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Negative regulation of inflammation by SIRT1

Xie, Jun, Zhang, Xiaoming, Zhang, Li·2013·Pharmacological Research
DOI 10.1016/j.phrs.2012.10.010
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Abstract

Sirtuin 1 (SIRT1), the mammalian Sir2 homologue, is a class III histone deacetylase shown to act on a wide range of histones and non-histone substrates. Numerous studies have demonstrated that SIRT1 regulates critical metabolic and physiological processes including senescence, stress resistance, metabolism and apoptosis. Recently, SIRT1 was also found to play an important role in modulating the development and progression of inflammation through deacetylating histones and critical transcription factor such as nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1), thus leading to transcriptional repression of various inflammation-related genes. There is increasing evidence that reduction of SIRT1 levels is closely correlated with many inflammatory diseases while pharmacologic activation of SIRT1 would be a promising therapeutic strategy for inflammation-related diseases.

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  • SIRT1 can down-regulate inflammation-related genes by deacetylating histones and components of inflammatory signaling pathways such as NF-κB.

    “by deacetylating histones and components of inflammatory signaling pathways such as NF-κB, SIRT1 can down-regulate inflammation-related genes”

    From The Hallmarks of Aging (2013) · cites this paper as Xie et al., 2012

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Metadata

Authors
Xie, J., Zhang, X., & Zhang, L.
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2013-01
Volume
67
Issue
1
Pages
60-67
ISSN
1043-6618
DOI
10.1016/j.phrs.2012.10.010
Cited by
234
References
8
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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