudet, A. D., Gaier, K. R., Nelson, R. J., & Popovich, P. G. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.019 · Cited by 56
RNAi-mediated serotonin transporter suppression rapidly increases serotonergic neurotransmission and hippocampal neurogenesis
Ferrés‐Coy, A., Pilar-Cuéllar, F., Vidal, R., Paz, V., Masana, M., Cortés, R., Carmona, M. C., Campa, L., Pazos, Á., Montefeltro, A., et al. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.135 · Cited by 53
Self-citation
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Zharikov, A., Bai, Q., Miranda, B. R. D., Laar, A. D. V., Greenamyre, J. T., & Burton, E. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.004 · Cited by 51
miR-30 Family miRNAs Mediate the Effect of Chronic Social Defeat Stress on Hippocampal Neurogenesis in Mouse Depression Model
Khandelwal, N., Dey, S. K., Chakravarty, S., & Kumar, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00188 · Cited by 51
The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression‐like behaviours in mice
Ma, K., Zhang, H., Wang, S., Wang, H., Wang, Y., Liu, J., Song, X., Dong, Z., Han, X., Zhang, Y., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14596 · Cited by 51
miR-214-3p Targets β-Catenin to Regulate Depressive-like Behaviors Induced by Chronic Social Defeat Stress in Mice
Deng, Z., Zheng, H., Chen, J., Luo, Y., Xu, J., Zhao, G., Lu, J.-J., Li, H., Gao, S., Zhang, D.-Z., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy047 · Cited by 50
PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease
Beecham, G. W., Dickson, D. W., Scott, W. K., Martin, E. R., Schellenberg, G. D., Nuytemans, K., Larson, E. B., Buxbaum, J. D., Trojanowski, J. Q., Deerlin, V. M. V., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001332 · Cited by 49
miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala
Mannironi, C., Biundo, A., Rajendran, S., De Vito, F., Saba, L., Caioli, S., Zona, C., Ciotti, T., Caristi, S., Perlas, E., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0564-9 · Cited by 49
Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and d -altritol nucleic acid-modified 2′-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro
Le, B. T., Chen, S., Abramov, M., et al. (2016) · Chemical Communications · doi:10.1039/c6cc07447b · Cited by 48
Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease
Spencer, B. J., Trinh, I., Rockenstein, E. M., Mante, M., Florio, J. B., Adame, A., El‐Agnaf, O. M. A., Kim, C., Masliah, E., & Rissman, R. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.03.001 · Cited by 48
Amygdala protein kinase C epsilon regulates corticotropin‐releasing factor and anxiety‐like behavior
Lesscher, H. M. B., McMahon, T., Lasek, A. W., Chou, W.-H., Connolly, J., Kharazia, V., & Messing, R. O. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00356.x · Cited by 47
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Meng, F., Dai, E., Yu, X., Zhang, Y., Chen, X., Liu, X., Wang, S., Wang, L., & Jiang, W. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.1057 · Cited by 47
Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson’s disease
Gully, J. C., Sergeyev, V., Bhootada, Y., Mendez-Gomez, H. R., Meyers, C., Zolotukhin, S., Gorbatyuk, M., & Gorbatyuk, O. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.039 · Cited by 47
TASK-3 as a potential antidepressant target
Gotter, A. L., Santarelli, V. P., Doran, S. M., Tannenbaum, P. L., Kraus, R. L., Rosahl, T. W., Méziane, H., Montial, M., Reiss, D. R., Wessner, K., et al. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.021 · Cited by 46
Family-based study of HTR2A in suicide attempts: observed gene, gene × environment and parent-of-origin associations
Ben-Efraim, Y. J., Wasserman, D., Wasserman, J., & Sokolowski, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.86 · Cited by 45
Electroconvulsive stimulation alters levels of BDNF-associated microRNAs
Ryan, K. M., O'Donovan, S. M., & McLoughlin, D. M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.05.035 · Cited by 44
microRNA-124: a putative therapeutic target and biomarker for major depression
Dwivedi, Y. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1328501 · Cited by 44
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Tang, C., Zhang, D., Yang, J., Liu, Q.-H., Wang, Y., & Wang, W. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1522-4 · Cited by 44
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Schlich, M., Longhena, F., Faustini, G., O’Driscoll, C. M., Sinico, C., Fadda, A. M., Bellucci, A., & Lai, F. (2017) · Nano Research · doi:10.1007/s12274-017-1561-z · Cited by 42
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Daniel, G., Musso, A., Tsika, E., Fiser, A., Glauser, L., Pletniková, O., Schneider, B. L., & Moore, D. J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.007 · Cited by 41
Nucleic acid aptamers for neurodegenerative diseases
Bouvier‐Müller, A., & Ducongè, F. (2017) · Biochimie · doi:10.1016/j.biochi.2017.10.026 · Cited by 41
Effects of duloxetine on microRNA expression profile in frontal lobe and hippocampus in a mouse model of depression.
(2015) · PubMed Central · Cited by 40
Research Progress of nucleic acid delivery vectors for gene therapy
Jiao, Y., Xia, Z. L., Ze, L. J., Jing, H., Bai, X., & Fu, S. (2020) · Biomedical Microdevices · doi:10.1007/s10544-020-0469-7 · Cited by 40
MiR-124 suppression in the prefrontal cortex reduces depression-like behavior in mice
Gu, Z., Pan, J., & Chen, L. (2019) · Bioscience Reports · doi:10.1042/bsr20190186 · Cited by 39
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Rompuy, A. V., Lobbestael, E., der Perren, A. V., den Haute, C. V., & Baekelandt, V. (2014) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000039 · Cited by 38
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Xie, L., Chen, J., Yong-min, D., Gui, X., Wu, L., Tian, S., & Wu, W. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.078 · Cited by 38
Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease
Podlesniy, P., Puigròs, M., Serra, N., Fernández‐Santiago, R., Ezquerra, M., TOLOSA, E. S., & Trullás, R. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.015 · Cited by 38
Role of the unfolded protein response in the pathogenesis of Parkinson’s disease
Varma, D. V. S. N. S., & Sen, D. (2015) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2015-2012 · Cited by 35
Effects of sleep deprivation on behaviors and abnormal hippocampal BDNF/miR-10B expression in rats with chronic stress depression.
Jiang, Y., & Zhu, J.-F. (2015) · Europe PMC (PubMed Central) · Cited by 35
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain
Nikan, M., Osborn, M. F., Coles, A. H., Biscans, A., Godinho, B. M. D. C., Haraszti, R. A., Sapp, E., Echeverria, D., DiFiglia, M., Aronin, N., et al. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00226 · Cited by 35
Treatment with TREK1 and TRPC3/6 ion channel inhibitors upregulates microRNA expression in a mouse model of chronic mild stress
Kavuran, İ. B., Etem, E. Ö., Tektemur, A., & Elyas, H. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.07.017 · Cited by 35
microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens
Guo, L., Zhu, Z., Wang, G., Cui, S., Shen, M., Song, Z., & Wang, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012047 · Cited by 34
Therapeutic antisense oligonucleotides for movement disorders
Doxakis, E. (2020) · Medicinal Research Reviews · doi:10.1002/med.21706 · Cited by 34
miR-138 Increases Depressive-Like Behaviors by Targeting SIRT1 in Hippocampus
Li, C., Wang, F., Pei, M., Yan, L., Liu, S., Wang, X., Jin, Z., & Gu, Z. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s237558 · Cited by 33
Early adolescent stress‐induced changes in prefrontal cortex miRNA‐135a and hippocampal miRNA‐16 in male rats
Liu, Y., Liu, D., Xu, J., Jiang, H., & Pan, F. (2017) · Developmental Psychobiology · doi:10.1002/dev.21558 · Cited by 32
A microarray study of chronic unpredictable mild stress rat blood serum with electro-acupuncture intervention
Duan, D. M., Dong, X., Tu, Y., & Liu, P. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.05.054 · Cited by 28
Cellular Uptake of Neutral Phosphorodiamidate Morpholino Oligomers
Iversen, P. L., Aird, K. M., Wu, R. C., et al. (2009) · Current Pharmaceutical Biotechnology · doi:10.2174/138920109789069279 · Cited by 26
Prospective treatment of Parkinson's disease by a siRNA–LDH nanoconjugate
Acharya, R., Chakraborty, M., & Chakraborty, J. (2019) · MedChemComm · doi:10.1039/c8md00501j · Cited by 26
Plasma ubiquitin C-terminal hydrolase L1 levels reflect disease stage and motor severity in Parkinson’s disease
Ng, A. S. L., Tan, Y. J., Lu, Z., Ng, E. Y., Ng, S. Y., Chia, N. S. Y., Setiawan, F., Xu, Z., Keong, N. C. H., Tay, K. Y., et al. (2020) · Aging · doi:10.18632/aging.102695 · Cited by 26
Intracerebral Administration of a Ligand-ASO Conjugate Selectively Reduces α-Synuclein Accumulation in Monoamine Neurons of Double Mutant Human A30P*A53T*α-Synuclein Transgenic Mice
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LRRK2 and autophagy: a common pathway for disease
Manzoni, C. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120126 · Cited by 25
Resilient Phenotype in Chronic Mild Stress Paradigm Is Associated with Altered Expression Levels of miR-18a-5p and Serotonin 5-HT1a Receptor in Dorsal Part of the Hippocampus
Żurawek, D., Gruca, P., Antkiewicz‐Michaluk, L., & Dziedzicka‐Wasylewska, M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1622-2 · Cited by 23
Can we increase the speed and efficacy of antidepressant treatments? Part II. Glutamatergic and RNA interference strategies
Artigas, F., Celada, P., & Bortolozzi, A. A. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.01.005 · Cited by 20
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Fullana, M. N., Ferrés‐Coy, A., Ortega, J. E., Ruiz‐Bronchal, E., Paz, V., Meana, J. J., Artigas, F., & Bortolozzi, A. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1288-1 · Cited by 20
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KHG21834 attenuates glutamate-induced mitochondrial damage, apoptosis, and NLRP3 inflammasome activation in SH-SY5Y human neuroblastoma cells
Yang, S.-J., Han, A. R., Kim, E.-A., Yang, J. W., Ahn, J., Na, J.-M., & Cho, S. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172412 · Cited by 20
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Yang, J., Zhang, L., Cao, L., Qi, J., Li, P., Wang, X., & Sun, X. (2019) · Cells · doi:10.3390/cells8091081 · Cited by 19
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Fiori, L. M., Lin, R., Ju, C., Belzeaux-R, R., & Turecki, G. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.004 · Cited by 18
siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain
Thakker, D. R., Natt, F., Hüsken, D., van der Putten, H., Maier, R., Hoyer, D., & Cryan, J. F. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001715 · Cited by 18
Snca targeted antisense oligonucleotides mediate progression of pathological deposition in alpha synuclein rodent transmission models of Parkinson’s disease (P6.239)
Cole, T. A., Paumier, K. L., Zhao, H. T., et al. (2016) · Neurology · doi:10.1212/wnl.86.16_supplement.p6.239 · Cited by 14
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Jacobsen, D. P., Eriksen, M. B., Rajalingam, D., Nymoen, I., Nielsen, M. B., Einarsen, S. V., & Gjerstad, J. (2019) · Stress · doi:10.1080/10253890.2019.1642320 · Cited by 13
Gene therapy for Parkinson’s disease
Mochizuki, H. (2007) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.7.8.957 · Cited by 12
Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide
Boursereau, R., Donadieu, A., Dabertrand, F., Dubayle, D., & Morel, J. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.027 · Cited by 10
Second‐generation dopamine agonists and recollection impairments in P arkinson's disease
Shepherd, T. A., Edelstyn, N. M. J., Mayes, A. R., & Ellis, S. J. (2013) · Journal of Neuropsychology · doi:10.1111/jnp.12025 · Cited by 10
Therapeutic Potential of Conjugated siRNAs for the Treatment of Major Depressive Disorder
Artigas, F., & Bortolozzi, A. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.182 · Cited by 10
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Handbook of Innovations in Central Nervous System Regenerative Medicine
(2020) · Elsevier eBooks · doi:10.1016/c2018-0-02548-7 · Cited by 10
Erratum to: Anionic liposomes for small interfering ribonucleic acid (siRNA) delivery to primary neuronal cells: Evaluation of alpha-synuclein knockdown efficacy
Schlich, M., Longhena, F., Faustini, G., O’Driscoll, C. M., Sinico, C., Fadda, A. M., Bellucci, A., & Lai, F. (2017) · Nano Research · doi:10.1007/s12274-017-1726-9 · Cited by 7
Anionic liposomes for small interfering ribonucleic acid （siRNA） delivery to primary neuronal cells： Evaluation of alpha-synuclein knockdown efficacy
Michèle, Schlich, Francesca, F., et al. (2017) · 纳米研究：英文版 · Cited by 7
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Effective biomarkers and therapeutic targets of nerve-immunity interaction in the treatment of depression: an integrated investigation of the miRNA-mRNA regulatory networks
Wu, Z., Cai, Z., Shi, H., Huang, X., Cai, M., Yuan, K., Huang, P., Shi, G., Yan, T., & Li, Z. (2022) · Aging · doi:10.18632/aging.204030 · Cited by 37

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Authors: Bortolozzi, A., Manashirov, S., Chen, A., & Artigas, F.
Affiliations: Instituto de Salud Carlos III (ES)
Max Planck Institute of Psychiatry (DE)
Consejo Superior de Investigaciones Científicas (ES)
ORCID: Chen, Alon
Artigas, Francesc
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2021-11
Volume: 227
Pages: 107873
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2021.107873
OpenAlex: W3159813053
Cited by: 37
References: 345
Citations by year: 2026: 3 · 2025: 7 · 2024: 9 · 2023: 9 · 2022: 9
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Centro de Investigación Biomédica en Red de Salud Mental
European Regional Development Fund
Government of Spain Ministry of Economy and Competitiveness
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: oligonucleotide therapeutics, antisense oligonucleotides, siRNA, miRNA mimics, antagomir, RNA interference, major depressive disorder, Parkinson's disease, brain disorders, sertraline, reboxetine, monoaminergic neurons, RNase H, RNA-induced silencing complex, intranasal administration, intracerebroventricular administration, gene knockdown
MeSH terms: Depressive Disorder, Major, Major Depressive Disorder, Humans, Oligonucleotides, Parkinson Disease

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Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.

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