Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery
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G-protein-coupled receptor n ligand
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A host of evidence reveals significant OT and V1aR crosstalk in other model species.
“A host of evidence reveals significant OT and V1aR crosstalk in other model species, including pharmacological studies (Gimpl and Fahrenholz, 2001; Gruber et al., 2012), physiological studies (Chini et al., 1996; Meyer-Lindenberg et al., 2011), and neuropeptide binding and behavioral changes (Loyens et al., 2012; Schorscher-Petcu et al., 2010; Song et al., 2014).”
From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Gruber et al., 2012
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Cites
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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design
Koehbach, J., O’Brien, M., Muttenthaler, M., Miazzo, M., Akcan, M., Elliott, A. G., Daly, N. L., Harvey, P. J., Arrowsmith, S., Gunasekera, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311183110 · Cited by 155 · see citing works
Self-citationPhysiology of invertebrate oxytocin and vasopressin neuropeptides
Gruber, C. W. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2013.072561 · Cited by 110 · see citing works
Self-citationNeuropeptide diversity and the regulation of social behavior in New World primates
French, J. A., Taylor, J. H., Mustoe, A. C., & Cavanaugh, J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.03.004 · Cited by 66 · see citing works
Insights into the molecular evolution of oxytocin receptor ligand binding
Koehbach, J., Stockner, T., Bergmayr, C., Muttenthaler, M., & Gruber, C. W. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120256 · Cited by 61 · see citing works
Self-citationGenetic Diversity in Oxytocin Ligands and Receptors in New World Monkeys
Ren, D., Lu, G., Moriyama, H., Mustoe, A. C., Harrison, E. B., & French, J. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0125775 · Cited by 47 · see citing works
- Authors
- Gruber, C. W., Koehbach, J., & Muttenthaler, M.
- Affiliations
- Medical University of Vienna (AT)
- Scripps Research Institute (US)
- Corresponding author
- Gruber, Christian W
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2012-09
- Volume
- 4
- Issue
- 14
- Pages
- 1791-1798
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- PMC
- PMC3816348
- OpenAlex
- W2153005615
- Cited by
- 49
- References
- 23
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 5
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Future Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Austrian Science Fund (P22889-B11)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- bioactive peptides, oxytocin, vasopressin, G protein-coupled receptors, peptide drug discovery, natural sources, peptidomimetics
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Oxytocin, Peptides, Vasopressins, Drug Discovery
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