Cited by 86Curcumin's Biomedical ApplicationsMedicinal Plants and NeuroprotectionNeurological Disease Mechanisms and Treatments

Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow

Awasthi, Himani, Tota, Santoshkumar, Hanif, Kashif, Nath, Chandiswar, Shukla, Rakesh·2010·Life Sciences

Abstract

Aims The aim of the present study is to investigate the effect of curcumin on cerebral blood flow (CBF), memory impairment, oxidative stress and cholinergic dysfunction in intracerebral (IC) streptozotocin (STZ) induced memory impairment in mice.Main methods Memory impairment was induced by STZ (0.5mg/kg, IC) administered twice with an interval of 48h in mice. Memory function was assessed by Morris water maze and passive avoidance test. CBF was measured by Laser Doppler Flowmetry (LDF). To study the preventive effect, curcumin (10, 20 and 50mg/kg, PO) was administered for 21days starting from the first dose of STZ. In another set of experiment, curcumin was administered for 7days from 19th day after confirming STZ induced dementia to observe its therapeutic effect. Biochemical parameters of oxidative stress and cholinergic function were estimated in brain on day 21.Key findings The major finding of this study is that STZ (IC) caused a significant reduction in CBF along with memory impairment, cholinergic dysfunction and enhanced oxidative stress. Curcumin dose dependently improved CBF in STZ treated mice together with amelioration of memory impairment both in preventive and therapeutic manner.Significance The present study clearly demonstrates the beneficial effects of curcumin, the dietary staple of India, on CBF, memory and oxidative stress which can be exploited for dementia associated with age related vascular and neurodegenerative disorders.

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Crossref · 10.1016/j.lfs.2009.11.007

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Authors
Awasthi, H., Tota, S., Hanif, K., Nath, C., & Shukla, R.
Affiliations
Central Drug Research Institute (IN)
Corresponding author
Shukla, Rakesh
Venue
Life Sciences
Publisher
Elsevier BV
Published
2010-01
Volume
86
Issue
3-4
Pages
87-94
ISSN
0024-3205 (ISSN-L)
OpenAlex
W1994339171
Cited by
86
References
64
Citations by year
2026: 2 · 2025: 8 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 10
FWCI
3.20
Type
journal article
Language
en
Open access
closed
Locations
  • Life Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
curcumin, streptozotocin, memory impairment, cerebral blood flow, oxidative stress, cholinergic dysfunction, neuroprotection, dementia, neurodegeneration, age-related vascular disease
MeSH terms
Acetylcholinesterase, Animals, Avoidance Learning, Blood Glucose, Brain, Cerebrovascular Circulation, Curcumin, Disease Models, Animal, Glutathione, Injections, Intraventricular, Male, Malondialdehyde, Memory Disorders, Motor Activity, Streptozocin, Laser-Doppler Flowmetry, Reactive Oxygen Species, Oxidative Stress, Neuroprotective Agents, Maze Learning, Mice

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