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Cited by 195Parkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on BehaviorDeep Brain Stimulation and Movement Disorders

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The serotonergic system in Parkinson's disease

Huot, Philippe, Fox, Susan H., Brotchie, Jonathan M.·2011·Progress in Neurobiology
DOI 10.1016/j.pneurobio.2011.08.004
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Abstract

Although the cardinal manifestations of Parkinson's disease (PD) are attributed to a decline in dopamine levels in the striatum, a breadth of non-motor features and treatment-related complications in which the serotonergic system plays a pivotal role are increasingly recognised. Serotonin (5-HT)-mediated neurotransmission is altered in PD and the roles of the different 5-HT receptor subtypes in disease manifestations have been investigated. The aims of this article are to summarise and discuss all published preclinical and clinical studies that have investigated the serotonergic system in PD and related animal models, in order to recapitulate the state of the current knowledge and to identify areas that need further research and understanding.

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Authors
Huot, P., Fox, S. H., & Brotchie, J. M.
Affiliations
University Health Network (CA)
Corresponding author
Brotchie, Jonathan M.
ORCID
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2011-10
Volume
95
Issue
2
Pages
163-212
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/j.pneurobio.2011.08.004
OpenAlex
W1970083936
Cited by
195
References
962
Citations by year
2026: 6 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 14 · 2021: 8 · 2020: 10 · 2019: 13 · 2018: 8 · 2017: 14 · 2016: 16 · 2015: 19 · 2014: 19 · 2013: 20 · 2012: 14
FWCI
2.22
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords
Parkinson's disease, serotonergic system, serotonin, 5-HT receptor subtypes, non-motor symptoms, treatment complications, dopamine depletion, striatum, animal models
MeSH terms
Animals, Disease Models, Animal, Humans, Synaptic Transmission, Parkinson Disease, Receptors, Serotonin, Serotonin, Protein Isoforms, Molecular Targeted Therapy, Serotonergic Neurons

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