Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders
Open accessAbstract
Prenatal stress is a risk factor for several psychiatric disorders in which inhibitory neuron pathology is implicated. A growing body of research demonstrates that inhibitory circuitry in the brain is directly and persistently affected by prenatal stress. This review synthesizes research that explores how this early developmental risk factor impacts inhibitory neurons and how these findings intersect with research on risk factors and inhibitory neuron pathophysiology in schizophrenia, anxiety, autism and Tourette syndrome. The specific impact of prenatal stress on inhibitory neurons, particularly developmental mechanisms, may elucidate further the pathophysiology of these disorders.
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Maternal physiology, particularly stress and nutrition, can greatly impact the neural and behavioral development of offspring.
“This is in keeping with a large body of research showing that maternal physiology, particularly stress (85–87) and nutrition (88–90), can greatly impact the neural and behavioral development of offspring.”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [86]
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Abbott, P. W., Gumusoglu, S. B., Bittle, J., Beversdorf, D. Q., & Stevens, H. E. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.01.019 · Cited by 109 · see citing works
Self-citationOtx2-PNN interaction to regulate cortical plasticity
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Oxytocin during Development: Possible Organizational Effects on Behavior
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- Authors
- Fine, R., Zhang, J., & Stevens, H. E.
- Affiliations
- Yale University (US)
- Shantou University (CN)
- Corresponding author
- Stevens, H E
- Venue
- Molecular Psychiatry
- Published
- 2014-04-22
- Volume
- 19
- Issue
- 6
- Pages
- 641-651
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC4031286
- OpenAlex
- W2033776469
- Cited by
- 96
- References
- 157
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 10 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 8 · 2014: 4
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K08MH086812, R25MH077823)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- prenatal stress, inhibitory neurons, neuropsychiatric disorders, schizophrenia, anxiety, autism spectrum disorder, Tourette syndrome, inhibitory circuitry, brain development, developmental risk factors, pathophysiology
- MeSH terms
- Animals, Mental Disorders, Brain, Female, Humans, Neural Inhibition, Neural Pathways, Pregnancy, Prenatal Exposure Delayed Effects
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