The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
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Sirt1 has been shown to be atheroprotective in Apoe−/− mice.
“Sirt1 has been shown to be atheroprotective in apolipoprotein E-deficient (Apoe−/−) mice2–4 whereas genetic overexpression of Sirt1 in LDL-receptor-deficient (Ldlr−/−) mice enhanced atherosclerosis.5”
From The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression (2015) · cites this paper as [2]
Overexpression of Sirt1 in endothelial cells of ApoE−/− mice fed a high-fat diet promotes endothelium-dependent vasodilation and protects against atherosclerosis by increasing eNOS activity.
“overexpression of Sirt1 in endothelial cells of ApoE−/− mice fed on a high-fat diet promotes endothelium-dependent vasodilation and protects against atherosclerosis by increasing eNOS activity.34”
From Sirtuin-1 directly binds and deacetylates hepatic PCSK9 thereby promoting the inhibition of LDL receptor degradation (2025) · cites this paper as [34]
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Citations
Cites
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107 · cited 1×
“Former research found that CR induces eNOS expression and mitochondrial biogenesis.(26) Here we give direct evidence that SIRT1 is a regulator of eNOS expression in vitro and in vivo.”
BackgroundCalorie restriction–the SIR2 connection
Guarente, L., & Picard, F. (2005) · Cell · doi:10.1016/j.cell.2005.01.029 · Cited by 793
Increase in Activity During Calorie Restriction Requires Sirt1
Chen, D., Steele, A. D., Lindquist, S., & Guarente, L. (2005) · Science · doi:10.1126/science.1118357 · Cited by 419
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Cited by
Sorted by citations
AMPK and SIRT1: a long-standing partnership?
Ruderman, N. B., Julia Xu, X., Nelson, L., Cacicedo, J. M., Saha, A. K., Lan, F., & Ido, Y. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00745.2009 · Cited by 903
The Aging Cardiovascular System
Paneni, F., Diaz Cañestro, C., Libby, P., Lüscher, T. F., & Camici, G. G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.01.064 · Cited by 618
Targeting vascular (endothelial) dysfunction
Daiber, A., Steven, S., Weber, A., Shuvaev, V. V., Muzykantov, V. R., Laher, I., Li, H., Lamas, S., & Münzel, T. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13517 · Cited by 501
Calorie restriction and sirtuins revisited
Guarente, L. (2013) · Genes & Development · doi:10.1101/gad.227439.113 · Cited by 464
Effects of aging on angiogenesis
Lähteenvuo, J., & Rosenzweig, A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246116 · Cited by 292
Chen, H.-Z., Wang, F., Gao, P., Pei, J.-F., Liu, Y., Xu, T.-T., Tang, X., Fu, W.-Y., Lu, J., Yan, Y.-F., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.308895 · Cited by 265
Self-citationDisturbed Flow Promotes Endothelial Senescence via a p53-Dependent Pathway
Warboys, C. M., de Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., White, A., Biswas, S., Khamis, R., Chong, C. K., et al. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.303415 · Cited by 227
Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1
Arunachalam, G., Samuel, S. M., Marei, I., Ding, H., & Triggle, C. R. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12496 · Cited by 221
Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol
Xia, N., Strand, S., Schlufter, F., Siuda, D., Reifenberg, G., Kleinert, H., Förstermann, U., & Li, H. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.04.001 · Cited by 157
Miranda, M. X., van Tits, L. J., Lohmann, C., Arsiwala, T., Winnik, S., Tailleux, A., Stein, S., Gomes, A. P., Suri, V., Ellis, J. L., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu095 · Cited by 153
Endothelial nitric oxide synthase transgenic models of endothelial dysfunction
Atochin, D. N., & Huang, P. L. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0867-4 · Cited by 145
Mammalian target of rapamycin signaling in diabetic cardiovascular disease
Chong, Z., & Maiese, K. (2012) · Cardiovascular Diabetology · doi:10.1186/1475-2840-11-45 · Cited by 95
Chan, S.-H., Hung, C.-H., Shih, J.-Y., Chu, P.-M., Cheng, Y.-H., Lin, H.-C., Hsieh, P.-L., & Tsai, K.-L. (2018) · Redox Biology · doi:10.1016/j.redox.2017.08.016 · Cited by 76
Bao, J., & Sack, M. N. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0402-y · Cited by 67
Velagapudi, S., Miranda, M. X., Adla, P., Kraler, S., Mohammed, S. A., Baki, S., Robert, J., Rohrer, L., Lee, H., Jang, H.-D., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf087 · Cited by 4
Metadata
- Authors
- Zhang, Q.-J., Wang, Z., Chen, H.-Z., Zhou, S., Zheng, W., Liu, G., Wei, Y.-S., Cai, H., Liu, D.-P., & Liang, C.-C.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-07-16
- Volume
- 80
- Issue
- 2
- Pages
- 191-199
- ISSN
- 0008-6363
- Cited by
- 349
- References
- 4
- Language
- en
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