The Ventral Hippocampus Is the Embryonic Origin for Adult Neural Stem Cells in the Dentate Gyrus

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works

Neural consequences of enviromental enrichment

van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

Harfe, B. D., Scherz, P., Nissim, S., Tian, H., McMahon, A. P., & Tabin, C. J. (2004) · Cell · doi:10.1016/j.cell.2004.07.024 · Cited by 970 · see citing works

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

Encinas, J. M., Michurina, T. V., Peunova, N. I., Park, J.-H., Tordo, J., Peterson, D. A., Fishell, G., Koulakov, A. A., & Enikolopov, G. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.03.010 · Cited by 891 · see citing works

Migration and distribution of two populations of hippocampal granule cell precursors during the perinatal and postnatal periods

Altman, J., & Bayer, S. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903010304 · Cited by 819 · see citing works

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

Lai, K., Kaspar, B. K., Gage, F. H., & Schaffer, D. V. (2002) · Nature Neuroscience · doi:10.1038/nn983 · Cited by 798 · see citing works

Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

Machold, R. P., Hayashi, S., Rutlin, M. L., Muzumdar, M. D., Nery, S. V., Corbin, J. G., Gritli-Linde, A., Dellovade, T., Porter, J. A., Rubin, L. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00561-0 · Cited by 710 · see citing works

In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

Ahn, S., & Joyner, A. L. (2005) · Nature · doi:10.1038/nature03994 · Cited by 699 · see citing works

<i>Gli2</i>, but not<i>Gli1</i>, is required for initial Shh signaling and ectopic activation of the Shh pathway

Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D., & Joyner, A. L. (2002) · Development · doi:10.1242/dev.129.20.4753 · Cited by 692 · see citing works

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma

Schüller, U., Heine, V., Mao, J., Kho, A., Dillon, A. K., Han, Y.-G., Huillard, E., Sun, T., Ligon, A., Qian, Y., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.005 · Cited by 656 · see citing works

Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice

Goebbels, S., Bormuth, I., Bode, U., Hermanson, O., Schwab, M. H., & Nave, K. (2006) · genesis · doi:10.1002/dvg.20256 · Cited by 579 · see citing works

Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

Han, Y.-G., Spassky, N., Romaguera-Ros, M., Garcia-Verdugo, J.-M., Aguilar, A., Schneider-Maunoury, S., & Alvarez-Buylla, A. (2008) · Nature Neuroscience · doi:10.1038/nn2059 · Cited by 547 · see citing works

Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning

Ahn, S., & Joyner, A. L. (2004) · Cell · doi:10.1016/j.cell.2004.07.023 · Cited by 525 · see citing works

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

Favaro, R., Valotta, M., Ferri, L., Latorre, E., Mariani, J., Giachino, C., Lancini, C., Tosetti, V., Ottolenghi, S., Taylor, V., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2397 · Cited by 504 · see citing works

Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells

Altman, J., & Bayer, S. A. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903010302 · Cited by 401 · see citing works

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1

Galcerán, J., Miyashita-Lin, E. M., Devaney, E. J., Rubenstein, J. L. R., & Grosschedl, R. (2000) · Development · doi:10.1242/dev.127.3.469 · Cited by 399 · see citing works

Postnatal Neurogenesis in the Guinea-pig

Altman, J., & Das, G. D. (1967) · Nature · doi:10.1038/2141098a0 · Cited by 356 · see citing works

Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling

Breunig, J. J., Sarkisian, M. R., Arellano, J. I., Morozov, Y. M., Ayoub, A. E., Sojitra, S., Wang, B., Flavell, R. A., Rakic, P., & Town, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804558105 · Cited by 344 · see citing works

Lhx2 Selector Activity Specifies Cortical Identity and Suppresses Hippocampal Organizer Fate

Mangale, V. S., Hirokawa, K. E., Satyaki, P. R. V., Gokulchandran, N., Chikbire, S., Subramanian, L., Shetty, A. S., Martynoga, B., Paul, J., Mai, M. V., et al. (2008) · Science · doi:10.1126/science.1151695 · Cited by 316 · see citing works

Radial organization of the hippocampal dentate gyrus: A Golgi, ultrastructural, and immunocytochemical analysis in the developing rhesus monkey

Eckenhoff, M. F., & RAKIC, P. T. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230102 · Cited by 239 · see citing works

A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus

Machoň, O., Backman, M., Machoňová, O., Kozmík, Z., Vacı́k, T., Andersen, L., & Krauss, S. J. K. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.038 · Cited by 208 · see citing works

Wnt Signaling Mutants Have Decreased Dentate Granule Cell Production and Radial Glial Scaffolding Abnormalities

Zhou, C. J., Zhao, C., & Pleasure, S. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4071-03.2004 · Cited by 196 · see citing works

The organization of the embronic and early postnatal murine hippocampus. II. Development of entorhinal, commissural, and septal connections studied with the lipophilic tracer DiI

Supèr, H., & Soriano, E. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903440108 · Cited by 193 · see citing works

Genetic inducible fate mapping in mouse: Establishing genetic lineages and defining genetic neuroanatomy in the nervous system

Joyner, A. L., & Zervas, M. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20884 · Cited by 174 · see citing works

Sonic Hedgehog Regulates Discrete Populations of Astrocytes in the Adult Mouse Forebrain

Garcia, A. D. R., Petrova, R., Eng, L., & Joyner, A. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0830-10.2010 · Cited by 169 · see citing works

Morphogenesis of the Dentate Gyrus: What We Are Learning from Mouse Mutants

Li, G., & Pleasure, S. J. (2005) · Developmental Neuroscience · doi:10.1159/000085980 · Cited by 156 · see citing works

Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling

Li, G., Kataoka, H., Coughlin, S. R., & Pleasure, S. J. (2008) · Development · doi:10.1242/dev.025742 · Cited by 120 · see citing works

Ongoing interplay between the neural network and neurogenesis in the adult hippocampus

Li, G., & Pleasure, S. J. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.12.008 · Cited by 40 · see citing works

Clonal Architecture of the Mouse Hippocampus

Martin, L. A., Tan, S., & Goldowitz, D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03520.2002 · Cited by 37 · see citing works

Hilar Mossy Cells Share Developmental Influences with Dentate Granule Neurons

Li, G., Berger, O., Han, S.-M., Paredes, M. F., Wu, N.-C., & Pleasure, S. J. (2007) · Developmental Neuroscience · doi:10.1159/000110347 · Cited by 22 · see citing works

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

Gonçalves, J. T., Schafer, S. T., & Gage, F. H. (2016) · Cell · doi:10.1016/j.cell.2016.10.021 · Cited by 1,122 · see citing works

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

Bond, A. M., Ming, G.-L., & Song, H. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.003 · Cited by 791 · see citing works

The role of adult hippocampal neurogenesis in brain health and disease

Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works

Anterior hippocampus: the anatomy of perception, imagination and episodic memory

Zeidman, P., & Maguire, E. A. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.24 · Cited by 542 · see citing works

Neurogenesis in the embryonic and adult brain: same regulators, different roles

Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493 · see citing works

Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications

Tartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408 · see citing works

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.010 · Cited by 267 · see citing works

Effects of Microglia on Neurogenesis

Sato, K. (2015) · Glia · doi:10.1002/glia.22858 · Cited by 187 · see citing works

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Harris, L., Rigo, P., Stiehl, T., Gaber, Z. B., Austin, S. H. L., Masdeu, M. D. M., Edwards, A., Urbán, N., Marciniak-Czochra, A., & Guillemot, F. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.01.003 · Cited by 173 · see citing works

Sonic hedgehog signaling in the postnatal brain

Álvarez-Buylla, A., & Ihrie, R. A. (2014) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2014.05.008 · Cited by 100 · see citing works

Serotonin signaling at cilia synapses

DeLong, K., & Sheu, S.-H. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.102994 · Cited by 7 · see citing works