High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels

Bocarsly, Miriam E.; Powell, Elyse S.; Avena, Nicole M.; Hoebel, Bartley G.

doi:10.1016/j.pbb.2010.02.012

Cited by 314Diet, Metabolism, and DiseaseRegulation of Appetite and ObesityBiochemical Analysis and Sensing Techniques

High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels

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Bocarsly, Miriam E., Powell, Elyse S., Avena, Nicole M., Hoebel, Bartley G.·2010·Pharmacology Biochemistry and Behavior

DOI 10.1016/j.pbb.2010.02.012PMC PMC3522469

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Abstract

High-fructose corn syrup (HFCS) accounts for as much as 40% of caloric sweeteners used in the United States. Some studies have shown that short-term access to HFCS can cause increased body weight, but the findings are mixed. The current study examined both short- and long-term effects of HFCS on body weight, body fat, and circulating triglycerides. In Experiment 1, male Sprague-Dawley rats were maintained for short term (8 weeks) on (1) 12 h/day of 8% HFCS, (2) 12 h/day 10% sucrose, (3) 24 h/day HFCS, all with ad libitum rodent chow, or (4) ad libitum chow alone. Rats with 12-h access to HFCS gained significantly more body weight than animals given equal access to 10% sucrose, even though they consumed the same number of total calories, but fewer calories from HFCS than sucrose. In Experiment 2, the long-term effects of HFCS on body weight and obesogenic parameters, as well as gender differences, were explored. Over the course of 6 or 7 months, both male and female rats with access to HFCS gained significantly more body weight than control groups. This increase in body weight with HFCS was accompanied by an increase in adipose fat, notably in the abdominal region, and elevated circulating triglyceride levels. Translated to humans, these results suggest that excessive consumption of HFCS may contribute to the incidence of obesity.

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High fructose corn syrup and other processed carbohydrates such as sucrose have been associated with fat accumulation.
“HFCS, and other processed carbohydrates such as sucrose, have been associated with fat accumulation [21, 22].”
From In a single-blind, matched group design: Branched-chain amino acid supplementation and resistance training maintains lean body mass during a caloric restricted diet (2016) · cites this paper as [22]

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Authors: Bocarsly, M. E., Powell, E. S., Avena, N. M., & Hoebel, B. G.
Affiliations: Princeton University (US)
Corresponding author: Hoebel, Bartley G.
ORCID: Bocarsly, Miriam E.
Avena, Nicole M.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2010-11
Volume: 97
Issue: 1
Pages: 101-106
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/j.pbb.2010.02.012
PMC: PMC3522469
OpenAlex: W2107572553
Cited by: 314
References: 58
Citations by year: 2026: 3 · 2025: 11 · 2024: 13 · 2023: 35 · 2022: 11 · 2021: 29 · 2020: 20 · 2019: 22 · 2018: 25 · 2017: 19 · 2016: 23 · 2015: 26 · 2014: 23 · 2013: 19 · 2012: 12
FWCI: 13.03
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Public Health Service
National Institute on Alcohol Abuse and Alcoholism (AA12882, R01AA012882)
National Institute of Diabetes and Digestive and Kidney Diseases (F32DK079793, DK-079793)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: high fructose corn syrup, obesity, weight gain, fat mass, abdominal fat, triglycerides, sucrose, caloric restriction, gender differences, obesogenic effects, dietary sweeteners
MeSH terms: Adipose Tissue, Animals, Body Weight, Zea mays, Female, Fructose, Male, Obesity, Sex Characteristics, Time Factors, Triglycerides, Weight Gain, Rats, Sprague-Dawley, Rats

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High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels

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