Cited by 527Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

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Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

Natividad, Jane M.M., Verdu, Elena F.·2013·Pharmacological Research

DOI 10.1016/j.phrs.2012.10.007

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Abstract

Mammals and their intestinal microbiota peacefully coexist in a mutualistic relationship. Commensal bacteria play an active role in shaping and modulating physiological processes in the host, which include, but are not restricted to, the immune system and the intestinal barrier. Both play a crucial role in containing intestinal bacteria and other potentially noxious luminal antigens within the lumen and mucosal compartment. Although mutualism defines the relationship between the host and the intestinal microbiota, disruptions in this equilibrium may promote disease. Thus, alterations in gut microbiota (dysbiosis) have been linked to the recent increased expression of obesity, allergy, autoimmunity, functional and inflammatory disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). In this article, we review the evidence supporting a role of gut microbiota in regulating intestinal barrier function. We discuss the hypothesis that microbial factors can modulate the barrier in ways that can prevent or promote gastrointestinal disease. A better understanding of the role of the intestinal microbiota in maintaining a functional intestinal barrier may help develop targeted strategies to prevent and treat disease.

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Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
van der Flier, L. G., & Clevers, H. C. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,994

Show all 146 references

Research works printed but not linked: 2

Hooper, 2001, Molecular analysis of commensal host–microbial relationships in the intestine, Science (New York, NY), 291, 881, 10.1126/science.291.5505.881 · DOI · Paper page
Kobayashi, 2005, Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract, Science (New York, NY), 307, 731, 10.1126/science.1104911 · DOI

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Luo, Z., Xu, W., Zhang, Y., Di, L., & Shan, J. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105088 · Cited by 96
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Kim, W.-K., Han, D. H., Jang, Y. J., Park, S., Jang, S. J., Lee, G., Han, H. S., & Ko, G. (2020) · Food & Function · doi:10.1039/d0fo01724h · Cited by 93
Implication of G Protein-Coupled Receptor 43 in Intestinal Inflammation: A Mini-Review
Yang, G., Chen, S., Deng, B., Tan, C., Deng, J., Zhu, G., Yin, Y., & Ren, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01434 · Cited by 95
The Microbiota and Cancer Cachexia
Herremans, K. M., Riner, A. N., Cameron, M. E., & Trevino, J. G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246267 · Cited by 89
“It serves to protect the body from intraluminal pathogens through the recognition of foreign microbes and secretion of antibodies, antimicrobial peptides and mucus [29].”
Background
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Santacroce, L., Man, A., Charitos, I. A., Haxhirexha, K., & Topi, S. (2021) · Frontiers in Bioscience-Landmark · doi:10.52586/4930 · Cited by 90
“In particular, therefore, the components of microbes can promote or protect against diseases [22, 25, 26].”
Background
Probiotics’ Effects in the Treatment of Anxiety and Depression: A Comprehensive Review of 2014–2023 Clinical Trials
Merkouris, E., Mavroudi, T., Miliotas, D., Tsiptsios, D., Serdari, A., Christidi, F., Doskas, T. K., Mueller, C., & Tsamakis, K. (2024) · Microorganisms · doi:10.3390/microorganisms12020411 · Cited by 101
“…microorganisms, that are critical for a variety of physiological functions, including preserving gut integrity or forming the intestinal epithelium [4], obtaining energy [5], protecting against infections [6], and controlling host immunity [7]; it is thus considered an “invisible organ” of the…”
Background
Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis
Fang, X. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1096271 · Cited by 84
“Changes in the intestinal microbiota have been correlated with alterations in the intestinal barrier in gastrointestinal diseases, such as irritable bowel syndrome [31].”
Background
Does microbiota composition affect thyroid homeostasis?
Virili, C., & Centanni, M. (2014) · Endocrine · doi:10.1007/s12020-014-0509-2 · Cited by 85
“Mucus layer, produced by goblet cells, may vary in composition, fluidity, and electric properties [5].”
BackgroundInfluential
Pea ( Pisum sativum L.) seed albumin extracts show anti‐inflammatory effect in the DSS model of mouse colitis
Utrilla, M. P., Peinado, M. J., Ruiz, R., Rodríguez‐Nogales, A., Algieri, F., Rodríguez‐Cabezas, M. E., Clemente, A., Gálvez, J., & Rubio, L. A. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400630 · Cited by 86
“This is relevant, since the inflamed mucosal epithelium in these intestinal conditions is frequently characterized by the presence of ulceration and necrosis, and the restoration of the intestinal tissue implies the renovation of these cells, a process that requires an adequate protein supply through the diet [45].”
Background
Insights Into a Possible Influence on Gut Microbiota and Intestinal Barrier Function During Chronic Exposure of Mice to Imazalil
Jin, C., Xia, J., Wu, S., Tu, W., Pan, Z., Fu, Z., Wang, Y., & Jin, Y. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx227 · Cited by 84
Sulforaphane Normalizes Intestinal Flora and Enhances Gut Barrier in Mice with BBN‐Induced Bladder Cancer
He, C., Huang, L., Peng, L., Liu, X., Li, B., & Shan, Y. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800427 · Cited by 83
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Zhang, L., Gui, S., Wang, J., Chen, Q., Zeng, J., Liu, A., Chen, Z., & Lu, X. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103654 · Cited by 81
Factors influencing development of the infant microbiota: from prenatal period to early infancy
Jeong, S. (2021) · Korean Journal of Pediatrics · doi:10.3345/cep.2021.00955 · Cited by 89
“(2) Proton pump inhibitors The impact of proton pump inhibitors (PPIs) and other acidblocking medications in young infants is gaining more attention, as disturbances in the microbiome have been reported.”
Background
Age-related cognitive decline is associated with microbiota-gut-brain axis disorders and neuroinflammation in mice
Wu, M., Yang, X., Li, X., Duan, W., & Du, J. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113125 · Cited by 86
First evidence of altered microbiota and intestinal damage and their link to absence epilepsy in a genetic animal model, the WAG/Rij rat
Citraro, R., Lembo, F., Caro, C. D., Tallarico, M., Coretti, L., Iannone, L. F., Leo, A., Palumbo, D., Cuomo, M., Buommino, E., et al. (2021) · Epilepsia · doi:10.1111/epi.16813 · Cited by 86
Intestinal Microbiome‐Macrophage Crosstalk Contributes to Cholestatic Liver Disease by Promoting Intestinal Permeability in Mice
Isaacs‐Ten, A., Echeandia, M., Moreno‐Gonzalez, M., Brion, A., Goldson, A. J., Philo, M. R., Patterson, A. M., Parker, A., Galduroz, M., Baker, D., et al. (2020) · Hepatology · doi:10.1002/hep.31228 · Cited by 80
“aNIt-INDUCeD CHoleStaSIS pRoMoteS CHaNgeS IN tHe MICRoBIoMe CoMpoSItIoN oF gF + Wt MICe Previous studies have shown that changes in the microbiome are associated with altered TJ protein expression.(30,31) We performed 16s ribosomal RNA (rRNA) sequence analysis of fecal samples with LotuS(32) and found significant taxo…”
Background
Metallobiology of Lactobacillaceae in the gut microbiome
Huynh, U., & Zastrow, M. L. (2022) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2022.112023 · Cited by 86
Bifidobacterium animalis ssp. lactis CNCM-I2494 Restores Gut Barrier Permeability in Chronically Low-Grade Inflamed Mice
Martín, R., Laval, L., Chain, F., Miquel, S., Natividad, J. M., Cherbuy, C., Sokol, H., Verdu, E. F., Vlieg, J. V. H., Bermúdez‐Humarán, L. G., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00608 · Cited by 78
“The physical barrier is formed by a mucus layer followed by a monolayer of epithelial cells (Denker and Nigam, 1998; Natividad and Verdu, 2013) performing the paracellular transport across the barrier controlled by apical junction proteins (Natividad and Verdu, 2013).”
Self-citation
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Cai, J., Zhang, J., Tian, Y., Zhang, L., Hatzakis, E., Krausz, K. W., Smith, P. B. W., Gonzalez, F. J., & Patterson, A. D. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b00848 · Cited by 78
Novel perspectives on therapeutic modulation of the gut microbiota
McCarville, J. L., Caminero, A., & Verdu, E. F. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16637819 · Cited by 78
“This includes both functionality (permeability) and immune or structural parameters of the barrier such as secretion of antimicrobial peptides and mucins, in which the microbiota can play a central role [Vaishnava et al. 2008; Natividad and Verdu, 2013].”
Self-citation
Dietary Gluten as a Conditioning Factor of the Gut Microbiota in Celiac Disease
Bascuñán, K. A., Araya, M., Roncoroni, L., Doneda, L., & Elli, L. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz080 · Cited by 79
Subchronic exposure of environmentally relevant concentrations of F-53B in mice resulted in gut barrier dysfunction and colonic inflammation in a sex-independent manner
Pan, Z., Yuan, X., Tu, W., Fu, Z., & Jin, Y. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.07.021 · Cited by 75
A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats
Gil‐Cardoso, K., Ginés, I., Pinent, M., Ardèvol, A., Terra, X., & Blay, M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004608 · Cited by 75
“Other data suggest that certain bacterial species produce metabolites that can influence intestinal permeability and integrity((42)).”
Background
Could the beneficial effects of dietary calcium on obesity and diabetes control be mediated by changes in intestinal microbiota and integrity?
Gomes, J. M. G., Costa, J. A., & Alfenas, R. D. C. G. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515003608 · Cited by 72
In Vitro Probiotic and Antioxidant Potential of Lactococcus lactis subsp. cremoris LL95 and Its Effect in Mice Behaviour
Ramalho, J. B., Soares, M. B., Spiazzi, C. C., Bicca, D. F., Soares, V. M., Pereira, J. G., da Silva, W. P., Sehn, C. P., & Cibin, F. W. S. (2019) · Nutrients · doi:10.3390/nu11040901 · Cited by 72
β-Sitosterol Ameliorates Endometrium Receptivity in PCOS-Like Mice: The Mediation of Gut Microbiota
Yu, Y., Cao, Y., Huang, W., Liu, Y., Lü, Y., & Zhao, J. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.667130 · Cited by 73
A Preliminary Study Examining the Binding Capacity of Akkermansia muciniphila and Desulfovibrio spp., to Colonic Mucin in Health and Ulcerative Colitis
Earley, H., Lennon, G., Balfe, Á., Kilcoyne, M., Clyne, M., Joshi, L., Carrington, S. D., Martin, S., Coffey, J. C., Winter, D. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135280 · Cited by 71
Impact of molecular interactions with phenolic compounds on food polysaccharides functionality
Dobson, C., Mottawea, W., Rodrigue, A. F., Pereira, B. L. B., Hammami, R., Power, K. A., & Bordenave, N. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.02.010 · Cited by 73
Microbiome Metabolites and Thyroid Dysfunction
Bargiel, P., Szczuko, M., Stachowska, L., Prowans, P., Czapla, N., Markowska, M., Petriczko, J., Kledzik, J., Jędrzejczyk-Kledzik, A., Palma, J., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163609 · Cited by 74
“Some gastrointestinal disorders alter microbiome composition, contributing to an increased requirement for oral levothyroxine [50].”
Background
Prebiotic milk oligosaccharides prevent development of obese phenotype, impairment of gut permeability, and microbial dysbiosis in high fat-fed mice
Hamilton, M. K., Ronveaux, C. C., RUST, B. M., Newman, J. W. I., Hawley, M. M., Barile, D., Mills, D. A., & Raybould, H. E. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00427.2016 · Cited by 70
Fermented infant formula (with Bifidobacterium breve C50 and Streptococcus thermophilus O65) with prebiotic oligosaccharides is safe and modulates the gut microbiota towards a microbiota closer to that of breastfed infants
Béghin, L., Tims, S., Roelofs, M., Rougé, C., Oozeer, R., Rakza, T., Chirico, G., Roeselers, G., Knol, J., Rozé, J., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.07.024 · Cited by 70
“Subjects’ stool consistency was scored during the seven days before each visit, based on five categories: watery [1], loose [2], soft [3], formed [4] and hard [5].”
BackgroundMethod
Nerves in gastrointestinal cancer: from mechanism to modulations
Vaes, N., Idris, M., Boesmans, W., Alves, M. M., & Melotte, V. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00669-9 · Cited by 68
The Gut–Brain Axis in the Neuropsychological Disease Model of Obesity: A Classical Movie Revised by the Emerging Director “Microbiome”
Niccolai, E., Boem, F., Russo, E., & Amedei, A. (2019) · Nutrients · doi:10.3390/nu11010156 · Cited by 70
“In particular, the microbiota offers benefits to the host maintaining the gut integrity [104], harvesting energy [105], providing protection against pathogens [106] and regulating the immune system [107].”
Background
Cancer cachexia induces morphological and inflammatory changes in the intestinal mucosa
Costa, R., Caro, P. L., de Matos‐Neto, E. M., Lima, J. D. C. C., Radloff, K., Alves, M. J., Camargo, R. G., Pessoa, A. F. M., Simoes, E., Gama, P., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12449 · Cited by 66
“tion with perturbations in the intestinal microbiota composition, yielding persistent immune activation, as previously proposed.(9) Local intestinal inflammation may induce the ex-”
Background
Crosstalk among intestinal barrier, gut microbiota and serum metabolome after a polyphenol-rich diet in older subjects with “leaky gut”: The MaPLE trial
Peron, G., Gargari, G., Meroño, T., Miñarro, A., Vegas, E., Castellano‐Escuder, P., González‐Domínguez, R., Hidalgo‐Liberona, N., Bo’, C. D., Bernardi, S., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.08.027 · Cited by 69
Current understanding of the role of gut dysbiosis in type 1 diabetes
Abdellatif, A. M., & Sarvetnick, N. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12915 · Cited by 65
“These structures include the gut immune system, epithelium, mucus, and microbiota.(22) The gut barrier displays selective permeability, thus limiting host exposure to microbes while permitting efficient absorption of water and nutrients.”
Background
The vaginal microbiome amplifies sex hormone‐associated cyclic changes in cervicovaginal inflammation and epithelial barrier disruption
Bradley, F., Birse, K., Hasselrot, K., Noël‐Romas, L., Introini, A., Wefer, H. A., Seifert, M., Engstrand, L. G., Tjernlund, A., Broliden, K., et al. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12863 · Cited by 64

Authors: Natividad, J. M. M., & Verdu, E. F.
Affiliations: McMaster University (CA)
Corresponding author: Verdu, Elena F.
ORCID: Verdu, Elena F.
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2013-03
Volume: 69
Issue: 1
Pages: 42-51
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2012.10.007
OpenAlex: W2149848289
Cited by: 525
References: 146
Citations by year: 2026: 30 · 2025: 44 · 2024: 68 · 2023: 79 · 2022: 56 · 2021: 65 · 2020: 53 · 2019: 45 · 2018: 23 · 2017: 19 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 7
FWCI: 0.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: intestinal barrier, gut microbiota, dysbiosis, commensal bacteria, host-microbe mutualism, obesity, allergy, autoimmunity, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal diseases, treatment options
MeSH terms: Animals, Gastrointestinal Diseases, Humans, Intestines, Bacterial Physiological Phenomena, Metagenome

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Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

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