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Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat
Abstract
Curcumin, the principal curcuminoid of turmeric, exhibits beneficial role in several neurodegenerative disorders such as dementia of Alzheimer type. Recent evidences suggest the involvement of brain insulin receptors (IRs) in the pathophysiology of dementia disorders. Therefore, the present study was undertaken to investigate the effect of curcumin on memory functions, brain IRs, acetylcholinesterase (AChE) activity and oxidative stress in intracerebroventricular (ICV) administered streptozotocin (STZ) induced dementia in rats. Rats were injected with STZ (3 mg/kg, ICV) bilaterally twice, on day 1 and 3 and curcumin (200 mg/kg, po) was administered in pre- and post-treatment schedules. STZ (ICV) treated group had shown memory deficit as indicated by no significant decrease in latency time in Morris water maze test and significant decrease in IR protein level in both hippocampus and cerebral cortex. Pre- and post-treatment of curcumin in STZ (ICV) treated rats significantly restored the memory deficit and IR protein level in both the regions. Furthermore, STZ (ICV) resulted into enhanced AChE activity in hippocampus and cerebral cortex which was normalized by curcumin pre- and post-treatment. An increase in MDA level and decrease in GSH level were obtained in both hippocampus and cerebral cortex in STZ treated group, indicating state of oxidative stress, which was also attenuated by pre- and post-treatment of curcumin. The results suggest that besides the anticholinesterase and antioxidant activity, effect on brain IR may also be an important factor for protective effect of curcumin against STZ induced dementia model.
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“Furthermore, curcumin has been found to improve memory and cognitive deficits in rats [57].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [57]
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“Another experimental study showed that curcumin treatment restored learning and memory functions in the STZ model of AD by reducing the oxidative stress, enhancing ChAT activity and restoring insulin receptor protein [117,118].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [117]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐I
Glowinski, J., & Iversen, L. L. (1966) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1966.tb09873.x · Cited by 5,436
Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336
The cholinergic hypothesis of Alzheimer’s disease: A review of progress
Francis, P. T., Palmer, A. M., Snape, M., & Wilcock, G. K. (1999) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.2.137 · Cited by 2,198 · cited 2×
“[5] Francis PT, Palmer AM, Snape M, Wilcock GK.”
BackgroundLim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530
Lowry determination of protein in the presence of Triton X-100
Wang, C., & Smith, R. L. (1975) · Analytical Biochemistry · doi:10.1016/0003-2697(75)90363-2 · Cited by 763
Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease
Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748
Brain Insulin Receptors and Spatial Memory
Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M. J., & Alkon, D. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34893 · Cited by 532
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Items 101–133 of 133
Tavares, J., Oliveira, A. V., Nascimento, T. D. S., Gomes, J. M. P., Parente, A. C. B., Bezerra, J. R., da Costa, M. D. R., Soares, M. S. P., Sampaio, T. L., Lima, F. A. V., et al. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01477-7 · Cited by 10
(2011) · Asia-Pacific Biotech News · doi:10.1142/s021903031100053x · Cited by 8
Gupta, T., Singh, V., Hefnawy, M., Alanazi, M. M., Alsuwayt, B., Kabra, A., Kumar, A., Pasricha, C., & Singh, R. (2023) · ACS Omega · doi:10.1021/acsomega.3c02550 · Cited by 7
RetractedSingh, N. K., & Garabadu, D. (2021) · Indian Journal of Pharmaceutical Education and Research · doi:10.5530/ijper.55.1.17 · Cited by 6
Meng, X., Gong, Y., Xiao, F., Cao, Z., Zhuang, Z., Yi, X., Wang, J., Feng, R., Gong, C., & Ni, P. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251344188 · Cited by 6
Dubey, H., Ray, A., Dubey, A., & Gulati, K. (2024) · Neuropsychobiology · doi:10.1159/000538348 · Cited by 5
Potential Therapeutic Impacts of Curcumin for Improving Memory Impairment
Farooqui, T., & Farooqui, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815461-8.00014-1 · Cited by 5
Bavafa, A., Meftahi, G. H., & Jahromi, G. P. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04467-y · Cited by 5
Potential Role of Curcumin and Its Derivatives Against Alzheimer Disease
Das, M., & Devi, K. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815461-8.00011-6 · Cited by 4
Polyphenols as Potential Therapeutic Drugs in Neurodegeneration
de Laureto, P. P., Palazzi, L., & Acquasaliente, L. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.89575 · Cited by 3
Beneficial Effects of Curcumin on Neurological Disorders
Farooqui, A. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3804-5_6 · Cited by 3
Exploring the role of tocotrienol-rich fraction (TRF) in ameliorating neuroinflammation
Tan, J. Y., Retinasamy, T., Lee, V. L. L., Radhakrishnan, A. K., & Yeong, K. Y. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02249-8 · Cited by 2
Dorman, G. S., Flores, I., Gutiérrez, C., Castaño, R. F., Aldecoa, M., & Kim, L. M. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210809121230 · Cited by 3
Prevention of Stress-Induced Cognitive Impairment: Today and Tomorrow
Trofimiuk, E., & Braszko, J. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-17103-6_10 · Cited by 2
León, F., Zakid, A. A., Gupta, S., Mukhopadhyay, S., Tarawneh, A. H., Obeng, S., Cutler, S. J., & McCurdy, C. R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95702-1.00490-5 · Cited by 1
Neuroprotective Herbs Associated with Parkinson’s and Alzheimer’s Disease
Marțiș, G. S., Ungur, R. A., Anamaria, P. O. P., Bordean, E. M., Paşca, C., & Borda, I. M. (2026) · Nutrients · doi:10.3390/nu18030439 · Cited by 1
Herbal Components for the Treatment of Alzheimer's Disease
Bisht, T., Sundram, S., Malviya, R., & Pandey, A. (2023) · The Natural Products Journal · doi:10.2174/2210315513666230123111541 · Cited by 1
Elsadek, B. (2012) · Al-Azhar Journal of Pharmaceutical Sciences/Al-Azhar Journal of Pharmaceutical Sciences · doi:10.21608/ajps.2012.7260 · Cited by 1
Reslan, M. A., Issa, H., Al-Haj, N., Ibeh, S., Yehya, Y., Hassan, H. H., Kobeissy, F. H., Eid, A. H., Zibara, K., & Shaito, A. A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-16-6467-0_15 · Cited by 1
Paliwal, A., Nigam, A. K., Gour, J. K., Singh, D., Pandey, P., & Singh, M. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819212-2.00018-9 · Cited by 1
Treatment Mechanisms in Mild to Moderate Alzheimer’s Disease
Friel, H., & Frautschy, S. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812259-4.00005-9
Terapia celular y génica con timulina E IGF-1 en modelos animales de neuroinflamación
Villar, M. F. Z. (2018) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/71572
Tyagi, E. (2011) · Shodhganga
Self-citationZhang, Z., Li, H., Hui, S., Yi, M., Chen, X., Huang, J., Peng, W., & Yang, J. (2021) · Research Square · doi:10.21203/rs.3.rs-590600/v1
Moléculas nutracêuticas e sistema purinérgico
Assmann, C. E., & da Costa, P. (2021) · Editora UFFS eBooks · doi:10.7476/9786586545494.0005
Hosseini, R., Mirshekar, M. A., Montazerifar, F., Soltanmohammadi, M., & Behrasi, F. (2023) · Research Square · doi:10.21203/rs.3.rs-2900704/v1
Curcumin - Bio Conjugates as Chemotherapeutics: A Computational Study
Baboo, R. (2023) · International Journal of Current Research and Review · doi:10.31782/ijcrr.2023.151402
Hanotte, J. L. (2023) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/161150
Yang, W., Yu, Z., Wang, W., & Yan, S. (2025) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2025.29
Lipid‐ and Polymer‐Based Nanoscale Delivery of Anti‐Aging Phytochemicals
Gross, S., Vogtlander, C., Lewis, C. J., van Harmelen, E., Stolzing, A., & Radacsi, N. (2026) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.70060
Dhapola, R., Sharma, P., Kumari, S., Vellingiri, B., & HariKrishnaReddy, D. (2026) · Ibrain · doi:10.1002/ibra.70027
KHAN, F. B., Mandloi, A. S., Shahadat, M., Mohan, A. J., Kilor, V. A., Sapkal, N. P., & Dhote, V. V. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108825
Metadata
- Authors
- Agrawal, R., Mishra, B., Tyagi, E., Nath, C., & Shukla, R.
- Affiliations
- Central Drug Research Institute (IN)
- Corresponding author
- Shukla, Rakesh
- ORCID
- Shukla, Rakesh
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 61
- Issue
- 3
- Pages
- 247-252
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2065632662
- Cited by
- 133
- References
- 38
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 15 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 11
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, Alzheimer's disease model, memory impairment, acetylcholinesterase activity, oxidative stress, lipid peroxidation, glutathione, hippocampus, cerebral cortex, neuroprotection
- MeSH terms
- Animals, Brain, Curcumin, Dementia, Disease Models, Animal, Male, Memory, Memory Disorders, Receptor, Insulin, Streptozocin, Rats, Sprague-Dawley, Rats
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