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Cited by 11Sleep and Wakefulness ResearchCircadian rhythm and melatoninSleep and Work-Related Fatigue

Cold exposure and/or fasting modulate the relationship between sleep and body temperature rhythms in mice

Sato, Nobuo, Marui, Shuri, Ozaki, Makoto, Nagashima, Kei·2015·Physiology & Behavior
DOI 10.1016/j.physbeh.2015.05.024
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Abstract

We assessed the relationship between core temperature (Tc) and sleep rhythms in mice, and examined the effects of ambient temperature and fasting. Tc, electroencephalograms (EEG), electromyograms (EMG), and spontaneous activity in male ICR mice (n=9) were measured by telemetry for 3 days under a 12:12h dark-light cycle. Mice were fed or fasted at an ambient temperature (Ta) of 27°C or 20°C for the final 30h of the experiment. The vigilance state was categorized into a wake state, rapid-eye movement (REM) sleep, and non-REM (NREM) sleep, and the total sleep time (TST) was assessed. Relationships between Tc and TST, NREM periods, and REM sleep were estimated using Pearson's correlation coefficient. During cold exposure, Tc decreased during the dark and light phases, and TST and the periods of NREM and REM sleep decreased during the dark phase. Throughout the fasting period, Tc also decreased during the dark and light phases. Furthermore, the decrease in Tc was augmented when fasting and cold were combined. TST and NREM sleep periods decreased in the light and dark phases, respectively, whereas REM sleep periods decreased in both phases. Negative linear correlations (r=-0.884 to -0.987) were observed between Tc and TST, NREM sleep periods, and REM sleep periods, except for Tc and REM sleep periods where fasting and cold conditions were combined. The correlations between sleep and Tc rhythms were well maintained during cold exposure and fasting. However, when cold and fasting were combined, REM sleep and Tc rhythms were desynchronized.

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  • Fever and sickness behavior in response to infection or inflammatory diseases are mediated by inflammatory mediators, including cytokines and prostaglandins that signal to the brain.

    “fever and sickness behavior in response to infection or inflammatory diseases are mediated by inflammatory mediators, including cytokines and PGs that signal to the brain (131, 487).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [487]

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Authors
Sato, N., Marui, S., Ozaki, M., & Nagashima, K.
Affiliations
  • Waseda University (JP)
  • Tokyo Women's Medical University (JP)
Corresponding author
Nagashima, Kei
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2015-10
Volume
149
Pages
69-75
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2015.05.024
OpenAlex
W1945076633
Cited by
11
References
41
Citations by year
2025: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2
FWCI
0.40
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
cold exposure, fasting, sleep rhythm, core body temperature, REM sleep, NREM sleep, total sleep time, ambient temperature, circadian rhythm, mice
MeSH terms
Analysis of Variance, Animals, Body Temperature, Circadian Rhythm, Cold Temperature, Electroencephalography, Electromyography, Fasting, Male, Mice, Inbred ICR, Motor Activity, Sleep, Time Factors, Mice

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