Cited by 140Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionTryptophan and brain disorders

Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens

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Alexander, Brian, Warner-Schmidt, Jennifer, Eriksson, Therese M., Tamminga, Carol, Arango-Lievano, Margarita, Ghose, Subroto, Vernov, Mary, Stavarache, Mihaela +5 more·2010·Science Translational Medicine

Abstract

Reduction of the 5-HT 1B receptor–binding protein p11 in the mouse nucleus accumbens induces depression-like behaviors, and gene therapy to restore p11 expression in this region reverses depression-like behaviors.

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Crossref · 10.1126/scitranslmed.3001079

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  • p11 deficiency, p11 reductions in NAc, or p11 knockout in NAc ChIs is sufficient to reduce sucrose preference and increase forced-swim immobility.

    “Mice lacking p11 [162], p11 reductions in NAc [163], or p11 knockout in NAc ChIs [158] is sufficient to reduce sucrose preference and increase forced-swim immobility (Fig. 2, top).”

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Authors
Alexander, B., Warner-Schmidt, J., Eriksson, T. M., Tamminga, C., Arango-Lievano, M., Ghose, S., Vernov, M., Stavarache, M., Musatov, S., Flajolet, M., Svenningsson, P., Greengard, P., & Kaplitt, M. G.
Affiliations
  • Weill Cornell Medicine (US)
  • Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA.
  • Karolinska Institutet (SE)
  • The University of Texas Southwestern Medical Center (US)
  • Neurologix Inc., Fort Lee, NJ 07024, USA.
  • Rockefeller University (US)
Corresponding author
Kaplitt, Michael G.
Venue
Science Translational Medicine
Published
2010-10-20
Volume
2
Issue
54
Pages
54ra76-54ra76
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W2151057590
Cited by
140
References
27
Citations by year
2026: 5 · 2025: 9 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 13
FWCI
5.56
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (NH074866)
  • National Institute of Mental Health (MH062236, P50MH074866, R01MH062236)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
p11, major depressive disorder, nucleus accumbens, serotonin receptors, 5-HT1B receptor, 5-HT4 receptor, S-100 protein, gene therapy, adeno-associated virus, RNA interference, somatic gene transfer, depression-like behavior, anterior cingulate cortex, depression pathophysiology
MeSH terms
S100 Calcium Binding Protein A10, Dependovirus, Animals, Depression, Genetic Vectors, S100 Proteins, Nucleus Accumbens, Genetic Therapy, Annexin A2, Mice

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