Inhibition of vasopressin-stimulated flank marking behavior by V1-receptor antagonists
Abstract
Flank marking, a form of olfactory communication displayed by hamsters, is dependent upon vasopressin-sensitive neurons in the anterior hypothalamus. In the present study two vasopressin type-1 (V1) receptor antagonists, d(CH2)5Tyr(Me)AVP and dPTyr(Me)AVP were tested for their ability to block flank marking stimulated by the microinjection of arginine vasopressin (AVP) into the anterior hypothalamus. Dose-response curves were established for AVP and flank marking in the presence or absence of different concentrations of each antagonist. DPTyr(Me)AVP was microinjected into the anterior hypothalamus 1 h before the microinjection of AVP while d(CH2)5Tyr(Me)AVP and AVP were prepared together and delivered as a single microinjection. This procedure was necessary because dPTyr(Me)AVP, but not d(CH2)5Tyr(Me)AVP, had agonist activity when initially injected into the anterior hypothalamus in concentrations ranging from 0.90-900 microM. The ED50 values (microM) for dPTyr(Me)AVP and AVP were 17.9 and 0.90, respectively. The initial agonist activity of dPTyr(Me)AVP was always followed by blocker activity. Both V1-receptor antagonists caused a dose-dependent decrease in AVP-stimulated flank marking. Maximal inhibition of AVP-stimulated flank marking was produced with approximately 1.0 mM of either antagonist. Both antagonists blocked AVP-stimulated flank marking behavior for over 12 h following their microinjection.
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AVP acts on V1aRs to stimulate flank marking.
“Structure-activity studies as well as the central injection of highly selective V1a agonists and antagonists indicates that AVP acts on V1aRs to stimulate flank marking [59; 60].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [60]
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- Authors
- Ferris, C. F., Singer, E. A., Meenan, D. M., & Elliott Albers, H.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- University of Vienna (AT)
- Corresponding author
- Ferris, Craig F.
- ORCID
- Ferris, Craig F.
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 154
- Issue
- 2
- Pages
- 153-159
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2046364593
- Cited by
- 74
- References
- 21
- Citations by year
- 2023: 1 · 2022: 3 · 2020: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-23557)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- flank marking, vasopressin, V1 receptor antagonist, anterior hypothalamus, olfactory communication, hamster, d(CH2)5Tyr(Me)AVP, behavioral inhibition
- MeSH terms
- Animals, Animal Communication, Arginine Vasopressin, Dose-Response Relationship, Drug, Cricetinae, Male, Mesocricetus, Receptors, Angiotensin, Scent Glands, Vasopressins, Receptors, Vasopressin
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