Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow
Abstract
Aims The aim of the present study is to investigate the effect of curcumin on cerebral blood flow (CBF), memory impairment, oxidative stress and cholinergic dysfunction in intracerebral (IC) streptozotocin (STZ) induced memory impairment in mice.Main methods Memory impairment was induced by STZ (0.5mg/kg, IC) administered twice with an interval of 48h in mice. Memory function was assessed by Morris water maze and passive avoidance test. CBF was measured by Laser Doppler Flowmetry (LDF). To study the preventive effect, curcumin (10, 20 and 50mg/kg, PO) was administered for 21days starting from the first dose of STZ. In another set of experiment, curcumin was administered for 7days from 19th day after confirming STZ induced dementia to observe its therapeutic effect. Biochemical parameters of oxidative stress and cholinergic function were estimated in brain on day 21.Key findings The major finding of this study is that STZ (IC) caused a significant reduction in CBF along with memory impairment, cholinergic dysfunction and enhanced oxidative stress. Curcumin dose dependently improved CBF in STZ treated mice together with amelioration of memory impairment both in preventive and therapeutic manner.Significance The present study clearly demonstrates the beneficial effects of curcumin, the dietary staple of India, on CBF, memory and oxidative stress which can be exploited for dementia associated with age related vascular and neurodegenerative disorders.
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Pretreatment with curcumin (10, 20 and 50 mg/kg, p.o for 21 days) ameliorated memory impairment in the sporadic Alzheimer's disease model in mice.
“Pretreatment with curcumin (10, 20 and 50 mg/kg, p.o for 21 days) ameliorated memory impairment in the sporadic AD model in mice [108].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [108]
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- Authors
- Awasthi, H., Tota, S., Hanif, K., Nath, C., & Shukla, R.
- Affiliations
- Central Drug Research Institute (IN)
- Corresponding author
- Shukla, Rakesh
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 86
- Issue
- 3-4
- Pages
- 87-94
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W1994339171
- Cited by
- 86
- References
- 64
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 10
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- curcumin, streptozotocin, memory impairment, cerebral blood flow, oxidative stress, cholinergic dysfunction, neuroprotection, dementia, neurodegeneration, age-related vascular disease
- MeSH terms
- Acetylcholinesterase, Animals, Avoidance Learning, Blood Glucose, Brain, Cerebrovascular Circulation, Curcumin, Disease Models, Animal, Glutathione, Injections, Intraventricular, Male, Malondialdehyde, Memory Disorders, Motor Activity, Streptozocin, Laser-Doppler Flowmetry, Reactive Oxygen Species, Oxidative Stress, Neuroprotective Agents, Maze Learning, Mice
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