Cited by 69Treatment of Major DepressionMicroRNA in disease regulationTryptophan and brain disorders

MicroRNA expression profile and functional analysis reveal that miR-206 is a critical novel gene for the expression of BDNF induced by ketamine.

Yang, Xiaolin, Yang, Qinyan, Wang, Xiaobin, Luo, Chunqiong, Wan, Yunqiang, Li, Jiali, Liu, Kezhi, Zhou, Min +1 more·2014·NeuroMolecular Medicine

Abstract

Depression is a major social and health concern, and ketamine exerts a quick, remarkable and persistent anti-depressive effect. microRNAs (miRNAs) show remarkable potential in the treatment of clinical depression. Here, we determined the expression profile of miRNAs in the hippocampus of rats treated with ketamine (15 mg/kg). The results suggest that multiple miRNAs were aberrantly expressed in rat hippocampus after ketamine injection (18 miRNAs were significantly reduced, while 22 miRNAs were significantly increased). Among them, miR-206 was down-regulated in ketamine-treated rats. In both cultured neuronal cells in vitro and hippocampus in vivo, we identified that the brain-derived neurotrophic factor (BDNF) was a direct target gene of miR-206. Via this target gene, miR-206 strongly modulated the expression of BDNF. Moreover, overexpression of miR-206 significantly attenuated ketamine-induced up-regulation of BDNF. The results indicated that miRNA-206 was involved in novel therapeutic targets for the anti-depressive effect of ketamine.

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Crossref · 10.1007/s12017-014-8312-z

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Authors
Yang, X., Yang, Q., Wang, X., Luo, C., Wan, Y., Li, J., Liu, K., Zhou, M., & Zhang, C.
Affiliations
  • Southwest Medical University (CN)
  • University of Medicine and Dentistry of New Jersey (US)
  • Rush University (US)
Corresponding author
Wang, Xiaobin
Venue
NeuroMolecular Medicine
Published
2014-05-18
Volume
16
Issue
3
Pages
594-605
ISSN
  • 1535-1084 (ISSN-L)
  • 1559-1174
OpenAlex
W2043756937
Cited by
69
References
55
Citations by year
2026: 4 · 2025: 4 · 2024: 8 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 8 · 2014: 1
FWCI
5.58
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroMolecular Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
miR-206, microRNA expression profiles, ketamine, depression, antidepressant effects, brain-derived neurotrophic factor, hippocampus, microRNA therapeutic target
MeSH terms
Anesthetics, Dissociative, Animals, Cells, Cultured, Gene Expression Regulation, Hippocampus, Ketamine, Male, Neurons, Oligodeoxyribonucleotides, Random Allocation, Transfection, Rats, Sprague-Dawley, Apoptosis, Antidepressive Agents, Second-Generation, Excitatory Amino Acid Antagonists, Brain-Derived Neurotrophic Factor, Gene Expression Profiling, MicroRNAs, Rats, Gene Knockdown Techniques

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