The DOI matches its Crossref record; 145 of the 146 references it cites were found in a registry or an index.
Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications
Abstract
Mammals and their intestinal microbiota peacefully coexist in a mutualistic relationship. Commensal bacteria play an active role in shaping and modulating physiological processes in the host, which include, but are not restricted to, the immune system and the intestinal barrier. Both play a crucial role in containing intestinal bacteria and other potentially noxious luminal antigens within the lumen and mucosal compartment. Although mutualism defines the relationship between the host and the intestinal microbiota, disruptions in this equilibrium may promote disease. Thus, alterations in gut microbiota (dysbiosis) have been linked to the recent increased expression of obesity, allergy, autoimmunity, functional and inflammatory disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). In this article, we review the evidence supporting a role of gut microbiota in regulating intestinal barrier function. We discuss the hypothesis that microbial factors can modulate the barrier in ways that can prevent or promote gastrointestinal disease. A better understanding of the role of the intestinal microbiota in maintaining a functional intestinal barrier may help develop targeted strategies to prevent and treat disease.
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“Although a large number of studies have demonstrated the effectiveness of probiotics in treating liver diseases both in animal models and in patients (reviewed elsewhere118,119), substantial controversy remains”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [118]
Citations
Cites
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
van der Flier, L. G., & Clevers, H. C. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,994
Research works printed but not linked: 2
- Hooper, 2001, Molecular analysis of commensal host–microbial relationships in the intestine, Science (New York, NY), 291, 881, 10.1126/science.291.5505.881 · DOI · Paper page
- Kobayashi, 2005, Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract, Science (New York, NY), 307, 731, 10.1126/science.1104911 · DOI
Cited by
Sorted by citations
Introduction to the human gut microbiota
Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600
The gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634
The Intestinal Microbiota and Colorectal Cancer
Cheng, Y., Ling, Z., & Li, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.615056 · Cited by 609
“A healthy human intestinal microbiota plays a crucial role in harvesting energy (20), shaping the intestinal epithelium (21), protecting against pathogens (22), and maintaining immunity (23).”
BackgroundAnalysis of Gut Microbiota in Patients with Parkinson’s Disease
Petrov, V. A., Saltykova, I. V., Zhukova, I. A., Alifirova, V. M., Zhukova, N. G., Dorofeeva, Y. B., Tyakht, A. V., Kovarsky, B. A., Alekseev, D. G., Kostryukova, E. S., et al. (2017) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-017-3700-7 · Cited by 487
Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives
Liu, J., Tan, Y., Cheng, H., Zhang, D., Feng, W., & Peng, C. (2022) · Aging and disease · doi:10.14336/ad.2022.0104 · Cited by 529
“cells and Paneth cells), and the inner lamina propria layer where innate and adaptive immune cells dwell, such as T cells, B cells, dendritic cells, macrophages, and IgA producing plasma cells [5,114,115].”
Background
Metadata
- Authors
- Natividad, J. M. M., & Verdu, E. F.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Verdu, Elena F.
- ORCID
- Verdu, Elena F.
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 69
- Issue
- 1
- Pages
- 42-51
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2149848289
- Cited by
- 525
- References
- 146
- Citations by year
- 2026: 30 · 2025: 44 · 2024: 68 · 2023: 79 · 2022: 56 · 2021: 65 · 2020: 53 · 2019: 45 · 2018: 23 · 2017: 19 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- intestinal barrier, gut microbiota, dysbiosis, commensal bacteria, host-microbe mutualism, obesity, allergy, autoimmunity, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal diseases, treatment options
- MeSH terms
- Animals, Gastrointestinal Diseases, Humans, Intestines, Bacterial Physiological Phenomena, Metagenome
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