High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · see citing works

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science · doi:10.1126/science.1099196 · Cited by 1,924 · see citing works

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,918 · see citing works

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

Kamata, H., Honda, S.-I., Maeda, S., Chang, L., Hirata, H., & Karin, M. (2005) · Cell · doi:10.1016/j.cell.2004.12.041 · Cited by 1,792 · see citing works

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404184101 · Cited by 1,361 · see citing works

Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

Alcendor, R. R., Gao, S., Zhai, P., Zablocki, D., Holle, E., Yu, X., Tian, B., Wagner, T., Vatner, S. F., & Sadoshima, J. (2007) · Circulation Research · doi:10.1161/01.res.0000267723.65696.4a · Cited by 1,147 · see citing works

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., & Li, X. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.006 · Cited by 1,112 · see citing works

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601758 · Cited by 1,074 · see citing works

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060 · see citing works

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047 · see citing works

Sirt1 protects against high-fat diet-induced metabolic damage

Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., & Tschöp, M. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802917105 · Cited by 928 · see citing works

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

Satoh, A., Brace, C. S., Rensing, N., Cliften, P. F., Wozniak, D. F., Herzog, E. D., Yamada, K. A., & Imai, S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.07.013 · Cited by 734 · see citing works

Tumor Suppressor HIC1 Directly Regulates SIRT1 to Modulate p53-Dependent DNA-Damage Responses

Chen, W., Wang, D. H., Yen, R.-W. C., Luo, J., Gu, W. J., & Baylin, S. B. (2005) · Cell · doi:10.1016/j.cell.2005.08.011 · Cited by 649 · see citing works

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

Banks, A. S., Kon, N., Knight, C. M., Matsumoto, M., Juárez, R. G., Rossetti, L., Gu, W. J., & Accili, D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.014 · Cited by 636 · see citing works

SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR

Li, X., Zhang, S., Blander, G., Tse, J. G., Krieger, M., & Guarente, L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.032 · Cited by 631 · see citing works

Sirtuins in aging and age-related disease

Longo, V. D., & Kennedy, B. K. (2006) · Cell · doi:10.1016/j.cell.2006.07.002 · Cited by 628 · see citing works

Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction

Qin, W., Yang, T., Ho, L., Zhao, Z., Wang, J., Chen, L., Zhao, W., Thiyagarajan, M., MacGrogan, D., Rodgers, J. T., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602909200 · Cited by 626 · see citing works

Silent Information Regulator 1 Protects the Heart From Ischemia/Reperfusion

Hsu, C., Zhai, P., Yamamoto, T., Maejima, Y., Matsushima, S., Hariharan, N., Shao, D., Takagi, H., Oka, S., & Sadoshima, J. (2010) · Circulation · doi:10.1161/circulationaha.110.958033 · Cited by 561 · see citing works

PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells

VALLE, I., ALVAREZBARRIENTOS, A., ARZA, E., LAMAS, S., & MONSALVE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.026 · Cited by 556 · see citing works

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease

Rajendrasozhan, S., Yang, S.-R., Kinnula, V. L., & Rahman, I. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200708-1269oc · Cited by 520 · see citing works

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513 · see citing works

Sirtuins, Aging, and Medicine

Guarente, L. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1100831 · Cited by 510 · see citing works

Sirtuin Functions in Health and Disease

Yamamoto, H., Schoonjans, K., & Auwerx, J. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0079 · Cited by 480 · cited 1× · see citing works

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

Julien, C., Tremblay, C., Émond, V., Lebbadi, M., Salem, N., Bennett, D. A., & Calon, F. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181922348 · Cited by 467 · see citing works

Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14023834 · Cited by 457 · see citing works

How does calorie restriction work?Preprint

Koubova, J., & Guarente, L. (2003) · Genes & Development · doi:10.1101/gad.1052903 · Cited by 455 · see citing works

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

Wang, C., Chen, L., Hou, X., Li, Z., Kabra, N., Ma, Y., Nemoto, S., Finkel, T., Gu, W. J., Cress, W. D., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1468 · Cited by 447 · see citing works

Caloric restriction, SIRT1 and longevity

Cantó, C., & Auwerx, J. (2009) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.03.008 · Cited by 395 · see citing works

Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging

Yang, S.-R., Wright, J., Bauter, M., Seweryniak, K., Kode, A., & Rahman, I. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00308.2006 · Cited by 391 · see citing works

Selective Deletion ofBdnfin the Ventromedial and Dorsomedial Hypothalamus of Adult Mice Results in Hyperphagic Behavior and Obesity

Unger, T. J., Calderon, G. A., Bradley, L., Sena‐Esteves, M., & Rios, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3308-07.2007 · Cited by 370 · see citing works

SIRT1 and energy metabolism

Li, X. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms108 · Cited by 360 · see citing works

Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

Tanno, M., Kuno, A., Yano, T., Miura, T., Hisahara, S., Ishikawa, S., Shimamoto, K., & Horio, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090266 · Cited by 358 · see citing works

The ASK1-MAP Kinase Cascades in Mammalian Stress Response

Matsukawa, J. (2004) · Journal of Biochemistry · doi:10.1093/jb/mvh134 · Cited by 343 · see citing works

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

Liu, T. F., Vachharajani, V., Yoza, B. K., & McCall, C. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.362343 · Cited by 341 · see citing works

Caloric restriction attenuates Aβ-deposition in Alzheimer transgenic models

Patel, N. V., Gordon, M. N., Connor, K. E., Good, R. A., Engelman, R. W., Mason, J., Morgan, D. G., Morgan, T. E., & Finch, C. E. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.09.014 · Cited by 329 · see citing works

Sirtuins Link Inflammation and Metabolism

Vachharajani, V., Liu, T., Wang, X., Hoth, J. J., Yoza, B. K., & McCall, C. E. (2016) · Journal of Immunology Research · doi:10.1155/2016/8167273 · Cited by 326 · see citing works

Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice

Ramsey, K. M., Mills, K. F., Satoh, A., & Imai, S. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00355.x · Cited by 321 · see citing works

Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease

Mudó, G., Mäkelä, J., Liberto, V. D., Tselykh, T. V., Olivieri, M., Piepponen, P., Eriksson, O., Mälkiä, A., Bonomo, A., Kairisalo, M., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0850-z · Cited by 315 · see citing works

Sirtuin 1 in lipid metabolism and obesity

Schug, T. T., & Li, X. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.547211 · Cited by 292 · see citing works

Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats

Koltai, E., Szabo, Z., Atalay, M., Boldogh, I., Naito, H., Goto, S., Nyakas, C., & Radak, Z. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.11.002 · Cited by 283 · see citing works

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

Nasrin, N., Kaushik, V. K., Fortier, E., Wall, D., Pearson, K. J., de Cabo, R., & Bordone, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008414 · Cited by 271 · see citing works

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

Jęśko, H. M., Wencel, P. L., Strosznajder, R. P., & Strosznajder, J. B. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2110-y · Cited by 262 · see citing works

Negative regulation of inflammation by SIRT1

Xie, J., Zhang, X., & Zhang, L. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.010 · Cited by 240 · see citing works

Mechanisms Underlying Caloric Restriction and Lifespan Regulation

Ungvari, Z. I., Parrado‐Fernández, C., Csiszár, A., & de Cabo, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.168369 · Cited by 239 · see citing works

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus

Satoh, A., Brace, C. S., Ben-Josef, G., West, T., Wozniak, D. F., Holtzman, D. M., Herzog, E. D., & Imai, S.-I. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1385-10.2010 · Cited by 237 · see citing works

Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase–Dependent Cyclooxygenase-2 Expression in Macrophages

Yano, M., Matsumura, T., Senokuchi, T., Ishii, N., Murata, Y., Taketa, K., Motoshima, H., Taguchi, T., Sonoda, K., Kukidome, D., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000268411.49545.9c · Cited by 236 · see citing works

Sirtuin deacetylases in neurodegenerative diseases of aging

Herskovits, A. Z., & Guarente, L. (2013) · Cell Research · doi:10.1038/cr.2013.70 · Cited by 222 · see citing works

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

Bonda, D., Lee, H., Camins, A., Pallàs, M., Casadesús, G., Smith, M. A., & Zhu, X. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70013-8 · Cited by 221 · see citing works

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

Han, L., Zhou, R., Niu, J., McNutt, M. A., Wang, P., & Tong, T. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq609 · Cited by 218 · see citing works

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

Çakır, I., Perelló, M., Lansari, O., Messier, N. J., Vaslet, C. A., & Nillni, E. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008322 · Cited by 195 · see citing works

SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson’s disease

Singh, P., Hanson, P. S., & Morris, C. M. (2017) · BMC Neuroscience · doi:10.1186/s12868-017-0364-1 · Cited by 193 · see citing works

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

Matsuzaki, T., Matsushita, T., Takayama, K., Matsumoto, T., Nishida, K., Kuroda, R., & Kurosaka, M. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202620 · Cited by 175 · see citing works

MicroRNA-34a regulates the longevity-associated protein SIRT1 in coronary artery disease: effect of statins on SIRT1 and microRNA-34a expression

Tabuchi, T., Satoh, M., Itoh, T., & Nakamura, M. (2012) · Clinical Science · doi:10.1042/cs20110563 · Cited by 174 · see citing works

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

Mukhopadhyay, P., Horváth, B., Rajesh, M., Varga, Z. V., Gariani, K., Ryu, D., Cao, Z., Holovac, E., Park, O., Zhou, Z., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.10.023 · Cited by 168 · see citing works

Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD)

Campo, J. A. D., Gallego‐Durán, R., Gallego, P., & Grande, L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030911 · Cited by 146 · see citing works

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

Fujita, N., Matsushita, T., Ishida, K., Kubo, S., Matsumoto, T., Takayama, K., Kurosaka, M., & Kuroda, R. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21284 · Cited by 145 · see citing works

Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease

Lutz, M. I., Milenković, I., Regelsberger, G., & Kovács, G. G. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8288-8 · Cited by 131 · see citing works

Plasma levels of SIRT1 associate with non-alcoholic fatty liver disease in obese patients

Mariani, S., Fiore, D., Basciani, S., Persichetti, A., Contini, S., Lubrano, C., Salvatori, L., Lenzi, A., & Gnessi, L. (2014) · Endocrine · doi:10.1007/s12020-014-0465-x · Cited by 121 · see citing works

Intra‐articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF‐2α

Li, W., Cai, L., Zhang, Y., Cui, L., & Shen, G. (2015) · Journal of Orthopaedic Research® · doi:10.1002/jor.22859 · Cited by 117 · see citing works

Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women

Pedersen, S. B., Ølholm, J., Paulsen, S. K., Bennetzen, M., & Richelsen, B. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.78 · Cited by 117 · see citing works

SIRT 1 but not its increased expression is essential for lifespan extension in caloric‐restricted mice

Mercken, E. M., Hu, J. H., Krzysik-Walker, S. M., Wei, M., Li, Y., McBurney, M. W., de Cabo, R., & Longo, V. D. (2013) · Aging Cell · doi:10.1111/acel.12151 · Cited by 112 · see citing works

Modulation of SIRT1 expression in different neurodegenerative models and human pathologies

Pallàs, M., Pizarro, J. G., Cuesta, J., Crespo‐Biel, N., Alvira, D., Tajes, M., Yeste‐Velasco, M., Folch, J., Canudas, A. M., Sureda, F. X., et al. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.065 · Cited by 112 · see citing works

A Remarkable Age-Related Increase in SIRT1 Protein Expression against Oxidative Stress in Elderly: SIRT1 Gene Variants and Longevity in Human

Kılıç, Ü., Gök, Ö., Erenberk, U., Dündaröz, M. R., Torun, E., Küçükardalı, Y., Elibol, B., Uysal, Ö., & Dündar, T. T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117954 · Cited by 109 · see citing works

SIRT1 Transcription Is Decreased in Visceral Adipose Tissue of Morbidly Obese Patients with Severe Hepatic Steatosis

Costa, C. D. S., Hammes, T. O., Rohden, F., Margis, R., Bortolotto, J. W., Padoin, A. V., Mottin, C. C., & Guaragna, R. M. V. D. C. (2009) · Obesity Surgery · doi:10.1007/s11695-009-0052-z · Cited by 108 · see citing works

SIRT1 Gene Polymorphisms Affect the Protein Expression in Cardiovascular Diseases

Kılıç, Ü., Gök, Ö., Bacaksız, A., İzmirli, M., Elibol, B., & Uysal, Ö. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090428 · Cited by 101 · see citing works

Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer.

Olmos, Y., Brosens, J., & Lam, E. (2011) · Drug resistance updates · doi:10.1016/j.drup.2010.12.001 · Cited by 100 · see citing works

Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit

Wang, J., Gao, J., Chen, J., Li, F., & Tian, J. (2011) · Rheumatology International · doi:10.1007/s00296-010-1720-y · Cited by 97 · see citing works

SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease

Chan, S., Hung, C., Shih, J., Chu, P., Cheng, Y., Lin, H.-C., & Tsai, K. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.027 · Cited by 90 · see citing works

Epigenetic Switching by the Metabolism-sensing Factors in the Generation of Orexin Neurons from Mouse Embryonic Stem Cells

Hayakawa, K., Hirosawa, M., Tabei, Y., Arai, D., Tanaka, S., Murakami, N., Yagi, S., & Shiota, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.455899 · Cited by 84 · see citing works

Sirtuin 1 and Alzheimer's disease: An up-to-date review

Rizzi, L., & Roriz‐Cruz, M. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.07.001 · Cited by 83 · see citing works

Sirtuins in cognitive ageing and Alzheimer's disease

Braidy, N., Jayasena, T., Poljak, A., & Sachdev, P. S. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835112c1 · Cited by 79 · see citing works

Cellular stress response, sirtuins and UCP proteins in Alzheimer disease: role of vitagenes

Cornelius, C., Salinaro, A. T., Scuto, M. C., Fronte, V., Cambria, M. T., Pennisi, M., Bella, R., Milone, P., Graziano, A., Crupi, R., et al. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-41 · Cited by 73 · see citing works

Treating myocardial ischemia-reperfusion injury by targeting endothelial cell transcription

Boyle, E. M., Canty, T. G., Morgan, E. N., Yun, W., Pohlman, T. H., & Verrier, E. D. (1999) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)01033-4 · Cited by 62 · see citing works

Integration of β-Catenin, Sirtuin, and FOXO Signaling Protects from Mutant Huntingtin Toxicity

Parker, J. A., Vázquez‐Manrique, R. P., Tourette, C., Farina, F., Offner, N., Mukhopadhyay, A., Orfila, A.-M., Darbois, A., Menet, S., Tissenbaum, H. A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0277-12.2012 · Cited by 60 · see citing works

Simvastatin inhibits cysteine‐rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin‐1/FoxO3a signaling

Kok, S., Lin, L., Hou, K., Hong, C., Chang, C., Hsiao, M., Wang, J., Lai, E. H., & Lin, S. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37807 · Cited by 58 · see citing works

TNF-α inhibits PPARβ/δ activity and SIRT1 expression through NF-κB in human adipocytes

Serrano, L., Chacón, M. R., Maymó‐Masip, E., Barroso, E., Salvadó, L., Wabitsch, M., Garrido‐Sánchez, L., Tinahones, F. J., Palomer, X., Vendrell, J. J., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.05.006 · Cited by 55 · see citing works

A Review on SIRtuins in Diabetes

Aditya, R., Kiran, A. R., Varma, D. S., Vemuri, R., & Gundamaraju, R. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170125153334 · Cited by 50 · see citing works

Sirt1 alleviates LPS induced inflammation of periodontal ligament fibroblasts via downregulation of TLR4

Li, K., Lv, G., & Pan, L. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.099 · Cited by 49 · see citing works

Evidence supporting a mechanistic role of sirtuins in mood and metabolic disorders

Alageel, A., Tomasi, J., Tersigni, C., Brietzke, E., Zuckerman, H., Subramaniapillai, M., Lee, Y., Iacobucci, M., Rosenblat, J. D., Mansur, R. B., et al. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.05.017 · Cited by 45 · see citing works

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

Wencel, P. L., Lukiw, W. J., Strosznajder, J. B., & Strosznajder, R. P. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0646-8 · Cited by 43 · see citing works

NAD to the Rescue

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Intraperitoneal injection of the SIRT1 activator SRT1720 attenuates the progression of experimental osteoarthritis in mice

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Efficacy of statins on sirtuin 1 and endothelial nitric oxide synthase expression: the role of sirtuin 1 gene variants in human coronary atherosclerosis

Kılıç, Ü., Gök, Ö., Elibol, B., Uysal, Ö., & Bacaksız, A. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12362 · Cited by 38 · see citing works

SIRT1 is increased in affected brain regions and hypothalamic metabolic pathways are altered in Huntington disease

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Hypothalamic Dysfunction of the Thrombospondin Receptor α2δ-1 Underlies the Overeating and Obesity Triggered by Brain-Derived Neurotrophic Factor Deficiency

Cordeira, J., Felsted, J. A., Teillon, S., Daftary, S. S., Panessiti, M., Wirth, J. R., Sena‐Esteves, M., & Rios, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1572-13.2014 · Cited by 29 · see citing works

NF-κΒ Signaling in Neurite Growth and Neuronal Survival

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Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia

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Regulated expression of neuronal SIRT1 and related genes by aging and neuronal β2-containing nicotinic cholinergic receptors

Huang, P.-S., Son, J., Abbott, L. C., & Winzer‐Serhan, U. H. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.09.007 · Cited by 26 · see citing works

Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population

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Phosphorylated SIRT1 as a biomarker of relapse and response to treatment with glatiramer acetate in multiple sclerosis

Ciriello, J., Tatomir, A., Hewes, D., Boodhoo, D., Anselmo, F., Rus, V., & Rus, H. (2018) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2018.07.008 · Cited by 23 · see citing works

SIRT1 gene variants are related to risk of childhood obesity

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Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress

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The metabolic sensor Sirt1 and the hypothalamus: Interplay between peptide hormones and pro-hormone convertases

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Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice

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Spontaneous caloric restriction associated with increased leptin levels in obesity-resistant αMUPA mice

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Aging, melatonin, and the pro- and anti-inflammatory networks

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A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278 · see citing works

Metformin: Is it a drug for all reasons and diseases?

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The Effects of Resveratrol in the Treatment of Metabolic Syndrome

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Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics

Pokharel, M. D., Flores, A. G., Marciano, D. P., Franco, M. C., Fineman, J. R., Aggarwal, S., Wang, T., & Black, S. M. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103049 · Cited by 113 · see citing works

CD38: T Cell Immuno-Metabolic Modulator

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Hallmarks of aging-based dual-purpose disease and age-associated targets predicted using PandaOmics AI-powered discovery engine

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Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress

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Mitoprotective Effects of Centella asiatica (L.) Urb.: Anti-Inflammatory and Neuroprotective Opportunities in Neurodegenerative Disease

Wong, J. H., Barron, A. M., & Abdullah, J. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.687935 · Cited by 79 · see citing works

The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective

Thapa, R., Moglad, E. H. O., Afzal, M., Gupta, G., Bhat, A. A., Almalki, W. H., Kazmi, I. A., Alzarea, S. I., Pant, K., Singh, T. G., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102545 · Cited by 84 · see citing works

Effects of Time-Restricted Feeding and Ramadan Fasting on Body Weight, Body Composition, Glucose Responses, and Insulin Resistance: A Systematic Review of Randomized Controlled Trials

Tsitsou, S., Zacharodimos, N., Poulia, K., Karatzi, K., Dimitriadis, G., & Papakonstantinou, E. (2022) · Nutrients · doi:10.3390/nu14224778 · Cited by 63 · see citing works

Role of the AMPK/SIRT1 pathway in non‑alcoholic fatty liver disease (Review)

Anggreini, P., Kuncoro, H., Sumiwi, S. A., & Levita, J. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12922 · Cited by 59 · see citing works

A Molecular Perspective on Sirtuin Activity

Teixeira, C. S. S., Cerqueira, N. M. F. S. A., Gomes, P., & Sousa, S. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228609 · Cited by 56 · see citing works

Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease

Tovar‐Palacio, C., Noriega, L. G., & Mercado, A. (2022) · Nutrients · doi:10.3390/nu14030653 · Cited by 51 · see citing works

A Comprehensive Study on the Anti-cancer Effects of Quercetin and Its Epigenetic Modifications in Arresting Progression of Colon Cancer Cell Proliferation

Bhatiya, M., Pathak, S., Jothimani, G., Duttaroy, A. K., & Banerjee, A. (2023) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-023-00669-w · Cited by 51 · see citing works

Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome

Okur, M. N., Mao, B., Kimura, R., Haraczy, S. J., Fitzgerald, T. S., Edwards‐Hollingsworth, K., Tian, J. Y., Osmani, W. A., Croteau, D. L., Kelley, M. W., et al. (2020) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-019-0040-z · Cited by 51 · see citing works

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Jiang, Y.-Z., Yan, F., Feng, Z., Lazarovici, P., & Zheng, W. (2019) · Cells · doi:10.3390/cells9010100 · Cited by 49 · see citing works

Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals

Eddin, L. B., Meeran, M. F. N., Jha, N. K., Goyal, S. N., & Ojha, S. K. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12496 · Cited by 45 · see citing works

Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice

Kwon, J., Kim, B., Lee, C., Joung, H., Kim, B.-K., Choi, I. S., & Hyun, C. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228932 · Cited by 39 · see citing works

Protective potential of naringenin and its nanoformulations in redox mechanisms of injury and disease

Mehranfard, N., Ghasemi, M., Rajabian, A., & Ansari, L. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22820 · Cited by 37 · see citing works

Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins.

Meng, J., Liu, Y.-C., Xie, Z., Qing, H., Lei, P., & Ni, J. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.09.001 · Cited by 34 · see citing works

SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin

Caruso, G. I., Spampinato, S. F., Costantino, G., Merlo, S., & Sortino, M. A. (2021) · Biomedicines · doi:10.3390/biomedicines9050466 · Cited by 34 · see citing works

Renoprotective Effect of Pediococcus acidilactici GKA4 on Cisplatin-Induced Acute Kidney Injury by Mitigating Inflammation and Oxidative Stress and Regulating the MAPK, AMPK/SIRT1/NF-κB, and PI3K/AKT Pathways

Lin, W., Jiang, W., Chen, C., Lee, L., Tsai, Y., Chien, L.-H., Chou, Y.-N., Deng, J., & Huang, G. (2022) · Nutrients · doi:10.3390/nu14142877 · Cited by 33 · see citing works

Astaxanthin Ameliorates high-fat diet-induced cardiac damage and fibrosis by upregulating and activating SIRT1

Shatoor, A. S., & Humayed, S. A. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.07.079 · Cited by 32 · see citing works

From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1

Law, M., Wang, P., Zhou, Z.-Y., & Wang, Y. (2024) · Pharmaceuticals · doi:10.3390/ph17111495 · Cited by 30 · see citing works

Interaction between resveratrol and SIRT1: role in neurodegenerative diseases

Zhu, L., Yang, M., Fan, L., Yan, Q., Zhang, L., Mu, P., & Lu, F. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03319-w · Cited by 31 · see citing works

Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis

Sahm, A., Platzer, M., Koch, P., Henning, Y., Bens, M., Groth, M., Burda, H., Begall, S., Ting, S., Goetz, M., et al. (2021) · eLife · doi:10.7554/elife.57843 · Cited by 23 · see citing works

Citicoline and COVID-19-Related Cognitive and Other Neurologic Complications

Turana, Y., Nathaniel, M., Shen, R., Ali, S., & Aparasu, R. R. (2021) · Brain Sciences · doi:10.3390/brainsci12010059 · Cited by 33 · see citing works

Cognitive decline in heart failure: Biomolecular mechanisms and benefits of exercise

Maroofi, A., Moro, T., Agrimi, J., & Safari, F. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166511 · Cited by 30 · see citing works

Citrus Flavanones Upregulate Thyrotroph Sirt1 and Differently Affect Thyroid Nrf2 Expressions in Old-Aged Wistar Rats

Miler, M., Živanović, J., Ajdžanović, V. Z., Milenković, D., Jarić, I., Šošić‐Jurjević, B., & Milošević, V. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03079 · Cited by 28 · see citing works

Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: Role of SIRT-1 / adipokines / PPARγ and IGF-1

Shamardl, H. A., Ibrahim, N. A., Merzeban, D. H., Elamir, A. M., Golam, R. M., & Elsayed, A. M. (2023) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-023-00458-y · Cited by 27 · see citing works

Transcriptional and epigenetic effects of Vitis vinifera L. leaf extract on UV-stressed human dermal fibroblasts

Letsiou, S., Kapazoglou, A., Tsaftaris, A. S., Spanidi, E., & Gardikis, Κ. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05645-7 · Cited by 26 · see citing works

Pterostilbene ameliorates type-2 diabetes mellitus – Induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain

Patil, R., Aswar, U. M., & Vyas, N. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148494 · Cited by 25 · see citing works

Sirtuin 1 Mediates Protection Against Delayed Cerebral Ischemia in Subarachnoid Hemorrhage in Response to Hypoxic Postconditioning

Diwan, D., Vellimana, A. K., Aum, D. J., Clarke, J. V., Nelson, J. W., Lawrence, M., Han, B. H., Gidday, J. M., & Zipfel, G. J. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.021113 · Cited by 24 · see citing works

Multi-Systemic Alterations by Chronic Exposure to a Low Dose of Bisphenol A in Drinking Water: Effects on Inflammation and NAD+-Dependent Deacetylase Sirtuin1 in Lactating and Weaned Rats

Santoro, A., Scafuro, M., Troisi, J., Piegari, G., Pietro, P. D., Mele, E., Cappetta, D., Marino, M., Angelis, A. D., Vecchione, C., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189666 · Cited by 23 · see citing works

Specific epigenetic regulators serve as potential therapeutic targets in idiopathic pulmonary fibrosis

Sehgal, M., Jakhete, S. M., Manekar, A. G., & Sasikumar, S. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09773 · Cited by 23 · see citing works

Effect of bovine oocyte vitrification with EGTA and post-warming recovery with resveratrol on meiotic spindle, mitochondrial function, reactive oxygen species, and developmental competence

Gutierrez, E. J., Diaz, F., Talbot, S. A., & Bondioli, K. R. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.11.006 · Cited by 23 · see citing works

Terpenoids of Ganoderma lucidum reverse cognitive impairment through attenuating neurodegeneration via suppression of PI3K/AKT/mTOR expression in vivo model

Wang, A., Xiao, C., Zheng, J., Ye, C., Dai, Z., Wu, Q., Liu, J., Strappe, P., & Zhou, Z. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104142 · Cited by 23 · see citing works

Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor

Affortit, C., Casas, F., Ladrech, S., Ceccato, J., Bourien, J., Coyat, C., Puel, J., Lenoir, M., & Wang, J. (2021) · BMC Biology · doi:10.1186/s12915-021-00953-1 · Cited by 22 · see citing works

Oxidative Stress Induced by High Salt Diet—Possible Implications for Development and Clinical Manifestation of Cutaneous Inflammation and Endothelial Dysfunction in Psoriasis vulgaris

Krajina, I., Stupin, A., Šola, M., & Mihalj, M. (2022) · Antioxidants · doi:10.3390/antiox11071269 · Cited by 25 · see citing works

SIRT1 activation by resveratrol reverses atrophy of apical dendrites of hippocampal CA1 pyramidal neurons and neurobehavioral impairments in moderate grade hepatic encephalopathy rats

Khanna, A., Anamika, A., Chakraborty, S., Tripathi, S. J., Acharjee, A., Bs, S. R., & Trigun, S. K. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101797 · Cited by 22 · see citing works

Repurposing Metformin for Vascular Disease

Triggle, C. R., Marei, I., Ye, K., Ding, H., Anderson, T. J., Hollenberg, M. D., & Hill, M. A. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220729154615 · Cited by 22 · see citing works

The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease

Ghafouri‐Fard, S., Khoshbakht, T., Hussen, B. M., Taheri, M. N., Ebrahimzadeh, K., & Noroozi, R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.987174 · Cited by 22 · see citing works

Insights into the Therapeutic and Pharmacological Properties of Resveratrol as a Nutraceutical Antioxidant Polyphenol in Health Promotion and Disease Prevention

Mohammadi, S., Moghadam, M. D., Nasiriasl, M., Akhzari, M., & Barazesh, M. (2024) · Current Clinical Pharmacology · doi:10.2174/0127724328268507231218051058 · Cited by 22 · see citing works

Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD)

Çiçek, A. U., Işık, C. M., Bakır, S., Özbek, D. Ü., Sarı, S. A., Bakır, D., & Cam, S. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02231-w · Cited by 19 · see citing works

Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence

Rodríguez, S., Bermúdez, L. G., González, D. M., Bernal, C., Cañas, A., Morales‐Ruíz, T., Henríquez, B., & Rojas, A. P. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12861 · Cited by 19 · see citing works

Melatonin Improves Skeletal Muscle Structure and Oxidative Phenotype by Regulating Mitochondrial Dynamics and Autophagy in Zücker Diabetic Fatty Rat

Salagre, D., Álvarez, E. R., Cendán, C. M., Aouichat, S., & Agil, A. (2023) · Antioxidants · doi:10.3390/antiox12081499 · Cited by 18 · see citing works

Effects of resveratrol on biochemical and structural outcomes in osteoarthritis: A systematic review and meta-analysis of preclinical studies

Zhao, W., Zhu, Y., Wong, S. K., Muhammad, N., Pang, K.-L., & Chin, K. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34064 · Cited by 17 · see citing works

Role of the p53/miR-34a/SIRT1 Feedback Loop in Metformin-induced Radiosensitivity of Colorectal Cancer Cells

Bahadoran, E., Zafari, Y., Homaei, A., Jalilvand, M., & Moghbelinejad, S. (2025) · Current Radiopharmaceuticals · doi:10.2174/0118744710331660250127115004 · Cited by 17 · see citing works

A Review of the Potential Effects of Melatonin in Compromised Mitochondrial Redox Activities in Elderly Patients With COVID-19

Su, W., Wu, C., Wu, S. V., Lee, M., Liao, M.-T., Lu, K., & Lu, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.865321 · Cited by 17 · see citing works

Neuroprotective Properties of Bis-Sulfonamide Derivatives Against 6-OHDA-Induced Parkinson's Model via Sirtuin 1 Activity and in silico Pharmacokinetic Properties

Apiraksattayakul, S., Pingaew, R., Prachayasittikul, V., Ruankham, W., Jongwachirachai, P., Songtawee, N., Suwanjang, W., Tantimongcolwat, T., Prachayasittikul, S., Prachayasittikul, V., et al. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.890838 · Cited by 17 · see citing works

The Effects of Vitamin Therapy on ASD and ADHD: A Narrative Review

Olangian‐Tehrani, S., Poudineh, M., Parvin, S., Omidali, M., Nikzad, F., Mohammadyari, F., Ranjbar, F. S. P., Rasouli, F., & Nanbakhsh, S. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220517205813 · Cited by 18 · see citing works

Hepatic PPARα Is Destabilized by SIRT1 Deacetylase in Undernourished Male Mice

Suh, J. H., Kim, K. H., Conner, M. E., Moore, D. D., & Preidis, G. A. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.831879 · Cited by 16 · see citing works

Modulation of Sirtuins to address aging related disorders through the use of selected phytochemicals

Wang, J., Ren, Y., & Qu, S. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156648 · Cited by 15 · see citing works

Enhanced Therapeutic Efficacy of Omeprazole Nanosuspension in Ethanol-Induced Gastric Ulcer: A Focus on Oxidative Stress and Inflammatory Pathways

Albalawi, M., & Khateeb, S. (2025) · Biomolecules · doi:10.3390/biom15060902 · Cited by 16 · see citing works

Parkinson’s Disease: Is there a Role for Dietary and Herbal Supplements?

Onaolapo, O. J., Odeniyi, A. O., & Onaolapo, A. Y. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210218082954 · Cited by 15 · see citing works

MicroRNAs in Age-Related Proteostasis and Stress Responses

Matai, L., & Slack, F. J. (2023) · Non-Coding RNA · doi:10.3390/ncrna9020026 · Cited by 15 · see citing works

Maternal stressors disrupt mouse placental proteome and fetal brain development in a sex-specific fashion through inflammation and oxidative stress

Musillo, C., Ajmone‐Cat, M. A., Simone, R. D., Tassinari, R., Maranghi, F., Tait, S., Samà, M., Giona, L., Pieroni, E. M., Alessi, R., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03090-1 · Cited by 14 · see citing works

MiR-217 Regulates SIRT1 Expression and Promotes Inflammatory and Apoptotic Responses in Osteoarthritis

Papageorgiou, A.-A., Roussos, A., Papathanasiou, I. V., Balis, C., Karachalios, T. S., Varitimidis, S. E., Malizos, Κ. Ν., & Tsezou, A. (2023) · Genes · doi:10.3390/genes14122155 · Cited by 14 · see citing works

Calorie restriction and breast cancer treatment: a mini-review

Isaac-Lam, M. F., & DeMichael, K. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02226-y · Cited by 15 · see citing works

NKT-like (CD3 + CD56+) cells differ from T cells in expression level of cellular protective proteins and sensitivity to stimulation in the process of ageing

Kaszubowska, L., Foerster, J., & Kmieć, Z. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00274-z · Cited by 13 · see citing works

ALTERED LEVELS OF H3K9AC, H3K4ME3, AND H3K27ME3 IN PROMOTERS OF DIFFERENTIALLY EXPRESSED GENES RELATED TO INNATE IMMUNE RESPONSE IN SEPTIC PATIENTS WITH DIFFERENT CLINICAL OUTCOMES

Holanda, R. D. B. F., Leite, G. G. F., Brunialti, M. K. C., Jasiulionis, M. G., & Salomão, R. (2023) · Shock · doi:10.1097/shk.0000000000002131 · Cited by 12 · see citing works

Cordycepin, a bioactive compound from Cordyceps spp ., moderates Alzheimer’s disease-associated pathology via anti-oxidative stress and autophagy activation

Sorraksa, N., Heebkaew, N., Promjantuek, W., Kunhorm, P., Kaokean, P., Chaicharoenaudomung, N., & Noisa, P. (2023) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2023.2258797 · Cited by 13 · see citing works

Effects of oleoylethanolamide supplementation on the expression of lipid metabolism-related genes and serum NRG4 levels in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Tutunchi, H., Ebrahimi‐Mameghani, M., Hosseinzadeh‐Attar, M. J., Roshanravan, N., Mobasseri, M., Najafipour, F., Naeini, F., Naghshi, S., Asghari, S., Akbarzadeh, M., et al. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.10.013 · Cited by 12 · see citing works

In diabetic male Wistar rats, quercetin-conjugated superparamagnetic iron oxide nanoparticles have an effect on the SIRT1/p66Shc-mediated pathway related to cognitive impairment

Chamgordani, M. K., Bardestani, A., Ebrahimpour, S., & Esmaeili, A. (2023) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-023-00725-3 · Cited by 12 · see citing works

Sirtuin 1 regulates the phenotype and functions of dendritic cells through Ido1 pathway in obesity

de Lima, J., Leite, J. A., Basso, P. J., Ghirotto, B., da Silva, E. M., Menezes-Silva, L., Hiyane, M. I., Goes, C. P., Coutinho, L. L., Andrade‐Oliveira, V., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07125-3 · Cited by 13 · see citing works

SIRT1 rs7896005 polymorphism affects major vascular outcomes, not all‐cause mortality, in Caucasians with type 2 diabetes: A 13‐year observational study

Dardano, A., Lucchesi, D., Garofolo, M., Gualdani, E., Falcetta, P., Sancho, V., Francesconi, P., Prato, S. D., & Penno, G. (2022) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3523 · Cited by 12 · see citing works

Melatonin Activates Anti-Inflammatory Features in Microglia in a Multicellular Context: Evidence from Organotypic Brain Slices and HMC3 Cells

Merlo, S., Caruso, G. I., Korde, D. S., Khodorovska, A. A., Humpel, C., & Sortino, M. A. (2023) · Biomolecules · doi:10.3390/biom13020373 · Cited by 11 · see citing works

Enhanced upregulation of SIRT1 via pioglitazone and ligustrazine confers protection against ethanol-induced gastric ulcer in rats

Mahmoud, S. A., Elkhoely, A. A., El-Sayed, E. K., & Ahmed, A. A. E. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03026-6 · Cited by 11 · see citing works

DNA methylation regulates Sirtuin 1 expression in osteoarthritic chondrocytes

Papageorgiou, A.-A., Litsaki, M., Mourmoura, E., Papathanasiou, I. V., & Tsezou, A. (2023) · Advances in Medical Sciences · doi:10.1016/j.advms.2023.02.002 · Cited by 11 · see citing works

Reversing Uteropathies Including Cancer-Like Changes in Mice by Transplanting Mesenchymal Stromal Cells or XAR Treatment

Singh, P., Metkari, S., Tripathi, A., & Bhartiya, D. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10632-z · Cited by 10 · see citing works

Aging, Age-Related Diseases, and the Zebrafish Model

Abou-Dahech, M. S., & Williams, F. E. (2024) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad1010004 · Cited by 11 · see citing works

Allogeneic platelet lysate activates the SIRT1-PINK1/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration

Ding, Z., Du, W., Huang, J., Han, J., Bai, J., Yang, G., Zhang, Y., & Ding, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113700 · Cited by 10 · see citing works

Harnessing SIRT1 activators for effective PCOS treatment: A new frontier

Moharir, S. R., Talamadla, M. K., Bhardwaj, P., Banerjee, A., Dey, R. J., & Sekhar, K. V. G. C. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118361 · Cited by 11 · see citing works

The COVID-19-diabetes mellitus molecular tetrahedron

Mahmudpour, M., Vahdat, K., Keshavarz, M., & Nabipour, I. (2022) · Molecular Biology Reports · doi:10.1007/s11033-021-07109-y · Cited by 10 · see citing works

Increased SIRT1 Concentration Following Four Years of Selenium and Q10 Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial

Opstad, T. B., Alexander, J., Aaseth, J., Larsson, A. O., Seljeflot, I., & Alehagen, U. (2023) · Antioxidants · doi:10.3390/antiox12030759 · Cited by 11 · see citing works

Urinary phenotyping of SARS-CoV-2 infection connects clinical diagnostics with metabolomics and uncovers impaired NAD+ pathway and SIRT1 activation

Lonati, C., Berezhnoy, G., Lawler, N. G., Masuda, R., Kulkarni, A., Sala, S., Nitschke, P., Zizmare, L., Bucci, D., Cannet, C., et al. (2023) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2023-1017 · Cited by 10 · see citing works

Chitooligosaccharide-epigallocatechin gallate conjugate ameliorates lipid accumulation and promotes browning of white adipose tissue in high fat diet fed rats

Tonphu, K., Mueangaun, S., Lerkdumnernkit, N., Sengking, J., Tocharus, J., Benjakul, S., Mittal, A., & Tocharus, C. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111316 · Cited by 9 · see citing works

Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation

Swiatlowska, P., & Iskratsch, T. (2023) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-022-07422-z · Cited by 9 · see citing works

SIRT1 gene polymorphisms are associated with nondiabetic type 1 cardiorenal syndrome

Hou, J., Xie, X., Tu, Q., Li, J., Ding, J., Shao, G., Jiang, Q., Yuan, L., & Lai, X. (2019) · Annals of Human Genetics · doi:10.1111/ahg.12338 · Cited by 9 · see citing works

Sirtuins in Central Nervous System Tumors—Molecular Mechanisms and Therapeutic Targeting

Nowacka, A., Śniegocka, M., Śniegocki, M., & Ziółkowska, E. (2025) · Cells · doi:10.3390/cells14141113 · Cited by 8 · see citing works

Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis

Pai, P., Wong, J. K. S., Cui, Z.-Y., Lin, Y.-Y., & Lee, S. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9080266 · Cited by 8 · see citing works

Perindopril Ameliorates Sodium Valproate-Induced Rat Model of Autism: Involvement of Sirtuin-1, JAK2/STAT3 Axis, PI3K/Akt/GSK-3β Pathway, and PPAR-Gamma Signaling

Alnakhli, A. M., Saleh, A., Kabel, A. M., Estfanous, R. S., Borg, H. M., Alsufyani, K. M., Sabry, N. M., Gomaa, F. A. M., & Elmaaboud, M. A. A. (2024) · Medicina · doi:10.3390/medicina60111802 · Cited by 8 · see citing works

Gongjin-Dan Enhances Neurite Outgrowth of Cortical Neuron by Ameliorating H2O2-Induced Oxidative Damage via Sirtuin1 Signaling Pathway

Kim, H., Jeon, W., Hong, J., Lee, J., Yeo, C., Lee, Y. J., Baek, S. H., & Ha, I. (2021) · Nutrients · doi:10.3390/nu13124290 · Cited by 8 · see citing works

Computational Studies of Thiourea Derivatives as Anticancer Candidates through Inhibition of Sirtuin-1 (SIRT1)

Ruswanto, R., Mardianingrum, R., & Yanuar, A. (2022) · Jurnal Kimia Sains dan Aplikasi · doi:10.14710/jksa.25.3.87-96 · Cited by 7 · see citing works

FA-HA-Amygdalin@Fe2O3 and/or γ-Rays Affecting SIRT1 Regulation of YAP/TAZ-p53 Signaling and Modulates Tumorigenicity of MDA-MB231 or MCF-7 Cancer Cells

Abdel-Rafei, M. K., Azab, K. S., El-Sayyad, G. S., Askar, M. A., Elkodous, M. A., Fatih, N. M. E., Tawill, G. E., & Thabet, N. M. (2022) · Current Cancer Drug Targets · doi:10.2174/1568009622666220816123508 · Cited by 7 · see citing works

Diverse and Composite Roles of miRNA in Non-Neuronal Cells and Neuronal Synapses in Alzheimer’s Disease

Li, X., Chen, S., & Ip, J. P. K. (2022) · Biomolecules · doi:10.3390/biom12101505 · Cited by 7 · see citing works

Pancreatic β-Cell Apoptosis in Normoglycemic Rats is Due to Mitochondrial Translocation of p53-Induced by the Consumption of Sugar-Sweetened Beverages

Barzalobre-Geronimo, R., Contreras‐Ramos, A., Cervantes-Cruz, A. I., Cruz, M., Suárez‐Sánchez, F., Gómez-Zamudio, J. H., Díaz-Rosas, G., Ávalos‐Rodríguez, A., Díaz-Flores, M., & Ortega‐Camarillo, C. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01147-y · Cited by 6 · see citing works

Mito-TEMPO Mitigates Fibromyalgia Induced by Reserpine in Rats: Orchestration Between SIRT1, Mitochondrial Dynamics, Endoplasmic Reticulum and miRNA-320

Zaky, H. S., El-Said, N. T., Aboutaleb, A. S., Allam, A., Mansour, M., Ahmed, H. I., & Abdel-Sattar, S. A. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04424-9 · Cited by 6 · see citing works

Hepatoprotective Potential of Green Synthesized Nanoparticles from Citrus reticulata Peel Extract against HFS Diet-Induced NASH in Mice, Integrated with Chemical Profiling and Molecular Modeling

Elhady, S. S., Wahba, A. S., Ibrahim, A. K., El-Sayyad, G. S., El-Batal, A. I., Wahba, N. S., Nafie, M. S., Ahmed, S. A., Ibrahim, A. K., Badr, J. M., et al. (2025) · ACS Omega · doi:10.1021/acsomega.5c03992 · Cited by 6 · see citing works

The Value of Myocardium and Kidney Histopathological and Immunohistochemical Findings in Accidental Hypothermia-Related Fatalities

Hleșcu, A. A., Grigoraş, A., Covatariu, G., Moscalu, M., & Amălinei, C. (2022) · Medicina · doi:10.3390/medicina58111507 · Cited by 6 · see citing works

Aminochalcones Attenuate Neuronal Cell Death under Oxidative Damage via Sirtuin 1 Activity

Apiraksattayakul, S., Pingaew, R., Leechaisit, R., Prachayasittikul, V., Ruankham, W., Songtawee, N., Tantimongcolwat, T., Ruchirawat, S., Prachayasittikul, V., Prachayasittikul, S., et al. (2023) · ACS Omega · doi:10.1021/acsomega.3c03047 · Cited by 6 · see citing works

Role of sirtuins in attenuating plaque vulnerability in atherosclerosis

Velpuri, P., Rai, V., & Agrawal, D. K. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04714-2 · Cited by 6 · see citing works

Urinary exosomal metabolites: Overlooked clue for predicting cardiovascular risk

Yalameha, B., & Nejabati, H. R. (2023) · Clinica Chimica Acta · doi:10.1016/j.cca.2023.117445 · Cited by 6 · see citing works

Intracranial self-stimulation reverses impaired spatial learning and regulates serum microRNA levels in a streptozotocin-induced rat model of Alzheimer disease

Riberas‐Sánchez, A., Puig-Parnau, I., Vila-Solés, L., García‐Brito, S., Aldavert-Vera, L., Segura-Torres, P., Huguet, G., & Kádár, E. (2024) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.230066 · Cited by 6 · see citing works

Changes in circulating sirtuin 1 after bariatric surgery

Opstad, T. B., Farup, P. G., Rootwelt, H., & Aaseth, J. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.09.009 · Cited by 6 · see citing works

Piceatannol attenuates chronic unpredictable stress-induced neurobehavioral deficits in mice via SIRT1-mediated modulation of neuroinflammation, oxidative stress, and neurotransmitter imbalance

Kaur, P., Sharma, O., Grewal, A. K., Kumar, A., Khan, H., Singh, V., Singh, T., Silakari, P., Singh, T. G., Ahmad, S. F., et al. (2025) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2025.578682 · Cited by 5 · see citing works

Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic liver disease and steatohepatitis

Canová, N. K., Šípková, J., Arora, M., Pavlíková, Z., Kučera, T., Šeda, O., Šopin, T., Vacı́k, T., & Slanař, O. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1476994 · Cited by 5 · see citing works

Evaluation of Sirtuin 1 Levels in Peripheral Blood Mononuclear Cells of Patients With Idiopathic Pulmonary Fibrosis

Deskata, K., Malli, F., JAGIRDAR, R. M., Vavougios, G. D., Zarogiannis, S. G., Gourgoulianis, K. I., & Daniil, Z. D. (2022) · Cureus · doi:10.7759/cureus.30862 · Cited by 5 · see citing works

The Role of Epigenetic Regulator SIRT1 in Balancing the Homeostasis and Preventing the Formation of Specific “Soil” of Metabolic Disorders and Related Cancers

Németh, Z., Kiss, É., & Takács, I. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2709253 · Cited by 12 · see citing works

Silent information regulator, Sirtuin 1, and age‐related diseases

Zeng, L., Chen, R., Liang, F.-X., Tsuchiya, H., Murai, H., Nakahashi, T., Iwai, K., Takahashi, T., Kanda, T., & Morimoto, S. (2009) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2008.00504.x · Cited by 70 · see citing works

A Healthy Balance of Homeostasis by Epigenetic Regulator SIRT1 May Prevent the Development of a Specific "Soil" that Supports Metabolic Disorders and Related Cancers

Németh, Z., Kiss, E., & Takács, I. (2022) · Book Publisher International (a part of SCIENCEDOMAIN International) · doi:10.9734/bpi/codhr/v4/3433a · Cited by 3 · see citing works

SIRT1 Regulation in Ageing and Obesity

Pardo, P. S., & Boriek, A. M. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111249 · Cited by 90 · see citing works

Sirtuins and Aging

Pukhalskaia, A. E., Kvetnoy, I. M., Linkova, N. S., Diatlova, A., Gutop, E. O., Kozlov, K. L., & Paltsev, M. A. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01379-8 · Cited by 3 · see citing works