Cited by 57Skin Protection and Agingmelanin and skin pigmentationGenomics, phytochemicals, and oxidative stress

Dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating of Nrf2 and inhibiting MAPK pathways

Sun, Zhengwang, Park, Sang Yong, Hwang, Eunson, Park, Bom, Seo, Seul A, Cho, Jin-Gyeong, Zhang, Mengyang, Yi, Tae-Hoo·2016·Phytomedicine

Abstract

Background Foeniculum vulgare Mill (FV) has long been prescribed in traditional medicine due to its antioxidant anti-inflammatory properties. However, little research has been done on the use of FV to alleviate changes in UVB-induced photoaging PURPOSE: This study was to investigate the photoprotective effects and mechanism of FV in vitro and in vivo.Methods The anti-photoaging effect of FV was assessed in normal human dermal fibroblasts (NHDFs) in vitro. The secretion of reactive oxygen species (ROS), lactate dehydrogenase (LDH), GSH, matrix metalloproteinases (MMPs), procollagen type I, IL-6 and transforming growth factor-β1 (TGF-β1) were measured by kits. Additionally, the level of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), p-ERK and p38 were evaluated by western blotting. In vivo, H&E and Masson's trichrome staining were employed. The expression of MMP-1, procollagen type I, TGF-β1 and elastin were measured by western blot.Results FV significantly increased the production of collagen, elastin and TGF-β1 levels, while blocked matrix metalloproteinases (MMPs) production in UVB irradiation induced hairless mice, which were consistent with the result in NHDFs. Furthermore, FV dose-dependently decreased the production of ROS and LDH by promoting the nuclear amount of Nrf2 and enhancing the expression of cytoprotective antioxidants such as GSH. FV also significantly quenched UVB-induced phosphorylation of ERK and p38 in NHDFs.Conclusion Our results indicate that FV is a potential botanical agent for the treatment of skin damage induced by UV irradiation.

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Crossref · 10.1016/j.phymed.2016.06.008

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  • Oral supplementation with dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating Nrf2 and inhibiting MAPK pathways in HR-1 mice.

    “Oral supplementation with dietary Foeniculum vulgare Mill extract attenuated UVB irradiation-induced skin photoaging by activating Nrf2 and inhibiting MAPK pathways in HR-1 mice.”
  • Foeniculum vulgare extract dramatically improved production of collagen, elastin, and TGF-beta1 in mouse dorsal skin, while reducing skin MMP levels under UVB irradiation.

    “This extract dramatically improved the production of collagen, elastin, and TGF-β1 in mouse dorsal skin, while reducing skin MMP levels under UVB irradiation [119].”

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Authors
Sun, Z., Park, S. Y., Hwang, E., Park, B., Seo, S. A., Cho, J.-G., Zhang, M., & Yi, T.-H.
Affiliations
Kyung Hee University (KR)
Corresponding author
Yi, Tae-Hoo
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2016-11
Volume
23
Issue
12
Pages
1273-1284
ISSN
0944-7113 (ISSN-L)
OpenAlex
W2462600012
Cited by
57
References
32
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 2 · 2019: 11 · 2018: 10 · 2017: 2
FWCI
9.20
Type
journal article
Language
en
Open access
closed
Locations
  • Phytomedicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords
fennel, fennel extract, photoaging, UVB irradiation, Nrf2, MAPK signaling, ERK, p38 MAPK, reactive oxygen species, matrix metalloproteinases, collagen, elastin, TGF-β1, dermal fibroblasts, photoprotection, botanical medicine
MeSH terms
Antioxidants, Diet, Fibroblasts, Humans, Phosphorylation, Plant Extracts, Radiation-Protective Agents, Seeds, Skin, Ultraviolet Rays, Skin Aging, Gene Expression, MAP Kinase Signaling System, Foeniculum, p38 Mitogen-Activated Protein Kinases, NF-E2-Related Factor 2

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