Cited by 63Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia

Tooney, Paul A., Chahl, Loris A.·2004·Progress in Neuro-Psychopharmacology and Biological Psychiatry

Abstract

Increased neuronal density, cortical thinning, and alterations of GABAergic interneurons in the prefrontal cortex have been associated with the pathophysiology of schizophrenia. This study used antibodies directed against the calcium-binding proteins, calretinin (CR), parvalbumin (PV), and calbindin (CB) to compare the relative density of subpopulations of GABAergic interneurons in BA9 of the prefrontal cortex from six subjects with schizophrenia and six control subjects matched for age, gender, and postmortem interval. The relative density of interneurons expressing CR, PV, or CB did not differ significantly between subjects with schizophrenia and control subjects. In addition, no change in somal size of immunoreactive (IR) neurons or cortical thickness was observed between the two groups. This study supports previous reports consistently demonstrating no change in the relative density of interneurons expressing CR in the dorsolateral prefrontal cortex in schizophrenia but does not support previous inconsistent findings that the relative density of interneurons expressing PV and CB might be altered in this disorder.

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Crossref · 10.1016/j.pnpbp.2003.10.004

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Authors
Tooney, P. A., & Chahl, L. A.
Affiliations
University of Newcastle Australia (AU)
Corresponding author
Tooney, Paul A.
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2004-03
Volume
28
Issue
2
Pages
273-278
ISSN
0278-5846 (ISSN-L)
OpenAlex
W2129283634
Cited by
63
References
22
Citations by year
2025: 1 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Sylvia and Charles Viertel Charitable Foundation
  • National Health and Medical Research Council
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
schizophrenia, prefrontal cortex, GABAergic interneurons, calcium-binding proteins, calretinin, parvalbumin, calbindin, dorsolateral prefrontal cortex, interneuron density, cortical thinning, somal size
MeSH terms
Adult, Aged, Analysis of Variance, Calcium-Binding Proteins, Cell Count, Female, gamma-Aminobutyric Acid, Humans, Immunohistochemistry, Male, Middle Aged, Neurons, Postmortem Changes, Schizophrenia, Case-Control Studies, Prefrontal Cortex, Cell Size

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