Cited by 504Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Vasopressin: Behavioral roles of an “original” neuropeptide

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Caldwell, Heather K., Lee, Heon-Jin, Macbeth, Abbe H., Young, W. Scott·2008·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2007.10.007PMC PMC2292122

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Abstract

Vasopressin (Avp) is mainly synthesized in the magnocellular cells of the hypothalamic supraoptic (SON) and paraventricular nuclei (PVN) whose axons project to the posterior pituitary. Avp is then released into the blood stream upon appropriate stimulation (e.g., hemorrhage or dehydration) to act at the kidneys and blood vessels. The brain also contains several populations of smaller, parvocellular neurons whose projections remain within the brain. These populations are located within the PVN, bed nucleus of the stria terminalis (BNST), medial amygdala (MeA) and suprachiasmatic nucleus (SCN). Since the 1950s, research examining the roles of Avp in the brain and periphery has intensified. The development of specific agonists and antagonists for Avp receptors has allowed for a better elucidation of its contributions to physiology and behavior. Anatomical, pharmacological and transgenic, including "knockout," animal studies have implicated Avp in the regulation of various social behaviors across species. Avp plays a prominent role in the regulation of aggression, generally of facilitating or promoting it. Affiliation and certain aspects of pair-bonding are also influenced by Avp. Memory, one of the first brain functions of Avp that was investigated, has been implicated especially strongly in social recognition. The roles of Avp in stress, anxiety, and depressive states are areas of active exploration. In this review, we concentrate on the scientific progress that has been made in understanding the role of Avp in regulating these and other behaviors across species. We also discuss the implications for human behavior.

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See all 504

Authors: Caldwell, H. K., Lee, H.-J., Macbeth, A. H., & Young, W. S.
Affiliations: United States Department of Health and Human Services (US)
Corresponding author: Young, W. Scott
ORCID: Caldwell, Heather K.
Lee, Heon-Jin
Young, W. Scott
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2008-01
Volume: 84
Issue: 1
Pages: 1-24
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2007.10.007
PMC: PMC2292122
OpenAlex: W2007086728
Cited by: 504
References: 327
Citations by year: 2026: 13 · 2025: 22 · 2024: 29 · 2023: 12 · 2022: 16 · 2021: 25 · 2020: 31 · 2019: 19 · 2018: 19 · 2017: 31 · 2016: 21 · 2015: 22 · 2014: 39 · 2013: 43 · 2012: 42
FWCI: 3.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (Z01MH002498)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: vasopressin, neuropeptides, social behavior, aggression, pair bonding, social recognition memory, stress, anxiety, depression, vasopressin receptor, parvocellular neurons, magnocellular neurons, hypothalamus, suprachiasmatic nucleus, bed nucleus of the stria terminalis, medial amygdala, knockout mice
MeSH terms: Aggression, Animals, Behavior, Animal, Brain, Humans, Hypothalamo-Hypophyseal System, Memory, Social Behavior, Stress, Psychological, Vasopressins, Receptors, Vasopressin

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Vasopressin: Behavioral roles of an “original” neuropeptide

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