CoChat
Sign Up
Cited by 115Regulation of Appetite and ObesityStress Responses and CortisolAdipokines, Inflammation, and Metabolic Diseases

Dynamic body weight and body composition changes in response to subordination stress

Open access
Tamashiro, Kellie L.K., Hegeman, Maria A., Nguyen, Mary M.N., Melhorn, Susan J., Ma, Li Yun, Woods, Stephen C., Sakai, Randall R.·2007·Physiology & Behavior
DOI 10.1016/j.physbeh.2007.04.004PMC PMC1986729
Open this paper in CoChat — free account

Abstract

Social stress is prevalent in many facets of modern society. Epidemiological data suggest that stress is linked to the development of overweight, obesity and metabolic disease. Although there are strong associations between the incidence of obesity with stress and elevated levels of hormones such as cortisol, there are limited animal models to allow investigation of the etiology of increased adiposity resulting from exposure to stress. Perhaps more importantly, an animal model that mirrors the consequences of stress in humans will provide a vehicle to develop rational clinical therapy to treat or prevent adverse outcomes from exposure to chronic social stress. In the visible burrow system (VBS) model of chronic social stress mixed gender colonies are housed for 2 week periods during which male rats of the colony quickly develop a dominance hierarchy. We found that social stress has significant effects on body weight and body composition such that subordinate rats progressively develop characteristics of obesity that occurs, in part, through neuroendocrine alterations and changes in food intake amount. Although subordinate rats are hyperphagic following social stress they do not increase their intake of sucrose solution as control and dominants do suggesting that they are anhedonic. Consumption of a high fat diet does not appear to affect development of a social hierarchy and appears to enhance the effect that chronic stress has on body composition. The visible burrow system (VBS) model of social stress may be a potential laboratory model for studying stress-associated metabolic disease, including the metabolic syndrome.

Integrity signals

Registry

Crossref · 10.1016/j.physbeh.2007.04.004

Cites

66 of 66 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Chronic high levels of insulin downregulate HPA axis responses and increase basal sympathetic tone.

    “chronic high levels of insulin have been shown to downregulate HPA axis responses and increase basal sympathetic tone”

    From Role of addiction and stress neurobiology on food intake and obesity (2018) · cites this paper as Tamashiro et al., 2007

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Tamashiro, K. L. K., Hegeman, M. A., Nguyen, M. M. N., Melhorn, S. J., Ma, L. Y., Woods, S. C., & Sakai, R. R.
Affiliations
University of Cincinnati (US)
Corresponding author
Sakai, Randall R.
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2007-07
Volume
91
Issue
4
Pages
440-448
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2007.04.004
PMC
PMC1986729
OpenAlex
W1997183808
Cited by
115
References
66
Citations by year
2025: 3 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 6 · 2017: 10 · 2016: 7 · 2015: 8 · 2014: 3 · 2013: 7 · 2012: 10
FWCI
0.88
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK17844, DK-066596, R01DK017844, R37DK017844, R01DK066596)
  • National Institute of Neurological Disorders and Stroke (NS 047791, F31NS047791)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
chronic social stress, subordination, body weight, body composition, obesity, hyperphagia, anhedonia, sucrose intake, high-fat diet, dominance hierarchy, neuroendocrine changes, cortisol, metabolic syndrome
MeSH terms
Animals, Body Composition, Body Weight, Dominance-Subordination, Humans, Stress, Psychological, Nonlinear Dynamics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review