Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia
Abstract
Increased neuronal density, cortical thinning, and alterations of GABAergic interneurons in the prefrontal cortex have been associated with the pathophysiology of schizophrenia. This study used antibodies directed against the calcium-binding proteins, calretinin (CR), parvalbumin (PV), and calbindin (CB) to compare the relative density of subpopulations of GABAergic interneurons in BA9 of the prefrontal cortex from six subjects with schizophrenia and six control subjects matched for age, gender, and postmortem interval. The relative density of interneurons expressing CR, PV, or CB did not differ significantly between subjects with schizophrenia and control subjects. In addition, no change in somal size of immunoreactive (IR) neurons or cortical thickness was observed between the two groups. This study supports previous reports consistently demonstrating no change in the relative density of interneurons expressing CR in the dorsolateral prefrontal cortex in schizophrenia but does not support previous inconsistent findings that the relative density of interneurons expressing PV and CB might be altered in this disorder.
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Research on parvalbumin cell density in schizophrenia has yielded conflicting results.
“However, studies investigating PV cell density in schizophrenia have provided mixed results (Beasley et al, 2002;Hashimoto et al, 2003;Tooney and Chahl, 2004;Woo et al, 1997).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Tooney and Chahl, 2004
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- Authors
- Tooney, P. A., & Chahl, L. A.
- Affiliations
- University of Newcastle Australia (AU)
- Corresponding author
- Tooney, Paul A.
- ORCID
- Tooney, Paul A.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2004-03
- Volume
- 28
- Issue
- 2
- Pages
- 273-278
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2129283634
- Cited by
- 63
- References
- 22
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sylvia and Charles Viertel Charitable Foundation
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, prefrontal cortex, GABAergic interneurons, calcium-binding proteins, calretinin, parvalbumin, calbindin, dorsolateral prefrontal cortex, interneuron density, cortical thinning, somal size
- MeSH terms
- Adult, Aged, Analysis of Variance, Calcium-Binding Proteins, Cell Count, Female, gamma-Aminobutyric Acid, Humans, Immunohistochemistry, Male, Middle Aged, Neurons, Postmortem Changes, Schizophrenia, Case-Control Studies, Prefrontal Cortex, Cell Size
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