Cited by 96Neuroscience and Neuropharmacology ResearchMaternal Mental Health During Pregnancy and PostpartumStress Responses and Cortisol

Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders

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Fine, R, Zhang, J, Stevens, H E·2014·Molecular Psychiatry

Abstract

Prenatal stress is a risk factor for several psychiatric disorders in which inhibitory neuron pathology is implicated. A growing body of research demonstrates that inhibitory circuitry in the brain is directly and persistently affected by prenatal stress. This review synthesizes research that explores how this early developmental risk factor impacts inhibitory neurons and how these findings intersect with research on risk factors and inhibitory neuron pathophysiology in schizophrenia, anxiety, autism and Tourette syndrome. The specific impact of prenatal stress on inhibitory neurons, particularly developmental mechanisms, may elucidate further the pathophysiology of these disorders.

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Crossref · 10.1038/mp.2014.35

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  • Maternal physiology, particularly stress and nutrition, can greatly impact the neural and behavioral development of offspring.

    “This is in keeping with a large body of research showing that maternal physiology, particularly stress (85–87) and nutrition (88–90), can greatly impact the neural and behavioral development of offspring.”

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Authors
Fine, R., Zhang, J., & Stevens, H. E.
Affiliations
  • Yale University (US)
  • Shantou University (CN)
Corresponding author
Stevens, H E
Venue
Molecular Psychiatry
Published
2014-04-22
Volume
19
Issue
6
Pages
641-651
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2033776469
Cited by
96
References
157
Citations by year
2026: 4 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 4
FWCI
1.22
Type
journal article
Language
en
Open access
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (K08MH086812, R25MH077823)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
prenatal stress, inhibitory neurons, neuropsychiatric disorders, schizophrenia, anxiety, autism spectrum disorder, Tourette syndrome, inhibitory circuitry, brain development, developmental risk factors, pathophysiology
MeSH terms
Animals, Mental Disorders, Brain, Female, Humans, Neural Inhibition, Neural Pathways, Pregnancy, Prenatal Exposure Delayed Effects

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