Cited by 429Neuroendocrine regulation and behaviorEvolutionary Psychology and Human BehaviorOlfactory and Sensory Function Studies

Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: A review of single administration studies

Bos, Peter A., Panksepp, Jaak, Bluthé, Rose-Marie, Honk, Jack van·2012·Frontiers in Neuroendocrinology

Abstract

Steroids and peptides mediate a diverse array of animal social behaviors. Human research is restricted by technical-ethical limitations, and models of the neuroendocrine regulation of social-emotional behavior are therefore mainly limited to non-human species, often under the assumption that human social-emotional behavior is emancipated from hormonal control. Development of acute hormone administration procedures in human research, together with the advent of novel non-invasive neuroimaging techniques, have opened up opportunities to systematically study the neuroendocrinology of human social-emotional behavior. Here, we review all placebo-controlled single hormone administration studies addressing human social-emotional behavior, involving the steroids testosterone and estradiol, and the peptides oxytocin and vasopressin. These studies demonstrate substantial hormonal control over human social-emotional behavior and give insights into the underlying neural mechanisms. Finally, we propose a theoretical model that synthesizes detailed knowledge of the neuroendocrinology of social-emotional behavior in animals with the recently gained data from humans described in our review.

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Crossref · 10.1016/j.yfrne.2011.01.002

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Authors
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V.
Affiliations
  • Utrecht University (NL)
  • Washington State University (US)
  • Université de Bordeaux (FR)
  • University of Cape Town (ZA)
Corresponding author
Bos, Peter A.
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2012-01
Volume
33
Issue
1
Pages
17-35
ISSN
0091-3022 (ISSN-L)
OpenAlex
W2043985159
Cited by
429
References
227
Citations by year
2026: 9 · 2025: 11 · 2024: 9 · 2023: 16 · 2022: 18 · 2021: 19 · 2020: 19 · 2019: 33 · 2018: 23 · 2017: 31 · 2016: 38 · 2015: 51 · 2014: 43 · 2013: 56 · 2012: 38
FWCI
6.14
Type
journal article
Language
en
Open access
closed
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Evolutionary Psychology and Human Behavior
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Keywords
social-emotional behavior, neuroendocrinology, testosterone, estradiol, oxytocin, vasopressin, neuropeptides, steroid hormones, human social behavior
MeSH terms
Aggression, Animals, Arginine Vasopressin, Emotions, Empathy, Estradiol, Humans, Models, Neurological, Object Attachment, Oxytocin, Social Behavior, Social Perception, Testosterone, Vasopressins

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