Decreased Glutamic Acid Decarboxylase67 Messenger RNA Expression in a Subset of Prefrontal Cortical γ-Aminobutyric Acid Neurons in Subjects With Schizophrenia

Volk, David W.; Austin, Mark C.; Pierri, Joseph N.; Sampson, Allan R.; Lewis, David A.

doi:10.1001/archpsyc.57.3.237

Cited by 697Schizophrenia research and treatmentNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Decreased Glutamic Acid Decarboxylase67 Messenger RNA Expression in a Subset of Prefrontal Cortical γ-Aminobutyric Acid Neurons in Subjects With Schizophrenia

Volk, David W., Austin, Mark C., Pierri, Joseph N., Sampson, Allan R., Lewis, David A.·2000·Archives of General Psychiatry

DOI 10.1001/archpsyc.57.3.237

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Abstract

BACKGROUND: Markers of gamma-aminobutyric acid (GABA) neurotransmission seem to be altered in the prefrontal cortex (PFC) of subjects with schizophrenia. We sought to determine whether the expression of the messenger RNA (mRNA) for the synthesizing enzyme of GABA, glutamic acid decarboxylase67 (GAD67), is decreased in the PFC of subjects with schizophrenia, whether this change is present in all or only some GABA neurons, and whether long-term treatment with haloperidol decanoate contributes to altered GAD67 mRNA expression. METHODS: Tissue sections from 10 pairs of subjects with schizophrenia and control subjects and 4 pairs of haloperidol-treated and control monkeys were processed for in situ hybridization histochemical analysis with sulfur-35-labeled oligonucleotide probes for GAD67 mRNA and exposed to nuclear emulsion. Within each layer of PFC area 9, neurons expressing a detectable level of GAD67 mRNA were quantified for cell density and the relative level of mRNA expression per cell (grain density per neuron). RESULTS: In subjects with schizophrenia, the density of labeled neurons was significantly (P<.05) decreased by 25% to 35% in cortical layers 3 to 5. In contrast, the mean grain density per labeled neuron did not differ across subject groups. Similar analyses in monkeys revealed no effect of long-term haloperidol treatment on either the density of the labeled neurons or the grain density per labeled neuron. CONCLUSIONS: These findings indicate that in subjects with schizophrenia, GAD67 mRNA expression is relatively unaltered in most PFC GABA neurons but is reduced below a detectable level in a subset of GABA neurons. Altered GABA neurotransmission in this subset may contribute to PFC dysfunction in subjects with schizophrenia.

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Post-mortem brain tissues from schizophrenia patients exhibit reduced PV and/or GAD67 mRNA, particularly in prefrontal cortex.
“In situ hybridization and RT-PCR studies indicate that post-mortem brain tissues from schizophrenia patients exhibit reduced PV and/or GAD67 mRNA, particularly in prefrontal cortex (Akbarian et al., 1995; Volk et al., 2000; Hashimoto et al., 2003, 2008a,b; Mellios et al., 2009).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Volk et al., 2000

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526 · see citing works
Applied Linear Statistical Models
Ziegel, E. R., Neter, J., Wasserman, W., & Kutner, M. (1992) · Technometrics · doi:10.2307/1269588 · Cited by 9,906 · see citing works
Applied Linear Statistical Models
Kutner, M., Nachtsheim, C. J., Neter, J., & Li, W. (1997) · Technometrics · doi:10.1080/00401706.1997.10485141 · Cited by 7,186 · see citing works
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD): Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476 · see citing works
Applied Linear Statistical Models.
Barnett, V., Neter, J., & Wasserman, W. (1975) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2984653 · Cited by 2,304 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Self-citation
Applied Linear Statistical Models
Ziegel, E. R., Neter, J., Kutner, M., Nachtsheim, C. J., & Wasserman, W. (1997) · Technometrics · doi:10.2307/1271154 · Cited by 1,309 · see citing works
Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works
Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients
Benes, F. M. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810350036005 · Cited by 894 · see citing works
Abnormally High Neuronal Density in the Schizophrenic Cortex
Selemon, L. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950220015005 · Cited by 876 · see citing works
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 753 · see citing works
Profound neuronal plasticity in response to inactivation of the dopamine transporter.
Jones, S., Gainetdinov, R., Jaber, M., Giros, B., Wightman, R., & Caron, M. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.7.4029 · Cited by 729 · see citing works
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
Garey, L. J., Ong, W., Patel, T. S., Kanani, M., Davis, A., Mortimer, A. M., Barnes, T., & Hirsch, S. R. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.4.446 · Cited by 719 · see citing works
Local and diffuse synaptic actions of GABA in the hippocampus
Isaacson, J. S., Solis, J. M., & Nicoll, R. A. (1993) · Neuron · doi:10.1016/0896-6273(93)90308-e · Cited by 688 · see citing works
Numbers and proportions of GABA-immunoreactive neurons in different areas of monkey cerebral cortex
Hendry, S., Schwark, H. D., Jones, E. G., & Yan, J. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-05-01503.1987 · Cited by 601 · see citing works
Pronounced Reduction of Total Neuron Number in Mediodorsal Thalamic Nucleus and Nucleus Accumbens in Schizophrenics
Pakkenberg, B. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810230039007 · Cited by 566 · see citing works
Brain Morphology and Schizophrenia: A Magnetic Resonance Imaging Study of Limbic, Prefrontal Cortex, and Caudate Structures
Breier, A. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120009003 · Cited by 513 · see citing works
Dopamine differentially regulates dynorphin, substance P, and enkephalin expression in striatal neurons: in situ hybridization histochemical analysis
Gerfen, C. R., McGinty, J. F., & Young, W. S. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-04-01016.1991 · Cited by 506 · see citing works
Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene.
Bu, D.-F., Erlander, M. G., Hitz, B. C., Tillakaratne, N. J. K., Kaufman, D. L., Wagner-McPherson, C., Evans, G. A., & Tobin, A. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2115 · Cited by 493 · see citing works
Distribution of D1- and D2-Dopamine Receptors, and Dopamine and Its Metabolites in the Human Brain
Hall, H., Sedvall, G., Magnusson, O., Kopp, J., Halldin, C., & Farde, L. (1994) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380111 · Cited by 441 · see citing works
Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia
Zipursky, R. B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820030027004 · Cited by 425 · see citing works
A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia
Woo, T.-U. W., Whitehead, R. E., Melchitzky, D. S., & Lewis, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5341 · Cited by 410 · see citing works
Self-citation
Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects
Akil, M., Pierri, J. N., Whitehead, R. E., Edgar, C. L., Mohila, C., Sampson, A. R., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.10.1580 · Cited by 393 · see citing works
Self-citation
Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics
Benes, F., Vincent, S. L., Alsterberg, G., Bird, E. D., & SanGiovanni, J. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00924.1992 · Cited by 367 · see citing works
The relative importance of premortem acidosis and postmortem interval for human brain gene expression studies: selective mRNA vulnerability and comparison with their encoded proteins
Harrison, P. J., Heath, P. R., Eastwood, S. L., Burnet, P. W. J., McDonald, B., & Pearson, R. C. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12102-a · Cited by 342 · see citing works
Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia. Regional and diagnostic specificity.
Glantz, L., & Lewis, D. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220065010 · Cited by 328 · see citing works
Self-citation
Regional Brain Abnormalities in Schizophrenia Measured With Magnetic Resonance Imaging
Andreasen, N. C. (1994) · JAMA · doi:10.1001/jama.1994.03520220057031 · Cited by 315 · see citing works
Dopamine receptors in human brain: Autoradiographic distribution of D2 sites
Camps, M., Cortés, R., Gueye, B., Probst, A., & Palacios, J. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90179-6 · Cited by 305 · see citing works
Alterations in Chandelier Neuron Axon Terminals in the Prefrontal Cortex of Schizophrenic Subjects
Pierri, J. N., Chaudry, A. S., Woo, T.-U. W., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1709 · Cited by 294 · see citing works
Self-citation
Activity-dependent regulation of GABA expression in the visual cortex of adult monkeys
Hendry, S. H. C. (1988) · Neuron · doi:10.1016/0896-6273(88)90169-9 · Cited by 273 · see citing works
Heterogeneity of chandelier neurons in monkey neocortex: Corticotropin‐releasing factor‐and parvalbumin‐immunoreactive populations
Lewis, D. A., & Lund, J. S. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930406 · Cited by 220 · see citing works
Self-citation
Reduced GABA uptake sites in the temporal lobe in schizophrenia
Simpson, M. D. C., Slater, P., Deakin, J. F. W., Royston, M. C., & Skan, W. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90819-7 · Cited by 192 · see citing works
Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons
Woo, T., Miller, J. L., & Lewis, D. A. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.1013 · Cited by 191 · see citing works
Self-citation
Principles and practice of psychopharmacotherapy
Janicak, P. G. (2001) · Cited by 190 · see citing works
Dopamine receptors in human brain: Autoradiographic distribution of D1 sites
Cortés, R., Gueye, B., Pazos, Á., Probst, A., & Palacios, J. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90178-4 · Cited by 190 · see citing works
Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons
DAVISS, S. R., & Lewis, D. A. (1995) · Psychiatry Research · doi:10.1016/0165-1781(95)02720-3 · Cited by 187 · see citing works
Self-citation
Cerebral structural pathology in schizophrenia: evidence for a selective prefrontal cortical defect
Shelton, R. C., Karson, C. N., Doran, A. R., Pickar, D., Bigelow, L. B., & Weinberger, D. R. (1988) · American Journal of Psychiatry · doi:10.1176/ajp.145.2.154 · Cited by 155 · see citing works
Evidence of glutamatergic deficiency in schizophrenia
Sherman, A. D., Davidson, A. T., Baruah, S., Hegwood, T. S., & Waziri, R. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90653-b · Cited by 154 · see citing works
Cerebral Gray Matter Volume Deficits in First Episode Psychosis
Zipursky, R. B., Lambe, E. K., Kapur, S., & Mikulis, D. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.6.540 · Cited by 148 · see citing works
Basal ganglia organization in amphibians: Chemoarchitecture
Marín, Ó., Smeets, W. J. A. J., & González, A. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980316)392:3 · Cited by 145 · see citing works
[3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics
Hanada, S., Mita, T., Nishino, N., & Tanaka, C. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90341-9 · Cited by 140 · see citing works
Altered ratios of alternatively spliced long and short γ2 subunit mRNAs of the γ-amino butyrate type A receptor in prefrontal cortex of schizophrenics
Huntsman, M. M., Tran, B., Potkin, S. G., Bunney, W. E., & Jones, E. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15066 · Cited by 134 · see citing works
Activity-dependent Changes in GAD and Preprotachykinin mRNAs in Visual Cortex of Adult Monkeys
Benson, D. L., Huntsman, M. M., & Jones, E. G. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.1.40 · Cited by 133 · see citing works
Sensory neuron number in neonatal and adult rats estimated by means of stereologic and profile-based methods
Popken, G. J., & Farel, P. B. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970915)386:1 · Cited by 117 · see citing works
Expression of Serotonin Transporter Messenger RNA in the Human Brain
Austin, M. C., Bradley, C. C., Mann, J. J., & Blakely, R. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.62062362.x · Cited by 85 · see citing works
Self-citation
Regionally selective deficits in uptake sites for glutamate and gamma-aminobutyric acid in the basal ganglia in schizophrenia
Simpson, M. D. C., Slater, P., Royston, M. C., et al. (1992) · Psychiatry Research · doi:10.1016/0165-1781(92)90119-n · Cited by 81 · see citing works
Regional brain abnormalities in schizophrenia measured with magnetic resonance imaging
Andreasen, N. C. (1994) · JAMA · doi:10.1001/jama.272.22.1763 · Cited by 78 · see citing works
Glutamate decarboxylase messenger RNA in rat pallidum: Comparison of the effects of haloperidol, clozapine and combined haloperidol-scopolamine treatments
Delfs, J. M., Anegawa, N. J., & Chesselet, M. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00572-m · Cited by 49 · see citing works
The sexually dimorphic nucleus of the hypothalamus contains GABA neurons in rat and man
Gao, B., & Moore, R. Y. (1996) · Brain Research · doi:10.1016/s0006-8993(96)01005-0 · Cited by 42 · see citing works
Expression of Glutamic Acid Decarboxylase mRNA in Striatum and Pallidum in an Animal Model of Tardive Dyskinesia
Delfs, J. M., Ellison, G. D., Mercugliano, M., & Chesselet, M. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1020 · Cited by 42 · see citing works
Neural Circuitry of the Prefrontal Cortex in Schizophrenia
Lewis, D. A. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160019004 · Cited by 34 · see citing works
Self-citation
Regional Distribution and Cellular Expression of Tryptophan Hydroxylase Messenger RNA in Postmortem Human Brainstem and Pineal Gland
Austin, M. C., & O'Donnell, S. M. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0722065.x · Cited by 25 · see citing works
Self-citation
Postnatal changes in enzyme activities of rat myocardial adenine nucleotide catabolic pathway
Wang, T., Tan, Z.-T., & Webb, W. R. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90338-9 · Cited by 19 · see citing works
GABAergic modulation of striatal peptide expression in rats and the alterations induced by dopamine antagonist treatment
Jolkkonen, J., Jenner, P., & MARSDEN, C. D. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90537-1 · Cited by 18 · see citing works
Irreversible blockade of D2 dopamine receptors by fluphenazine-N-mustard increases glutamic acid decarboxylase mRNA in rat striatum
Chen, J., & Weiss, B. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90539-w · Cited by 17 · see citing works
Increased frontal cortical GABA(A) receptors and decreased serotonin(2a) receptors in schizophrenia
Dean, B., Hussain, T., Scarr, E., et al. (1999) · Journal of Neurochemistry · Cited by 3 · see citing works

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Authors: Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Lewis, David A.
ORCID: Volk, David W.
Lewis, David A.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2000-03-01
Volume: 57
Issue: 3
Pages: 237
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.57.3.237
OpenAlex: W2162916231
Cited by: 697
References: 58
Citations by year: 2026: 8 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 10 · 2021: 17 · 2020: 19 · 2019: 25 · 2018: 16 · 2017: 19 · 2016: 25 · 2015: 43 · 2014: 40 · 2013: 42 · 2012: 34
FWCI: 19.07
Type: journal article
Language: en
Open access: closed
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH43784, MH-00519, MH 45156, P50MH045156)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, glutamic acid decarboxylase 67, GABAergic neurons, prefrontal cortex, GABAergic neurotransmission, haloperidol decanoate, antipsychotic treatment effects, prefrontal cortex dysfunction
MeSH terms: Adult, Animals, Female, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Humans, Isoenzymes, Macaca fascicularis, Male, Synaptic Transmission, Neurons, RNA, Messenger, Schizophrenia, Oligonucleotide Probes, Gene Expression, Prefrontal Cortex

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Decreased Glutamic Acid Decarboxylase67 Messenger RNA Expression in a Subset of Prefrontal Cortical γ-Aminobutyric Acid Neurons in Subjects With Schizophrenia

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