Cited by 527Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

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Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

Natividad, Jane M.M., Verdu, Elena F.·2013·Pharmacological Research

DOI 10.1016/j.phrs.2012.10.007

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Abstract

Mammals and their intestinal microbiota peacefully coexist in a mutualistic relationship. Commensal bacteria play an active role in shaping and modulating physiological processes in the host, which include, but are not restricted to, the immune system and the intestinal barrier. Both play a crucial role in containing intestinal bacteria and other potentially noxious luminal antigens within the lumen and mucosal compartment. Although mutualism defines the relationship between the host and the intestinal microbiota, disruptions in this equilibrium may promote disease. Thus, alterations in gut microbiota (dysbiosis) have been linked to the recent increased expression of obesity, allergy, autoimmunity, functional and inflammatory disorders such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). In this article, we review the evidence supporting a role of gut microbiota in regulating intestinal barrier function. We discuss the hypothesis that microbial factors can modulate the barrier in ways that can prevent or promote gastrointestinal disease. A better understanding of the role of the intestinal microbiota in maintaining a functional intestinal barrier may help develop targeted strategies to prevent and treat disease.

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Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241
Development of the Human Infant Intestinal Microbiota
Palmer, C., Bik, E. M., DiGiulio, D. B., Relman, D. A., & Brown, P. O. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050177 · Cited by 2,877
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science · doi:10.1126/science.291.5505.881 · Cited by 2,202
Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130
Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
van der Flier, L. G., & Clevers, H. C. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,994
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Susan, M. L., Gong, Q., Abbas, A. R., Modrusan, Z. D., Ghilardi, N., de Sauvage, F. J., et al. (2008) · Nature Medicine · doi:10.1038/nm1720 · Cited by 1,972
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,834
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
Sartor, R. B. (2006) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0528 · Cited by 1,806
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types
Cheng, H., & Leblond, C. P. (1974) · American Journal of Anatomy · doi:10.1002/aja.1001410407 · Cited by 1,737
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection
Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
Chemically induced mouse models of intestinal inflammation
Wirtz, S., Neufert, C., Weigmann, B., & Neurath, M. F. (2007) · Nature Protocols · doi:10.1038/nprot.2007.41 · Cited by 1,567
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Symbiotic bacteria direct expression of an intestinal bactericidal lectin
Cash, H. L., Whitham, C. V., Behrendt, C. L., & Hooper, L. V. (2006) · Science · doi:10.1126/science.1127119 · Cited by 1,432
The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412
Enteric defensins are essential regulators of intestinal microbial ecology
Salzman, N. H., Hung, K., Haribhai, D., Chu, H., Karlsson-Sjöberg, J., Amir, E., Teggatz, P., Barman, M., Hayward, M., Eastwood, D., et al. (2010) · Nature Immunology · doi:10.1038/ni.1825 · Cited by 1,156
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
Artis, D. (2008) · Nature reviews. Immunology · doi:10.1038/nri2316 · Cited by 1,136
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Nenci, A., Becker, C., Wullaert, A., Gareus, R., Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C. F., Madison, B., et al. (2007) · Nature · doi:10.1038/nature05698 · Cited by 1,077
Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense
Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076
Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria
Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-γ and RelA
Kelly, D., Campbell, J. I., King, T. P., Grant, G., Jansson, E. Å., Coutts, A., Pettersson, S., & Conway, S. (2003) · Nature Immunology · doi:10.1038/ni1018 · Cited by 1,026
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L., & Hooper, L. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808723105 · Cited by 1,019
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012
Angiogenins: a new class of microbicidal proteins involved in innate immunity
Hooper, L. V., Stappenbeck, T. S., Hong, C. V., & Gordon, J. I. (2003) · Nature Immunology · doi:10.1038/ni888 · Cited by 947
Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine
Yang, Q., Bermingham, N. A., Finegold, M. J., & Zoghbi, H. Y. (2001) · Science · doi:10.1126/science.1065718 · Cited by 919
Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes
Kurokawa, K., Itoh, T., Kuwahara, T., Oshima, K., Toh, H., Toyoda, A., Takami, H., Morita, H., Sharma, V. K., Srivastava, T. P., et al. (2007) · DNA Research · doi:10.1093/dnares/dsm018 · Cited by 869
Probiotic bacteria and intestinal epithelial barrier function
Ohland, C., & MacNaughton, W. K. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00243.2009 · Cited by 832
Homeostasis and Inflammation in the Intestine
Garrett, W. S., Gordon, J. I., & Glimcher, L. H. (2010) · Cell · doi:10.1016/j.cell.2010.01.023 · Cited by 822
Use of axenic animals in studying the adaptation of mammals to their commensal intestinal microbiota
Smith, K., McCoy, K. D., & Macpherson, A. J. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.10.002 · Cited by 789
Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice
Madsen, K. L., Doyle, J. S. G., Jewell, L. D., Tavernini, M. M., & Fedorak, R. N. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70013-2 · Cited by 761
Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.
Madara, J. L., & Stafford, J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113938 · Cited by 758
The immune system and the gut microbiota: friends or foes?
Cerf-Bensussan, N., & Gaboriau-Routhiau, V. (2010) · Nature Reviews Immunology · doi:10.1038/nri2850 · Cited by 704
Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin
Hermiston, M. L., & Gordon, J. I. (1995) · Science · doi:10.1126/science.270.5239.1203 · Cited by 669
Trefoil factors: initiators of mucosal healing
Taupin, D. R., & Podolsky, D. K. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1203 · Cited by 643
Intestinal barrier dysfunction in inflammatory bowel diseases
McGuckin, M. A., Eri, R., Simms, L. A., Florin, T. H. J., & Radford-Smith, G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20539 · Cited by 627
The Microbial Ecology of the Large Bowel of Breastfed and Formula-fed Infants During the First Year of Life
Stark, P. L., & Lee, A. (1982) · Journal of Medical Microbiology · doi:10.1099/00222615-15-2-189 · Cited by 616
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.
O′Neil, D. A., Porter, E. M., Elewaut, D. S., Anderson, G. M., Eckmann, L., Ganz, T., & Kagnoff, M. F. (1999) · PubMed · Cited by 596
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation
Berkes, J., Viswanathan, V. K., Savkovic, S. D., & Hecht, G. (2003) · Gut · doi:10.1136/gut.52.3.439 · Cited by 594
Nod2 is required for the regulation of commensal microbiota in the intestine
Petnicki-Ocwieja, T., Hrncir, T., Liu, Y.-J., Biswas, A., Hudcovic, T., Tlaskalova-Hogenova, H., & Kobayashi, K. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907722106 · Cited by 564
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
Sancho, E., Batlle, E., & Clevers, H. C. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.092805 · Cited by 560
Bacterial contributions to mammalian gut development
Hooper, L. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.01.001 · Cited by 541
Organization, Chemistry, and Assembly of the Cytoskeletal Apparatus of the Intestinal Brush Border
Mooseker, M. S. (1985) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.01.110185.001233 · Cited by 527
Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium
O′Neil, D. A., Porter, E. M., Elewaut, D. S., Anderson, G. M., Eckmann, L., Ganz, T., & Kagnoff, M. F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6718 · Cited by 522
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
Slack, E. M. C., Hapfelmeier, S., Stecher, B., Velykoredko, Y., Stoel, M., Lawson, M. A., Geuking, M. B., Beutler, B., Tedder, T. F., Hardt, W., et al. (2009) · Science · doi:10.1126/science.1172747 · Cited by 520
Self-citation
The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells
Caballero‐Franco, C., Keller, K., Simone, C. D., & Chadee, K. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00265.2006 · Cited by 513
JAM-A regulates permeability and inflammation in the intestine in vivo
Laukoetter, M. G., Nava, P., Lee, W. Y., Severson, E. A., Capaldo, C., Babbin, B. A., Williams, I. R., Koval, M. H., Peatman, E., Campbell, J. A., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071416 · Cited by 512
Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis
Mennigen, R. B., Nolte, K., Rijcken, E. J. M., Utech, M., Loeffler, B., Senninger, N. J., & Bruewer, M. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90534.2008 · Cited by 484
Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice.
Abrams, G. D., Bauer, H., & Sprinz, H. (1963) · PubMed · Cited by 482
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482
Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C
Cario, E., Gerken, G., & Podolsky, D. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.015 · Cited by 475
Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation
Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472
NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells byEscherichia coliNissle 1917: a Novel Effect of a Probiotic Bacterium
Wehkamp, J., Harder, J., Wehkamp, K., Meissner, B. W.-V., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S., Fellermann, K., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5750-5758.2004 · Cited by 471
Primate defensins
Lehrer, R. I. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro976 · Cited by 466
Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β
Dignass, A. U., & Podolsky, D. K. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90136-z · Cited by 449
Paneth cell trypsin is the processing enzyme for human defensin-5
Ghosh, D., Porter, E. M., Shen, B., Lee, S. K., Wilk, D. J., Drazba, J. A., Yadav, S. P., Crabb, J. W., Ganz, T., & Bevins, C. L. (2002) · Nature Immunology · doi:10.1038/ni797 · Cited by 428
Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress
Zareie, M., Johnson‐Henry, K. C., Jury, J., Yang, P.-C., Ngan, B., McKay, D. M., Söderholm, J. D., Perdue, M. H., & Sherman, P. M. (2006) · Gut · doi:10.1136/gut.2005.080739 · Cited by 423
Genomic and Metabolic Studies of the Impact of Probiotics on a Model Gut Symbiont and Host
Sonnenburg, J. L., Chen, C. T. L., & Gordon, J. I. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040413 · Cited by 423
Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414
Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis
Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L. R., Ruggiero, F. M., & Koltun, W. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.050 · Cited by 414
MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection
Brandl, K., Plitas, G., Schnabl, B., DeMatteo, R. P., & Pamer, E. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070563 · Cited by 385
Importance and regulation of the colonic mucus barrier in a mouse model of colitis
Petersson, J., Schreiber, O., Hansson, G. C., Gendler, S. J., Velcich, A., Lundberg, J. O., Roos, S., Holm, L., & Phillipson, M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00422.2010 · Cited by 384
A Re-evaluation of the Role of Host Defence Peptides in Mammalian Immunity
Bowdish, D. M. E., Davidson, D. J., & Hancock, R. E. W. (2005) · Current Protein and Peptide Science · doi:10.2174/1389203053027494 · Cited by 373
Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability
Suzuki, T., Yoshida, S., & Hara, H. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508888733 · Cited by 370
BACTERIAL INTERACTIONS WITH CELLS OF THE INTESTINAL MUCOSA: TOLL-LIKE RECEPTORS AND NOD2
Cario, E. (2005) · Gut · doi:10.1136/gut.2004.062794 · Cited by 369
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
Watanabe, T., Asano, N., Murray, P. J., Ozato, K., Tailor, P. B., Fuss, I. J., Kitani, A., & Strober, W. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33145 · Cited by 341
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis
Taylor, B. C., Zaph, C., Troy, A. E., Du, Y., Guild, K. J., Comeau, M. R., & Artis, D. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081499 · Cited by 340
Mast Cell Tryptase Controls Paracellular Permeability of the Intestine
Jacob, C., Yang, P.-C., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G. S., Coelho, A.-M., Singh, P., Grady, E. F., Perdue, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506338200 · Cited by 334
Interleukin-10 Gene-Deficient Mice Develop a Primary Intestinal Permeability Defect in Response to Enteric Microflora
Madsen, K. L., Malfair, D., Gray, D., Doyle, J. S. G., Jewell, L. D., & Fedorak, R. N. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199911000-00004 · Cited by 318
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine III. Entero‐endocrine cells
Cheng, H., & Leblond, C. P. (1974) · American Journal of Anatomy · doi:10.1002/aja.1001410405 · Cited by 313
Proprioceptor Pathway Development Is Dependent on MATH1
Bermingham, N. A., Hassan, B. A., Wang, V. Y., Fernandez, M., Banfi, S., Bellen, H. J., Fritzsch, B., & Zoghbi, H. Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00305-1 · Cited by 304
Human Enteric Defensins
Mallow, E. B., Harris, A., Salzman, N. H., Russell, J. P., DeBerardinis, R. J., Ruchelli, E. D., & Bevins, C. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4038 · Cited by 296
Microbiota, Disease, and Back to Health: A Metastable Journey
Blumberg, R. S., & Powrie, F. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004184 · Cited by 287
Changes in Colonic Mucosal Permeability in Mouse Colitis Induced with Dextran Sulfate Sodium.
Kitajima, S., TAKUMA, S., & MORIMOTO, M. (1999) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.48.137 · Cited by 283
Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology
Yu, L. C. (2012) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v3.i1.27 · Cited by 280
Examining the Role of Paneth Cells in the Small Intestine by Lineage Ablation in Transgenic Mice
Garabedian, E. M., Roberts, L. J., McNevin, M. S., & Gordon, J. I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23729 · Cited by 279
Do symbiotic bacteria subvert host immunity?
Hooper, L. V. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2114 · Cited by 269
The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis
Chen, G. Y., Shaw, M. H., Redondo, G., & Núñez, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2061 · Cited by 261
Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease
Vetrano, S., Rescigno, M., Cera, M. R., Correale, C., Rumio, C., Doni, A., Fantini, M. C., Sturm, A., Borroni, E. M., Repici, A., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.04.002 · Cited by 254
Probiotics for maintenance of remission in Crohn's disease
Rolfe, V. E., Fortun, P., Hawkey, C. J., & Bath-Hextall, F. J. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004826.pub2 · Cited by 252
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach
Katz, J. P., Perreault, N., Goldstein, B. G., Actman, L., McNally, S. R., Silberg, D. G., Furth, E. E., & Kaestner, K. H. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.022 · Cited by 250
Host defense peptides and their antimicrobial-immunomodulatory duality
Steinstraesser, L., Kraneburg, U. M., Jacobsen, F., & Al‐Benna, S. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.07.003 · Cited by 250
Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.
Ouellette, A. J., Greco, R. M., James, M. F., Frederick, D., Naftilan, J., & Fallon, J. T. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.5.1687 · Cited by 249
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease
Kosiewicz, M. M., Nast, C. C., Krishnan, A., Rivera–Nieves, J., Moskaluk, C. A., Matsumoto, S., Kozaiwa, K., & Cominelli, F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10956 · Cited by 248
Nutrition and colonic health: the critical role of the microbiota
O’Keefe, S. J. (2008) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3282f323f3 · Cited by 218
Lysate of Probiotic Lactobacillus casei DN-114 001 Ameliorates Colitis by Strengthening the Gut Barrier Function and Changing the Gut Microenvironment
Zakostelska, Z. J., Kverka, M., Kostovcikova, K., Rossmann, P., Mrázek, J., Kopečný, J., Hornová, M., Šrůtková, D., Hudcovic, T., Rídl, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027961 · Cited by 207
MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis
Gibson, D. L., Ma, C., Bergstrom, K., Huang, J. T., Man, C., & Vallance, B. A. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.01071.x · Cited by 195
Autocrine regulation of epithelial permeability by hypoxia: Role for polarized release of tumor necrosis factor α
Taylor, C. T., Dzus, A. L., & Colgan, S. P. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70579-7 · Cited by 188
Probiotic-Derived Polyphosphate Enhances the Epithelial Barrier Function and Maintains Intestinal Homeostasis through Integrin–p38 MAPK Pathway
Segawa, S., Fujiya, M., Konishi, H., Ueno, N., Kobayashi, N., Shigyo, T., & Kohgo, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023278 · Cited by 186
NOD2 and Crohn’s Disease: Loss or Gain of Function?
Eckmann, L., & Karin, M. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.004 · Cited by 185
Defensins and inflammation: The role of defensins in inflammatory bowel disease
Ramasundara, M., Leach, S. T., Lemberg, D. A., & Day, A. S. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05772.x · Cited by 182
Bacterial Exposure Induces and Activates Matrilysin in Mucosal Epithelial Cells
López-Boado, Y. S., Wilson, C. L., Hooper, L. V., Gordon, J. I., Hultgren, S. J., & Parks, W. C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.6.1305 · Cited by 179
Innate Immune Response of Oral and Foreskin Keratinocytes: Utilization of Different Signaling Pathways by Various Bacterial Species
Chung, W. O., & Dale, B. A. (2003) · Infection and Immunity · doi:10.1128/iai.72.1.352-358.2004 · Cited by 176
The primary defect in experimental ileitis originates from a nonhematopoietic source
Olson, T. S., Reuter, B. K., Scott, K. G. –., MORRIS, M. A., Wang, X.-M., Hancock, L. N., Burcin, T. L., Cohn, S. M., Ernst, P. B., Cominelli, F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050407 · Cited by 172
Increased Expression of HIP/PAP and Regenerating Gene III in Human Inflammatory Bowel Disease and a Murine Bacterial Reconstitution Model
Ogawa, H., Fukushima, K., Naito, H., Funayama, Y., Unno, M., Takahashi, K.-I., Kitayama, T., Matsuno, S., Ohtani, H., Takasawa, S., et al. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200305000-00003 · Cited by 172
Effect of normal microbial flora on intestinal surface area
Gordon, H. A., & Bruckner-Kardoss, E. (1961) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1961.201.1.175 · Cited by 172
Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases
Swanson, P. A., Kumar, A., Samarin, S., Vijay–Kumar, M., Kundu, K., Murthy, N., Hansen, J. M., Nusrat, A., & Neish, A. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010042108 · Cited by 171
Host Defense Peptide LL-37 Selectively Reduces Proinflammatory Macrophage Responses
Brown, K. L., Poon, G. F. T., Birkenhead, D., Pena, O. M., Falsafi, R., Dahlgren, C., Karlsson, A., Bylund, J., Hancock, R. E. W., & Johnson, P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002508 · Cited by 163
Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans
Möndel, M., Schroeder, B. O., Zimmermann, K., Huber, H., Nuding, S., Beisner, J., Fellermann, K., Stange, E. F., & Wehkamp, J. (2009) · Mucosal Immunology · doi:10.1038/mi.2008.77 · Cited by 157
Viscosity gradient within the mucus layer determines the mucosal barrier function and the spatial organization of the intestinal microbiota
Swidsinski, A. V., Sydora, B. C., Dörffel, Y., Loening-Baucke, V. A., Vaneechoutte, M., Lupicki, M., Scholze, J. E., Lochs, H. H., & Dieleman, L. A. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20163 · Cited by 155
Multi-layered regulation of intestinal antimicrobial defense
Mukherjee, S., Vaishnava, S., & Hooper, L. V. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8182-3 · Cited by 154
The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis
Sheng, Y., Lourie, R., Lindén, S. K., Jeffery, P. L., Roche, D., Tran, T. V., Png, C. W., Waterhouse, N. J., SUTTON, P. R. N., Florin, T. H., et al. (2011) · Gut · doi:10.1136/gut.2011.239194 · Cited by 144
Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease
Wehkamp, J., Koslowski, M. J., Wang, G., & Stange, E. F. (2008) · Mucosal Immunology · doi:10.1038/mi.2008.48 · Cited by 143
Role of M Cells in Intestinal Barrier Function
Kucharzik, T. F., Lügering, N., Rautenberg, K., Lügering, A., Schmidt, M. A., Stoll, R., & Domschke, W. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05240.x · Cited by 141
Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene
Ghaleb, A. M., McConnell, B. B., Kaestner, K. H., & Yang, V. W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.001 · Cited by 140
Germ-free and Colonized Mice Generate the Same Products from Enteric Prodefensins
Pütsep, K., Axelsson, L.-G., Boman, A., Midtvedt, T., Normark, S. J., Boman, H. G., & Andersson, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007816200 · Cited by 140
Enteric Salmonella Infection Inhibits Paneth Cell Antimicrobial Peptide Expression
Salzman, N. H., Chou, M. M., de Jong, H., Liu, L., Porter, E. M., & Paterson, Y. Y. W. (2003) · Infection and Immunity · doi:10.1128/iai.71.3.1109-1115.2003 · Cited by 140
Commensal and Probiotic Bacteria Influence Intestinal Barrier Function and Susceptibility to Colitis in Nod1−/−;Nod2−/− Mice
Natividad, J. M. M., Petit, V., Huang, X., de Palma, G., Jury, J., Sanz, Y., Philpott, D., Garcia Rodenas, C. L., McCoy, K. D., & Verdu, E. F. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22848 · Cited by 139
Self-citation
Histochemical, Lectin-Histochemical and Morphometrical Characteristics of Intestinal Goblet Cells of Germfree and Conventional Mice.
Kandori, H., Hirayama, K., TAKEDA, M., & Doi, K. (1996) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.45.155 · Cited by 138
Paneth's disease
Wehkamp, J., & Stange, E. F. (2010) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2010.05.010 · Cited by 136
Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts
Kalischuk, L. D., Inglis, G. D., & Buret, A. G. (2009) · Gut Pathogens · doi:10.1186/1757-4749-1-2 · Cited by 135
Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a−/− mice
Resta‐Lenert, S. C., Smitham, J. E., & Barrett, K. E. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00395.2004 · Cited by 130
96 Muramyl Dipeptide Activation of Nucleotide-Binding Oligomerization Domain 2 Protects Mice from Experimental Colitis
Watanabe, T., Asano, N., Murray, P. J., Ozato, K., Kitani, A., Fuss, I. J., & Strober, W. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)60085-2 · Cited by 127
The VSL# 3 Probiotic Mixture Modifies Microflora but Does Not Heal Chronic Dextran-Sodium Sulfate–Induced Colitis or Reinforce the Mucus Barrier in Mice
Gaudier, E. A., Michel, C., Segain, J., Cherbut, C., & Hoebler, C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2753 · Cited by 116
Pre-epithelial mucus layer in the colon of conventional and germ-free rats
Szentkuti, L., Riedesel, H., Enss, M. ‐., Gaertner, K., & Engelhardt, W. V. (1990) · The Histochemical Journal · doi:10.1007/bf01007234 · Cited by 111
Regulation of C-type Lectin Antimicrobial Activity by a Flexible N-terminal Prosegment
Mukherjee, S., Partch, C. L., Lehotzky, R. E., Whitham, C. V., Chu, H., Bevins, C. L., Gardner, K. H., & Hooper, L. V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808077200 · Cited by 101
Modulation of Mouse Paneth Cell α-Defensin Secretion by mIKCa1, a Ca2+-activated, Intermediate Conductance Potassium Channel
Ayabe, T., Wulff, H., Darmoul, D., Cahalan, M. D., Chandy, K. G., & Ouellette, A. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107507200 · Cited by 91
Commensal Bacteria Exacerbate Intestinal Inflammation but Are Not Essential for the Development of Murine Ileitis
Bamias, G., Okazawa, A., Rivera–Nieves, J., Arseneau, K. O., Rue, S. A. D. L., Pizarro, T. T., & Cominelli, F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1809 · Cited by 88
SMALL INTESTINAL MUCOSAL CELL PROLIFERATION AND BACTERIAL FLORA IN THE CONVENTIONALIZATION OF THE GERMFREE MOUSE
Khoury, K. A., Floch, M. H., & Hersh, T. (1969) · The Journal of Experimental Medicine · doi:10.1084/jem.130.3.659 · Cited by 78
Cutting Edge: Transgenic Expression of Human MUC1 in IL-10−/− Mice Accelerates Inflammatory Bowel Disease and Progression to Colon Cancer
Beatty, P. L., Plevy, S. E., Sepulveda, A. R., & Finn, O. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.735 · Cited by 75
Lactobacillus plantarum ameliorates colonic epithelial barrier dysfunction by modulating the apical junctional complex and PepT1 in IL-10 knockout mice
Chen, H., Yang, J., Zhang, M., Zhou, Y.-K., Shen, T., Chu, Z.-X., Zhang, M., Hang, X., Jiang, Y., & Qin, H. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00196.2010 · Cited by 75
Host Responses to Intestinal Microbial Antigens in Gluten-Sensitive Mice
Natividad, J. M., Huang, X., Slack, E., Jury, J., Sanz, Y., David, C., Denou, E., Yang, P., Murray, J., McCoy, K. D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006472 · Cited by 73
Self-citation
The role of indigenous microflora in the development of murine intestinal fucosyl‐ and sialyltransferases
Nanthakumar, N. N., Dai, D., Newburg, D. S., & Walker, W. A. (2002) · The FASEB Journal · doi:10.1096/fj.02-0031fje · Cited by 72
Innate immunity and mucosal bacterial interactions in the intestine
Eckmann, L. (2004) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200403000-00006 · Cited by 71
A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells
Itoh, H., Beck, P. L., Inoue, N., Xavier, R. J., & Podolsky, D. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6211 · Cited by 62
Variation of mucin distribution in the rat intestine, caecum and colon: effect of the bacterial flora
Meslin, J.-C., Fontaine, N., & Andrieux, C. (1999) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/s1095-6433(99)00056-2 · Cited by 55
Altered Epithelial Cell Lineage Allocation and Global Expansion of the Crypt Epithelial Stem Cell Population Are Associated with Ileitis in SAMP1/YitFc Mice
Vidrich, A., Buzan, J. M., Barnes, S., Reuter, B. K., Skaar, K., Ilo, C., Cominelli, F., Pizarro, T. T., & Cohn, S. M. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62326-7 · Cited by 50
Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota
Comelli, E. M., Simmering, R., Faure, M., Donnicola, D., Mansourian, R., Rochat, F., Corthesy-Theulaz, I. E., & Cherbut, C. (2007) · Genomics · doi:10.1016/j.ygeno.2007.09.006 · Cited by 49
Changes in colonic mucins of germfree rats in response to the introduction of a "normal" rat microbial flora. Rat colonic mucin.
Enss, M. ‐., Grosse‐Siestrup, H., Schmidt-Wittig, U., & Gärtner, K. (1992) · PubMed · Cited by 49
Helping patients make informed choices about probiotics: a need for research
Sharp, R. R., Achkar, J.-P., Brinich, M. A., & Farrell, R. M. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.68 · Cited by 43
Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine
Ouellette, A. J., & Cordell, B. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90618-x · Cited by 41
Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders, from Rationale to Reality
Shanahan, F., & Collins, S. M. (2010) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.08.006 · Cited by 41
Modulation of Intestinal Barrier Properties by Probiotics: Role in Reversing Colitis
Resta‐Lenert, S. C., & Barrett, K. E. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04042.x · Cited by 40
Chronic colitis induces expression of β-defensins in murine intestinal epithelial cells
Rahman, A., Fahlgren, A., Sundstedt, C., Hammarström, S., Danielsson, A., & Hammarström, M. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04282.x · Cited by 39
Mechanisms of Tight Junction Dysregulation in the SAMP1/YitFc Model of Crohn's Disease–like Ileitis
Reuter, B. K., & Pizarro, T. T. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04035.x · Cited by 39
Effects of Perorally Applied Endotoxin on Colonic Mucins of Germfree Rats
Enss, M. ‐., Müller, H. E., Schmidt-Wittig, U., Kownatzki, R., Coenen, M., & Hedrich, H. J. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609051994 · Cited by 36
Defensins keep the peace too
Menéndez, A., Ferreira, R. B. R., & Finlay, B. B. (2009) · Nature Immunology · doi:10.1038/ni0110-49 · Cited by 21
β‐Defensin Expression in Immunocompetent and Immunodeficient Germ‐Free andCandida albicans–Monoassociated Mice
Schofield, D. A., Westwater, C., & Balish, E. (2004) · The Journal of Infectious Diseases · doi:10.1086/423856 · Cited by 21
Response of rat small intestinal active aldohexose transport to elevation of mucosal cyclic AMP by forskolin and 3-isobutyl-1-methylxanthine in vitro
Reymann, A., Braun, W., & Woermann, C. (1985) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00500824 · Cited by 6
Importance of cholinergic pathways in the regulation of colonic motility in the rabbit
Ponti, F. D., Cosentino, M., D’Angelo, L., Lecchini, S., Frigo, G. M., & Crema, A. (1990) · Pharmacological Research · doi:10.1016/s1043-6618(09)80010-8 · Cited by 2

Research works printed but not linked: 2

Hooper, 2001, Molecular analysis of commensal host–microbial relationships in the intestine, Science (New York, NY), 291, 881, 10.1126/science.291.5505.881 · DOI · Paper page
Kobayashi, 2005, Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract, Science (New York, NY), 307, 731, 10.1126/science.1104911 · DOI

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Authors: Natividad, J. M. M., & Verdu, E. F.
Affiliations: McMaster University (CA)
Corresponding author: Verdu, Elena F.
ORCID: Verdu, Elena F.
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2013-03
Volume: 69
Issue: 1
Pages: 42-51
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2012.10.007
OpenAlex: W2149848289
Cited by: 525
References: 146
Citations by year: 2026: 30 · 2025: 44 · 2024: 68 · 2023: 79 · 2022: 56 · 2021: 65 · 2020: 53 · 2019: 45 · 2018: 23 · 2017: 19 · 2016: 11 · 2015: 13 · 2014: 12 · 2013: 7
FWCI: 0.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: intestinal barrier, gut microbiota, dysbiosis, commensal bacteria, host-microbe mutualism, obesity, allergy, autoimmunity, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal diseases, treatment options
MeSH terms: Animals, Gastrointestinal Diseases, Humans, Intestines, Bacterial Physiological Phenomena, Metagenome

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Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications

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