The DOI matches its Crossref record; 180 of the 182 references it cites were found in a registry or an index.
Re-print of “Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host”
Open accessAbstract
Alimentary and endogenous proteins are mixed in the small intestinal lumen with the microbiota. Although experimental evidences suggest that the intestinal microbiota is able to incorporate and degrade some of the available amino acids, it appears that the microbiota is also able to synthesize amino acids raising the view that amino acid exchange between the microbiota and host can proceed in both directions. Although the net result of such exchanges remains to be determined, it is likely that a significant part of the amino acids recovered from the alimentary proteins are used by the microbiota. In the large intestine, where the density of bacteria is much higher than in the small intestine and the transit time much longer, the residual undigested luminal proteins and peptides can be degraded in amino acids by the microbiota. These amino acids cannot be absorbed to a significant extent by the colonic epithelium, but are precursors for the synthesis of numerous metabolic end products in reactions made by the microbiota. Among these products, some like short-chain fatty acids and organic acids are energy substrates for the colonic mucosa and several peripheral tissues while others like sulfide and ammonia can affect the energy metabolism of colonic epithelial cells. More work is needed to clarify the overall effects of the intestinal microbiota on nitrogenous compound metabolism and consequences on gut and more generally host health.
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In the citing paper
“Moreover, in the large intestine, the gut microbiota can also break down proteins to use as nitrogen sources to support their growth [17].”
From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [17]
In the citing paper
“Some taxa within the intestinal microbiota possess the enzymatic capacity (i.e., proteases) to degrade dietary protein (e.g., Bacteroides, Clostridium, Fusobacterium, Streptococcus), which could play especially important roles in protein-rich, low-fiber diets, in which microbial energy harvest shifts from carbohydrate to protein sources (373, 374).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [374]
Citations
Cites
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Review article: the role of butyrate on colonic function
HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03562.x · Cited by 2,721
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677
Regulation of short-chain fatty acid production
Macfarlane, S., & Macfarlane, G. T. (2003) · Proceedings of the Nutrition Society · doi:10.1079/pns2002207 · Cited by 1,939
Antibiotic growth promoters in agriculture: history and mode of action
Dibner, J. J., & Richards, J. D. (2005) · Poultry Science · doi:10.1093/ps/84.4.634 · Cited by 1,436
Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome
Abubucker, S., Segata, N., Goll, J. B., Schubert, A. M., Izard, J., Cantarel, B. L., Rodriguez-Mueller, B., Zucker, J., Thiagarajan, M., Henrissat, B., et al. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002358 · Cited by 1,076
Toxicology Of Hydrogen Sulfide
Reiffenstein, R. J., Hulbert, W. C., & Roth, S. (1992) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.32.040192.000545 · Cited by 971
Bacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970
Tabor, C. W., & Tabor, H. (1985) · Microbiological Reviews · doi:10.1128/mr.49.1.81-99.1985 · Cited by 907
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2 of the 182 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Dai, 2012, Regulatory role for l-arginine in the utilization of amino acids by pig small-intestinal bacteria, Amino Acids, 43, 233, 10.1007/s00726-011-1067-z · DOI
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Mohanan, A., Harilal, S. L., Plakkot, B., Pottakkat, B., & Kanakkaparambil, R. (2024) · Epigenetics and human health · doi:10.1007/978-3-031-54215-2_7 · Cited by 1
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Özcan, E., Levantovsky, R. M., & Sela, D. A. (2018) · Wiley eBooks · doi:10.1002/9781118823309.ch4 · Cited by 1
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Behr, C. (2019) · doi:10.18174/463891 · Cited by 1
Lei, Q., Cheng, Z., Huang, Y., Li, X., Datsomor, O., Jiang, M., Wang, K., Ma, Q., Gong, X., Huo, Y., et al. (2023) · Preprints.org · doi:10.20944/preprints202310.1357.v1
The Future of Prebiotics and Probiotics
Brunser, O., Bravo, J., & Gotteland, M. (2013) · CRC Press eBooks · doi:10.1201/b15561-24
Self-citationMulti-Omic Predictors of Steatohepatitis and Advanced Fibrosis in ChildrenPreprint
Kordy, K., Li, F., Lee, D. J., Kinchen, J. M., Jew, M., Rocque, M. E. L., Martínez, S., Zabih, S., Saavedra, M., Woodward, C. L., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3299431
Zhang, L., & Piao, X. (2021) · Research Square · doi:10.21203/rs.3.rs-143525/v1
An Industrial Diligence of Behooveful Soil Microorganisms
Mane, S. S., Khaire, P. B., & Pawar, S. V. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815039955122010006
A-Ani, Z. S. M. (2023) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs2023173271
Kim, K. H., & Park, B. K. (2023) · Indian Journal of Animal Research · doi:10.18805/ijar.bf-1653
Jiang, Q., Lin, L., Xie, F., Jin, W., Zhu, W., Wang, M., Qiu, Q., Li, Z., Liu, J., & Mao, S. (2022) · Figshare · doi:10.6084/m9.figshare.20356425
Jiang, Q., Lin, L., Xie, F., Jin, W., Zhu, W., Wang, M., Qiu, Q., Li, Z., Liu, J., & Mao, S. (2022) · Figshare · doi:10.6084/m9.figshare.20356419
Jiang, Q., Lin, L., Xie, F., Jin, W., Zhu, W., Wang, M., Qiu, Q., Li, Z., Liu, J., & Mao, S. (2022) · Figshare · doi:10.6084/m9.figshare.20356416
Jiang, Q., Lin, L., Xie, F., Jin, W., Zhu, W., Wang, M., Qiu, Q., Li, Z., Liu, J., & Mao, S. (2022) · Figshare · doi:10.6084/m9.figshare.20356422
Nagafusa, H., Shinmura, S., Kamiya, F., Hosokawa, M., Shigemura, Y., Nimura, K., & Sayama, K. (2024) · ACS Food Science & Technology · doi:10.1021/acsfoodscitech.4c00459
Wang, H., Li, Y., You, J., Feng, N., Wang, D., Su, Y., & Feng, X. (2025) · Animal Microbiome · doi:10.1186/s42523-025-00393-0
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Jiang, Q., Lin, L., Xie, F., Jin, W., Zhu, W., Wang, M., Qiu, Q., Li, Z., Liu, J., & Mao, S. (2022) · Figshare · doi:10.6084/m9.figshare.20356413
Quinger, F., Klein, N., Camarinha-Silva, A., Seifert, J., & Rodehutscord, M. (2026) · Archives of Animal Nutrition · doi:10.1080/1745039x.2025.2606085
Cho, S., Vasquez, R., Sampath, V., Song, J. H., Lee, J. S., Cai, D., Kang, D., & Kim, I. H. (2026) · Frontiers in Animal Science · doi:10.3389/fanim.2026.1719430
Microbiote intestinal, cancer du sein et métabolisme lipidique
Luu, T. H. (2018) · theses.fr (ABES) · doi:10.70675/5a95efcbzc6e9z41b8z84a5z058eda043638
Martin‐Gallausiaux, C. (2018) · theses.fr (ABES) · doi:10.70675/c6162413z61d4z4a51z889bze8ca8724b717
Modulations nutritionnelles du microbiote intestinal et du métabolisme chez le chien
Moinard, A. (2020) · theses.fr (ABES) · doi:10.70675/c720b82az313fz4d78z8570zc8273d3391da
Zhang, J., Wang, Y., Yang, Y., Lin, H., Yang, Y., & Hu, D. (2026) · Fishes · doi:10.3390/fishes11040228
Wu, Y., Yan, H., Gui, C., Chen, Z., Liu, X., & Zhang, L. (2026) · Animals · doi:10.3390/ani16091346
Jeon, H. J., Moon, J. S., Jeong, H. M., Bang, W. Y., Kim, H., Kim, D., Shin, M., Yang, J., Shin, J., & Jung, Y. H. (2026) · Nutrients · doi:10.3390/nu18152466
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Vijverman, L., Maddalena, T., Delrue, C., & Speeckaert, M. M. (2026) · Biomedicines · doi:10.3390/biomedicines14102143
Metadata
- Authors
- Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D.
- Affiliations
- AgroParisTech (FR)
- Instituto de Agroquímica y Tecnología de Alimentos (ES)
- Corresponding author
- Davila, Anne-Marie
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 69
- Issue
- 1
- Pages
- 114-126
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2084796563
- Cited by
- 231
- References
- 182
- Citations by year
- 2026: 17 · 2025: 19 · 2024: 17 · 2023: 22 · 2022: 34 · 2021: 28 · 2020: 21 · 2019: 18 · 2018: 18 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 4 · 2013: 3
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Universidad de Chile (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- gut microbiota, amino acid metabolism, short-chain fatty acids, sulfide, ammonia, colonic mucosa
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