Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens
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Reduction of the 5-HT 1B receptor–binding protein p11 in the mouse nucleus accumbens induces depression-like behaviors, and gene therapy to restore p11 expression in this region reverses depression-like behaviors.
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p11 deficiency, p11 reductions in NAc, or p11 knockout in NAc ChIs is sufficient to reduce sucrose preference and increase forced-swim immobility.
“Mice lacking p11 [162], p11 reductions in NAc [163], or p11 knockout in NAc ChIs [158] is sufficient to reduce sucrose preference and increase forced-swim immobility (Fig. 2, top).”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [163]
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- Authors
- Alexander, B., Warner-Schmidt, J., Eriksson, T. M., Tamminga, C., Arango-Lievano, M., Ghose, S., Vernov, M., Stavarache, M., Musatov, S., Flajolet, M., Svenningsson, P., Greengard, P., & Kaplitt, M. G.
- Affiliations
- Weill Cornell Medicine (US)
- Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021, USA.
- Karolinska Institutet (SE)
- The University of Texas Southwestern Medical Center (US)
- Neurologix Inc., Fort Lee, NJ 07024, USA.
- Rockefeller University (US)
- Corresponding author
- Kaplitt, Michael G.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2010-10-20
- Volume
- 2
- Issue
- 54
- Pages
- 54ra76-54ra76
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3026098
- OpenAlex
- W2151057590
- Cited by
- 140
- References
- 27
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 13
- FWCI
- 5.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NH074866)
- National Institute of Mental Health (MH062236, P50MH074866, R01MH062236)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- p11, major depressive disorder, nucleus accumbens, serotonin receptors, 5-HT1B receptor, 5-HT4 receptor, S-100 protein, gene therapy, adeno-associated virus, RNA interference, somatic gene transfer, depression-like behavior, anterior cingulate cortex, depression pathophysiology
- MeSH terms
- S100 Calcium Binding Protein A10, Dependovirus, Animals, Depression, Genetic Vectors, S100 Proteins, Nucleus Accumbens, Genetic Therapy, Annexin A2, Mice
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