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Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat
Abstract
Curcumin, the principal curcuminoid of turmeric, exhibits beneficial role in several neurodegenerative disorders such as dementia of Alzheimer type. Recent evidences suggest the involvement of brain insulin receptors (IRs) in the pathophysiology of dementia disorders. Therefore, the present study was undertaken to investigate the effect of curcumin on memory functions, brain IRs, acetylcholinesterase (AChE) activity and oxidative stress in intracerebroventricular (ICV) administered streptozotocin (STZ) induced dementia in rats. Rats were injected with STZ (3 mg/kg, ICV) bilaterally twice, on day 1 and 3 and curcumin (200 mg/kg, po) was administered in pre- and post-treatment schedules. STZ (ICV) treated group had shown memory deficit as indicated by no significant decrease in latency time in Morris water maze test and significant decrease in IR protein level in both hippocampus and cerebral cortex. Pre- and post-treatment of curcumin in STZ (ICV) treated rats significantly restored the memory deficit and IR protein level in both the regions. Furthermore, STZ (ICV) resulted into enhanced AChE activity in hippocampus and cerebral cortex which was normalized by curcumin pre- and post-treatment. An increase in MDA level and decrease in GSH level were obtained in both hippocampus and cerebral cortex in STZ treated group, indicating state of oxidative stress, which was also attenuated by pre- and post-treatment of curcumin. The results suggest that besides the anticholinesterase and antioxidant activity, effect on brain IR may also be an important factor for protective effect of curcumin against STZ induced dementia model.
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“Furthermore, curcumin has been found to improve memory and cognitive deficits in rats [57].”
From Nanoemulsions for “Nose-to-Brain” Drug Delivery (2019) · cites this paper as [57]
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“Another experimental study showed that curcumin treatment restored learning and memory functions in the STZ model of AD by reducing the oxidative stress, enhancing ChAT activity and restoring insulin receptor protein [117,118].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [117]
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Metadata
- Authors
- Agrawal, R., Mishra, B., Tyagi, E., Nath, C., & Shukla, R.
- Affiliations
- Central Drug Research Institute (IN)
- Corresponding author
- Shukla, Rakesh
- ORCID
- Shukla, Rakesh
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 61
- Issue
- 3
- Pages
- 247-252
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2065632662
- Cited by
- 133
- References
- 38
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 15 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 9 · 2014: 11 · 2013: 10 · 2012: 11
- FWCI
- 3.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, Alzheimer's disease model, memory impairment, acetylcholinesterase activity, oxidative stress, lipid peroxidation, glutathione, hippocampus, cerebral cortex, neuroprotection
- MeSH terms
- Animals, Brain, Curcumin, Dementia, Disease Models, Animal, Male, Memory, Memory Disorders, Receptor, Insulin, Streptozocin, Rats, Sprague-Dawley, Rats
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