Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response
Abstract
PURPOSE OF REVIEW: Major depressive disorder (MDD) is among the most prevalent and disabling medical conditions worldwide. Despite its considerable burden, our understanding of its pathophysiology remains rudimentary, and a validated biomarker has yet to be identified. Antidepressants are the most common treatment for MDD, yet roughly one-third of patients experience an inadequate response. Thus, there is a great need for not only identifying biomarkers of MDD but also those that can predict and monitor or just monitor response to treatment. RECENT FINDINGS: MicroRNAs (miRNAs) act as endogenous fine-tuners and on-off switches of gene expression. Several lines of evidence now suggest that miRNAs are involved in the pathogenesis of neuropsychiatric disorders. As such, miRNAs offer great hope as biomarkers of disease and response to treatment. SUMMARY: In this review, we discuss the growing field, investigating peripheral miRNAs as potential biomarkers of major depression and treatment response. A noninvasive and validated biomarker of MDD or treatment response will help clinicians guide treatment selection. Ultimately, these findings provide important steps in the development of early diagnostic tools, preventive strategies, and effective pharmacological treatment for psychiatric disorders.
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miRNAs have potential as biomarkers for treatment response.
“This highlights miRNAs’ potential as biomarkers for treatment response; however, further studies are needed.”
From Epigenetics and depression (2019) · cites this paper as [31]
Other studies of postmortem brain and peripheral tissues have identified altered levels of miRNAs in patients with MDD and after treatment with antidepressant medication.
“Other studies of postmortem brain and peripheral tissues have identified altered levels of miRNAs in patients with MDD and after treatment with antidepressant medication (see ref 31 for a review).”
From Epigenetics and depression (2019) · cites this paper as [31]
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Dysregulation of miR-185, miR-193a, and miR-450a in the skin are linked to the depressive phenotype
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miR-92aSuppresses Mushroom Body-Dependent Memory Consolidation inDrosophila
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- Authors
- Lopez, J. P., Kos, A., & Turecki, G.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Turecki, Gustavo
- Venue
- Current Opinion in Psychiatry
- Published
- 2018-01
- Volume
- 31
- Issue
- 1
- Pages
- 7-16
- ISSN
- 0951-7367 (ISSN-L)
- OpenAlex
- W2766080306
- Cited by
- 108
- References
- 67
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 13 · 2022: 19 · 2021: 15 · 2020: 20 · 2019: 14 · 2018: 6
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- eScholarship@McGill (McGill) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, microRNA, biomarkers, antidepressant response, peripheral biomarkers, depression pathophysiology, treatment response prediction, early detection of depression
- MeSH terms
- Antidepressive Agents, Depressive Disorder, Major, Major Depressive Disorder, Humans, Biomarkers, Treatment Outcome, MicroRNAs
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